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The map label for this gene is ttuC [H]

Identifier: 189351987

GI number: 189351987

Start: 8371

End: 9456

Strand: Reverse

Name: ttuC [H]

Synonym: BMULJ_03204

Alternate gene names: 189351987

Gene position: 9456-8371 (Counterclockwise)

Preceding gene: 189351989

Following gene: 189351982

Centisome position: 0.38

GC content: 66.67

Gene sequence:

>1086_bases
ATGAGCGACAGGATCTACAACATTGCCGTCATTCCCGGCGACGGCATCGGCCGTGAAGTGATGCCCGAAGGGTTGCGCGC
GCTCGACGCGGTCACCGCGCGGTTCGGCATCCGCTTTCAATTCACACATATCGACTGGGCCAGCTGCGACTACTACGCGC
AGCACGGCAAGATGATGCCGGACGACTGGAAGGCGCAGCTGTCCGGCATGGACGCGATCCTGTTCGGCGCGGTCGGCTGG
CCGGCCACGGTGCCCGACCACGTATCGCTGTGGGGCTCGCTGCTGAAATTCCGTCGCGAGTTCGACCAGTACATCAATCT
GCGGCCCGCGCGCCTGTTCGACGGCGTGCCTTCGCCGCTCGCCGGCCGTCGCGCCGGCGACATCGACTTCATGATCGTGC
GCGAAAACACCGAGGGCGAATATTCGTCGGTCGGCGGCACGATGTTCGAAGGCACCGAGCGCGAAGTCGTGATGCAGCAG
GCGATTTTCACGCGGCACGGCACCGAGCGCGTGCTGAAGTTCGCGTTCGAACTCGCGCAGCGGCGCGCGAAACAGCTCAC
CGTCGCGACCAAGAGCAACGGCATCGCGATCAGCATGCCGTGGTGGGACGCGCGCGCGGCCGAGATGGCCGAACGCTATC
CGGACGTCGCGTGGGACAAGCAGCACATCGACATTCTGTGCGCGCGCTTCGTGCTGCAGCCGGATCGCTTCGACGTCGTC
GTCGCGTCGAACCTGTTCGGCGACATCCTGTCCGATCTCGGCCCCGCCTGCACGGGCACGATCGGCATCGCACCGTCGGG
CAACCTGAACCCCGATCGCACGTTCCCGTCGCTGTTCGAGCCCGTGCACGGATCGGCGCCCGACATCGCGGGGCAGTTCA
TCGCAAACCCGATCGCGATGATCTGGTCGGCCGCGATGATGCTCGACTTCCTCGGCAACGGAGCAGGCCGCGAACGCGAC
GCGCACGATGCGATCGTCGCGGCGATCGAGGACGTGCTGCGCAACGGGCCGCGTACGCGCGATCTTGGCGGCCAGGCTGC
CACGCAGGAAGTGGGCGAGGCGATCGCGGCGCGAATCGCGGGGTGA

Upstream 100 bases:

>100_bases
CGTTTCGCACGATTCTAATCCGGATGGAAATAAATAGAATGACGAGACGTTGCCGCCGCGCATGGTGCCGGCGGTCGTCC
GATCGGCGAAGGAGCGTTGG

Downstream 100 bases:

>100_bases
TGCGGCGGCGGTGCGTGGCGGCGGGGTTCTGGTTTTGCGGTGCTTGTCGGGTCGATCGGTGAGCGGTCGAGCGCGGTCAT
GCGCATGTCGGTGACGATGG

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: D-malate degradation protein A; D-malate oxidase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSDRIYNIAVIPGDGIGREVMPEGLRALDAVTARFGIRFQFTHIDWASCDYYAQHGKMMPDDWKAQLSGMDAILFGAVGW
PATVPDHVSLWGSLLKFRREFDQYINLRPARLFDGVPSPLAGRRAGDIDFMIVRENTEGEYSSVGGTMFEGTEREVVMQQ
AIFTRHGTERVLKFAFELAQRRAKQLTVATKSNGIAISMPWWDARAAEMAERYPDVAWDKQHIDILCARFVLQPDRFDVV
VASNLFGDILSDLGPACTGTIGIAPSGNLNPDRTFPSLFEPVHGSAPDIAGQFIANPIAMIWSAAMMLDFLGNGAGRERD
AHDAIVAAIEDVLRNGPRTRDLGGQAATQEVGEAIAARIAG

Sequences:

>Translated_361_residues
MSDRIYNIAVIPGDGIGREVMPEGLRALDAVTARFGIRFQFTHIDWASCDYYAQHGKMMPDDWKAQLSGMDAILFGAVGW
PATVPDHVSLWGSLLKFRREFDQYINLRPARLFDGVPSPLAGRRAGDIDFMIVRENTEGEYSSVGGTMFEGTEREVVMQQ
AIFTRHGTERVLKFAFELAQRRAKQLTVATKSNGIAISMPWWDARAAEMAERYPDVAWDKQHIDILCARFVLQPDRFDVV
VASNLFGDILSDLGPACTGTIGIAPSGNLNPDRTFPSLFEPVHGSAPDIAGQFIANPIAMIWSAAMMLDFLGNGAGRERD
AHDAIVAAIEDVLRNGPRTRDLGGQAATQEVGEAIAARIAG
>Mature_360_residues
SDRIYNIAVIPGDGIGREVMPEGLRALDAVTARFGIRFQFTHIDWASCDYYAQHGKMMPDDWKAQLSGMDAILFGAVGWP
ATVPDHVSLWGSLLKFRREFDQYINLRPARLFDGVPSPLAGRRAGDIDFMIVRENTEGEYSSVGGTMFEGTEREVVMQQA
IFTRHGTERVLKFAFELAQRRAKQLTVATKSNGIAISMPWWDARAAEMAERYPDVAWDKQHIDILCARFVLQPDRFDVVV
ASNLFGDILSDLGPACTGTIGIAPSGNLNPDRTFPSLFEPVHGSAPDIAGQFIANPIAMIWSAAMMLDFLGNGAGRERDA
HDAIVAAIEDVLRNGPRTRDLGGQAATQEVGEAIAARIAG

Specific function: Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in th

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=363, Percent_Identity=33.0578512396694, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI28178816, Length=359, Percent_Identity=26.1838440111421, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI28178821, Length=359, Percent_Identity=25.6267409470752, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4758582, Length=353, Percent_Identity=28.0453257790368, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI28178838, Length=314, Percent_Identity=28.6624203821656, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI28178819, Length=217, Percent_Identity=28.110599078341, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1788101, Length=357, Percent_Identity=70.3081232492997, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI87081683, Length=366, Percent_Identity=39.8907103825137, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1787381, Length=384, Percent_Identity=26.5625, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=364, Percent_Identity=31.8681318681319, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=30.8781869688385, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144293, Length=353, Percent_Identity=27.1954674220963, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=311, Percent_Identity=26.6881028938907, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322097, Length=368, Percent_Identity=35.8695652173913, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324709, Length=363, Percent_Identity=32.5068870523416, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319830, Length=372, Percent_Identity=33.8709677419355, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324291, Length=361, Percent_Identity=29.9168975069252, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24643268, Length=361, Percent_Identity=32.409972299169, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24643270, Length=361, Percent_Identity=32.409972299169, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24661184, Length=357, Percent_Identity=31.9327731092437, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161078637, Length=262, Percent_Identity=30.1526717557252, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161078635, Length=354, Percent_Identity=27.683615819209, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078633, Length=261, Percent_Identity=30.2681992337165, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24650122, Length=261, Percent_Identity=30.2681992337165, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078639, Length=263, Percent_Identity=30.0380228136882, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI281362242, Length=358, Percent_Identity=27.6536312849162, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24648872, Length=358, Percent_Identity=27.6536312849162, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130355, Length=358, Percent_Identity=26.2569832402235, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.83 [H]

Molecular weight: Translated: 39614; Mature: 39483

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRIYNIAVIPGDGIGREVMPEGLRALDAVTARFGIRFQFTHIDWASCDYYAQHGKMMP
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHCCCCCC
DDWKAQLSGMDAILFGAVGWPATVPDHVSLWGSLLKFRREFDQYINLRPARLFDGVPSPL
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
AGRRAGDIDFMIVRENTEGEYSSVGGTMFEGTEREVVMQQAIFTRHGTERVLKFAFELAQ
CCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RRAKQLTVATKSNGIAISMPWWDARAAEMAERYPDVAWDKQHIDILCARFVLQPDRFDVV
HHHHHEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEE
VASNLFGDILSDLGPACTGTIGIAPSGNLNPDRTFPSLFEPVHGSAPDIAGQFIANPIAM
EHHHHHHHHHHHCCCHHCCCEECCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
IWSAAMMLDFLGNGAGRERDAHDAIVAAIEDVLRNGPRTRDLGGQAATQEVGEAIAARIA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure 
SDRIYNIAVIPGDGIGREVMPEGLRALDAVTARFGIRFQFTHIDWASCDYYAQHGKMMP
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHCCCCCC
DDWKAQLSGMDAILFGAVGWPATVPDHVSLWGSLLKFRREFDQYINLRPARLFDGVPSPL
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
AGRRAGDIDFMIVRENTEGEYSSVGGTMFEGTEREVVMQQAIFTRHGTERVLKFAFELAQ
CCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RRAKQLTVATKSNGIAISMPWWDARAAEMAERYPDVAWDKQHIDILCARFVLQPDRFDVV
HHHHHEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEE
VASNLFGDILSDLGPACTGTIGIAPSGNLNPDRTFPSLFEPVHGSAPDIAGQFIANPIAM
EHHHHHHHHHHHCCCHHCCCEECCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHH
IWSAAMMLDFLGNGAGRERDAHDAIVAAIEDVLRNGPRTRDLGGQAATQEVGEAIAARIA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]