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The map label for this gene is hemF [H]

Identifier: 189184685

GI number: 189184685

Start: 1804127

End: 1804963

Strand: Direct

Name: hemF [H]

Synonym: OTT_1778

Alternate gene names: 189184685

Gene position: 1804127-1804963 (Clockwise)

Preceding gene: 189184684

Following gene: 189184686

Centisome position: 89.8

GC content: 32.62

Gene sequence:

>837_bases
ATGATTGAATATCAGGAAAAATGTTATCAATGGTTTAAAGAACTACGAGATGAGCTTATCAAAGCGTTTGAACTAATAGA
ACAGCATTACGCAAGTAGCAAAAAAGTTAAAGTAGCTAAATTTTCCCAGAGTCAGTGGAGCAGAGCTGGTGGTGGCGGTG
GAGAAATGTCGATAATGCGAGGTAATGTATTTGCTAAGGTTGGAGTTAATATTTCAAAAGTTTATGGAGACATGCCAATA
GCATTATGCGATATCATACCTTGCACTAATTATAGTTCTAATTTTTTTGCTACAGGTATTTCAGTAGTAGCACATATGAA
ATCTCCCCTAGTTCCAGCTGTGCATTTCAATACCAGATATTTAGAAACTAACAACTATTGGTTTGGCGGTGGAAGTGATT
TAACACCATTATATCCGGATAAGCTTGAGACAAAAAAATTTCATCAGGCTTTTCAAGTAGTATGTGATAAATATAACCCA
TCATATTATGAAAAATTTAAAGCAGAATGCGATAATTATTTTTATTTACCTCATAGAAAAGAGGTTAGAGGAGTTGGAGG
AGTATTTTATGATTATCTAAATAGCAAGAATTTTGATATAGATTTTAATTTTACTAAGAGTATTGGAGAAGCTTTTCTAG
CTATTTATCCTGATATTGTAAAAAGCAAAATGTTTTTGCCATGGAGCAATAGTCAATATGAAGCTCTACTAGTTAAACGC
GGAAGATATGTAGAATTTAATTTATTATATGATAGAGGTACTAAATTTGGATTAATGACTGATGGTAACGTTGATGCTAT
ATTAATGTCACTTCCACCTGAAGTAAAGTGGCCATAA

Upstream 100 bases:

>100_bases
CGTGGTCATTGAAAGCACTAATTTTCAACATATTTTATTTTAACTATTCAAAAGCTATGGTATATAAAAACTTAAATACA
GTAAGCTAAGTTTGAGATTT

Downstream 100 bases:

>100_bases
ATTATTATAACAAATTAAAAACAAATAATATTAAAGATAGTATTTACTAATATTATGAAAATAAATAAGATAATGTAGTA
TAAAAATTAAGCTATTACTG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MIEYQEKCYQWFKELRDELIKAFELIEQHYASSKKVKVAKFSQSQWSRAGGGGGEMSIMRGNVFAKVGVNISKVYGDMPI
ALCDIIPCTNYSSNFFATGISVVAHMKSPLVPAVHFNTRYLETNNYWFGGGSDLTPLYPDKLETKKFHQAFQVVCDKYNP
SYYEKFKAECDNYFYLPHRKEVRGVGGVFYDYLNSKNFDIDFNFTKSIGEAFLAIYPDIVKSKMFLPWSNSQYEALLVKR
GRYVEFNLLYDRGTKFGLMTDGNVDAILMSLPPEVKWP

Sequences:

>Translated_278_residues
MIEYQEKCYQWFKELRDELIKAFELIEQHYASSKKVKVAKFSQSQWSRAGGGGGEMSIMRGNVFAKVGVNISKVYGDMPI
ALCDIIPCTNYSSNFFATGISVVAHMKSPLVPAVHFNTRYLETNNYWFGGGSDLTPLYPDKLETKKFHQAFQVVCDKYNP
SYYEKFKAECDNYFYLPHRKEVRGVGGVFYDYLNSKNFDIDFNFTKSIGEAFLAIYPDIVKSKMFLPWSNSQYEALLVKR
GRYVEFNLLYDRGTKFGLMTDGNVDAILMSLPPEVKWP
>Mature_278_residues
MIEYQEKCYQWFKELRDELIKAFELIEQHYASSKKVKVAKFSQSQWSRAGGGGGEMSIMRGNVFAKVGVNISKVYGDMPI
ALCDIIPCTNYSSNFFATGISVVAHMKSPLVPAVHFNTRYLETNNYWFGGGSDLTPLYPDKLETKKFHQAFQVVCDKYNP
SYYEKFKAECDNYFYLPHRKEVRGVGGVFYDYLNSKNFDIDFNFTKSIGEAFLAIYPDIVKSKMFLPWSNSQYEALLVKR
GRYVEFNLLYDRGTKFGLMTDGNVDAILMSLPPEVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=254, Percent_Identity=40.5511811023622, Blast_Score=193, Evalue=1e-49,
Organism=Escherichia coli, GI1788777, Length=250, Percent_Identity=40.4, Blast_Score=195, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320249, Length=271, Percent_Identity=39.8523985239852, Blast_Score=198, Evalue=9e-52,
Organism=Drosophila melanogaster, GI17864388, Length=252, Percent_Identity=43.2539682539683, Blast_Score=217, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 32004; Mature: 32004

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEYQEKCYQWFKELRDELIKAFELIEQHYASSKKVKVAKFSQSQWSRAGGGGGEMSIMR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCEEEEEE
GNVFAKVGVNISKVYGDMPIALCDIIPCTNYSSNFFATGISVVAHMKSPLVPAVHFNTRY
CCEEEEECCCHHHHHCCCCEEEHHEEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCEEE
LETNNYWFGGGSDLTPLYPDKLETKKFHQAFQVVCDKYNPSYYEKFKAECDNYFYLPHRK
EECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCCCH
EVRGVGGVFYDYLNSKNFDIDFNFTKSIGEAFLAIYPDIVKSKMFLPWSNSQYEALLVKR
HHHHCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCEEECCCCCCCCEEEEEEC
GRYVEFNLLYDRGTKFGLMTDGNVDAILMSLPPEVKWP
CCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MIEYQEKCYQWFKELRDELIKAFELIEQHYASSKKVKVAKFSQSQWSRAGGGGGEMSIMR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCCCCEEEEEE
GNVFAKVGVNISKVYGDMPIALCDIIPCTNYSSNFFATGISVVAHMKSPLVPAVHFNTRY
CCEEEEECCCHHHHHCCCCEEEHHEEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCEEE
LETNNYWFGGGSDLTPLYPDKLETKKFHQAFQVVCDKYNPSYYEKFKAECDNYFYLPHRK
EECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCCCH
EVRGVGGVFYDYLNSKNFDIDFNFTKSIGEAFLAIYPDIVKSKMFLPWSNSQYEALLVKR
HHHHCCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCEEECCCCCCCCEEEEEEC
GRYVEFNLLYDRGTKFGLMTDGNVDAILMSLPPEVKWP
CCEEEEEEEEECCCEEEEEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA