Click here to switch to the map view.

The map label for this gene is uup [H]

Identifier: 189184299

GI number: 189184299

Start: 1419320

End: 1421125

Strand: Direct

Name: uup [H]

Synonym: OTT_1392

Alternate gene names: 189184299

Gene position: 1419320-1421125 (Clockwise)

Preceding gene: 189184293

Following gene: 189184302

Centisome position: 70.65

GC content: 29.24

Gene sequence:

>1806_bases
ATGAAACTATTACCAATATACTATATCAAGTATGGAGAACTATCTTTCGCCAACCAGAAGATTTTTGATAATTTAAATAT
TTATTTATACCCTGGTGACAAAATTTGTCTAATTGGTAAAAACGGATCTGGTAAATCAAGTCTAATGAAAATAATTAACT
CAGATTATCAATTAAATAAAGGTGAAATATTTCAGCATTCTGCAACTAAAATTGCTTACCTGCAACAAAATGTTACATGC
AACTTATCACTTAAAGTATATGACTTCATTACACAATCTATACCTAATAAAGAAAATTACTATCAGGCAGAAATTTTTAT
TGAAAAATTACAAATTGATGCTAGTAAAACTTTACGTAAACTTTCTGGAGGACAATTACGCAGAGTTCAACTAGCTAAAG
TTCTAGCTTCACATGCTGAAATATTATTGCTAGATGAACCAACTAATCATCTTGATATACAAGCAATTGAATGGTTAGAA
AGTTATGTAAAATCATATAAAGGAAGTATAATATGTATTAGCCATGATAGAGCATTTTTAACAGCAATAAGCAATAAAGT
TTGGTGGTTAGACAGATGCATTTTGCACCAATCAAATAAAGGATTTCAATTTTTTGAACAATGGCAAACTCAAATTATTG
ATCAAGAAGAATCTAATTTAATAAAATTAAATAAAAAAATTAATACTGAGCAACTTTGGCTACATCAAGGGATTTCTGCT
AGACGTAAGCGAAATCAGCGCAGATTATCAAATTTAAAAACATTACGAGAACAATTGAGATTTAGTTCGCAAAGGTTAGC
TAAAGCATCGCAGAAGGTTCAATTTTATCATAGTAATAATGAAAGTAATAAAGCTAAGTTTATTATTAGAGCGGAAAATG
TATGTTTTAAATATAATGACCAATTTGTTATTAAAAACTTTAATATTAATATAATTAAAGGTAATAAAATTGGAATAATT
GGCCCTAATGGTACTGGGAAATCTACTTTATTAAAACTATTCACTAAAAGTATTAAACCTAGCTCTGGTTCGATAGAACA
TGGCACTACTTTAGAAATAACTTATTTTGACCAGAATAAAAGCTCTTTAAATCCTAATCACACATTACAGCAAACACTTT
GCCCTACTGGAGGAGATCAAATTTTTTTGTCTGATAGAACTATACATGCAGGAGCATATCTTAAAAGTTTCATGTTCGAT
CCAAAGCTATTATCAGCAAAAGTGAGCACACTATCTGGTGGGGAAGCTACTCGTTTATTGTTAGCTAAGGCATTAATTAA
ACCTGGTAACCTATTGATACTTGATGAACCTACAAATGATTTAGATATTGACACTATAGAAATATTGCTAGATATATTGT
CAGATTATTCTGGTACGCTAATTGTTGTTAGCCACGATCGTGATTTCTTAAACAGATTAGTTACTAATACATTAGTATTT
GAAGGAAATGGTAATATTATCAACGTAATTGGTGGCTATCAGGATTACCTAGAATATTACTCTAGGTTAAATCAGCATAT
CACTAATACCAAGCTAGCAAAAAATAACAAAACAGTTAAACATCTAACTCCTAAACTTTCTACAAAACTATCTTATAAAT
TCCAGAGAATGCTCGATAGTATCCCTGAAGAAATAACTCAATTAGAAACTCAAGTTAAAGATTTAGAGAAAAAATTAGCT
GATCCTAACCTTTATCAAAATAACCCAGATGAATTTTTGCTATTTTCTAAGGAACTTGAAACATCAAAACTTAGAATAGA
AGAATTATTTGATACATGGCAAAAAATTGAAAACCGAAATATATAG

Upstream 100 bases:

>100_bases
GCAAATATTCATATTATTTTTTTAATGATATTTATTGTATAATCTAGCTGCATTAATATTAACTGGTACTTTAAAGTAAA
CTAACAATCTAAATATTTCA

Downstream 100 bases:

>100_bases
TCATTTACAATGAAGTTTGAACATAGAAAAAGCGGCAATAGCATCATAAGATTTACTAACAAGATATTTTATACGCAAAC
TTCATTGTAAATGACTATAG

Product: ABC transporter ATP-binding protein Uup

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MKLLPIYYIKYGELSFANQKIFDNLNIYLYPGDKICLIGKNGSGKSSLMKIINSDYQLNKGEIFQHSATKIAYLQQNVTC
NLSLKVYDFITQSIPNKENYYQAEIFIEKLQIDASKTLRKLSGGQLRRVQLAKVLASHAEILLLDEPTNHLDIQAIEWLE
SYVKSYKGSIICISHDRAFLTAISNKVWWLDRCILHQSNKGFQFFEQWQTQIIDQEESNLIKLNKKINTEQLWLHQGISA
RRKRNQRRLSNLKTLREQLRFSSQRLAKASQKVQFYHSNNESNKAKFIIRAENVCFKYNDQFVIKNFNINIIKGNKIGII
GPNGTGKSTLLKLFTKSIKPSSGSIEHGTTLEITYFDQNKSSLNPNHTLQQTLCPTGGDQIFLSDRTIHAGAYLKSFMFD
PKLLSAKVSTLSGGEATRLLLAKALIKPGNLLILDEPTNDLDIDTIEILLDILSDYSGTLIVVSHDRDFLNRLVTNTLVF
EGNGNIINVIGGYQDYLEYYSRLNQHITNTKLAKNNKTVKHLTPKLSTKLSYKFQRMLDSIPEEITQLETQVKDLEKKLA
DPNLYQNNPDEFLLFSKELETSKLRIEELFDTWQKIENRNI

Sequences:

>Translated_601_residues
MKLLPIYYIKYGELSFANQKIFDNLNIYLYPGDKICLIGKNGSGKSSLMKIINSDYQLNKGEIFQHSATKIAYLQQNVTC
NLSLKVYDFITQSIPNKENYYQAEIFIEKLQIDASKTLRKLSGGQLRRVQLAKVLASHAEILLLDEPTNHLDIQAIEWLE
SYVKSYKGSIICISHDRAFLTAISNKVWWLDRCILHQSNKGFQFFEQWQTQIIDQEESNLIKLNKKINTEQLWLHQGISA
RRKRNQRRLSNLKTLREQLRFSSQRLAKASQKVQFYHSNNESNKAKFIIRAENVCFKYNDQFVIKNFNINIIKGNKIGII
GPNGTGKSTLLKLFTKSIKPSSGSIEHGTTLEITYFDQNKSSLNPNHTLQQTLCPTGGDQIFLSDRTIHAGAYLKSFMFD
PKLLSAKVSTLSGGEATRLLLAKALIKPGNLLILDEPTNDLDIDTIEILLDILSDYSGTLIVVSHDRDFLNRLVTNTLVF
EGNGNIINVIGGYQDYLEYYSRLNQHITNTKLAKNNKTVKHLTPKLSTKLSYKFQRMLDSIPEEITQLETQVKDLEKKLA
DPNLYQNNPDEFLLFSKELETSKLRIEELFDTWQKIENRNI
>Mature_601_residues
MKLLPIYYIKYGELSFANQKIFDNLNIYLYPGDKICLIGKNGSGKSSLMKIINSDYQLNKGEIFQHSATKIAYLQQNVTC
NLSLKVYDFITQSIPNKENYYQAEIFIEKLQIDASKTLRKLSGGQLRRVQLAKVLASHAEILLLDEPTNHLDIQAIEWLE
SYVKSYKGSIICISHDRAFLTAISNKVWWLDRCILHQSNKGFQFFEQWQTQIIDQEESNLIKLNKKINTEQLWLHQGISA
RRKRNQRRLSNLKTLREQLRFSSQRLAKASQKVQFYHSNNESNKAKFIIRAENVCFKYNDQFVIKNFNINIIKGNKIGII
GPNGTGKSTLLKLFTKSIKPSSGSIEHGTTLEITYFDQNKSSLNPNHTLQQTLCPTGGDQIFLSDRTIHAGAYLKSFMFD
PKLLSAKVSTLSGGEATRLLLAKALIKPGNLLILDEPTNDLDIDTIEILLDILSDYSGTLIVVSHDRDFLNRLVTNTLVF
EGNGNIINVIGGYQDYLEYYSRLNQHITNTKLAKNNKTVKHLTPKLSTKLSYKFQRMLDSIPEEITQLETQVKDLEKKLA
DPNLYQNNPDEFLLFSKELETSKLRIEELFDTWQKIENRNI

Specific function: Unknown

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=525, Percent_Identity=26.6666666666667, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI10947135, Length=532, Percent_Identity=26.6917293233083, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI69354671, Length=532, Percent_Identity=26.6917293233083, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI27881506, Length=525, Percent_Identity=25.3333333333333, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI10947137, Length=525, Percent_Identity=25.3333333333333, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1787182, Length=626, Percent_Identity=34.0255591054313, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI2367384, Length=545, Percent_Identity=30.2752293577982, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1789751, Length=620, Percent_Identity=26.6129032258064, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1787041, Length=528, Percent_Identity=26.5151515151515, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1788761, Length=242, Percent_Identity=25.2066115702479, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1790190, Length=476, Percent_Identity=20.1680672268908, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789672, Length=220, Percent_Identity=25.9090909090909, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788165, Length=188, Percent_Identity=27.1276595744681, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788225, Length=229, Percent_Identity=23.1441048034935, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789891, Length=218, Percent_Identity=27.0642201834862, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786803, Length=219, Percent_Identity=28.7671232876712, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787712, Length=229, Percent_Identity=22.2707423580786, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788472, Length=186, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787758, Length=190, Percent_Identity=24.7368421052632, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786319, Length=176, Percent_Identity=28.4090909090909, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786698, Length=204, Percent_Identity=27.4509803921569, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=541, Percent_Identity=26.0628465804067, Blast_Score=178, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17553372, Length=545, Percent_Identity=26.7889908256881, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17555318, Length=513, Percent_Identity=24.1715399610136, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI115533608, Length=286, Percent_Identity=25.8741258741259, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=219, Percent_Identity=26.027397260274, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=219, Percent_Identity=26.027397260274, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321121, Length=409, Percent_Identity=26.6503667481663, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320874, Length=515, Percent_Identity=23.495145631068, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325030, Length=356, Percent_Identity=23.5955056179775, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324314, Length=355, Percent_Identity=23.6619718309859, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323278, Length=191, Percent_Identity=26.7015706806283, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24666836, Length=545, Percent_Identity=26.605504587156, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24641342, Length=550, Percent_Identity=26.5454545454545, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642252, Length=555, Percent_Identity=25.5855855855856, Blast_Score=152, Evalue=9e-37,
Organism=Drosophila melanogaster, GI18859989, Length=555, Percent_Identity=25.5855855855856, Blast_Score=152, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 69025; Mature: 69025

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLPIYYIKYGELSFANQKIFDNLNIYLYPGDKICLIGKNGSGKSSLMKIINSDYQLNK
CCCEEEEEEEECCCCCCCHHHHCCCEEEEECCCEEEEEECCCCCHHHHHHHHCCCCCCCC
GEIFQHSATKIAYLQQNVTCNLSLKVYDFITQSIPNKENYYQAEIFIEKLQIDASKTLRK
CCEECCCCCEEEEEECCCEEEEEEHHHHHHHHHCCCCCCCEEHEEEEEHHHCCHHHHHHH
LSGGQLRRVQLAKVLASHAEILLLDEPTNHLDIQAIEWLESYVKSYKGSIICISHDRAFL
HCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEE
TAISNKVWWLDRCILHQSNKGFQFFEQWQTQIIDQEESNLIKLNKKINTEQLWLHQGISA
HHHCCCHHEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCHHH
RRKRNQRRLSNLKTLREQLRFSSQRLAKASQKVQFYHSNNESNKAKFIIRAENVCFKYND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEECCEEEEECC
QFVIKNFNINIIKGNKIGIIGPNGTGKSTLLKLFTKSIKPSSGSIEHGTTLEITYFDQNK
EEEEEEEEEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCC
SSLNPNHTLQQTLCPTGGDQIFLSDRTIHAGAYLKSFMFDPKLLSAKVSTLSGGEATRLL
CCCCCCCCHHHHCCCCCCCEEEEECCEEEHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
LAKALIKPGNLLILDEPTNDLDIDTIEILLDILSDYSGTLIVVSHDRDFLNRLVTNTLVF
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEEE
EGNGNIINVIGGYQDYLEYYSRLNQHITNTKLAKNNKTVKHLTPKLSTKLSYKFQRMLDS
ECCCCEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCHHHCCCHHHHHHHHHHHHHHHH
IPEEITQLETQVKDLEKKLADPNLYQNNPDEFLLFSKELETSKLRIEELFDTWQKIENRN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
I
C
>Mature Secondary Structure
MKLLPIYYIKYGELSFANQKIFDNLNIYLYPGDKICLIGKNGSGKSSLMKIINSDYQLNK
CCCEEEEEEEECCCCCCCHHHHCCCEEEEECCCEEEEEECCCCCHHHHHHHHCCCCCCCC
GEIFQHSATKIAYLQQNVTCNLSLKVYDFITQSIPNKENYYQAEIFIEKLQIDASKTLRK
CCEECCCCCEEEEEECCCEEEEEEHHHHHHHHHCCCCCCCEEHEEEEEHHHCCHHHHHHH
LSGGQLRRVQLAKVLASHAEILLLDEPTNHLDIQAIEWLESYVKSYKGSIICISHDRAFL
HCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEE
TAISNKVWWLDRCILHQSNKGFQFFEQWQTQIIDQEESNLIKLNKKINTEQLWLHQGISA
HHHCCCHHEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCHHH
RRKRNQRRLSNLKTLREQLRFSSQRLAKASQKVQFYHSNNESNKAKFIIRAENVCFKYND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEECCEEEEECC
QFVIKNFNINIIKGNKIGIIGPNGTGKSTLLKLFTKSIKPSSGSIEHGTTLEITYFDQNK
EEEEEEEEEEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCC
SSLNPNHTLQQTLCPTGGDQIFLSDRTIHAGAYLKSFMFDPKLLSAKVSTLSGGEATRLL
CCCCCCCCHHHHCCCCCCCEEEEECCEEEHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
LAKALIKPGNLLILDEPTNDLDIDTIEILLDILSDYSGTLIVVSHDRDFLNRLVTNTLVF
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEEE
EGNGNIINVIGGYQDYLEYYSRLNQHITNTKLAKNNKTVKHLTPKLSTKLSYKFQRMLDS
ECCCCEEEEECCHHHHHHHHHHHHHHHCCCEECCCCCCHHHCCCHHHHHHHHHHHHHHHH
IPEEITQLETQVKDLEKKLADPNLYQNNPDEFLLFSKELETSKLRIEELFDTWQKIENRN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Endonuclease; Excision [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 9139905; 7751275 [H]