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The map label for this gene is ubiH [H]

Identifier: 189184257

GI number: 189184257

Start: 1376781

End: 1378043

Strand: Reverse

Name: ubiH [H]

Synonym: OTT_1350

Alternate gene names: 189184257

Gene position: 1378043-1376781 (Counterclockwise)

Preceding gene: 189184258

Following gene: 189184256

Centisome position: 68.59

GC content: 28.98

Gene sequence:

>1263_bases
ATGAAGAAAGAGGAAATAATTATATTAGGCTGTGGTTTCAATGGCATGATAACTGCACTAGGTCTAGCAAGTTATAATAT
TAAATCCACAATCATTGAAAAAAAAAATCTTTCAAATACAAACTATTTAGATACTAGAACAACAGCTTTAACTCAACGCT
CAAAATCAATTTTTAAGAACTTTAATATTTGGAAAGATATTGAGCCATATACCTCTAATATTAATGAAGTCTATGTCGTT
GATAACAAATCAACAATGATGGTACATCTAAATGCAAGTAAATCAGAGTTTGATAGTATTGGGTATATGATTGAAAACAG
TAACTTATATGTCAAATTAATAGAACTTGTTCAAAATAATCCTTTGATTAATGTAATTGATAATACTTCTTACGTATCGA
TTGATTCGCATCAACATAGCACTACAATTTACTTAACCAACAAGATATTTAACTCAAAAGATAATTCGAACATCACTGCA
ATTGATATTAATACTAGTAGTAAAATCAATTGCGAGCTCTTAATTGTTTGCGATGGCTGCAATTCAATTGCTAGAAAACA
ATATTTTGAATATTTTATTGATAAGGAGTATCATCAATCTGCAATAGTTTTTAACGTAAAACACCAAAAACAACACCTTG
GAACTGCTGTTGAGCATTTTTTGCCTAATGGTCCGTTTGCTACTTTACCTTTAGCTGATCAGCAGGTATCTTCAATAGTA
TGGGTAGAAAAGAGCAATTTAGCAACATTATATACTCAAATGGATAAAAAATCTCTAACCAATTATGTTCAAGATAAATT
TGGTTGGTCTCTTGGAAAAATTGAAATTATTACGACTCCAGTGTTATACCCATTAAAAGCTAAAATCGCAAAACAATATT
ATCATAATAACGTTGTATTAGTCGGAGATACTGCTCATATGATTCATCCTTTAGCTGGACAAGGGTTAAATCAAAGCATA
AAAGATATTGATAGCTTGACTAATATATTATACTCAAGAAAGTCATTAGGACTAGAGATGACAAGTAGTGAATTTAAACT
TTATCAAAGAGATAGATTCTTGGATAATTACACAATGTATTTACTTACTGATAATCTCAATAGACTATTTTCTAATAATT
TACCTTTGCTTGCTACAGCTCGTAAAATCAGCTTAGGGTTACTAGATAAATCTGTTATATTAAAAAGAATGATTATGAAA
TATGGCATGGGTAGCTATTCCGTTAGTTCCAAAATAATAAATATTGCAAATTATATTTTTTAA

Upstream 100 bases:

>100_bases
TAACTATTTCTCTGGATCGTATAATTACAGCTTTTAAATTTAGTTTACAAAGTATATCTTAATTAATTACTGTGTTCATA
TTTGGCAAGTAGGCAACTTA

Downstream 100 bases:

>100_bases
GTTACATTCAAGTAATAAATTATATTTAACACTAAAATGATTTATAGGATTAAGTAATGAATATACATGAATATCAGGCA
AAGGAAATTCTTAGTAAATA

Product: UbiH protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MKKEEIIILGCGFNGMITALGLASYNIKSTIIEKKNLSNTNYLDTRTTALTQRSKSIFKNFNIWKDIEPYTSNINEVYVV
DNKSTMMVHLNASKSEFDSIGYMIENSNLYVKLIELVQNNPLINVIDNTSYVSIDSHQHSTTIYLTNKIFNSKDNSNITA
IDINTSSKINCELLIVCDGCNSIARKQYFEYFIDKEYHQSAIVFNVKHQKQHLGTAVEHFLPNGPFATLPLADQQVSSIV
WVEKSNLATLYTQMDKKSLTNYVQDKFGWSLGKIEIITTPVLYPLKAKIAKQYYHNNVVLVGDTAHMIHPLAGQGLNQSI
KDIDSLTNILYSRKSLGLEMTSSEFKLYQRDRFLDNYTMYLLTDNLNRLFSNNLPLLATARKISLGLLDKSVILKRMIMK
YGMGSYSVSSKIINIANYIF

Sequences:

>Translated_420_residues
MKKEEIIILGCGFNGMITALGLASYNIKSTIIEKKNLSNTNYLDTRTTALTQRSKSIFKNFNIWKDIEPYTSNINEVYVV
DNKSTMMVHLNASKSEFDSIGYMIENSNLYVKLIELVQNNPLINVIDNTSYVSIDSHQHSTTIYLTNKIFNSKDNSNITA
IDINTSSKINCELLIVCDGCNSIARKQYFEYFIDKEYHQSAIVFNVKHQKQHLGTAVEHFLPNGPFATLPLADQQVSSIV
WVEKSNLATLYTQMDKKSLTNYVQDKFGWSLGKIEIITTPVLYPLKAKIAKQYYHNNVVLVGDTAHMIHPLAGQGLNQSI
KDIDSLTNILYSRKSLGLEMTSSEFKLYQRDRFLDNYTMYLLTDNLNRLFSNNLPLLATARKISLGLLDKSVILKRMIMK
YGMGSYSVSSKIINIANYIF
>Mature_420_residues
MKKEEIIILGCGFNGMITALGLASYNIKSTIIEKKNLSNTNYLDTRTTALTQRSKSIFKNFNIWKDIEPYTSNINEVYVV
DNKSTMMVHLNASKSEFDSIGYMIENSNLYVKLIELVQNNPLINVIDNTSYVSIDSHQHSTTIYLTNKIFNSKDNSNITA
IDINTSSKINCELLIVCDGCNSIARKQYFEYFIDKEYHQSAIVFNVKHQKQHLGTAVEHFLPNGPFATLPLADQQVSSIV
WVEKSNLATLYTQMDKKSLTNYVQDKFGWSLGKIEIITTPVLYPLKAKIAKQYYHNNVVLVGDTAHMIHPLAGQGLNQSI
KDIDSLTNILYSRKSLGLEMTSSEFKLYQRDRFLDNYTMYLLTDNLNRLFSNNLPLLATARKISLGLLDKSVILKRMIMK
YGMGSYSVSSKIINIANYIF

Specific function: Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=418, Percent_Identity=26.7942583732057, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI32967307, Length=353, Percent_Identity=28.328611898017, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1786883, Length=407, Percent_Identity=27.7641277641278, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789274, Length=386, Percent_Identity=24.8704663212435, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789273, Length=409, Percent_Identity=24.4498777506112, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI25146631, Length=454, Percent_Identity=24.6696035242291, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321694, Length=467, Percent_Identity=23.5546038543897, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19920760, Length=407, Percent_Identity=22.1130221130221, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 47776; Mature: 47776

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEEIIILGCGFNGMITALGLASYNIKSTIIEKKNLSNTNYLDTRTTALTQRSKSIFKN
CCCCCEEEEECCCCHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
FNIWKDIEPYTSNINEVYVVDNKSTMMVHLNASKSEFDSIGYMIENSNLYVKLIELVQNN
CCCCCCCCHHHCCCCEEEEEECCCEEEEEEECCCCCCCCCCEEEECCCEEEEEEHHHHCC
PLINVIDNTSYVSIDSHQHSTTIYLTNKIFNSKDNSNITAIDINTSSKINCELLIVCDGC
CEEEEECCCEEEEEECCCCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCC
NSIARKQYFEYFIDKEYHQSAIVFNVKHQKQHLGTAVEHFLPNGPFATLPLADQQVSSIV
CHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCEEECCCCHHHHCEEE
WVEKSNLATLYTQMDKKSLTNYVQDKFGWSLGKIEIITTPVLYPLKAKIAKQYYHNNVVL
EEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEE
VGDTAHMIHPLAGQGLNQSIKDIDSLTNILYSRKSLGLEMTSSEFKLYQRDRFLDNYTMY
EECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHCCCCEEEE
LLTDNLNRLFSNNLPLLATARKISLGLLDKSVILKRMIMKYGMGSYSVSSKIINIANYIF
EEECCHHHHHHCCCCEEEEEEEHEEHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKEEIIILGCGFNGMITALGLASYNIKSTIIEKKNLSNTNYLDTRTTALTQRSKSIFKN
CCCCCEEEEECCCCHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
FNIWKDIEPYTSNINEVYVVDNKSTMMVHLNASKSEFDSIGYMIENSNLYVKLIELVQNN
CCCCCCCCHHHCCCCEEEEEECCCEEEEEEECCCCCCCCCCEEEECCCEEEEEEHHHHCC
PLINVIDNTSYVSIDSHQHSTTIYLTNKIFNSKDNSNITAIDINTSSKINCELLIVCDGC
CEEEEECCCEEEEEECCCCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCC
NSIARKQYFEYFIDKEYHQSAIVFNVKHQKQHLGTAVEHFLPNGPFATLPLADQQVSSIV
CHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCEEECCCCHHHHCEEE
WVEKSNLATLYTQMDKKSLTNYVQDKFGWSLGKIEIITTPVLYPLKAKIAKQYYHNNVVL
EEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEE
VGDTAHMIHPLAGQGLNQSIKDIDSLTNILYSRKSLGLEMTSSEFKLYQRDRFLDNYTMY
EECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHCCCCEEEE
LLTDNLNRLFSNNLPLLATARKISLGLLDKSVILKRMIMKYGMGSYSVSSKIINIANYIF
EEECCHHHHHHCCCCEEEEEEEHEEHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydroxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10802164 [H]