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The map label for this gene is hemN [C]

Identifier: 189184081

GI number: 189184081

Start: 1201136

End: 1202338

Strand: Direct

Name: hemN [C]

Synonym: OTT_1174

Alternate gene names: 189184081

Gene position: 1201136-1202338 (Clockwise)

Preceding gene: 189184080

Following gene: 189184082

Centisome position: 59.79

GC content: 30.92

Gene sequence:

>1203_bases
TTGGTTTTTCCTGGTAATTTAGCCGATGAAAGTATATCTGTTTATATTCATTGGCCTTTTTGTTTGTCAAAATGTCCTTA
TTGTGATTTTAACTCTCATGTTGCTACTAAAGTTAATTTCAATGATTGGCAGCTAGCATTTCGTAAATCAATTAAGTATT
TTGAACCTTTGCTAACAGGTAAGATAATTAAGTCTATATTTTTTGGCGGAGGAACTCCTTCGTTAATGGATCCAGAATTA
GTAGCAAGTATTCTTAATTTGCTTTCTAGTTTAGCAAAATTTAGTGACACAGTTGAAATTACTCTTGAAGCTAATCCAAC
ATCCGTAGAAGCTAAAAAGTTTCAACAATTTAGGTTAGCTGGTATAAATAGAGTATCCATTGGTGTGCAGTCTTTGCGGC
TTAATAACTTAAAATTTTTAGGTCGTACTCATGATGTAGAATCAGCAAAACATGCTGTTACTTTAGCTAAAACAATATTT
CCAAAATTTTCATTTGATTTAATCTATGCTATAGCAGAGCAAGAAGTTGAAGAATGGAAACAAGAATTACAAGAAGCAAT
GCTGATTGCTGGTAGCCATGTTTCCATTTATCAATTAACAATTGAGAAAGGAACTAAATTTTTTGGCGATTATCGTAAAG
GAAAGTTTACACTGCCTAGTGATGAAACAGCTGCTAAACTTTATAACTATACTAACCACTATTTGAAAAATCTTGGTTAT
CATCGTTATGAAATTTCAAATTATAGTAAAATTGGAGCTGAATGTTATCATAACTTAAATTATTGGAATTATGGAAGCTA
TTTAGGAATAGGTCCAGGAGCACATAGCCGCATTGTCTGTTATAATAATGGAGTTAATGGTGATAGCAAATCTGTTAAAG
CAATAACTATGCAATATAATCCTCAAAAATGGCTGAATGATATTCTACTAGCTAGTGGTAATGGCATTCAAGACTTACAT
ACTTTAACTGATGATGACGTTATTAAAGAAGTCATAATAATGGGTCTACGTCTATCAACAGGAATATCGCACGATAGACT
ATTAGAATTAACTGGATGTAATTTTCAGCAAGCATTAAGCATGAAATATGTACATCAATTACAAGATACTGGATATATTG
TTATGTCTAATAATAATATTAGACTAACAGATAAGGCAATGTTAGTTTATAACTATATAGTTAATAAAATAGTTATTGGA
TAG

Upstream 100 bases:

>100_bases
TGAAATAACAAATGTTATTAGAGATAAAGGTTTTGATTATTTAATTAATAGTTTAAGGAATAAAAGTATATAAATTAAGA
TTTAAAAATTAAGTAAAATT

Downstream 100 bases:

>100_bases
GTATTTAGTTGCAGAGTAGCAAATAAAATAAAAAGATATAATGAACATTTTTGTCTTACATCAAGACCCCAATATTGCAG
CCCAAATGCTTTGTGATAAG

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MVFPGNLADESISVYIHWPFCLSKCPYCDFNSHVATKVNFNDWQLAFRKSIKYFEPLLTGKIIKSIFFGGGTPSLMDPEL
VASILNLLSSLAKFSDTVEITLEANPTSVEAKKFQQFRLAGINRVSIGVQSLRLNNLKFLGRTHDVESAKHAVTLAKTIF
PKFSFDLIYAIAEQEVEEWKQELQEAMLIAGSHVSIYQLTIEKGTKFFGDYRKGKFTLPSDETAAKLYNYTNHYLKNLGY
HRYEISNYSKIGAECYHNLNYWNYGSYLGIGPGAHSRIVCYNNGVNGDSKSVKAITMQYNPQKWLNDILLASGNGIQDLH
TLTDDDVIKEVIIMGLRLSTGISHDRLLELTGCNFQQALSMKYVHQLQDTGYIVMSNNNIRLTDKAMLVYNYIVNKIVIG

Sequences:

>Translated_400_residues
MVFPGNLADESISVYIHWPFCLSKCPYCDFNSHVATKVNFNDWQLAFRKSIKYFEPLLTGKIIKSIFFGGGTPSLMDPEL
VASILNLLSSLAKFSDTVEITLEANPTSVEAKKFQQFRLAGINRVSIGVQSLRLNNLKFLGRTHDVESAKHAVTLAKTIF
PKFSFDLIYAIAEQEVEEWKQELQEAMLIAGSHVSIYQLTIEKGTKFFGDYRKGKFTLPSDETAAKLYNYTNHYLKNLGY
HRYEISNYSKIGAECYHNLNYWNYGSYLGIGPGAHSRIVCYNNGVNGDSKSVKAITMQYNPQKWLNDILLASGNGIQDLH
TLTDDDVIKEVIIMGLRLSTGISHDRLLELTGCNFQQALSMKYVHQLQDTGYIVMSNNNIRLTDKAMLVYNYIVNKIVIG
>Mature_400_residues
MVFPGNLADESISVYIHWPFCLSKCPYCDFNSHVATKVNFNDWQLAFRKSIKYFEPLLTGKIIKSIFFGGGTPSLMDPEL
VASILNLLSSLAKFSDTVEITLEANPTSVEAKKFQQFRLAGINRVSIGVQSLRLNNLKFLGRTHDVESAKHAVTLAKTIF
PKFSFDLIYAIAEQEVEEWKQELQEAMLIAGSHVSIYQLTIEKGTKFFGDYRKGKFTLPSDETAAKLYNYTNHYLKNLGY
HRYEISNYSKIGAECYHNLNYWNYGSYLGIGPGAHSRIVCYNNGVNGDSKSVKAITMQYNPQKWLNDILLASGNGIQDLH
TLTDDDVIKEVIIMGLRLSTGISHDRLLELTGCNFQQALSMKYVHQLQDTGYIVMSNNNIRLTDKAMLVYNYIVNKIVIG

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=390, Percent_Identity=33.3333333333333, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1789325, Length=271, Percent_Identity=39.8523985239852, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87082341, Length=402, Percent_Identity=23.6318407960199, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 45231; Mature: 45231

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFPGNLADESISVYIHWPFCLSKCPYCDFNSHVATKVNFNDWQLAFRKSIKYFEPLLTG
CCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KIIKSIFFGGGTPSLMDPELVASILNLLSSLAKFSDTVEITLEANPTSVEAKKFQQFRLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHC
GINRVSIGVQSLRLNNLKFLGRTHDVESAKHAVTLAKTIFPKFSFDLIYAIAEQEVEEWK
CCCEEEECHHHHEECCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QELQEAMLIAGSHVSIYQLTIEKGTKFFGDYRKGKFTLPSDETAAKLYNYTNHYLKNLGY
HHHHHHHHHCCCCEEEEEEEEHHCCHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCC
HRYEISNYSKIGAECYHNLNYWNYGSYLGIGPGAHSRIVCYNNGVNGDSKSVKAITMQYN
EEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEEEEC
PQKWLNDILLASGNGIQDLHTLTDDDVIKEVIIMGLRLSTGISHDRLLELTGCNFQQALS
HHHHHHHHEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHH
MKYVHQLQDTGYIVMSNNNIRLTDKAMLVYNYIVNKIVIG
HHHHHHHCCCCEEEEECCEEEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVFPGNLADESISVYIHWPFCLSKCPYCDFNSHVATKVNFNDWQLAFRKSIKYFEPLLTG
CCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
KIIKSIFFGGGTPSLMDPELVASILNLLSSLAKFSDTVEITLEANPTSVEAKKFQQFRLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHC
GINRVSIGVQSLRLNNLKFLGRTHDVESAKHAVTLAKTIFPKFSFDLIYAIAEQEVEEWK
CCCEEEECHHHHEECCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QELQEAMLIAGSHVSIYQLTIEKGTKFFGDYRKGKFTLPSDETAAKLYNYTNHYLKNLGY
HHHHHHHHHCCCCEEEEEEEEHHCCHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCC
HRYEISNYSKIGAECYHNLNYWNYGSYLGIGPGAHSRIVCYNNGVNGDSKSVKAITMQYN
EEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEEEEC
PQKWLNDILLASGNGIQDLHTLTDDDVIKEVIIMGLRLSTGISHDRLLELTGCNFQQALS
HHHHHHHHEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHH
MKYVHQLQDTGYIVMSNNNIRLTDKAMLVYNYIVNKIVIG
HHHHHHHCCCCEEEEECCEEEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]