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The map label for this gene is adk

Identifier: 189183972

GI number: 189183972

Start: 1094492

End: 1095136

Strand: Direct

Name: adk

Synonym: OTT_1065

Alternate gene names: 189183972

Gene position: 1094492-1095136 (Clockwise)

Preceding gene: 189183971

Following gene: 189183973

Centisome position: 54.48

GC content: 27.6

Gene sequence:

>645_bases
GTGAGGATAAGTTTGATATTAGTTTTTATAGGACCGCCTGGCTCTGGTAAAGGTACACAAGCTTCTTTATTGTCAGAAAA
GTTTAGTATTATTTCTGTAGGAAAAGTTTTGCGAACTGTTATGGAAAGCAATACTGCTGAAGCAGATGTTGTTAAAAAAT
TTATCAAAAGTGGTAAGTTAGTACCATCAAATATTACTAATAAAATTGTAGTTAATGCTTTAAAAAATATAGATCAATGT
AAGAGTATAATACTAGATGGTTATCCTAGAGATATTTTTCAAGCTGATTTTTTGCAAGAAAATTTACAAATGGATTTCAA
AGTATTATTTTTTGATATTGATGATGCAGTAGTTCTGCGTAGGTTGAGTGGACGAATTAGTTGCACTGATTGTGGAACAA
TATATAATAAACTTTATTGTATGCCTAAAATTAATGGAGTTTGTGATATTTGTAATAGTTCAAGCTTTCAAAATAGAGTT
GATGATGATGAAAGTATAATTAAATTAAGGCTTGAATCTTATAAGAAGGAGACTTTGCCATTACTAGAATTTTATAAAGC
TCAAGATAAGCTAACATTAATTGATGCTAATCAATCTACAGAAAATATATTAAAAAAAATAAAAAAAATATCAGGAATAT
ATTGA

Upstream 100 bases:

>100_bases
TTGTAGTAAATGTAGTGCTTGATACTTTGTCACAAATTCAAACTTATATTTTTACTAGTAGATATGATTCATTGGTTAAG
AAAATGAAATACAAAGATAA

Downstream 100 bases:

>100_bases
TTTTTTATGACAATTTTATATTATTCAAGGCTTGTAAGCCAGATTATTTTAAGAAAGTAAACTAAGAGGAGTAAGGTTTA
TGGCTAGGATCTCAAATGTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRISLILVFIGPPGSGKGTQASLLSEKFSIISVGKVLRTVMESNTAEADVVKKFIKSGKLVPSNITNKIVVNALKNIDQC
KSIILDGYPRDIFQADFLQENLQMDFKVLFFDIDDAVVLRRLSGRISCTDCGTIYNKLYCMPKINGVCDICNSSSFQNRV
DDDESIIKLRLESYKKETLPLLEFYKAQDKLTLIDANQSTENILKKIKKISGIY

Sequences:

>Translated_214_residues
MRISLILVFIGPPGSGKGTQASLLSEKFSIISVGKVLRTVMESNTAEADVVKKFIKSGKLVPSNITNKIVVNALKNIDQC
KSIILDGYPRDIFQADFLQENLQMDFKVLFFDIDDAVVLRRLSGRISCTDCGTIYNKLYCMPKINGVCDICNSSSFQNRV
DDDESIIKLRLESYKKETLPLLEFYKAQDKLTLIDANQSTENILKKIKKISGIY
>Mature_214_residues
MRISLILVFIGPPGSGKGTQASLLSEKFSIISVGKVLRTVMESNTAEADVVKKFIKSGKLVPSNITNKIVVNALKNIDQC
KSIILDGYPRDIFQADFLQENLQMDFKVLFFDIDDAVVLRRLSGRISCTDCGTIYNKLYCMPKINGVCDICNSSSFQNRV
DDDESIIKLRLESYKKETLPLLEFYKAQDKLTLIDANQSTENILKKIKKISGIY

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=210, Percent_Identity=32.3809523809524, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=32.7014218009479, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=33.502538071066, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=28.9340101522843, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=28.9340101522843, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=28.9340101522843, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=28.9340101522843, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI28144899, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI28144897, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22749187, Length=183, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=30.8411214953271, Blast_Score=111, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=31.7535545023697, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=26.6355140186916, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=205, Percent_Identity=25.8536585365854, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=211, Percent_Identity=33.175355450237, Blast_Score=115, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=34.9462365591398, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=27.3584905660377, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=219, Percent_Identity=33.7899543378995, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=32.6530612244898, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=32.6530612244898, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=28.169014084507, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=28.169014084507, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24582962, Length=212, Percent_Identity=24.0566037735849, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=24.390243902439, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ORITI (B3CT26)

Other databases:

- EMBL:   AP008981
- RefSeq:   YP_001937757.1
- GeneID:   6338099
- GenomeReviews:   AP008981_GR
- KEGG:   ott:OTT_1065
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   CLSK2325654
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24016; Mature: 24016

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISLILVFIGPPGSGKGTQASLLSEKFSIISVGKVLRTVMESNTAEADVVKKFIKSGKL
CEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
VPSNITNKIVVNALKNIDQCKSIILDGYPRDIFQADFLQENLQMDFKVLFFDIDDAVVLR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
RLSGRISCTDCGTIYNKLYCMPKINGVCDICNSSSFQNRVDDDESIIKLRLESYKKETLP
HHCCCEEECHHHHHHHHEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCH
LLEFYKAQDKLTLIDANQSTENILKKIKKISGIY
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRISLILVFIGPPGSGKGTQASLLSEKFSIISVGKVLRTVMESNTAEADVVKKFIKSGKL
CEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
VPSNITNKIVVNALKNIDQCKSIILDGYPRDIFQADFLQENLQMDFKVLFFDIDDAVVLR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
RLSGRISCTDCGTIYNKLYCMPKINGVCDICNSSSFQNRVDDDESIIKLRLESYKKETLP
HHCCCEEECHHHHHHHHEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCH
LLEFYKAQDKLTLIDANQSTENILKKIKKISGIY
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA