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The map label for this gene is fabF [H]

Identifier: 189183944

GI number: 189183944

Start: 1077725

End: 1078996

Strand: Reverse

Name: fabF [H]

Synonym: OTT_1037

Alternate gene names: 189183944

Gene position: 1078996-1077725 (Counterclockwise)

Preceding gene: 189183945

Following gene: 189183942

Centisome position: 53.71

GC content: 35.3

Gene sequence:

>1272_bases
ATGGGTAACAGACGAGTAGTCATTACTGGAATAGGCATGGTAACTCCTTTAGGTGTCAATGCTAAAAGCTCATGGGAAAA
TCTTATACAATGCAAAAGTGGCATTACACGAATTCATAGATTTGACACTTCTAATCTAAAATGTAAAATTGCTGGGCTAG
TTTTACATGATAGCACACTAAAAATTTATAGCATTAGAGGGCATGAATTACTAGTTGACTCAACAGATAAAAAAAAGGAT
ATTTTCATTCAATATGGAATTATTGCTGCCCAAGAAGCTATAGAAGATAGTGGAATTGATCTTAGTAATAATGAAGAAGT
CAAAGACAATACAGGCGTCATTATTGGAACTGGCCTTGGAGGAATTCAATCAACAGCCGATAATGTGATCAATCTTTATA
TTAATAATAAAATAAGCACTTATTTTATTCCATCAATCCTATCAAACTTGATATCAGGCCATATTTCTATAATGTATGGC
TTTCGAGGACCAAATCAATCAGTTAACTCAGCATGCGCTACAGGAGCACAAGCAATCAGCGATGCAGCCCGTATGATAAA
ATGCAATGAAGCCAATATCATGATTGCAGGAGGCGCAGAAGCAGCTATCACAGATATTAGCATGGCTGGATTTAACGCAA
TTAAAGCTTTAAGCACAAAATATAACGACAATCCAAAAGCCGCTTGTAGACCCTGGGACAAAGATCGTAACGGTTTTGTA
ATGTCTGAAGGAGCAGGAGTAGTAGTTCTAGAGGAGCTAGAACATGCCAAAAAGCGCAAAGCAAAAATATATGCTGAATT
GACTGGATATGGACTAAGCAGCGATGCATATCATATTACCTCACCACACCCAGAAGGAATAGGTAGCAAAATAGCAATGT
TAAAAGCAATTAAAACTTCTAAAATTCATATTGGAGATATTAATTATATTAATGCTCATGCTACCTCTACAGAAAAGGGA
GACTTAATAGAATTAAAGGCCATTAAAAACCTCATTCTAAAAGAAAATTCTAAAGTTGCTATTTCATCAACTAAATCTTC
TACAGGTCACTTACTTGGTGCTAGCGGCAGCGTTGAAATAATATTTTCAGCTCTAGCATTACAAAATCAAGTTATACCAG
CAACATTAAATCTTGATAATCCTATAGAAGAAGCTAAAGATATTAACTTAGTACCAAACATACCTCAAGAATGCAAAATG
AACCATATACTGAGCAACTCGTTTGGCTTTGGCAGCACTAATGTTAGTATAGTACTAACAAAATTTGCCTAA

Upstream 100 bases:

>100_bases
CTTTAACAAAATAAAATTTAATTTTAAAATTAAATTATTTTAAACATCTAAAGGCTTATAAACATTATTTAACCTAACAA
AATTTCAACTTAAAATATCA

Downstream 100 bases:

>100_bases
AATTAACTCATAAAACTTACGCTATAATACTAACTGTTCAAAATGAGAAATATAATAAACCTTCTGAACTCTAGATTAAG
ATAATGCAATATAAGAAAAA

Product: 3-oxoacyl-[acyl carrier protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MGNRRVVITGIGMVTPLGVNAKSSWENLIQCKSGITRIHRFDTSNLKCKIAGLVLHDSTLKIYSIRGHELLVDSTDKKKD
IFIQYGIIAAQEAIEDSGIDLSNNEEVKDNTGVIIGTGLGGIQSTADNVINLYINNKISTYFIPSILSNLISGHISIMYG
FRGPNQSVNSACATGAQAISDAARMIKCNEANIMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFV
MSEGAGVVVLEELEHAKKRKAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTSKIHIGDINYINAHATSTEKG
DLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEIIFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKM
NHILSNSFGFGSTNVSIVLTKFA

Sequences:

>Translated_423_residues
MGNRRVVITGIGMVTPLGVNAKSSWENLIQCKSGITRIHRFDTSNLKCKIAGLVLHDSTLKIYSIRGHELLVDSTDKKKD
IFIQYGIIAAQEAIEDSGIDLSNNEEVKDNTGVIIGTGLGGIQSTADNVINLYINNKISTYFIPSILSNLISGHISIMYG
FRGPNQSVNSACATGAQAISDAARMIKCNEANIMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFV
MSEGAGVVVLEELEHAKKRKAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTSKIHIGDINYINAHATSTEKG
DLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEIIFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKM
NHILSNSFGFGSTNVSIVLTKFA
>Mature_422_residues
GNRRVVITGIGMVTPLGVNAKSSWENLIQCKSGITRIHRFDTSNLKCKIAGLVLHDSTLKIYSIRGHELLVDSTDKKKDI
FIQYGIIAAQEAIEDSGIDLSNNEEVKDNTGVIIGTGLGGIQSTADNVINLYINNKISTYFIPSILSNLISGHISIMYGF
RGPNQSVNSACATGAQAISDAARMIKCNEANIMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFVM
SEGAGVVVLEELEHAKKRKAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTSKIHIGDINYINAHATSTEKGD
LIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEIIFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKMN
HILSNSFGFGSTNVSIVLTKFA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=44.6808510638298, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=49.3243243243243, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=25.5269320843091, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1787337, Length=424, Percent_Identity=47.877358490566, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788663, Length=430, Percent_Identity=34.4186046511628, Blast_Score=225, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=428, Percent_Identity=35.981308411215, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=270, Percent_Identity=41.8518518518518, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=26.8115942028986, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=344, Percent_Identity=26.453488372093, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=38.963963963964, Blast_Score=286, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24644341, Length=430, Percent_Identity=41.1627906976744, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI19920632, Length=357, Percent_Identity=24.6498599439776, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI221330659, Length=357, Percent_Identity=24.6498599439776, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24581345, Length=338, Percent_Identity=23.3727810650888, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45329; Mature: 45197

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNRRVVITGIGMVTPLGVNAKSSWENLIQCKSGITRIHRFDTSNLKCKIAGLVLHDSTL
CCCCEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEEEECCEE
KIYSIRGHELLVDSTDKKKDIFIQYGIIAAQEAIEDSGIDLSNNEEVKDNTGVIIGTGLG
EEEEECCCEEEEECCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
GIQSTADNVINLYINNKISTYFIPSILSNLISGHISIMYGFRGPNQSVNSACATGAQAIS
CCHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHH
DAARMIKCNEANIMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFV
HHHHEEEECCCCEEEECCCCEEEEEEEHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
MSEGAGVVVLEELEHAKKRKAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTS
EECCCCEEEEHHHHHHHHHHHEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHCCC
KIHIGDINYINAHATSTEKGDLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEI
EEEECCCEEEECCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHH
IFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKMNHILSNSFGFGSTNVSIVLT
HHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE
KFA
ECC
>Mature Secondary Structure 
GNRRVVITGIGMVTPLGVNAKSSWENLIQCKSGITRIHRFDTSNLKCKIAGLVLHDSTL
CCCEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEEEECCEE
KIYSIRGHELLVDSTDKKKDIFIQYGIIAAQEAIEDSGIDLSNNEEVKDNTGVIIGTGLG
EEEEECCCEEEEECCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
GIQSTADNVINLYINNKISTYFIPSILSNLISGHISIMYGFRGPNQSVNSACATGAQAIS
CCHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHH
DAARMIKCNEANIMIAGGAEAAITDISMAGFNAIKALSTKYNDNPKAACRPWDKDRNGFV
HHHHEEEECCCCEEEECCCCEEEEEEEHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
MSEGAGVVVLEELEHAKKRKAKIYAELTGYGLSSDAYHITSPHPEGIGSKIAMLKAIKTS
EECCCCEEEEHHHHHHHHHHHEEEEEEECCCCCCCCEEECCCCCCCCCHHHHHHHHHCCC
KIHIGDINYINAHATSTEKGDLIELKAIKNLILKENSKVAISSTKSSTGHLLGASGSVEI
EEEECCCEEEECCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHH
IFSALALQNQVIPATLNLDNPIEEAKDINLVPNIPQECKMNHILSNSFGFGSTNVSIVLT
HHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE
KFA
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]