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The map label for this gene is nuoE [H]

Identifier: 189183822

GI number: 189183822

Start: 957237

End: 957791

Strand: Direct

Name: nuoE [H]

Synonym: OTT_0915

Alternate gene names: 189183822

Gene position: 957237-957791 (Clockwise)

Preceding gene: 189183821

Following gene: 189183823

Centisome position: 47.65

GC content: 27.93

Gene sequence:

>555_bases
ATGAATTCAGCTACAAAACAAGAATTTTCATTTTCCAGTGACACGTTAGTGATAGCAAAAAAAATCATTAATAATTATCC
AGCAGGAAAAGAAGCAAGTGCAGTTTTAGCAATATTAGACCTAGCGCAAAATCAAAATAATAATTGGCTTTCTAATAGTT
GTATTGAATATGTTGCAAAGTTACTTAAGATGCCATATATCAAGGTATATGAAATTGCAAGTTTTTATACTATGTTTAAT
CTACAACCAATAGGTAAATATCATATACAAATTTGCTGTACTACACCATGTTGGTTAAGAGGATCAGATGACATCATGAA
TTTCTGTAAAAAATTATTAAAAATTGAAACTGGCAAAACTTCTCAGGATAAATTATTTACAGTAAGTGAAACTGAATGTC
TTGGAGCTTGTAGAAATGCTCCAGTAGTACAAATTAATCATGATTATTACGAAAATCTTACTAATGATAAAATCGAAGAA
ATTATCAATAATCTGCATGCTAAAGATTTACAAAAAAAATCTGAACTAAAACCTGATAATAAAACTGACTTATAA

Upstream 100 bases:

>100_bases
CTCATCTGCAAGGATTAGATTTTATGGCTCGAGGACATTCACTATCTGATATTATAACCATTATAGCAACACTTGATATA
GTTTTTGGAGAAATAGACAG

Downstream 100 bases:

>100_bases
CTCAAGAGCAATTATAAATGTTAAATATTGAGGATAAAATTTTTACCAATTTATCTGGTTCTATGGCAGTTGACCTTGCC
AGCGCTAAAAAGCGCGGTGA

Product: NADH dehydrogenase I chain E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MNSATKQEFSFSSDTLVIAKKIINNYPAGKEASAVLAILDLAQNQNNNWLSNSCIEYVAKLLKMPYIKVYEIASFYTMFN
LQPIGKYHIQICCTTPCWLRGSDDIMNFCKKLLKIETGKTSQDKLFTVSETECLGACRNAPVVQINHDYYENLTNDKIEE
IINNLHAKDLQKKSELKPDNKTDL

Sequences:

>Translated_184_residues
MNSATKQEFSFSSDTLVIAKKIINNYPAGKEASAVLAILDLAQNQNNNWLSNSCIEYVAKLLKMPYIKVYEIASFYTMFN
LQPIGKYHIQICCTTPCWLRGSDDIMNFCKKLLKIETGKTSQDKLFTVSETECLGACRNAPVVQINHDYYENLTNDKIEE
IINNLHAKDLQKKSELKPDNKTDL
>Mature_184_residues
MNSATKQEFSFSSDTLVIAKKIINNYPAGKEASAVLAILDLAQNQNNNWLSNSCIEYVAKLLKMPYIKVYEIASFYTMFN
LQPIGKYHIQICCTTPCWLRGSDDIMNFCKKLLKIETGKTSQDKLFTVSETECLGACRNAPVVQINHDYYENLTNDKIEE
IINNLHAKDLQKKSELKPDNKTDL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=166, Percent_Identity=53.0120481927711, Blast_Score=187, Evalue=3e-48,
Organism=Escherichia coli, GI1788621, Length=132, Percent_Identity=31.0606060606061, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561328, Length=160, Percent_Identity=49.375, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI18859877, Length=159, Percent_Identity=52.2012578616352, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI21355353, Length=159, Percent_Identity=42.1383647798742, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 20940; Mature: 20940

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSATKQEFSFSSDTLVIAKKIINNYPAGKEASAVLAILDLAQNQNNNWLSNSCIEYVAK
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LLKMPYIKVYEIASFYTMFNLQPIGKYHIQICCTTPCWLRGSDDIMNFCKKLLKIETGKT
HHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
SQDKLFTVSETECLGACRNAPVVQINHDYYENLTNDKIEEIINNLHAKDLQKKSELKPDN
CCCCEEEECHHHHHHHHCCCCEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
KTDL
CCCC
>Mature Secondary Structure
MNSATKQEFSFSSDTLVIAKKIINNYPAGKEASAVLAILDLAQNQNNNWLSNSCIEYVAK
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LLKMPYIKVYEIASFYTMFNLQPIGKYHIQICCTTPCWLRGSDDIMNFCKKLLKIETGKT
HHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
SQDKLFTVSETECLGACRNAPVVQINHDYYENLTNDKIEEIINNLHAKDLQKKSELKPDN
CCCCEEEECHHHHHHHHCCCCEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
KTDL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]