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The map label for this gene is nuoD [H]

Identifier: 189183821

GI number: 189183821

Start: 956050

End: 957240

Strand: Direct

Name: nuoD [H]

Synonym: OTT_0914

Alternate gene names: 189183821

Gene position: 956050-957240 (Clockwise)

Preceding gene: 189183820

Following gene: 189183822

Centisome position: 47.59

GC content: 35.1

Gene sequence:

>1191_bases
ATGGCATTAAAAAAAAGGTCCAAACATTCTAAAAAATTCAAGTTAAATCTTGGGCCACAGCATCCTGCTACACATGGAGT
ATTACGGCTAATATTAGAAATGGATGGCGAAATAGTTGAAAGGGCTGATCCGCATATTGGACTCTTACATCGCGGCACCG
AAAAGTTAATTGAATATAAAACATATTTGCAGGCAATACCTTATTTTGATAGGTTAGATTATGTTTCTCCAATGTGTCAA
GAACATGCTTTTGCTTTAGCAATAGAGCATTTATTAAAGTGCGAAGTGCCCTTAAGAGCTCAATATATTAGAGTTATGTT
TTCTGAGTTAACTAGAATACTAAATCATACATTAAATATAGCTACTCAAGCACTTGATGTTGGAGCTACTACTCCATTAT
TGTGGATGTTTGAAGAACGAGAAAAAATCATGGAATTTTACGAAAGAGTTTCAGGATCGAGGTTACATGCTAATTATTTT
CGCCCTGGAGGTGTATCGCAAGATTTACCTGAAGGTTTAATTGAGAATATCGCAGATTTTTGTGAACAATTTCCATGCAA
AATAGCAGATCTTGAAACCTTGCTTACCGATAATCGAATTTGGAAACAAAGAACAGTAGATATTGGTATTGTATCTAAGC
AGCAAGCTATGGATTGGGGATTCTCAGGAGTAATGCTTAGAGGATCTGGCATTGCTTGGGATTTAAGAAAATCACAACCT
TATGACCAATATGCTAATTTAGATTTTGATGTAGCTATTGGTAAAAATGGTGACTGTTATGATAGATATTTGATTAGAAT
TGAAGAAATGTATCAATCAATAAAAATAATTAAGCAATGCATTCAAAAAATGCCAGCAGGAGAAATTAGAACTCAGGATC
CCTCTATTTCGCCTCCTAAAAGATCAGAAATAAAAAAATCAATGGAAGCACTCATTAATCATTTTAAACTCTACTCTGAA
GGATATAATGTTCCAGCAGGAGAAGTATATGCAGCAGTTGAAGCCCCTAAAGGTGAATTTGGAGTTTACTTATATTCTGA
TGGTACTAATCGACCGTATCGGTGCCGCATTAAAGCCCCAGGCTTTGCTCATCTGCAAGGATTAGATTTTATGGCTCGAG
GACATTCACTATCTGATATTATAACCATTATAGCAACACTTGATATAGTTTTTGGAGAAATAGACAGATGA

Upstream 100 bases:

>100_bases
TATATGAACCTGTAAAATTAGATCAAGAATATCGAAATTTTAACTTTTCTTCTCCTTGGCAAGGGCCAAAATCAACAATT
CAAGACTAAGTAATATTATA

Downstream 100 bases:

>100_bases
ATTCAGCTACAAAACAAGAATTTTCATTTTCCAGTGACACGTTAGTGATAGCAAAAAAAATCATTAATAATTATCCAGCA
GGAAAAGAAGCAAGTGCAGT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MALKKRSKHSKKFKLNLGPQHPATHGVLRLILEMDGEIVERADPHIGLLHRGTEKLIEYKTYLQAIPYFDRLDYVSPMCQ
EHAFALAIEHLLKCEVPLRAQYIRVMFSELTRILNHTLNIATQALDVGATTPLLWMFEEREKIMEFYERVSGSRLHANYF
RPGGVSQDLPEGLIENIADFCEQFPCKIADLETLLTDNRIWKQRTVDIGIVSKQQAMDWGFSGVMLRGSGIAWDLRKSQP
YDQYANLDFDVAIGKNGDCYDRYLIRIEEMYQSIKIIKQCIQKMPAGEIRTQDPSISPPKRSEIKKSMEALINHFKLYSE
GYNVPAGEVYAAVEAPKGEFGVYLYSDGTNRPYRCRIKAPGFAHLQGLDFMARGHSLSDIITIIATLDIVFGEIDR

Sequences:

>Translated_396_residues
MALKKRSKHSKKFKLNLGPQHPATHGVLRLILEMDGEIVERADPHIGLLHRGTEKLIEYKTYLQAIPYFDRLDYVSPMCQ
EHAFALAIEHLLKCEVPLRAQYIRVMFSELTRILNHTLNIATQALDVGATTPLLWMFEEREKIMEFYERVSGSRLHANYF
RPGGVSQDLPEGLIENIADFCEQFPCKIADLETLLTDNRIWKQRTVDIGIVSKQQAMDWGFSGVMLRGSGIAWDLRKSQP
YDQYANLDFDVAIGKNGDCYDRYLIRIEEMYQSIKIIKQCIQKMPAGEIRTQDPSISPPKRSEIKKSMEALINHFKLYSE
GYNVPAGEVYAAVEAPKGEFGVYLYSDGTNRPYRCRIKAPGFAHLQGLDFMARGHSLSDIITIIATLDIVFGEIDR
>Mature_395_residues
ALKKRSKHSKKFKLNLGPQHPATHGVLRLILEMDGEIVERADPHIGLLHRGTEKLIEYKTYLQAIPYFDRLDYVSPMCQE
HAFALAIEHLLKCEVPLRAQYIRVMFSELTRILNHTLNIATQALDVGATTPLLWMFEEREKIMEFYERVSGSRLHANYFR
PGGVSQDLPEGLIENIADFCEQFPCKIADLETLLTDNRIWKQRTVDIGIVSKQQAMDWGFSGVMLRGSGIAWDLRKSQPY
DQYANLDFDVAIGKNGDCYDRYLIRIEEMYQSIKIIKQCIQKMPAGEIRTQDPSISPPKRSEIKKSMEALINHFKLYSEG
YNVPAGEVYAAVEAPKGEFGVYLYSDGTNRPYRCRIKAPGFAHLQGLDFMARGHSLSDIITIIATLDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=66.0621761658031, Blast_Score=563, Evalue=1e-161,
Organism=Homo sapiens, GI260898743, Length=380, Percent_Identity=65.5263157894737, Blast_Score=548, Evalue=1e-156,
Organism=Escherichia coli, GI145693162, Length=396, Percent_Identity=38.8888888888889, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1789076, Length=382, Percent_Identity=26.4397905759162, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788832, Length=381, Percent_Identity=26.509186351706, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555284, Length=393, Percent_Identity=62.5954198473283, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=61.5776081424936, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24638644, Length=389, Percent_Identity=66.0668380462725, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=59.1623036649215, Blast_Score=504, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45254; Mature: 45123

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKKRSKHSKKFKLNLGPQHPATHGVLRLILEMDGEIVERADPHIGLLHRGTEKLIEYK
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEHHCCHHHHHHHH
TYLQAIPYFDRLDYVSPMCQEHAFALAIEHLLKCEVPLRAQYIRVMFSELTRILNHTLNI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ATQALDVGATTPLLWMFEEREKIMEFYERVSGSRLHANYFRPGGVSQDLPEGLIENIADF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
CEQFPCKIADLETLLTDNRIWKQRTVDIGIVSKQQAMDWGFSGVMLRGSGIAWDLRKSQP
HHHCCCCHHHHHHHHHCCHHHHHHCEEEEEECHHHHHHCCCCCEEEECCCCEEECCCCCC
YDQYANLDFDVAIGKNGDCYDRYLIRIEEMYQSIKIIKQCIQKMPAGEIRTQDPSISPPK
CHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RSEIKKSMEALINHFKLYSEGYNVPAGEVYAAVEAPKGEFGVYLYSDGTNRPYRCRIKAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQGLDFMARGHSLSDIITIIATLDIVFGEIDR
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALKKRSKHSKKFKLNLGPQHPATHGVLRLILEMDGEIVERADPHIGLLHRGTEKLIEYK
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEHHCCHHHHHHHH
TYLQAIPYFDRLDYVSPMCQEHAFALAIEHLLKCEVPLRAQYIRVMFSELTRILNHTLNI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ATQALDVGATTPLLWMFEEREKIMEFYERVSGSRLHANYFRPGGVSQDLPEGLIENIADF
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
CEQFPCKIADLETLLTDNRIWKQRTVDIGIVSKQQAMDWGFSGVMLRGSGIAWDLRKSQP
HHHCCCCHHHHHHHHHCCHHHHHHCEEEEEECHHHHHHCCCCCEEEECCCCEEECCCCCC
YDQYANLDFDVAIGKNGDCYDRYLIRIEEMYQSIKIIKQCIQKMPAGEIRTQDPSISPPK
CHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RSEIKKSMEALINHFKLYSEGYNVPAGEVYAAVEAPKGEFGVYLYSDGTNRPYRCRIKAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQGLDFMARGHSLSDIITIIATLDIVFGEIDR
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA