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The map label for this gene is lysC [H]

Identifier: 189183586

GI number: 189183586

Start: 707778

End: 708992

Strand: Reverse

Name: lysC [H]

Synonym: OTT_0679

Alternate gene names: 189183586

Gene position: 708992-707778 (Counterclockwise)

Preceding gene: 189183587

Following gene: 189183585

Centisome position: 35.29

GC content: 30.78

Gene sequence:

>1215_bases
ATGAATATTATTGTACAAAAATTTGGTGGAGCATGTGTAGCTGATACTGCTAAAATTGCTAACTTAGTAACAAAAGTACA
GTGTGAAATTGATGCTAGCAATAAGGTTATAGTAGTAGTTTCAGCTATGGCTGGCATTACTAAAAAATTAATTTCATTTT
GTTGCAATTTAAACAGTGAATTATATACTCCTGAAACATTAGCAGAGTATGATAGTGCTTTAAGTAGTGGAGAGATTATG
ACAGCCTCACTATTTGCATTAGCTTTGCAACAAAAATCAATTAAGTCTAGATCATTACACTCATGGCAAATACCTATTAA
AACTAATAATTATCATTCTAAAGCAATAATTATAGATATTAATACTAACTTAATTCATGATATGCTATTACAAGGTATAG
TACCAGTTATTTCTGGCTTTCAAGGTATCACGAATCACAATAGAATTACAACTTTAGGACGTGGAGGATCTGATATTACA
GCTGTGGCTATTGCAGCAGCATTGCAAGCAAAAAGATGTGATATATATACTACTGTTGATGGAGTATTTTCAGCTGATCC
AGAACTAATACCACAAGCCTGTAAGCATGATAAAATCACTTATACAGAAATGTTGGAATTAGCTTCACTTGGAGCAAGAG
TCGTTCATTATCGAGCAGTACAAATGGGTATGCGCTATAATGTTCCTATCAAAGTAATACATGCATTTGGTAAAAGTCAA
GGAACAATAATTCAAGAGATTACAACAATGGAACAACCTCAAATTACAAGCATTACGTATAATAAAGATATAATTTTGGT
AACTATATGCATCGATGATAACAAACAATTTTTTCTTGTTATAAATCATATGCTTAAATATTCAGTCTCAATAGAGCAAA
TTACTAACTACCAGTTAAATAAGGTTAGTATAATCATACCATTATCTGATTTAACTGCATCAAAAAAGGCATTTGATGAA
TTACAGAACCAATGTATCATTAATAGCTACCAAATTAATAATGTAGCATCAGTATCAGTAGTAGGATATGCAATAAAATA
TAACCCATCAATATTTCAGCAAATTACCATGGTTCTTAGCAAGTTTGAAGTGCAAATTTTAGGAATATTAGCCTTAGAAG
CTAGAATATCTATTATATTGAATAAAATAGATGTTGAACCAATAGTAGCTGAGCTACATCATCATCTAATTTTAACTGCT
AGTTCCACAATCTAG

Upstream 100 bases:

>100_bases
GTAGTTTGGGCTAAAAACATAAATTAATACTACAGTAAATAATAATTTTTTTAAAATTTTTTGACACATAAAAAAAGATA
TACGCTGACTATTAATTTAT

Downstream 100 bases:

>100_bases
TAACAAGGAAGTGTTGCAATATCTTTGTTACATAAGTATAGTCGAGTGAAGGCGTAGTAGTTTAGTTATCAACATATCCA
TTACACGCCATGTTAAACTT

Product: aspartokinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNIIVQKFGGACVADTAKIANLVTKVQCEIDASNKVIVVVSAMAGITKKLISFCCNLNSELYTPETLAEYDSALSSGEIM
TASLFALALQQKSIKSRSLHSWQIPIKTNNYHSKAIIIDINTNLIHDMLLQGIVPVISGFQGITNHNRITTLGRGGSDIT
AVAIAAALQAKRCDIYTTVDGVFSADPELIPQACKHDKITYTEMLELASLGARVVHYRAVQMGMRYNVPIKVIHAFGKSQ
GTIIQEITTMEQPQITSITYNKDIILVTICIDDNKQFFLVINHMLKYSVSIEQITNYQLNKVSIIIPLSDLTASKKAFDE
LQNQCIINSYQINNVASVSVVGYAIKYNPSIFQQITMVLSKFEVQILGILALEARISIILNKIDVEPIVAELHHHLILTA
SSTI

Sequences:

>Translated_404_residues
MNIIVQKFGGACVADTAKIANLVTKVQCEIDASNKVIVVVSAMAGITKKLISFCCNLNSELYTPETLAEYDSALSSGEIM
TASLFALALQQKSIKSRSLHSWQIPIKTNNYHSKAIIIDINTNLIHDMLLQGIVPVISGFQGITNHNRITTLGRGGSDIT
AVAIAAALQAKRCDIYTTVDGVFSADPELIPQACKHDKITYTEMLELASLGARVVHYRAVQMGMRYNVPIKVIHAFGKSQ
GTIIQEITTMEQPQITSITYNKDIILVTICIDDNKQFFLVINHMLKYSVSIEQITNYQLNKVSIIIPLSDLTASKKAFDE
LQNQCIINSYQINNVASVSVVGYAIKYNPSIFQQITMVLSKFEVQILGILALEARISIILNKIDVEPIVAELHHHLILTA
SSTI
>Mature_404_residues
MNIIVQKFGGACVADTAKIANLVTKVQCEIDASNKVIVVVSAMAGITKKLISFCCNLNSELYTPETLAEYDSALSSGEIM
TASLFALALQQKSIKSRSLHSWQIPIKTNNYHSKAIIIDINTNLIHDMLLQGIVPVISGFQGITNHNRITTLGRGGSDIT
AVAIAAALQAKRCDIYTTVDGVFSADPELIPQACKHDKITYTEMLELASLGARVVHYRAVQMGMRYNVPIKVIHAFGKSQ
GTIIQEITTMEQPQITSITYNKDIILVTICIDDNKQFFLVINHMLKYSVSIEQITNYQLNKVSIIIPLSDLTASKKAFDE
LQNQCIINSYQINNVASVSVVGYAIKYNPSIFQQITMVLSKFEVQILGILALEARISIILNKIDVEPIVAELHHHLILTA
SSTI

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartokinase family [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=458, Percent_Identity=24.0174672489083, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1786183, Length=278, Percent_Identity=25.8992805755396, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790376, Length=422, Percent_Identity=22.5118483412322, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=307, Percent_Identity=26.3843648208469, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR001057 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44469; Mature: 44469

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIVQKFGGACVADTAKIANLVTKVQCEIDASNKVIVVVSAMAGITKKLISFCCNLNSE
CCEEEEECCCCCHHHHHHHHHHHEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCCC
LYTPETLAEYDSALSSGEIMTASLFALALQQKSIKSRSLHSWQIPIKTNNYHSKAIIIDI
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEE
NTNLIHDMLLQGIVPVISGFQGITNHNRITTLGRGGSDITAVAIAAALQAKRCDIYTTVD
CCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEC
GVFSADPELIPQACKHDKITYTEMLELASLGARVVHYRAVQMGMRYNVPIKVIHAFGKSQ
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GTIIQEITTMEQPQITSITYNKDIILVTICIDDNKQFFLVINHMLKYSVSIEQITNYQLN
CCHHHHHHHCCCCCEEEEEECCCEEEEEEEEECCCEEEEEEEHHHHHCCCHHHHCCCEEC
KVSIIIPLSDLTASKKAFDELQNQCIINSYQINNVASVSVVGYAIKYNPSIFQQITMVLS
EEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHH
KFEVQILGILALEARISIILNKIDVEPIVAELHHHLILTASSTI
HHHHEEEEHHHHHHHEEEEHHHCCCCHHHHHHHCEEEEEECCCC
>Mature Secondary Structure
MNIIVQKFGGACVADTAKIANLVTKVQCEIDASNKVIVVVSAMAGITKKLISFCCNLNSE
CCEEEEECCCCCHHHHHHHHHHHEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCCC
LYTPETLAEYDSALSSGEIMTASLFALALQQKSIKSRSLHSWQIPIKTNNYHSKAIIIDI
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEE
NTNLIHDMLLQGIVPVISGFQGITNHNRITTLGRGGSDITAVAIAAALQAKRCDIYTTVD
CCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEC
GVFSADPELIPQACKHDKITYTEMLELASLGARVVHYRAVQMGMRYNVPIKVIHAFGKSQ
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GTIIQEITTMEQPQITSITYNKDIILVTICIDDNKQFFLVINHMLKYSVSIEQITNYQLN
CCHHHHHHHCCCCCEEEEEECCCEEEEEEEEECCCEEEEEEEHHHHHCCCHHHHCCCEEC
KVSIIIPLSDLTASKKAFDELQNQCIINSYQINNVASVSVVGYAIKYNPSIFQQITMVLS
EEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHH
KFEVQILGILALEARISIILNKIDVEPIVAELHHHLILTASSTI
HHHHEEEEHHHHHHHEEEEHHHCCCCHHHHHHHCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]