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The map label for this gene is 189183309

Identifier: 189183309

GI number: 189183309

Start: 422602

End: 423741

Strand: Reverse

Name: 189183309

Synonym: OTT_0402

Alternate gene names: NA

Gene position: 423741-422602 (Counterclockwise)

Preceding gene: 189183310

Following gene: 189183308

Centisome position: 21.09

GC content: 26.84

Gene sequence:

>1140_bases
ATGAAAAACGTGTGTAAAAATTTAGCCATTATTTTATCATTAATATTATTAAATACACCAGCTGTTGCAGCAGAGCAAAG
CATACAACAAAATTTAATTCAAGATAGAACTGTACTAGCTAAGGAATATTTTAATATTGCAAGCTCTTTTCTGAAATTAA
AAAAATATCAAGAGGCAATAGAAAATTTTGATATTGCTATTAAGTATGATTCAAGTTATGCATCAGCATATAATGGAAAA
GGAATGGCTTTAGATGATCTTGGAAAGCTACTAGAAGCTGTAGAAAATTATGATTTAGCTATTAAATATAATCCTCATTT
TGCAGAAGCATATAATAATAAAGCTGTATCTTATAGGAAATTTGGAAAAAATAAAGAAGCTATAATACTTTGTGATCTTG
CTATTCAATATAAACCTTATTTTGTAGGGGCTTATAATAATAAAGGAGCTTCTTTAGCTAGATTAGGACAGTATGAAGAT
GCAATGGAAAATTATGATATAGCTATTAAATATGAACCTAATAATCCAGAAGCTTATTATAACAAAGGCATAGCTTTAAT
GAATTTAGGGTACATTCAAGAGGCTATTGAAAACTATGATATAGCTATTAGATACAGACCAAATTATTCAGAAGCATATC
ATAATAAAGGTTTAACTTTAGCAATTTTAGGACAATTGCAGAGTGCAATAGAACATTTTGATTTAGCTATTAAATACGAT
CCTAATGATTTGAATGCATACTGTAATAAGAGCTATGTATTAAATCTATTAAAAAGATATTCAGAAGCGATGGAAAGTTG
TAACATAGCTATTAAAATTGATCCAAATTGTGCAGATTCTTATTATATCAAAGGAATGATTTTTGAAAAATTAGGTAAAC
ATCAAGATGCGATTAAAAATTATGATATAGCTGCTAAATATAATCCTAATTTTGCTAAAAACTATCTAGAAAAAGGAATA
TCATTAGTAAGTTTAGGACAGTACTCAAAAGCTAAAGAGAATTTTAAGTTAGCTATTAAATATATGCCTAATTTTATAGC
AGAATATGAAGCAACAATTAAAAGGTTAACAGAATTAGAGAATTTTACTATTGCAAAAGAATTTGAGCAAAAACTACAGA
TATTGAAAAAATACTCTTGA

Upstream 100 bases:

>100_bases
AGGAATTTGATAATACCTCTAATTCAGCAGTTATTTTGACAGGTAAAGAGGTATTAAAAGCAGTAAAAAATTTAAATGGT
ACTAAAGATTAGTAATTAAT

Downstream 100 bases:

>100_bases
GATAGATGAATTTTCAGAATCAAGGAAATTTCACCAGAGGATCGCAGTTATTTGCCCATAAGTTAAGAATGTTTGGGCAA
GGTAGTACCAACGTTTTTAT

Product: TPR repeat-containing protein 01_03

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKNVCKNLAIILSLILLNTPAVAAEQSIQQNLIQDRTVLAKEYFNIASSFLKLKKYQEAIENFDIAIKYDSSYASAYNGK
GMALDDLGKLLEAVENYDLAIKYNPHFAEAYNNKAVSYRKFGKNKEAIILCDLAIQYKPYFVGAYNNKGASLARLGQYED
AMENYDIAIKYEPNNPEAYYNKGIALMNLGYIQEAIENYDIAIRYRPNYSEAYHNKGLTLAILGQLQSAIEHFDLAIKYD
PNDLNAYCNKSYVLNLLKRYSEAMESCNIAIKIDPNCADSYYIKGMIFEKLGKHQDAIKNYDIAAKYNPNFAKNYLEKGI
SLVSLGQYSKAKENFKLAIKYMPNFIAEYEATIKRLTELENFTIAKEFEQKLQILKKYS

Sequences:

>Translated_379_residues
MKNVCKNLAIILSLILLNTPAVAAEQSIQQNLIQDRTVLAKEYFNIASSFLKLKKYQEAIENFDIAIKYDSSYASAYNGK
GMALDDLGKLLEAVENYDLAIKYNPHFAEAYNNKAVSYRKFGKNKEAIILCDLAIQYKPYFVGAYNNKGASLARLGQYED
AMENYDIAIKYEPNNPEAYYNKGIALMNLGYIQEAIENYDIAIRYRPNYSEAYHNKGLTLAILGQLQSAIEHFDLAIKYD
PNDLNAYCNKSYVLNLLKRYSEAMESCNIAIKIDPNCADSYYIKGMIFEKLGKHQDAIKNYDIAAKYNPNFAKNYLEKGI
SLVSLGQYSKAKENFKLAIKYMPNFIAEYEATIKRLTELENFTIAKEFEQKLQILKKYS
>Mature_379_residues
MKNVCKNLAIILSLILLNTPAVAAEQSIQQNLIQDRTVLAKEYFNIASSFLKLKKYQEAIENFDIAIKYDSSYASAYNGK
GMALDDLGKLLEAVENYDLAIKYNPHFAEAYNNKAVSYRKFGKNKEAIILCDLAIQYKPYFVGAYNNKGASLARLGQYED
AMENYDIAIKYEPNNPEAYYNKGIALMNLGYIQEAIENYDIAIRYRPNYSEAYHNKGLTLAILGQLQSAIEHFDLAIKYD
PNDLNAYCNKSYVLNLLKRYSEAMESCNIAIKIDPNCADSYYIKGMIFEKLGKHQDAIKNYDIAAKYNPNFAKNYLEKGI
SLVSLGQYSKAKENFKLAIKYMPNFIAEYEATIKRLTELENFTIAKEFEQKLQILKKYS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 9 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI32307150, Length=246, Percent_Identity=31.7073170731707, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI32307148, Length=246, Percent_Identity=31.7073170731707, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI118766330, Length=274, Percent_Identity=26.6423357664234, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI118766328, Length=274, Percent_Identity=26.6423357664234, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI83415184, Length=389, Percent_Identity=22.879177377892, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI310123097, Length=311, Percent_Identity=24.1157556270096, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI310131789, Length=311, Percent_Identity=24.1157556270096, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI310110582, Length=311, Percent_Identity=24.1157556270096, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI301336134, Length=389, Percent_Identity=22.879177377892, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI170784867, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI22749211, Length=319, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI262206280, Length=288, Percent_Identity=21.5277777777778, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI225735595, Length=270, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI225735591, Length=270, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI225735593, Length=243, Percent_Identity=25.1028806584362, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532692, Length=340, Percent_Identity=26.1764705882353, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115532690, Length=357, Percent_Identity=26.0504201680672, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147174, Length=224, Percent_Identity=24.5535714285714, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319387, Length=196, Percent_Identity=26.0204081632653, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17647755, Length=343, Percent_Identity=26.530612244898, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24585827, Length=343, Percent_Identity=26.530612244898, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24585829, Length=343, Percent_Identity=26.530612244898, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24647123, Length=220, Percent_Identity=28.1818181818182, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161076610, Length=300, Percent_Identity=26, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920486, Length=300, Percent_Identity=26, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17137540, Length=228, Percent_Identity=23.6842105263158, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008940
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF00515 TPR_1 [H]

EC number: NA

Molecular weight: Translated: 43330; Mature: 43330

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVCKNLAIILSLILLNTPAVAAEQSIQQNLIQDRTVLAKEYFNIASSFLKLKKYQEAI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENFDIAIKYDSSYASAYNGKGMALDDLGKLLEAVENYDLAIKYNPHFAEAYNNKAVSYRK
HCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCEEHHH
FGKNKEAIILCDLAIQYKPYFVGAYNNKGASLARLGQYEDAMENYDIAIKYEPNNPEAYY
CCCCCCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
NKGIALMNLGYIQEAIENYDIAIRYRPNYSEAYHNKGLTLAILGQLQSAIEHFDLAIKYD
HCCEEEEEHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEHHHHHHHHHHHCEEEEEEC
PNDLNAYCNKSYVLNLLKRYSEAMESCNIAIKIDPNCADSYYIKGMIFEKLGKHQDAIKN
CCHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHC
YDIAAKYNPNFAKNYLEKGISLVSLGQYSKAKENFKLAIKYMPNFIAEYEATIKRLTELE
CCEEEEECCHHHHHHHHCCCCEEECCCHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
NFTIAKEFEQKLQILKKYS
CCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNVCKNLAIILSLILLNTPAVAAEQSIQQNLIQDRTVLAKEYFNIASSFLKLKKYQEAI
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENFDIAIKYDSSYASAYNGKGMALDDLGKLLEAVENYDLAIKYNPHFAEAYNNKAVSYRK
HCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCEEHHH
FGKNKEAIILCDLAIQYKPYFVGAYNNKGASLARLGQYEDAMENYDIAIKYEPNNPEAYY
CCCCCCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
NKGIALMNLGYIQEAIENYDIAIRYRPNYSEAYHNKGLTLAILGQLQSAIEHFDLAIKYD
HCCEEEEEHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEHHHHHHHHHHHCEEEEEEC
PNDLNAYCNKSYVLNLLKRYSEAMESCNIAIKIDPNCADSYYIKGMIFEKLGKHQDAIKN
CCHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHC
YDIAAKYNPNFAKNYLEKGISLVSLGQYSKAKENFKLAIKYMPNFIAEYEATIKRLTELE
CCEEEEECCHHHHHHHHCCCCEEECCCHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
NFTIAKEFEQKLQILKKYS
CCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 9697413 [H]