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The map label for this gene is atpB [H]

Identifier: 189183295

GI number: 189183295

Start: 401242

End: 401970

Strand: Reverse

Name: atpB [H]

Synonym: OTT_0388

Alternate gene names: 189183295

Gene position: 401970-401242 (Counterclockwise)

Preceding gene: 189183297

Following gene: 189183294

Centisome position: 20.01

GC content: 29.9

Gene sequence:

>729_bases
ATGTTAGCTAATCCATTAAGCCAGTTTTTGATTAAACCCATTATACCTCTAGAAGCGCTAGGTTATAATATCAGCATTAC
TAACTCAGCAGTAGCTATGATATTTGTTAGCATAGCTGCTAGTATGTTGTTGATTACAGCATTTGTTAATAGTAAACTTG
TTCCTTCAAGATGGCAAGCTTTTGGAGAAATATTATATGAGTCAAACATAAAACTAGTACATAGCATTATAGGTCCACAA
GGGAAAAAATTTTTTCCTTTGATACTTACATTGTTTCTTTTTATTAGTCTTGGCAACATTCTTGGAATGGTACCACATGC
CTTTACATTTACTAGCCATATAATAGTTACATTCAGTTTAGCAATGATAGTATTTACTACTACTTTAGTTTATGGCATCT
ATAGACACAAGTTAGGATTTTTTTCGTTATTCTTACCAAAAAATATACCTCTTTGGTTAGCACCGATAATGGTCATAATT
GAATTATGTGTTTTCATTTCTAAACCAATTAGTTTGTCTTTACGACTAACTGCAAATATGGTAGCAGGACATATATTACT
AAAAATTATTGCTTGGTCTATTGTTAGTTTAACTTGGCTTTTTAAGCCATTACCTATAGCTTTAGTTATTGTACTCATTG
GATTTGAATTATTTATTTCTATCCTACAAGCATACATTTTTACAATTTTATCTTGTGTCTATTTAAGAGATGTAGTAAAT
TTACATTGA

Upstream 100 bases:

>100_bases
TTAAAGGAATTAACGTACTGAGCGGTAGTAGGGCTTACCGGGCAACAGAAAAGCCCTAATTAATCTACTTAAAACACAAA
AAAATACACTATTTCTTGTA

Downstream 100 bases:

>100_bases
AAATATAGCATGTAATACTATATTTAAATAACAAAATTATACAGGAGATTAATGCATGGACCCTATATCTTTTAAGTACA
TAGCTATAGCTTTCATGGCA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLANPLSQFLIKPIIPLEALGYNISITNSAVAMIFVSIAASMLLITAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQ
GKKFFPLILTLFLFISLGNILGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVII
ELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWLFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
LH

Sequences:

>Translated_242_residues
MLANPLSQFLIKPIIPLEALGYNISITNSAVAMIFVSIAASMLLITAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQ
GKKFFPLILTLFLFISLGNILGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVII
ELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWLFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
LH
>Mature_242_residues
MLANPLSQFLIKPIIPLEALGYNISITNSAVAMIFVSIAASMLLITAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQ
GKKFFPLILTLFLFISLGNILGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVII
ELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWLFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
LH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=194, Percent_Identity=28.8659793814433, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6226527, Length=253, Percent_Identity=33.201581027668, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 27036; Mature: 27036

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANPLSQFLIKPIIPLEALGYNISITNSAVAMIFVSIAASMLLITAFVNSKLVPSRWQA
CCCCHHHHHHHHCCCCHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FGEILYESNIKLVHSIIGPQGKKFFPLILTLFLFISLGNILGMVPHAFTFTSHIIVTFSL
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVIIELCVFISKPISLSLRLTANM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
VAGHILLKIIAWSIVSLTWLFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LH
CC
>Mature Secondary Structure
MLANPLSQFLIKPIIPLEALGYNISITNSAVAMIFVSIAASMLLITAFVNSKLVPSRWQA
CCCCHHHHHHHHCCCCHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FGEILYESNIKLVHSIIGPQGKKFFPLILTLFLFISLGNILGMVPHAFTFTSHIIVTFSL
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVIIELCVFISKPISLSLRLTANM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
VAGHILLKIIAWSIVSLTWLFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LH
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA