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The map label for this gene is purC [H]

Identifier: 189182995

GI number: 189182995

Start: 92016

End: 92750

Strand: Direct

Name: purC [H]

Synonym: OTT_0088

Alternate gene names: 189182995

Gene position: 92016-92750 (Clockwise)

Preceding gene: 189182994

Following gene: 189182996

Centisome position: 4.58

GC content: 25.85

Gene sequence:

>735_bases
ATGGTAAGACTTTCTAAGGAAAAAATTTTCGAAGGAAATAGTAAAATTATTTATAGAATTGATGAGTATACTTTAATACA
GTTTTTTAAAGATGATATGAGAATTAATGCAGAAAAAGTAATTCAAGTATCTGGTAAAGGAGTTTTGAATAATGTAATAT
CTAATTATATTTTCAAAAGAGTTAGTATTGTAGGTATTAATCACCATTTAATACAGAAAATAAATATGAGAGAGCAGCTT
ATTTACGCTCTTAATATTATTCCAGTTAAAGTATGCATCACTAATATTGCTTCTGGTAGATATGTTAGTCAATTTGGCAT
TGAAGATGGTTACGTATTTGATACTCCTATTATTGATTTTATGGTAAAACATGGAGCTAATAATTATTCCATTATTAATG
AAGATCAAATGATAAAATTTAACTGGATAGATTATTATGAATTAAAAAATATAAAAACGTTAGCATTAAAATTATACACT
TTTTTAGTTGGAATGTTTTCTAGCATTAATATTAGATTGGTAGAGTGTCAATTAGAGTTTGGGCGAATTAATAATTTAAG
CGGAGATATCATTTTACTAGCAGATGAAATTACTCCTGATACTTGTAAGTTATGGGATCTGCAAAGTAATTGTAAATTAG
GCTACGAGCGTGCATGTGCTGAACTAGATAACGCAATTATGTTTTATAAAGAAATAATTAAAAGATTTAATTTAGATGAA
TATAGTATAGAATGA

Upstream 100 bases:

>100_bases
ACTCTTAAGTCTATAATTTTGGAAAAAATCTTAAAGCTAGTAGCTGATGATGTTGCATGTAAAACAATGACAGCTTTTGA
AAATAGGGCAAAGAAAATAT

Downstream 100 bases:

>100_bases
ACAATTTAGGTAAGTATCAGGATATATTGTTATTCGAAAACTATCTCCAATAATACTATCTTTAAATTGCACCTTAGATT
TATTCTATCATTTTCACCAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MVRLSKEKIFEGNSKIIYRIDEYTLIQFFKDDMRINAEKVIQVSGKGVLNNVISNYIFKRVSIVGINHHLIQKINMREQL
IYALNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDFMVKHGANNYSIINEDQMIKFNWIDYYELKNIKTLALKLYT
FLVGMFSSINIRLVECQLEFGRINNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNLDE
YSIE

Sequences:

>Translated_244_residues
MVRLSKEKIFEGNSKIIYRIDEYTLIQFFKDDMRINAEKVIQVSGKGVLNNVISNYIFKRVSIVGINHHLIQKINMREQL
IYALNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDFMVKHGANNYSIINEDQMIKFNWIDYYELKNIKTLALKLYT
FLVGMFSSINIRLVECQLEFGRINNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNLDE
YSIE
>Mature_244_residues
MVRLSKEKIFEGNSKIIYRIDEYTLIQFFKDDMRINAEKVIQVSGKGVLNNVISNYIFKRVSIVGINHHLIQKINMREQL
IYALNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDFMVKHGANNYSIINEDQMIKFNWIDYYELKNIKTLALKLYT
FLVGMFSSINIRLVECQLEFGRINNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNLDE
YSIE

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=209, Percent_Identity=24.8803827751196, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI5453539, Length=209, Percent_Identity=24.8803827751196, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788820, Length=233, Percent_Identity=26.6094420600858, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28418; Mature: 28418

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLSKEKIFEGNSKIIYRIDEYTLIQFFKDDMRINAEKVIQVSGKGVLNNVISNYIFKR
CCCCCHHHHHCCCCEEEEEECCHHEEHHHHHHHCCCHHHEEEECCCHHHHHHHHHHHHHH
VSIVGINHHLIQKINMREQLIYALNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDF
HEEEECCHHHHHHHCHHHHHHHHHHHHEEEHHHHHCCCCCEEEECCCCCCEEECCHHHHH
MVKHGANNYSIINEDQMIKFNWIDYYELKNIKTLALKLYTFLVGMFSSINIRLVECQLEF
HHHCCCCCCEEECCCCEEEEECCCEEHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GRINNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNLDE
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
YSIE
CCCC
>Mature Secondary Structure
MVRLSKEKIFEGNSKIIYRIDEYTLIQFFKDDMRINAEKVIQVSGKGVLNNVISNYIFKR
CCCCCHHHHHCCCCEEEEEECCHHEEHHHHHHHCCCHHHEEEECCCHHHHHHHHHHHHHH
VSIVGINHHLIQKINMREQLIYALNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDF
HEEEECCHHHHHHHCHHHHHHHHHHHHEEEHHHHHCCCCCEEEECCCCCCEEECCHHHHH
MVKHGANNYSIINEDQMIKFNWIDYYELKNIKTLALKLYTFLVGMFSSINIRLVECQLEF
HHHCCCCCCEEECCCCEEEEECCCEEHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GRINNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNLDE
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
YSIE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA