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The map label for this gene is tlyC [H]

Identifier: 189025874

GI number: 189025874

Start: 713306

End: 714103

Strand: Reverse

Name: tlyC [H]

Synonym: TPASS_0649

Alternate gene names: 189025874

Gene position: 714103-713306 (Counterclockwise)

Preceding gene: 189025875

Following gene: 189025873

Centisome position: 62.67

GC content: 47.37

Gene sequence:

>798_bases
ATGGGAGTCATAGACTGGTTGAGGCGCAGGCACGCTGTTACCCATATTTTTCAGCAACCGCTGAATGAAGAAAAGCAGGA
TATGATCCGCGGTATAGTGGATCTTTCTGACACTTCGGTGCGCGAGGTGATGATACCGCGTATTGACGTGGATTTTCTTG
AGCTTTCTATGAGCGGTGAAACACTCGTTGAAAAGGTAACCGAGAGTGGACACTCACGCTTTCCTGTCTACGAACAAACT
ATTGATAATGTGGTGGGTGTGCTGTACGTCAAAGATTTAATAAAGCTGTTTGGAAGGCCACAGGAGGTGCGGTTAGAAAG
ACTGCTGCGTAAGCCCTTCTTTGTCCCCGAGTCCAAACGAATTGACAGTCTTCTGCGAGAGTTTAAGCGCAGGCACGTGC
ACATTGCGATCGCGGTGGACGAGTACGGCGGCGTTTCGGGTATTGCGTGCATGGAAGACATTATTGAAGAGATTGTTGGG
GATATCCAGGATGAGTTTGACCACGAGCGGGAGGATATCGAACCGCTCGGACAGGGCGTGTGGTTGTGCGATGCGCGTGT
GGATTTGGAAGATTTGTCTGAGTGTTTGCATACTGTTTTTCCTTCTCAAGAGTTTGGAACGTTAGGTGGATTTGTATTTA
ATCTTTTTGGAAAAATTCCCGTAAAGTACGAGAAGGTTTCGTGGGGTGCCTTCGATTTTATTATCCAAGACATGGAAGCA
CATAAGATAAATACTATAAAGATTGTATCTGTCCTGCGGGGTGATTCCGAGCCTGCATGTGTATCTGAGCGGCCATAG

Upstream 100 bases:

>100_bases
GCGGTATGGATCACCAGGACAATTCTCCCGGTCAAGAGATGTTGCGTTTGCAGGAGCGCATACTGGCGCAGCACTGTCGG
GTGCTATCATCGGGTATACC

Downstream 100 bases:

>100_bases
AGGAAAGGGAAAAAGCATGAAAGGCCTGCTGTGCGTGTATTACGGTGCGCTTTGCAGCATAGTGTTTGCTCAGACGGGCG
TGCAGCTTTACGAAGCAGGA

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MGVIDWLRRRHAVTHIFQQPLNEEKQDMIRGIVDLSDTSVREVMIPRIDVDFLELSMSGETLVEKVTESGHSRFPVYEQT
IDNVVGVLYVKDLIKLFGRPQEVRLERLLRKPFFVPESKRIDSLLREFKRRHVHIAIAVDEYGGVSGIACMEDIIEEIVG
DIQDEFDHEREDIEPLGQGVWLCDARVDLEDLSECLHTVFPSQEFGTLGGFVFNLFGKIPVKYEKVSWGAFDFIIQDMEA
HKINTIKIVSVLRGDSEPACVSERP

Sequences:

>Translated_265_residues
MGVIDWLRRRHAVTHIFQQPLNEEKQDMIRGIVDLSDTSVREVMIPRIDVDFLELSMSGETLVEKVTESGHSRFPVYEQT
IDNVVGVLYVKDLIKLFGRPQEVRLERLLRKPFFVPESKRIDSLLREFKRRHVHIAIAVDEYGGVSGIACMEDIIEEIVG
DIQDEFDHEREDIEPLGQGVWLCDARVDLEDLSECLHTVFPSQEFGTLGGFVFNLFGKIPVKYEKVSWGAFDFIIQDMEA
HKINTIKIVSVLRGDSEPACVSERP
>Mature_264_residues
GVIDWLRRRHAVTHIFQQPLNEEKQDMIRGIVDLSDTSVREVMIPRIDVDFLELSMSGETLVEKVTESGHSRFPVYEQTI
DNVVGVLYVKDLIKLFGRPQEVRLERLLRKPFFVPESKRIDSLLREFKRRHVHIAIAVDEYGGVSGIACMEDIIEEIVGD
IQDEFDHEREDIEPLGQGVWLCDARVDLEDLSECLHTVFPSQEFGTLGGFVFNLFGKIPVKYEKVSWGAFDFIIQDMEAH
KINTIKIVSVLRGDSEPACVSERP

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=195, Percent_Identity=31.2820512820513, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40068053, Length=166, Percent_Identity=31.9277108433735, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40068055, Length=166, Percent_Identity=31.9277108433735, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI94681046, Length=168, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40068049, Length=163, Percent_Identity=31.9018404907975, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786879, Length=225, Percent_Identity=34.2222222222222, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI145693175, Length=245, Percent_Identity=24.8979591836735, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI87082033, Length=251, Percent_Identity=27.8884462151394, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790664, Length=248, Percent_Identity=26.6129032258064, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788119, Length=253, Percent_Identity=24.901185770751, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 30399; Mature: 30268

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVIDWLRRRHAVTHIFQQPLNEEKQDMIRGIVDLSDTSVREVMIPRIDVDFLELSMSGE
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHCCCCHH
TLVEKVTESGHSRFPVYEQTIDNVVGVLYVKDLIKLFGRPQEVRLERLLRKPFFVPESKR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHH
IDSLLREFKRRHVHIAIAVDEYGGVSGIACMEDIIEEIVGDIQDEFDHEREDIEPLGQGV
HHHHHHHHHHCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCE
WLCDARVDLEDLSECLHTVFPSQEFGTLGGFVFNLFGKIPVKYEKVSWGAFDFIIQDMEA
EEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
HKINTIKIVSVLRGDSEPACVSERP
HCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
GVIDWLRRRHAVTHIFQQPLNEEKQDMIRGIVDLSDTSVREVMIPRIDVDFLELSMSGE
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHCCCCHH
TLVEKVTESGHSRFPVYEQTIDNVVGVLYVKDLIKLFGRPQEVRLERLLRKPFFVPESKR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHH
IDSLLREFKRRHVHIAIAVDEYGGVSGIACMEDIIEEIVGDIQDEFDHEREDIEPLGQGV
HHHHHHHHHHCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCE
WLCDARVDLEDLSECLHTVFPSQEFGTLGGFVFNLFGKIPVKYEKVSWGAFDFIIQDMEA
EEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
HKINTIKIVSVLRGDSEPACVSERP
HCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968456 [H]