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The map label for this gene is serS

Identifier: 189025872

GI number: 189025872

Start: 709983

End: 711263

Strand: Reverse

Name: serS

Synonym: TPASS_0647

Alternate gene names: 189025872

Gene position: 711263-709983 (Counterclockwise)

Preceding gene: 189025873

Following gene: 189025871

Centisome position: 62.42

GC content: 49.41

Gene sequence:

>1281_bases
GTGCTTGATTATCGGTTTATTAGAGAGAACGTGGATGCAGTAAAAGAAAATGTGAAGGTCAGGAACGTGCATGCAGATGT
GGACGCGATTGTGCACTTATATGATCAGCGCGTAAAGCTTTTAGCAGAGTTGCAAGAATTACAACGTGCGCGTAATGAGA
ACGCACAGACGATGAAAAGCTCTTTGGATGCGCTTGCGCGTTCGGCGTGTGTTGAAACGGGCAGAGCACTAAAAGATCGC
ATTGCTCACAGCGAGCGTCTATTGGTACAGATTTCCGATCAGCTTTTGTCTGCAACGCAAGCGTTGCCAAACATGACGCA
TATGTGCACTCCCCATGGTCGATCAGACAGTGATAATCTCGAAATCAAGCGCTGTGGGGTGCCTCCATGCTTTAGTTTTT
CGCCACGTGATCACGTGGAATTAGCGCGCTTGCTGGATATAGTTGATTTTGAAGCGGGGAAAAAGGTCTCGGGGATAAAG
TTTTATTATCTGAAGCGTGAAGGGGTGCTGCTTGAACAGGCATTGATTATGTTTGGTTTGCAGTTTTTACAAGAGCGCGG
TTTTGTGCCATTTCTCACTCCTGACATTGCTCGTGAGGGTATGGTGTGTGGTTTGGGTTTTAATCCGCGGGGGAGTGGAT
CGAATATCTATCGTATTGAGGGAGAACACCGCTGTTTAGTAGCAACTGCAGAAATTACGCTGGGGGCATACCATGCAGGC
GAGGTTCTTGAAGAGCGGAGTTTACCGCGTTTATACGCAGGGCTCTCGCATTGTTTTCGTAAAGAGGCTGGTGCTGCAGG
CCAGTTTTCTCGCGGTCTTTATCGCGTGCACCAATTTACCAAACTTGAAATGTTTGCGTACTGTACACCGAGTGATTCTG
AGTGCCTGCACGAACGCCTGCGGTCGCTTGAGGAAGAGATTTTTACTGCATTGGAAATTCCTTTTCGTGTGGTGGAAGTG
TGTGCGGGAGATTTGGGTGCGCCTGCGTATCGCAAGTGGGATTTGGAGGCGTGGATGCCTGGACGCCAGGGTGGTTCGTG
GGGAGAGGTGACTTCTGCGTCGAATTGCACAGACTATCAGGCGCGGCGCTTAAATGTCCGCTATAAGGATGCAGAAGGGA
AGAAGCATTATGTACACATGTTGAATGGGACGGCGCTTGCAATTTCTCGCGTGTTAATTGCGCTGCTAGAAAATGGGCAG
GATGCGGAAGGTCGCGTGCGCATTCCGCAAGCTTTGGTGCCGTTTTGTGGTTTTGAGTATCTCTATCCTCGTGTCCTGTA
G

Upstream 100 bases:

>100_bases
CACGATGGGGCGATGGGTATGTTGTTAGCGCTTCTGCGCAGCATTCGATGAGAGTGTCGTTTTTCTTGTACATTCAGAAT
AAGTAAGGGGAGAAAGGCGC

Downstream 100 bases:

>100_bases
CGTTGTGACGCGTCACCCGTTGCGGTTGGGATTTTTTACTTTTTTCTTGCTGGGTAGTTTTCTCGTGTTGGTGTCTTCCT
GCACACGGTGGATGGGGCGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKSSLDALARSACVETGRALKDR
IAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNLEIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIK
FYYLKREGVLLEQALIMFGLQFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAG
EVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERLRSLEEEIFTALEIPFRVVEV
CAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQ
DAEGRVRIPQALVPFCGFEYLYPRVL

Sequences:

>Translated_426_residues
MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKSSLDALARSACVETGRALKDR
IAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNLEIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIK
FYYLKREGVLLEQALIMFGLQFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAG
EVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERLRSLEEEIFTALEIPFRVVEV
CAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQ
DAEGRVRIPQALVPFCGFEYLYPRVL
>Mature_426_residues
MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKSSLDALARSACVETGRALKDR
IAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNLEIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIK
FYYLKREGVLLEQALIMFGLQFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAG
EVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERLRSLEEEIFTALEIPFRVVEV
CAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQ
DAEGRVRIPQALVPFCGFEYLYPRVL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=411, Percent_Identity=38.1995133819951, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI225579074, Length=413, Percent_Identity=37.5302663438257, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI16306548, Length=347, Percent_Identity=37.1757925072046, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787120, Length=438, Percent_Identity=32.8767123287671, Blast_Score=232, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17539260, Length=290, Percent_Identity=40.6896551724138, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=417, Percent_Identity=32.1342925659472, Blast_Score=181, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6321799, Length=383, Percent_Identity=37.0757180156658, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6320226, Length=438, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17737985, Length=334, Percent_Identity=39.5209580838323, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24581334, Length=327, Percent_Identity=37.3088685015291, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_TREPA (O83653)

Other databases:

- EMBL:   AE000520
- PIR:   F71299
- RefSeq:   NP_219084.1
- ProteinModelPortal:   O83653
- SMR:   O83653
- IntAct:   O83653
- GeneID:   2611725
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0647
- NMPDR:   fig|243276.1.peg.643
- TIGR:   TP_0647
- HOGENOM:   HBG629391
- OMA:   PKFDFKP
- ProtClustDB:   PRK05431
- BioCyc:   TPAL243276:TP_0647-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48015; Mature: 48015

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 276-276 BINDING 283-283 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKS
CCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLDALARSACVETGRALKDRIAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCC
EIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIKFYYLKREGVLLEQALIMFGL
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
QFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAG
HHHHHCCCCCCCCHHHHHCCEEEECCCCCCCCCCCEEEECCCCEEEEEEEEEEEECHHHH
EVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERL
HHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHH
RSLEEEIFTALEIPFRVVEVCAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHCCCCCCCCCCCCCCCCCCCCCHH
ARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQDAEGRVRIPQALVPFCGFEY
HHEEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHCHHH
LYPRVL
HHCCCC
>Mature Secondary Structure
MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKS
CCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLDALARSACVETGRALKDRIAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCC
EIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIKFYYLKREGVLLEQALIMFGL
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
QFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAG
HHHHHCCCCCCCCHHHHHCCEEEECCCCCCCCCCCEEEECCCCEEEEEEEEEEEECHHHH
EVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERL
HHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHH
RSLEEEIFTALEIPFRVVEVCAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHCCCCCCCCCCCCCCCCCCCCCHH
ARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQDAEGRVRIPQALVPFCGFEY
HHEEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHCHHH
LYPRVL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876