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The map label for this gene is msrA

Identifier: 189025859

GI number: 189025859

Start: 692841

End: 693716

Strand: Direct

Name: msrA

Synonym: TPASS_0633

Alternate gene names: 189025859

Gene position: 692841-693716 (Clockwise)

Preceding gene: 189025858

Following gene: 189025860

Centisome position: 60.8

GC content: 53.2

Gene sequence:

>876_bases
ATGCTTGCAAACCTTCAGCACCTGAGTGATATTCAGTACCGTGTTACCCAGCAGTCTGCCACTGAGACTCCCTTTAAGAA
TGAGTTCTGGAACTCTTACCAACCCGGTTTCTATCTTGATGTTGTTTCAGGAGAACTCCTCTTCCTCTCCGAAGATAAAT
TCGACTCAGGCTGTGGCTGGCCTAGCTTTTCTGCACCTGCATACGCGCGCGCGGTGATTGAAAAGGAGGATCGAACGCAC
AACATGCTCCGTACTGAGGTGCGGAGTCGGAACGCTAATTCTCATCTCGGGCACGTATTCAAAGACGGTCCGCCCGAACG
CGGGGGGCTCCGTTACTGCATCAATTCTGCAGCGTTGCGCTTTGTTGCTCGGGAAGAGGGGACTGCTCTTTTCGCCGCAG
GCTGCTTCTGGAGTACGGAAGCCTACTTTCGGCGCGTCAAGGGAGTGTTGCGCGTTCGAGTCGGGTACACGGGCGGTACC
ACCAAAAGTCCTACCTATCGAAACGTCTGCACCGGTACTACCGGACACGCAGAAGCGGTAGAGATCCTCTTTGATCCCCA
GGTTATTTCCTATGAGGATCTGCTCAAGCACTTTTTCCGCATGCATGACCCAACTAGTCTTAACAAACAGGGAGGAGACG
TTGGCACGCAATACCGTTCTGCAATTTTCTACCTCAGTGGTACGCAGAAGCAGCAAGCGGAGACGCTCATGGGTCGCTAT
GCAGGCGCGGGAAAGTTCACCCGTCCTTTGGTTACCACTTTGGAAGAGGCGCGTGACTTCTACCCTGCAGAAGAATATCA
CCAAGACTATTTGACCAAGAATCCTGGTGGTTACTGCCACGTGTCGCTCCACCTGGCGTCAGAGCCATTAGAGTGA

Upstream 100 bases:

>100_bases
GCAATCACGCTTCCGCCGGTTTCCCTCTTACCAGTGCGCCGAGTCCTGCCGCCGAGGAGGTGCCCTTGCAGGTCTGGCTC
TCATCGCCTAGAATGGCCCC

Downstream 100 bases:

>100_bases
CCGCTGCACTCACGCCCCCAGGGGACTGCGCCGCCGTTTTGGCATCTTCCGACAAGACGAAGGAGCGTTGCACGCGTGGG
AGGTGCGCCCCGGACGCTAC

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLANLQHLSDIQYRVTQQSATETPFKNEFWNSYQPGFYLDVVSGELLFLSEDKFDSGCGWPSFSAPAYARAVIEKEDRTH
NMLRTEVRSRNANSHLGHVFKDGPPERGGLRYCINSAALRFVAREEGTALFAAGCFWSTEAYFRRVKGVLRVRVGYTGGT
TKSPTYRNVCTGTTGHAEAVEILFDPQVISYEDLLKHFFRMHDPTSLNKQGGDVGTQYRSAIFYLSGTQKQQAETLMGRY
AGAGKFTRPLVTTLEEARDFYPAEEYHQDYLTKNPGGYCHVSLHLASEPLE

Sequences:

>Translated_291_residues
MLANLQHLSDIQYRVTQQSATETPFKNEFWNSYQPGFYLDVVSGELLFLSEDKFDSGCGWPSFSAPAYARAVIEKEDRTH
NMLRTEVRSRNANSHLGHVFKDGPPERGGLRYCINSAALRFVAREEGTALFAAGCFWSTEAYFRRVKGVLRVRVGYTGGT
TKSPTYRNVCTGTTGHAEAVEILFDPQVISYEDLLKHFFRMHDPTSLNKQGGDVGTQYRSAIFYLSGTQKQQAETLMGRY
AGAGKFTRPLVTTLEEARDFYPAEEYHQDYLTKNPGGYCHVSLHLASEPLE
>Mature_291_residues
MLANLQHLSDIQYRVTQQSATETPFKNEFWNSYQPGFYLDVVSGELLFLSEDKFDSGCGWPSFSAPAYARAVIEKEDRTH
NMLRTEVRSRNANSHLGHVFKDGPPERGGLRYCINSAALRFVAREEGTALFAAGCFWSTEAYFRRVKGVLRVRVGYTGGT
TKSPTYRNVCTGTTGHAEAVEILFDPQVISYEDLLKHFFRMHDPTSLNKQGGDVGTQYRSAIFYLSGTQKQQAETLMGRY
AGAGKFTRPLVTTLEEARDFYPAEEYHQDYLTKNPGGYCHVSLHLASEPLE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=46.9135802469136, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI208609995, Length=173, Percent_Identity=45.0867052023121, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI301336164, Length=130, Percent_Identity=45.3846153846154, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI301336162, Length=130, Percent_Identity=45.3846153846154, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI73089054, Length=130, Percent_Identity=45.3846153846154, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI37620216, Length=130, Percent_Identity=45.3846153846154, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=46.4285714285714, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI117606353, Length=127, Percent_Identity=38.5826771653543, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=167, Percent_Identity=46.1077844311377, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=43.2, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17553450, Length=114, Percent_Identity=45.6140350877193, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI115532676, Length=114, Percent_Identity=45.6140350877193, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=38.7323943661972, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=171, Percent_Identity=36.2573099415205, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45553335, Length=126, Percent_Identity=42.0634920634921, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356369, Length=126, Percent_Identity=42.0634920634921, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221378664, Length=118, Percent_Identity=42.3728813559322, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645799, Length=126, Percent_Identity=42.0634920634921, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI221378662, Length=125, Percent_Identity=42.4, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645804, Length=137, Percent_Identity=41.6058394160584, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645801, Length=137, Percent_Identity=41.6058394160584, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664627, Length=158, Percent_Identity=35.4430379746835, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664631, Length=158, Percent_Identity=34.1772151898734, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=36.9565217391304, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRAB_TREPA (O83641)

Other databases:

- EMBL:   AE000520
- PIR:   G71300
- RefSeq:   NP_219071.1
- ProteinModelPortal:   O83641
- SMR:   O83641
- GeneID:   2611495
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0633
- NMPDR:   fig|243276.1.peg.630
- TIGR:   TP_0633
- HOGENOM:   HBG748152
- OMA:   GEQPYCQ
- ProtClustDB:   PRK05550
- BioCyc:   TPAL243276:TP_0633-MONOMER
- BRENDA:   1.8.4.11
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- HAMAP:   MF_01401
- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00401
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01625 PMSR; PF01641 SelR; SSF55068 MsrA; SSF51316 Mss4_like

EC number: =1.8.4.12; =1.8.4.11

Molecular weight: Translated: 32802; Mature: 32802

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANLQHLSDIQYRVTQQSATETPFKNEFWNSYQPGFYLDVVSGELLFLSEDKFDSGCGW
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEEEECCEEEEEECCCCCCCCCC
PSFSAPAYARAVIEKEDRTHNMLRTEVRSRNANSHLGHVFKDGPPERGGLRYCINSAALR
CCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
FVAREEGTALFAAGCFWSTEAYFRRVKGVLRVRVGYTGGTTKSPTYRNVCTGTTGHAEAV
HHHHCCCCEEEEECCHHCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCEE
EILFDPQVISYEDLLKHFFRMHDPTSLNKQGGDVGTQYRSAIFYLSGTQKQQAETLMGRY
EEEECCCEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEEEECCCHHHHHHHHHHH
AGAGKFTRPLVTTLEEARDFYPAEEYHQDYLTKNPGGYCHVSLHLASEPLE
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MLANLQHLSDIQYRVTQQSATETPFKNEFWNSYQPGFYLDVVSGELLFLSEDKFDSGCGW
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEEEECCEEEEEECCCCCCCCCC
PSFSAPAYARAVIEKEDRTHNMLRTEVRSRNANSHLGHVFKDGPPERGGLRYCINSAALR
CCCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHH
FVAREEGTALFAAGCFWSTEAYFRRVKGVLRVRVGYTGGTTKSPTYRNVCTGTTGHAEAV
HHHHCCCCEEEEECCHHCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCEE
EILFDPQVISYEDLLKHFFRMHDPTSLNKQGGDVGTQYRSAIFYLSGTQKQQAETLMGRY
EEEECCCEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEEEECCCHHHHHHHHHHH
AGAGKFTRPLVTTLEEARDFYPAEEYHQDYLTKNPGGYCHVSLHLASEPLE
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876