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The map label for this gene is atpA2 [H]

Identifier: 189025758

GI number: 189025758

Start: 573793

End: 575610

Strand: Reverse

Name: atpA2 [H]

Synonym: TPASS_0529

Alternate gene names: 189025758

Gene position: 575610-573793 (Counterclockwise)

Preceding gene: 189025759

Following gene: 189025757

Centisome position: 50.52

GC content: 54.68

Gene sequence:

>1818_bases
GTGATCAAAGACGATGTGGTTACAGGCCGTGTAGTGAGGGTGTCTGGTCCCATTGTGTATGCCGAGGGCCTCTCTGCGTG
CAGCGTATACGATGTTGTCGACGTAGGGGAAGCATCGCTCATCGGAGAAATTATCCGGTTGGATGAGAGCAAGGCGGTCG
TGCAAGTATACGAGGATGACACAGGTATGCGAGTCGGGGAGAAGGTGACAAGCTTGCGTCGACCACTCTCAGTCCGCTTA
GGGCCTGGATTAATCGGCACCATTTATGACGGTATTCAGCGCCCACTTGAGCGCCTCTTCCAAGAAGACGGCGCCTTCTT
GCGTCCTGGTGCGCGTTCACAACCGCTTGATGGCTCCGTACGCTGGGATTTTCGTCCTCATTGTAACGAGCGCGGTGAGG
CCCTGTGCGCGGGGATTCCGATTGCACCTGGGTCAGTGTTAGGGACCGTGCAGGAGACTCCTTCTGTTGTGCACACTATC
ATGGTTCCTCCTGACATCCGGGGGAGCGTGCTATCTTCGTTCAAGGGCGCAGGTGCTTACACAATAGATGAAGAAATTGG
ACGCACTGATCTTGGTGAGCCGCTTTTTCTATCCCAGTACTGGCCAGTGCGTCGTGCGCGTCCTTTCAGCAAAAAACTTG
CAGTGTGTGAGCCACTAGTTACTGGACAGCGGGCGATTGATGTTTTCTTCCCCCTATCAAAGGGAGGAACGGCGGCTATT
CCAGGGGGATTTGGAACTGGGAAGACAATGACGCAGCATGCCGTTGCCAAGTGGTGTGATGCAGATATTATCGTGTACAT
CGGCTGCGGAGAGCGGGGCAACGAGATGACAGACGTGCTCTCTGAATTTCCCAAACTCATCGATCCGCGCACAGGACGCT
CTCTTATGGAGCGGACGATTTTGATCGCAAATACGTCCAATATGCCTGTGTCCGCACGCGAGGTGTCGCTGTATTCAGGG
ATTACCCTTGCGGAATACTACCGTGATATGGGTATGCATGTGGCCATCATGGCTGATTCTACCAGCCGCTGGGCGGAGGC
GCTGCGTGAATTGTCTGGGCGCATGGAAGAAATGCCTGCGGAGGAGGGATTCCCTGCGTACCTTCCGACGCGTCTTGCAG
AATTTTATGAGCGCGCAGGACGCGTGGAAACCTGTGTGGCGCGCGAGGGCTCTGTGAGCATCATTGGTGCTGTTTCTCCC
CCGGGTGGAGATTTCTCTGAGCCGGTGACGCAGCACACAAAGCGCTTCATCCGTTGCTTTTGGGCCTTGGATCGTGAACT
TGCACACGCGCGTCATTACCCTGCCATTGGGTGGATAGATTCATACTCTGAATATGCGCAGGAAGTAAGTGCATGGTGGA
GTAAGTATGACCCGCGCGCAGGCGCGTTGCGCGCCGCAGCCTTGGATTTGCTGAGAAAGGAACAGCGGTTACAGCAAATT
GTCAGGCTTGTCGGTCCTGATGCGCTGCCTGGAGAAGATCGTCTGGTGCTAATGGTGTGTGAAATGATCAAAGGTGGCTT
TCTGCAGCAGAACGCTTTTGATCCGACGGATGTGTTCTCCTGTCCCGAAAAGCAGGTGCAGATCTTGCGTACCATAGTGG
ATTTTCACGAACGTGCCGTGGTGCTGCTGCGTGCAGGTATTTCGCTTTCTGCGCTGTCCCAGCTTTCGTGCCGGGAGCTC
ATCGTACGTATGAAAACTACGTACGGGAATGAGGATGTACACAAGATGCAGAAAGTGTACGACACGATGTGCACTGAGTT
TGACCAACTGAGTGTGTGTGCTGCCGCGCGCACACAAGGGGGGGAGAAAGTCGAATGA

Upstream 100 bases:

>100_bases
CGCTCCAGTGTCGGAGTACAATCGAGGAGATCTGCGCGCAACTTTTGTCTGAAAAGAGACAGGAGTTGGCGTGTGCCCTG
TGCGGTAATGGAGTGGTAGC

Downstream 100 bases:

>100_bases
AGGGAGTGTGGTATCGGGGTCTGTCCTCCATCGACGGTCCGATCGTGGTGGCAAAGCGCCGGGAAGGTGCATTCTATGGG
GAGATTACGGCCATCCGTGA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A 2 [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MIKDDVVTGRVVRVSGPIVYAEGLSACSVYDVVDVGEASLIGEIIRLDESKAVVQVYEDDTGMRVGEKVTSLRRPLSVRL
GPGLIGTIYDGIQRPLERLFQEDGAFLRPGARSQPLDGSVRWDFRPHCNERGEALCAGIPIAPGSVLGTVQETPSVVHTI
MVPPDIRGSVLSSFKGAGAYTIDEEIGRTDLGEPLFLSQYWPVRRARPFSKKLAVCEPLVTGQRAIDVFFPLSKGGTAAI
PGGFGTGKTMTQHAVAKWCDADIIVYIGCGERGNEMTDVLSEFPKLIDPRTGRSLMERTILIANTSNMPVSAREVSLYSG
ITLAEYYRDMGMHVAIMADSTSRWAEALRELSGRMEEMPAEEGFPAYLPTRLAEFYERAGRVETCVAREGSVSIIGAVSP
PGGDFSEPVTQHTKRFIRCFWALDRELAHARHYPAIGWIDSYSEYAQEVSAWWSKYDPRAGALRAAALDLLRKEQRLQQI
VRLVGPDALPGEDRLVLMVCEMIKGGFLQQNAFDPTDVFSCPEKQVQILRTIVDFHERAVVLLRAGISLSALSQLSCREL
IVRMKTTYGNEDVHKMQKVYDTMCTEFDQLSVCAAARTQGGEKVE

Sequences:

>Translated_605_residues
MIKDDVVTGRVVRVSGPIVYAEGLSACSVYDVVDVGEASLIGEIIRLDESKAVVQVYEDDTGMRVGEKVTSLRRPLSVRL
GPGLIGTIYDGIQRPLERLFQEDGAFLRPGARSQPLDGSVRWDFRPHCNERGEALCAGIPIAPGSVLGTVQETPSVVHTI
MVPPDIRGSVLSSFKGAGAYTIDEEIGRTDLGEPLFLSQYWPVRRARPFSKKLAVCEPLVTGQRAIDVFFPLSKGGTAAI
PGGFGTGKTMTQHAVAKWCDADIIVYIGCGERGNEMTDVLSEFPKLIDPRTGRSLMERTILIANTSNMPVSAREVSLYSG
ITLAEYYRDMGMHVAIMADSTSRWAEALRELSGRMEEMPAEEGFPAYLPTRLAEFYERAGRVETCVAREGSVSIIGAVSP
PGGDFSEPVTQHTKRFIRCFWALDRELAHARHYPAIGWIDSYSEYAQEVSAWWSKYDPRAGALRAAALDLLRKEQRLQQI
VRLVGPDALPGEDRLVLMVCEMIKGGFLQQNAFDPTDVFSCPEKQVQILRTIVDFHERAVVLLRAGISLSALSQLSCREL
IVRMKTTYGNEDVHKMQKVYDTMCTEFDQLSVCAAARTQGGEKVE
>Mature_605_residues
MIKDDVVTGRVVRVSGPIVYAEGLSACSVYDVVDVGEASLIGEIIRLDESKAVVQVYEDDTGMRVGEKVTSLRRPLSVRL
GPGLIGTIYDGIQRPLERLFQEDGAFLRPGARSQPLDGSVRWDFRPHCNERGEALCAGIPIAPGSVLGTVQETPSVVHTI
MVPPDIRGSVLSSFKGAGAYTIDEEIGRTDLGEPLFLSQYWPVRRARPFSKKLAVCEPLVTGQRAIDVFFPLSKGGTAAI
PGGFGTGKTMTQHAVAKWCDADIIVYIGCGERGNEMTDVLSEFPKLIDPRTGRSLMERTILIANTSNMPVSAREVSLYSG
ITLAEYYRDMGMHVAIMADSTSRWAEALRELSGRMEEMPAEEGFPAYLPTRLAEFYERAGRVETCVAREGSVSIIGAVSP
PGGDFSEPVTQHTKRFIRCFWALDRELAHARHYPAIGWIDSYSEYAQEVSAWWSKYDPRAGALRAAALDLLRKEQRLQQI
VRLVGPDALPGEDRLVLMVCEMIKGGFLQQNAFDPTDVFSCPEKQVQILRTIVDFHERAVVLLRAGISLSALSQLSCREL
IVRMKTTYGNEDVHKMQKVYDTMCTEFDQLSVCAAARTQGGEKVE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=541, Percent_Identity=47.5046210720887, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI32189394, Length=353, Percent_Identity=28.328611898017, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI19913428, Length=237, Percent_Identity=29.957805907173, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI19913426, Length=237, Percent_Identity=29.957805907173, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI50345984, Length=238, Percent_Identity=26.4705882352941, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4757810, Length=238, Percent_Identity=26.4705882352941, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790170, Length=355, Percent_Identity=27.887323943662, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788251, Length=317, Percent_Identity=28.0757097791798, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790172, Length=241, Percent_Identity=25.3112033195021, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=541, Percent_Identity=46.3955637707948, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI25144756, Length=327, Percent_Identity=29.3577981651376, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=237, Percent_Identity=30.379746835443, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17510931, Length=339, Percent_Identity=27.1386430678466, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71988074, Length=287, Percent_Identity=26.1324041811847, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988080, Length=238, Percent_Identity=26.4705882352941, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71988063, Length=238, Percent_Identity=26.4705882352941, Blast_Score=79, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320016, Length=352, Percent_Identity=43.4659090909091, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6322581, Length=335, Percent_Identity=27.7611940298507, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319603, Length=237, Percent_Identity=30.8016877637131, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319370, Length=392, Percent_Identity=24.4897959183673, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20129479, Length=550, Percent_Identity=46.3636363636364, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583988, Length=542, Percent_Identity=47.6014760147601, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583986, Length=542, Percent_Identity=47.6014760147601, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583984, Length=542, Percent_Identity=47.6014760147601, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583992, Length=542, Percent_Identity=48.1549815498155, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI28574560, Length=327, Percent_Identity=29.0519877675841, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24638766, Length=327, Percent_Identity=28.7461773700306, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281361666, Length=237, Percent_Identity=29.957805907173, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646341, Length=237, Percent_Identity=29.957805907173, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136796, Length=237, Percent_Identity=29.957805907173, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24658560, Length=390, Percent_Identity=21.2820512820513, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 66725; Mature: 66725

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKDDVVTGRVVRVSGPIVYAEGLSACSVYDVVDVGEASLIGEIIRLDESKAVVQVYEDD
CCCCCCCCCEEEEEECCEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECC
TGMRVGEKVTSLRRPLSVRLGPGLIGTIYDGIQRPLERLFQEDGAFLRPGARSQPLDGSV
CCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCE
RWDFRPHCNERGEALCAGIPIAPGSVLGTVQETPSVVHTIMVPPDIRGSVLSSFKGAGAY
EECCCCCCCCCCCEEEECCCCCCCHHHCCHHHCCCEEEEEECCCCCCHHHHHHCCCCCCE
TIDEEIGRTDLGEPLFLSQYWPVRRARPFSKKLAVCEPLVTGQRAIDVFFPLSKGGTAAI
EEHHHCCCCCCCCCCCHHCCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEC
PGGFGTGKTMTQHAVAKWCDADIIVYIGCGERGNEMTDVLSEFPKLIDPRTGRSLMERTI
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEE
LIANTSNMPVSAREVSLYSGITLAEYYRDMGMHVAIMADSTSRWAEALRELSGRMEEMPA
EEEECCCCCCCHHHHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
EEGFPAYLPTRLAEFYERAGRVETCVAREGSVSIIGAVSPPGGDFSEPVTQHTKRFIRCF
CCCCCCHHHHHHHHHHHHCCCCEEEHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
WALDRELAHARHYPAIGWIDSYSEYAQEVSAWWSKYDPRAGALRAAALDLLRKEQRLQQI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VRLVGPDALPGEDRLVLMVCEMIKGGFLQQNAFDPTDVFSCPEKQVQILRTIVDFHERAV
HHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
VLLRAGISLSALSQLSCRELIVRMKTTYGNEDVHKMQKVYDTMCTEFDQLSVCAAARTQG
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GEKVE
CCCCC
>Mature Secondary Structure
MIKDDVVTGRVVRVSGPIVYAEGLSACSVYDVVDVGEASLIGEIIRLDESKAVVQVYEDD
CCCCCCCCCEEEEEECCEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECC
TGMRVGEKVTSLRRPLSVRLGPGLIGTIYDGIQRPLERLFQEDGAFLRPGARSQPLDGSV
CCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCE
RWDFRPHCNERGEALCAGIPIAPGSVLGTVQETPSVVHTIMVPPDIRGSVLSSFKGAGAY
EECCCCCCCCCCCEEEECCCCCCCHHHCCHHHCCCEEEEEECCCCCCHHHHHHCCCCCCE
TIDEEIGRTDLGEPLFLSQYWPVRRARPFSKKLAVCEPLVTGQRAIDVFFPLSKGGTAAI
EEHHHCCCCCCCCCCCHHCCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEC
PGGFGTGKTMTQHAVAKWCDADIIVYIGCGERGNEMTDVLSEFPKLIDPRTGRSLMERTI
CCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEE
LIANTSNMPVSAREVSLYSGITLAEYYRDMGMHVAIMADSTSRWAEALRELSGRMEEMPA
EEEECCCCCCCHHHHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
EEGFPAYLPTRLAEFYERAGRVETCVAREGSVSIIGAVSPPGGDFSEPVTQHTKRFIRCF
CCCCCCHHHHHHHHHHHHCCCCEEEHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
WALDRELAHARHYPAIGWIDSYSEYAQEVSAWWSKYDPRAGALRAAALDLLRKEQRLQQI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VRLVGPDALPGEDRLVLMVCEMIKGGFLQQNAFDPTDVFSCPEKQVQILRTIVDFHERAV
HHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
VLLRAGISLSALSQLSCRELIVRMKTTYGNEDVHKMQKVYDTMCTEFDQLSVCAAARTQG
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GEKVE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]