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The map label for this gene is atoC [H]

Identifier: 189025749

GI number: 189025749

Start: 560597

End: 561973

Strand: Reverse

Name: atoC [H]

Synonym: TPASS_0519

Alternate gene names: 189025749

Gene position: 561973-560597 (Counterclockwise)

Preceding gene: 189025750

Following gene: 189025748

Centisome position: 49.32

GC content: 42.99

Gene sequence:

>1377_bases
ATGAAATTCAGTATTCTCGTACTAGATGATGAAAAAAATATCCGTGAAGGTTTGCAAATGGCCCTCGAAGATGAAGGATA
TGAGGTGTTTACCGCAGAGGATGGAAATACAGGGGTAGAGATTGCCCTCAAAGGGGATATCGATCTTATTATCACTGATT
TAAAAATGCCTCGTATGAGCGGGGAATTGGTGCTGCAACATGTGCACGCGGTGTTGCCCGATATTCCTATCATTATTCTC
ACCGGGCATGGCACAGTAGAAAATGCAGTTGAAGCAATGCACAAGGGAGCTTACGATTTTTTAACTAAACCATTGGATCT
TAACCGATTGTCTTTGCTTGTGCGCCGGGCGCTACAAAACCGAGAGTTGATCGTTCAACATCGAGAGTTAATCAAACAAA
TAGGAAATCGCACCTCATTCGAGAACATTGTAGGAGAAAGTCCTGCAATGAACAAAGTGTTTGACATGGTAAAAAAGGCA
GCCGCCTCAAAAGCGTCCGTGCTCATTACTGGAGAAAGCGGGGTCGGTAAAGAACTTATCGCGAATGCAATCCATAATCT
TTCGCCGAGGAAGGCAAAACCTTTAATTAAAGTACACTGCGCTTCTTTTGCAGAAGGAGTGTTGGAAAGTGAGTTATTCG
GTCATGAAAGGGGTGCCTTTACCGGTGCGGTCAATCGCATGAAAGGTCGTTTTGAACTTGCGCACGAAGGATCAATGTTT
CTTGATGAAATCGGAGAAGTAAGTATGGCTGTGCAAATAAAACTACTCCGTGTGTTACAAGAACGTTCATTTGAACGTGT
AGGTGGAAGAGAAACAATAAAAGTTGATGTACGCGTAATTTCTGCAACAAATCGTAATCTTTTAGAAGAAATTAAACGCA
ATTTGTTTCGAGAGGATCTTTATTACCGATTAAATGTTGTGCACATTCACGTTCCTGCGCTGCGCGAGCGCAAGGAGGAT
TTGCCATTACTGATTGCAACATTTCTTAAAGAGATTGCAGAAGAAAACGGTAAAAAAATTACCTCTATAGATCCTCAGGC
CCAGTCTGCACTGCACGCGTATGATTGGCCTGGTAATATTCGTCAGCTGAGAAACTGCATTGAAAGCGCTGTCATTATGA
GCTCAGGTCCTGTTATCCACATAGAGGATCTCTCAGAGCCAATTCGATCTCTCGGTGAAACCTCTTCCATACGCATTCCT
ATAGGAGTGAGCATGGAGGATGCAGAAAAGGAAATCATCCTCCAGACACTGGAAGCACAAAAAGGTAATAAGAGCAAAAC
CGCAGACGTGCTTGGCATTGGGAGAAAGACGCTCTATCTAAAATTAGATCAATACACGAATACAAGCTTTGAACCTGATG
CCGCAGCAAAATCATGA

Upstream 100 bases:

>100_bases
TTTTACTCTCCTTTTACCCATAGATAAATTGGGACGATCGCTTTTACAAGAAAAAATATCCACCCACCTAAGACATACGA
GTAAAGAATAAGGAAATGCG

Downstream 100 bases:

>100_bases
AACGTGCTTTGATAATCACCGGAGGTGAATATGCACCCTATGAGTTTGTGCAATATTACCTGCCTGCGTACGATCTGCTC
ATTGCCGCTGATTCAGGGCT

Product: response regulatory protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKFSILVLDDEKNIREGLQMALEDEGYEVFTAEDGNTGVEIALKGDIDLIITDLKMPRMSGELVLQHVHAVLPDIPIIIL
TGHGTVENAVEAMHKGAYDFLTKPLDLNRLSLLVRRALQNRELIVQHRELIKQIGNRTSFENIVGESPAMNKVFDMVKKA
AASKASVLITGESGVGKELIANAIHNLSPRKAKPLIKVHCASFAEGVLESELFGHERGAFTGAVNRMKGRFELAHEGSMF
LDEIGEVSMAVQIKLLRVLQERSFERVGGRETIKVDVRVISATNRNLLEEIKRNLFREDLYYRLNVVHIHVPALRERKED
LPLLIATFLKEIAEENGKKITSIDPQAQSALHAYDWPGNIRQLRNCIESAVIMSSGPVIHIEDLSEPIRSLGETSSIRIP
IGVSMEDAEKEIILQTLEAQKGNKSKTADVLGIGRKTLYLKLDQYTNTSFEPDAAAKS

Sequences:

>Translated_458_residues
MKFSILVLDDEKNIREGLQMALEDEGYEVFTAEDGNTGVEIALKGDIDLIITDLKMPRMSGELVLQHVHAVLPDIPIIIL
TGHGTVENAVEAMHKGAYDFLTKPLDLNRLSLLVRRALQNRELIVQHRELIKQIGNRTSFENIVGESPAMNKVFDMVKKA
AASKASVLITGESGVGKELIANAIHNLSPRKAKPLIKVHCASFAEGVLESELFGHERGAFTGAVNRMKGRFELAHEGSMF
LDEIGEVSMAVQIKLLRVLQERSFERVGGRETIKVDVRVISATNRNLLEEIKRNLFREDLYYRLNVVHIHVPALRERKED
LPLLIATFLKEIAEENGKKITSIDPQAQSALHAYDWPGNIRQLRNCIESAVIMSSGPVIHIEDLSEPIRSLGETSSIRIP
IGVSMEDAEKEIILQTLEAQKGNKSKTADVLGIGRKTLYLKLDQYTNTSFEPDAAAKS
>Mature_458_residues
MKFSILVLDDEKNIREGLQMALEDEGYEVFTAEDGNTGVEIALKGDIDLIITDLKMPRMSGELVLQHVHAVLPDIPIIIL
TGHGTVENAVEAMHKGAYDFLTKPLDLNRLSLLVRRALQNRELIVQHRELIKQIGNRTSFENIVGESPAMNKVFDMVKKA
AASKASVLITGESGVGKELIANAIHNLSPRKAKPLIKVHCASFAEGVLESELFGHERGAFTGAVNRMKGRFELAHEGSMF
LDEIGEVSMAVQIKLLRVLQERSFERVGGRETIKVDVRVISATNRNLLEEIKRNLFREDLYYRLNVVHIHVPALRERKED
LPLLIATFLKEIAEENGKKITSIDPQAQSALHAYDWPGNIRQLRNCIESAVIMSSGPVIHIEDLSEPIRSLGETSSIRIP
IGVSMEDAEKEIILQTLEAQKGNKSKTADVLGIGRKTLYLKLDQYTNTSFEPDAAAKS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=46.6666666666667, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=44.9438202247191, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=38.3620689655172, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=40.4977375565611, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87082117, Length=332, Percent_Identity=42.1686746987952, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1789087, Length=355, Percent_Identity=43.6619718309859, Blast_Score=265, Evalue=7e-72,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=41.3793103448276, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082152, Length=313, Percent_Identity=39.9361022364217, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786524, Length=329, Percent_Identity=39.5136778115502, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=38.6075949367089, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87081872, Length=306, Percent_Identity=37.5816993464052, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081858, Length=325, Percent_Identity=32.3076923076923, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1789828, Length=297, Percent_Identity=28.6195286195286, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=35.042735042735, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=33.6206896551724, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786599, Length=153, Percent_Identity=32.0261437908497, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50964; Mature: 50964

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSILVLDDEKNIREGLQMALEDEGYEVFTAEDGNTGVEIALKGDIDLIITDLKMPRMS
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCEEEEECCCCCCCC
GELVLQHVHAVLPDIPIIILTGHGTVENAVEAMHKGAYDFLTKPLDLNRLSLLVRRALQN
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCC
RELIVQHRELIKQIGNRTSFENIVGESPAMNKVFDMVKKAAASKASVLITGESGVGKELI
CHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
ANAIHNLSPRKAKPLIKVHCASFAEGVLESELFGHERGAFTGAVNRMKGRFELAHEGSMF
HHHHHCCCCCCCCCHHEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCHH
LDEIGEVSMAVQIKLLRVLQERSFERVGGRETIKVDVRVISATNRNLLEEIKRNLFREDL
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHH
YYRLNVVHIHVPALRERKEDLPLLIATFLKEIAEENGKKITSIDPQAQSALHAYDWPGNI
HEEEEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCH
RQLRNCIESAVIMSSGPVIHIEDLSEPIRSLGETSSIRIPIGVSMEDAEKEIILQTLEAQ
HHHHHHHHHHHEECCCCEEEEHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHC
KGNKSKTADVLGIGRKTLYLKLDQYTNTSFEPDAAAKS
CCCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFSILVLDDEKNIREGLQMALEDEGYEVFTAEDGNTGVEIALKGDIDLIITDLKMPRMS
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCEEEEECCCCCCCC
GELVLQHVHAVLPDIPIIILTGHGTVENAVEAMHKGAYDFLTKPLDLNRLSLLVRRALQN
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCC
RELIVQHRELIKQIGNRTSFENIVGESPAMNKVFDMVKKAAASKASVLITGESGVGKELI
CHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
ANAIHNLSPRKAKPLIKVHCASFAEGVLESELFGHERGAFTGAVNRMKGRFELAHEGSMF
HHHHHCCCCCCCCCHHEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCHH
LDEIGEVSMAVQIKLLRVLQERSFERVGGRETIKVDVRVISATNRNLLEEIKRNLFREDL
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHH
YYRLNVVHIHVPALRERKEDLPLLIATFLKEIAEENGKKITSIDPQAQSALHAYDWPGNI
HEEEEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCH
RQLRNCIESAVIMSSGPVIHIEDLSEPIRSLGETSSIRIPIGVSMEDAEKEIILQTLEAQ
HHHHHHHHHHHEECCCCEEEEHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHC
KGNKSKTADVLGIGRKTLYLKLDQYTNTSFEPDAAAKS
CCCCCCCHHHHCCCCEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]