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The map label for this gene is atpA1

Identifier: 189025659

GI number: 189025659

Start: 454188

End: 455957

Strand: Direct

Name: atpA1

Synonym: TPASS_0426

Alternate gene names: 189025659

Gene position: 454188-455957 (Clockwise)

Preceding gene: 189025658

Following gene: 189025660

Centisome position: 39.86

GC content: 54.01

Gene sequence:

>1770_bases
ATGACGCAAACGAAGGGTATCGTGTCTGCGGTCAACGGCAATATGGTGAGCGTTACGTTCGAGGGTGTCGTTTCGCTCAA
CGAGGTCGGATACGTGCATGTTGGAAATGCGCGTTTGAAAGCGGAGATTATTCGTGTTCGTGGTCGTGAGGCACAGTTGC
AAGTGTTTGAGATCACAAGAGGGGTTTCCGTTGGGGACCGTGTTGAGTTTACAGGCGATTTGCTGTCTGTTGAGCTAGGT
CCTGGTTTGCTCGGTCAGGTGTACGACGGTTTACAGAATCCGTTGCCGCTGCTTGCAGAAAAGGTTGGGTATTTCTTGGA
GCGCGGGGTGTATTTGCCCGCCCTCTCTCGGACAAGTGAATGGATGTTTACCCCGCATGTTTCAGTGGGTGAGCGCGTGG
TGCGTGGGGACGTGCTCGGGTATACCCCAGAGGGTGCGCTCAAACACCGCATTATGGTTCCCTTTCATATGGGGGATTCC
TATGAGGTTGTCTTCATTCAGACTGCAGGGACGTACCGCGTGCACGATGTGATTGCGCGGGTCCGTGACGCGCAGGGACA
TGAGCACGAACTGACCATGGCATTTCGTTGGCCAGTGAAGCGACCCGTCCATTGTTACGCAGAGCGTTTGAAACCGACTG
AGCCATTGGTAACGAGCATTAGGACGATAGATACCTTTTTCCCGGTGGCCAAGGGGGGGACGTACTGTATTCCCGGTCCC
TTTGGTGCGGGAAAGACGGTGCTGCAGCATTCTACCAGTCGCAATGCGGATGTGGACGTGGTAGTGATTGCTGCGTGTGG
GGAGCGTGCAGGGGAGGTGGTTGAGACCCTGCGGGAGTTTCCTGATCTTACGGATCCTCGCACTGGTCGGTCGCTTATGG
AGCGGACGGTTATAGTGTGCAACACTTCTTCTATGCCCGTTGCCTCTCGTGAGGCTTCAGTGTACACGGGAGTGACGCTT
GCAGAATATTACCGTCAGATGGGGTTGGATGTTCTTTTGCTGGCGGACTCTACGAGCCGTTGGGCACAGGCCCTGCGTGA
AATGTCTGGGCGTTTGGAAGAGATTCCGGGGGAGGAGGCCTTTCCTGCGTACCTGGAGTCTTGTATCGCAGCCTTTTATG
AGCGGGCTGGTGTGGTCCGGCTGAGGAGTGGAGAGAAAGGATCGGTAACTATTGGAGGGACGGTTTCTCCGGCAGGTGGT
AATTTCGAAGAACCGGTAACGCAGGCTACATTGAAAGTGGTTGGGGCGTTTCACGGACTTTCTCGAGAGCGCTCTGACGC
GCGCAGGTATCCTGCGGTGCATCCGCTTGATTCATGGTCTAAGTATCCAAGTGTGCTTGACGCGCGGGCTGTTGCGTACG
GTCGCTCTTTTCTGCGCCGTGGGGCAGAGGTGGAGCAGATGATGAGGGTCGTCGGCGAAGAGGGCACAAGTATGGAGGAC
TTTCTCGTATATCTGAAAGGCTCGTTTCTTGATTCGGTGTATCTGCAGCAGAATTCTTTTGACACAGTCGATAGTGCAGT
ACCTGTTGCACGTCAAAAGCACTGCTATGCCATCGTCATGCGGGTTCTTGGCAGTGTTTTAGCGTTTGAATCAAAAGATG
ACGCGCGGGCATACTTCAGCAAGCTTGGGCATATGTTTATCGATTACAACTGTTGCGCCTGGAATTCTGAGGCGTTTGTG
GAGAAAGAAAAGGAGATACGTGCCTTTCTCCAGGGAGAATCGACGAAAATCGACAGCGAAGCAGAGGGAATTATACGGGG
GATGGAGTAG

Upstream 100 bases:

>100_bases
GGCTGCAGCTGATGTTGCTTACGCATCGGTCGCGTTTCACAATGCAGGCGGGGTCCAAAGCATACGCAGCTCTTTATTAT
ACAATTCTTGGAGCATATAC

Downstream 100 bases:

>100_bases
ACGATGTACAAGGTGTACGAGAAGATTGAGTCGATCAACGGTTCTGTCATCACGGTGCGGGCAAAGGGGGTGCATTACGG
GGAATTGGCCCGGGTAAAAA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A 1

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MTQTKGIVSAVNGNMVSVTFEGVVSLNEVGYVHVGNARLKAEIIRVRGREAQLQVFEITRGVSVGDRVEFTGDLLSVELG
PGLLGQVYDGLQNPLPLLAEKVGYFLERGVYLPALSRTSEWMFTPHVSVGERVVRGDVLGYTPEGALKHRIMVPFHMGDS
YEVVFIQTAGTYRVHDVIARVRDAQGHEHELTMAFRWPVKRPVHCYAERLKPTEPLVTSIRTIDTFFPVAKGGTYCIPGP
FGAGKTVLQHSTSRNADVDVVVIAACGERAGEVVETLREFPDLTDPRTGRSLMERTVIVCNTSSMPVASREASVYTGVTL
AEYYRQMGLDVLLLADSTSRWAQALREMSGRLEEIPGEEAFPAYLESCIAAFYERAGVVRLRSGEKGSVTIGGTVSPAGG
NFEEPVTQATLKVVGAFHGLSRERSDARRYPAVHPLDSWSKYPSVLDARAVAYGRSFLRRGAEVEQMMRVVGEEGTSMED
FLVYLKGSFLDSVYLQQNSFDTVDSAVPVARQKHCYAIVMRVLGSVLAFESKDDARAYFSKLGHMFIDYNCCAWNSEAFV
EKEKEIRAFLQGESTKIDSEAEGIIRGME

Sequences:

>Translated_589_residues
MTQTKGIVSAVNGNMVSVTFEGVVSLNEVGYVHVGNARLKAEIIRVRGREAQLQVFEITRGVSVGDRVEFTGDLLSVELG
PGLLGQVYDGLQNPLPLLAEKVGYFLERGVYLPALSRTSEWMFTPHVSVGERVVRGDVLGYTPEGALKHRIMVPFHMGDS
YEVVFIQTAGTYRVHDVIARVRDAQGHEHELTMAFRWPVKRPVHCYAERLKPTEPLVTSIRTIDTFFPVAKGGTYCIPGP
FGAGKTVLQHSTSRNADVDVVVIAACGERAGEVVETLREFPDLTDPRTGRSLMERTVIVCNTSSMPVASREASVYTGVTL
AEYYRQMGLDVLLLADSTSRWAQALREMSGRLEEIPGEEAFPAYLESCIAAFYERAGVVRLRSGEKGSVTIGGTVSPAGG
NFEEPVTQATLKVVGAFHGLSRERSDARRYPAVHPLDSWSKYPSVLDARAVAYGRSFLRRGAEVEQMMRVVGEEGTSMED
FLVYLKGSFLDSVYLQQNSFDTVDSAVPVARQKHCYAIVMRVLGSVLAFESKDDARAYFSKLGHMFIDYNCCAWNSEAFV
EKEKEIRAFLQGESTKIDSEAEGIIRGME
>Mature_588_residues
TQTKGIVSAVNGNMVSVTFEGVVSLNEVGYVHVGNARLKAEIIRVRGREAQLQVFEITRGVSVGDRVEFTGDLLSVELGP
GLLGQVYDGLQNPLPLLAEKVGYFLERGVYLPALSRTSEWMFTPHVSVGERVVRGDVLGYTPEGALKHRIMVPFHMGDSY
EVVFIQTAGTYRVHDVIARVRDAQGHEHELTMAFRWPVKRPVHCYAERLKPTEPLVTSIRTIDTFFPVAKGGTYCIPGPF
GAGKTVLQHSTSRNADVDVVVIAACGERAGEVVETLREFPDLTDPRTGRSLMERTVIVCNTSSMPVASREASVYTGVTLA
EYYRQMGLDVLLLADSTSRWAQALREMSGRLEEIPGEEAFPAYLESCIAAFYERAGVVRLRSGEKGSVTIGGTVSPAGGN
FEEPVTQATLKVVGAFHGLSRERSDARRYPAVHPLDSWSKYPSVLDARAVAYGRSFLRRGAEVEQMMRVVGEEGTSMEDF
LVYLKGSFLDSVYLQQNSFDTVDSAVPVARQKHCYAIVMRVLGSVLAFESKDDARAYFSKLGHMFIDYNCCAWNSEAFVE
KEKEIRAFLQGESTKIDSEAEGIIRGME

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=523, Percent_Identity=41.3001912045889, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI32189394, Length=304, Percent_Identity=29.6052631578947, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI19913426, Length=341, Percent_Identity=25.5131964809384, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI19913428, Length=332, Percent_Identity=26.5060240963855, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI50345984, Length=216, Percent_Identity=25.462962962963, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI4757810, Length=216, Percent_Identity=25.462962962963, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790170, Length=348, Percent_Identity=29.5977011494253, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790172, Length=247, Percent_Identity=25.1012145748988, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788251, Length=232, Percent_Identity=28.0172413793103, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565854, Length=523, Percent_Identity=40.3441682600382, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144756, Length=283, Percent_Identity=30.0353356890459, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17570191, Length=339, Percent_Identity=25.9587020648968, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17510931, Length=312, Percent_Identity=26.2820512820513, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988080, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988063, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988074, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320016, Length=265, Percent_Identity=43.3962264150943, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322581, Length=324, Percent_Identity=29.0123456790123, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319603, Length=346, Percent_Identity=27.1676300578035, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583988, Length=525, Percent_Identity=41.7142857142857, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24583986, Length=525, Percent_Identity=41.7142857142857, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24583984, Length=525, Percent_Identity=41.7142857142857, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24583992, Length=525, Percent_Identity=40.9523809523809, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI20129479, Length=526, Percent_Identity=39.7338403041825, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24638766, Length=284, Percent_Identity=31.3380281690141, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574560, Length=290, Percent_Identity=31.3793103448276, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281361666, Length=377, Percent_Identity=25.4641909814324, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646341, Length=377, Percent_Identity=25.4641909814324, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136796, Length=377, Percent_Identity=25.4641909814324, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24658560, Length=217, Percent_Identity=27.1889400921659, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA1_TREPA (O83441)

Other databases:

- EMBL:   AE000520
- PIR:   G71325
- RefSeq:   NP_218866.1
- ProteinModelPortal:   O83441
- SMR:   O83441
- GeneID:   2610927
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0426
- NMPDR:   fig|243276.1.peg.425
- TIGR:   TP_0426
- HOGENOM:   HBG288114
- OMA:   QMGLDIL
- ProtClustDB:   PRK04192
- BioCyc:   TPAL243276:TP_0426-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N

EC number: =3.6.3.14

Molecular weight: Translated: 65020; Mature: 64889

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTKGIVSAVNGNMVSVTFEGVVSLNEVGYVHVGNARLKAEIIRVRGREAQLQVFEITR
CCCCCCHHEECCCCEEEEEEECEEEECCCCEEEECCCHHEEEHHHCCCCCCEEEEEEEEC
GVSVGDRVEFTGDLLSVELGPGLLGQVYDGLQNPLPLLAEKVGYFLERGVYLPALSRTSE
CCCCCCCEEECCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
WMFTPHVSVGERVVRGDVLGYTPEGALKHRIMVPFHMGDSYEVVFIQTAGTYRVHDVIAR
EEECCCCHHCCHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHH
VRDAQGHEHELTMAFRWPVKRPVHCYAERLKPTEPLVTSIRTIDTFFPVAKGGTYCIPGP
HHHCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEECCC
FGAGKTVLQHSTSRNADVDVVVIAACGERAGEVVETLREFPDLTDPRTGRSLMERTVIVC
CCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHCEEEEE
NTSSMPVASREASVYTGVTLAEYYRQMGLDVLLLADSTSRWAQALREMSGRLEEIPGEEA
CCCCCCCCCCCCCCEECCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHHHCCCCCC
FPAYLESCIAAFYERAGVVRLRSGEKGSVTIGGTVSPAGGNFEEPVTQATLKVVGAFHGL
CHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCEECCCCCCCCHHHHHHHHHHHHHHHCC
SRERSDARRYPAVHPLDSWSKYPSVLDARAVAYGRSFLRRGAEVEQMMRVVGEEGTSMED
CCCHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
FLVYLKGSFLDSVYLQQNSFDTVDSAVPVARQKHCYAIVMRVLGSVLAFESKDDARAYFS
HHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KLGHMFIDYNCCAWNSEAFVEKEKEIRAFLQGESTKIDSEAEGIIRGME
HHCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TQTKGIVSAVNGNMVSVTFEGVVSLNEVGYVHVGNARLKAEIIRVRGREAQLQVFEITR
CCCCCHHEECCCCEEEEEEECEEEECCCCEEEECCCHHEEEHHHCCCCCCEEEEEEEEC
GVSVGDRVEFTGDLLSVELGPGLLGQVYDGLQNPLPLLAEKVGYFLERGVYLPALSRTSE
CCCCCCCEEECCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
WMFTPHVSVGERVVRGDVLGYTPEGALKHRIMVPFHMGDSYEVVFIQTAGTYRVHDVIAR
EEECCCCHHCCHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHH
VRDAQGHEHELTMAFRWPVKRPVHCYAERLKPTEPLVTSIRTIDTFFPVAKGGTYCIPGP
HHHCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEECCC
FGAGKTVLQHSTSRNADVDVVVIAACGERAGEVVETLREFPDLTDPRTGRSLMERTVIVC
CCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHCEEEEE
NTSSMPVASREASVYTGVTLAEYYRQMGLDVLLLADSTSRWAQALREMSGRLEEIPGEEA
CCCCCCCCCCCCCCEECCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHHHCCCCCC
FPAYLESCIAAFYERAGVVRLRSGEKGSVTIGGTVSPAGGNFEEPVTQATLKVVGAFHGL
CHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCEECCCCCCCCHHHHHHHHHHHHHHHCC
SRERSDARRYPAVHPLDSWSKYPSVLDARAVAYGRSFLRRGAEVEQMMRVVGEEGTSMED
CCCHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
FLVYLKGSFLDSVYLQQNSFDTVDSAVPVARQKHCYAIVMRVLGSVLAFESKDDARAYFS
HHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KLGHMFIDYNCCAWNSEAFVEKEKEIRAFLQGESTKIDSEAEGIIRGME
HHCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876