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The map label for this gene is ffh [H]

Identifier: 189025649

GI number: 189025649

Start: 443864

End: 445222

Strand: Reverse

Name: ffh [H]

Synonym: TPASS_0416

Alternate gene names: 189025649

Gene position: 445222-443864 (Counterclockwise)

Preceding gene: 189025650

Following gene: 189025646

Centisome position: 39.07

GC content: 55.04

Gene sequence:

>1359_bases
ATGTTTGAGCAACTGAGCGCGAGCTTTAAACGTATCGTAGGAGCGCTGGGAGGACGCGCAACTATCAGCGAACGGAATAT
TCAAGAAGCAGTAGAATCAATTAAGCGCGCACTGTTAGACGCCGACGTGCACGTTCGCGTAGTGCGTCGCTTTGTGAATC
AGACCATACAACACGCGCAGGGACAGACGGTGCTTGCGTCGGTTAGCCCTGCGCAGCAATTCATAAAAATTGTACACGAA
AGACTAACTGCCTTCCTCGGTGAACATACGCGGTCGCTGCATCTTAAGGGGCCCGATACGCAGTCGATTATTCTCTTGCT
TGGGCTCCAAGGATCGGGGAAAACTACCAGCGCAGCAAAGCTTGCTGCGTACCTGAAGGATGCAGGTCGCTCCCCTCTCC
TGGCCGCTTGCGATCACGTTCGTGCCGCAGCGAGTGCTCAGCTGGCCGTTCTCGGCACGCACATTGGCGTTCCCGTGTAC
CAGCATGCGCTGCCGCACGAACAGCAGCCGTGTGCTCTTGATACGGCGCGCGGTGCGCTTCAGTACGCGCGCTCACACGG
CAATGACGTACTTATCATTGACACTGCTGGCCGTCTCCACGTGGATGCCGCGCTCATGCAGGAGTTAATCCTTCTCAAAG
AAACACTGGTTCCTGTGGAAACACTCCTTGTTGCAGACGCTCTAACCGGTCAGACTGTGGTGCGCATTGCAGAAGAGTTC
CATGCCGCGGTGGGTATTTCAGGCGTTGTGCTCAGTAAGTTTGATTCAGACACCCGCGGCGGAGCTGCACTGTCTTTGAA
AAGTATTACCGGTCAGCCACTGCTGTTTGTTGGAACCGGTGAACGACCGCAGGACTTTGAACCGTTCCATCCCGAGCGAG
CCGCCGGAAGAATTCTGGGTATGGGGGACATCGTTTCTCTCGTGGAAAAGGCGCAAAAAGCCTTTGATGCACAGGAACAT
GCGCGTGCGCAGAAGAAAACGCAATCGCACGAGCGTTTCACGCTCAGCGATATGCTCGACCACCTGCAAACTATAGAAAA
AATGGGACCGCTGCACTCGTTGGTGGAGATGATTCCCGGTTTAGCGGTAGCCGTTTCTGCCGATGCTCTTGACGCGCGCG
CGTTCAAGCGTCAAAAGGCGATTATTCAATCGATGACCGTGCAAGAGCGTGACAATTTTCTCATTATCGGCCCCTCAAGG
AGGCGGCGCATCGCGGCAGGGTCAGGCACTTCGGTGGCTGATGTTAACCGTTTAATTAAGAATTTCGAGAGGATGCGCAC
GCTCATGCGCAAGACTGCATGGCAGTCACGCCGGGCACACCCTAAAGGAGATACACCCTATGGATGGCCACATCGCTAG

Upstream 100 bases:

>100_bases
GCGCTCATCTTTTTTGCAGAAGGAGTGCGCATGGCCGTGCACACCCGCCGGCACAGCACCACGCAGGCGGAAAGCTCACT
GCAGCAGATAAGGGGGGAGC

Downstream 100 bases:

>100_bases
ATACGCCGCCTGCGCCCTTTTCGCACTCAGTGCGCTGTGCGCCCCGCTTCGCGCGCAGAAGACGCGGACCACTCCTGGTC
CCCCGTACATACCCCACCCT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFEQLSASFKRIVGALGGRATISERNIQEAVESIKRALLDADVHVRVVRRFVNQTIQHAQGQTVLASVSPAQQFIKIVHE
RLTAFLGEHTRSLHLKGPDTQSIILLLGLQGSGKTTSAAKLAAYLKDAGRSPLLAACDHVRAAASAQLAVLGTHIGVPVY
QHALPHEQQPCALDTARGALQYARSHGNDVLIIDTAGRLHVDAALMQELILLKETLVPVETLLVADALTGQTVVRIAEEF
HAAVGISGVVLSKFDSDTRGGAALSLKSITGQPLLFVGTGERPQDFEPFHPERAAGRILGMGDIVSLVEKAQKAFDAQEH
ARAQKKTQSHERFTLSDMLDHLQTIEKMGPLHSLVEMIPGLAVAVSADALDARAFKRQKAIIQSMTVQERDNFLIIGPSR
RRRIAAGSGTSVADVNRLIKNFERMRTLMRKTAWQSRRAHPKGDTPYGWPHR

Sequences:

>Translated_452_residues
MFEQLSASFKRIVGALGGRATISERNIQEAVESIKRALLDADVHVRVVRRFVNQTIQHAQGQTVLASVSPAQQFIKIVHE
RLTAFLGEHTRSLHLKGPDTQSIILLLGLQGSGKTTSAAKLAAYLKDAGRSPLLAACDHVRAAASAQLAVLGTHIGVPVY
QHALPHEQQPCALDTARGALQYARSHGNDVLIIDTAGRLHVDAALMQELILLKETLVPVETLLVADALTGQTVVRIAEEF
HAAVGISGVVLSKFDSDTRGGAALSLKSITGQPLLFVGTGERPQDFEPFHPERAAGRILGMGDIVSLVEKAQKAFDAQEH
ARAQKKTQSHERFTLSDMLDHLQTIEKMGPLHSLVEMIPGLAVAVSADALDARAFKRQKAIIQSMTVQERDNFLIIGPSR
RRRIAAGSGTSVADVNRLIKNFERMRTLMRKTAWQSRRAHPKGDTPYGWPHR
>Mature_452_residues
MFEQLSASFKRIVGALGGRATISERNIQEAVESIKRALLDADVHVRVVRRFVNQTIQHAQGQTVLASVSPAQQFIKIVHE
RLTAFLGEHTRSLHLKGPDTQSIILLLGLQGSGKTTSAAKLAAYLKDAGRSPLLAACDHVRAAASAQLAVLGTHIGVPVY
QHALPHEQQPCALDTARGALQYARSHGNDVLIIDTAGRLHVDAALMQELILLKETLVPVETLLVADALTGQTVVRIAEEF
HAAVGISGVVLSKFDSDTRGGAALSLKSITGQPLLFVGTGERPQDFEPFHPERAAGRILGMGDIVSLVEKAQKAFDAQEH
ARAQKKTQSHERFTLSDMLDHLQTIEKMGPLHSLVEMIPGLAVAVSADALDARAFKRQKAIIQSMTVQERDNFLIIGPSR
RRRIAAGSGTSVADVNRLIKNFERMRTLMRKTAWQSRRAHPKGDTPYGWPHR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=427, Percent_Identity=30.2107728337237, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI226371618, Length=339, Percent_Identity=32.7433628318584, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI23308697, Length=317, Percent_Identity=27.4447949526814, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI295424842, Length=317, Percent_Identity=27.4447949526814, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI89061728, Length=147, Percent_Identity=31.9727891156463, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1788963, Length=458, Percent_Identity=39.7379912663755, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1789874, Length=256, Percent_Identity=34.375, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=28.9954337899543, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=303, Percent_Identity=28.7128712871287, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=448, Percent_Identity=30.8035714285714, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17647949, Length=427, Percent_Identity=27.8688524590164, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24641198, Length=316, Percent_Identity=28.7974683544304, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49258; Mature: 49258

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEQLSASFKRIVGALGGRATISERNIQEAVESIKRALLDADVHVRVVRRFVNQTIQHAQ
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GQTVLASVSPAQQFIKIVHERLTAFLGEHTRSLHLKGPDTQSIILLLGLQGSGKTTSAAK
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCCCHHHHH
LAAYLKDAGRSPLLAACDHVRAAASAQLAVLGTHIGVPVYQHALPHEQQPCALDTARGAL
HHHHHHHCCCCCHHHHHHHHHHHHHCHHEEEHHHCCCHHHHHCCCCCCCCCCHHHHHHHH
QYARSHGNDVLIIDTAGRLHVDAALMQELILLKETLVPVETLLVADALTGQTVVRIAEEF
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
HAAVGISGVVLSKFDSDTRGGAALSLKSITGQPLLFVGTGERPQDFEPFHPERAAGRILG
HHHHCCCHHHHECCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHCCEEC
MGDIVSLVEKAQKAFDAQEHARAQKKTQSHERFTLSDMLDHLQTIEKMGPLHSLVEMIPG
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCHHHHHHHHCCC
LAVAVSADALDARAFKRQKAIIQSMTVQERDNFLIIGPSRRRRIAAGSGTSVADVNRLIK
CEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCCCHHHHHHHHH
NFERMRTLMRKTAWQSRRAHPKGDTPYGWPHR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFEQLSASFKRIVGALGGRATISERNIQEAVESIKRALLDADVHVRVVRRFVNQTIQHAQ
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GQTVLASVSPAQQFIKIVHERLTAFLGEHTRSLHLKGPDTQSIILLLGLQGSGKTTSAAK
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCCCHHHHH
LAAYLKDAGRSPLLAACDHVRAAASAQLAVLGTHIGVPVYQHALPHEQQPCALDTARGAL
HHHHHHHCCCCCHHHHHHHHHHHHHCHHEEEHHHCCCHHHHHCCCCCCCCCCHHHHHHHH
QYARSHGNDVLIIDTAGRLHVDAALMQELILLKETLVPVETLLVADALTGQTVVRIAEEF
HHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
HAAVGISGVVLSKFDSDTRGGAALSLKSITGQPLLFVGTGERPQDFEPFHPERAAGRILG
HHHHCCCHHHHECCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHCCEEC
MGDIVSLVEKAQKAFDAQEHARAQKKTQSHERFTLSDMLDHLQTIEKMGPLHSLVEMIPG
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCHHHHHHHHCCC
LAVAVSADALDARAFKRQKAIIQSMTVQERDNFLIIGPSRRRRIAAGSGTSVADVNRLIK
CEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCCCHHHHHHHHH
NFERMRTLMRKTAWQSRRAHPKGDTPYGWPHR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9002524; 9695947; 10426959 [H]