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The map label for this gene is gnd

Identifier: 189025564

GI number: 189025564

Start: 355192

End: 356658

Strand: Reverse

Name: gnd

Synonym: TPASS_0331

Alternate gene names: 189025564

Gene position: 356658-355192 (Counterclockwise)

Preceding gene: 189025568

Following gene: 189025563

Centisome position: 31.3

GC content: 55.21

Gene sequence:

>1467_bases
ATGGGCGCAGACATTGGGTTCATTGGACTTGCTGTCATGGGAGAGAATCTGGTTCTCAACATTGAGCGCAACGGTTTTTC
CGTCGCAGTTTTCAATCGCACCACCACGGTGGTCGACCGATTTCTTGCAGGGCGCGCTCATGGCAAGCGAATCACCGGCG
CCCACTCCATTGCAGAACTTGTTTCACTTTTGGCACGTCCACGCAAAATCATGCTCATGGTCAAAGCAGGCAGCGCAGTC
GATGCGGTCATTGACCAGATACTGCCCCTTCTAGAAAAGGGGGACCTCGTTATCGACGGTGGCAACTCTCATTACCAGGA
TACCATCCGGCGCATGCATGCGCTAGAGGCCGCAGGTATTCATTTCATTGGCACAGGAGTTTCGGGGGGAGAAGAGGGGG
CCCTCCGTGGACCGTCCCTCATGCCTGGAGGCTCTGCTCAGGCTTGGCCGTTGGTTTCTCCCATTTTCTGTGCCATTGCC
GCCAAAGCCGACGATGGCACCCCGTGCTGCGACTGGGTCGGCAGTGATGGCGCCGGGCACTACGTGAAAATGATTCACAA
CGGCATTGAGTACGGCGACATGCAGATAATCGCCGAGGGCTACTGGTTTATGAAGCATGCGCTGGGCATGAGCTATGAGC
ACATGCACCATACGTTTACCCGCTGGAACACGGGCCGCTTACACTCGTACCTGATTGAGATTACCGCGGCTATTCTGGCA
CATCAGGACACAGACGGCACACCACTTTTAGAGAAAATTCTAGATGCCGCTGGACAGAAGGGGACGGGCAGGTGGACGTG
TGTTGCAGCGCTCGAAGAAGGCAGCCCGCTTACACTGATCACAGAGTCAGTGATGGCGCGTAGTCTTTCTGCGCAAAAGC
AAGCGCGCTGCAAGGCACATCGCGTTTTTGGTTCTCCCGTGAAAGTCTCCAAAGCAGAAACGCTAAGTGCACAGCAGCGC
GAAGAACTGGTGTCTGCACTGGAAGACGCGCTGTATTGCGCGAAAATAGTCTCGTATGCGCAGGGTTTTGAGCTGTTATC
GCATACGGCAAAGCGCCGAGGATGGACACTGGATTTTTCCCGGATTGCATCGCTGTGGCGTGGCGGGTGTATTATTCGTT
CAGGATTCCTGTCCAAGATCAGTGCGGCGTTTGCTCAGCAGCACGATCTAGAGAATTTGGTACTTGCTCCCTTTTTCGCA
GAGGAATTAAAGCGTGCGTGTCCAGGCTGGCGCACCATAGTGGCAGAATCGGTACGGCAGGCGTTGCCAGTTCCGGCCCT
CTCTGCTGCGTTAGCCTGGTTTGATGGGTTCACCGGTGCTGCTTTGCCGGCCAACCTCCTTCAGGCACAGCGAGATTATT
TTGGTGCGCACACCTACGAGCGCACAGATGCGCCGAGAGGAGAGTTTTTTCACACAAACTGGACAGGCACCGGCGGTGAT
ACCATTGCAGGAACCTACTCAATATAG

Upstream 100 bases:

>100_bases
CACAAAGAACGCGGATGTACACTGACAGCACCAGGTCCCCATCTCCTTTCAAAAAGTATCTAAACGCGCTACACTCGGCC
CGCACGCAGAGGAGGCACGC

Downstream 100 bases:

>100_bases
GGGATCCTCCCGTCGCTTGCCTTTCGTTCTATATTTATATTCCCAGGTGATCTTGACACCACCTCGGGTGCTGCGCTAGC
ATGCGCCCGTCCGGCGGATG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MGADIGFIGLAVMGENLVLNIERNGFSVAVFNRTTTVVDRFLAGRAHGKRITGAHSIAELVSLLARPRKIMLMVKAGSAV
DAVIDQILPLLEKGDLVIDGGNSHYQDTIRRMHALEAAGIHFIGTGVSGGEEGALRGPSLMPGGSAQAWPLVSPIFCAIA
AKADDGTPCCDWVGSDGAGHYVKMIHNGIEYGDMQIIAEGYWFMKHALGMSYEHMHHTFTRWNTGRLHSYLIEITAAILA
HQDTDGTPLLEKILDAAGQKGTGRWTCVAALEEGSPLTLITESVMARSLSAQKQARCKAHRVFGSPVKVSKAETLSAQQR
EELVSALEDALYCAKIVSYAQGFELLSHTAKRRGWTLDFSRIASLWRGGCIIRSGFLSKISAAFAQQHDLENLVLAPFFA
EELKRACPGWRTIVAESVRQALPVPALSAALAWFDGFTGAALPANLLQAQRDYFGAHTYERTDAPRGEFFHTNWTGTGGD
TIAGTYSI

Sequences:

>Translated_488_residues
MGADIGFIGLAVMGENLVLNIERNGFSVAVFNRTTTVVDRFLAGRAHGKRITGAHSIAELVSLLARPRKIMLMVKAGSAV
DAVIDQILPLLEKGDLVIDGGNSHYQDTIRRMHALEAAGIHFIGTGVSGGEEGALRGPSLMPGGSAQAWPLVSPIFCAIA
AKADDGTPCCDWVGSDGAGHYVKMIHNGIEYGDMQIIAEGYWFMKHALGMSYEHMHHTFTRWNTGRLHSYLIEITAAILA
HQDTDGTPLLEKILDAAGQKGTGRWTCVAALEEGSPLTLITESVMARSLSAQKQARCKAHRVFGSPVKVSKAETLSAQQR
EELVSALEDALYCAKIVSYAQGFELLSHTAKRRGWTLDFSRIASLWRGGCIIRSGFLSKISAAFAQQHDLENLVLAPFFA
EELKRACPGWRTIVAESVRQALPVPALSAALAWFDGFTGAALPANLLQAQRDYFGAHTYERTDAPRGEFFHTNWTGTGGD
TIAGTYSI
>Mature_487_residues
GADIGFIGLAVMGENLVLNIERNGFSVAVFNRTTTVVDRFLAGRAHGKRITGAHSIAELVSLLARPRKIMLMVKAGSAVD
AVIDQILPLLEKGDLVIDGGNSHYQDTIRRMHALEAAGIHFIGTGVSGGEEGALRGPSLMPGGSAQAWPLVSPIFCAIAA
KADDGTPCCDWVGSDGAGHYVKMIHNGIEYGDMQIIAEGYWFMKHALGMSYEHMHHTFTRWNTGRLHSYLIEITAAILAH
QDTDGTPLLEKILDAAGQKGTGRWTCVAALEEGSPLTLITESVMARSLSAQKQARCKAHRVFGSPVKVSKAETLSAQQRE
ELVSALEDALYCAKIVSYAQGFELLSHTAKRRGWTLDFSRIASLWRGGCIIRSGFLSKISAAFAQQHDLENLVLAPFFAE
ELKRACPGWRTIVAESVRQALPVPALSAALAWFDGFTGAALPANLLQAQRDYFGAHTYERTDAPRGEFFHTNWTGTGGDT
IAGTYSI

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=485, Percent_Identity=53.6082474226804, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI1788341, Length=470, Percent_Identity=50.4255319148936, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17542558, Length=485, Percent_Identity=54.4329896907216, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6321695, Length=489, Percent_Identity=53.1697341513292, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6321977, Length=492, Percent_Identity=54.2682926829268, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24639279, Length=484, Percent_Identity=55.1652892561983, Blast_Score=515, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_TREPA (O83351)

Other databases:

- EMBL:   AE000520
- PIR:   A71337
- RefSeq:   NP_218771.1
- ProteinModelPortal:   O83351
- SMR:   O83351
- GeneID:   2611604
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0331
- NMPDR:   fig|243276.1.peg.330
- TIGR:   TP_0331
- HOGENOM:   HBG286913
- OMA:   HTFRVLP
- ProtClustDB:   PRK09287
- BioCyc:   TPAL243276:TP_0331-MONOMER
- BRENDA:   1.1.1.44
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 52768; Mature: 52637

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 183-183 ACT_SITE 190-190 BINDING 102-102 BINDING 102-102 BINDING 191-191 BINDING 260-260 BINDING 287-287 BINDING 451-451 BINDING 457-457

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGADIGFIGLAVMGENLVLNIERNGFSVAVFNRTTTVVDRFLAGRAHGKRITGAHSIAEL
CCCCCHHHHHEEECCCEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VSLLARPRKIMLMVKAGSAVDAVIDQILPLLEKGDLVIDGGNSHYQDTIRRMHALEAAGI
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCE
HFIGTGVSGGEEGALRGPSLMPGGSAQAWPLVSPIFCAIAAKADDGTPCCDWVGSDGAGH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCHHHCCCCCCCCH
YVKMIHNGIEYGDMQIIAEGYWFMKHALGMSYEHMHHTFTRWNTGRLHSYLIEITAAILA
HHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HQDTDGTPLLEKILDAAGQKGTGRWTCVAALEEGSPLTLITESVMARSLSAQKQARCKAH
CCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHH
RVFGSPVKVSKAETLSAQQREELVSALEDALYCAKIVSYAQGFELLSHTAKRRGWTLDFS
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
RIASLWRGGCIIRSGFLSKISAAFAQQHDLENLVLAPFFAEELKRACPGWRTIVAESVRQ
HHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCHHEECHHHHHHHHHHCCCHHHHHHHHHHH
ALPVPALSAALAWFDGFTGAALPANLLQAQRDYFGAHTYERTDAPRGEFFHTNWTGTGGD
HCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCC
TIAGTYSI
CCCEECCC
>Mature Secondary Structure 
GADIGFIGLAVMGENLVLNIERNGFSVAVFNRTTTVVDRFLAGRAHGKRITGAHSIAEL
CCCCHHHHHEEECCCEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VSLLARPRKIMLMVKAGSAVDAVIDQILPLLEKGDLVIDGGNSHYQDTIRRMHALEAAGI
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCE
HFIGTGVSGGEEGALRGPSLMPGGSAQAWPLVSPIFCAIAAKADDGTPCCDWVGSDGAGH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCHHHCCCCCCCCH
YVKMIHNGIEYGDMQIIAEGYWFMKHALGMSYEHMHHTFTRWNTGRLHSYLIEITAAILA
HHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HQDTDGTPLLEKILDAAGQKGTGRWTCVAALEEGSPLTLITESVMARSLSAQKQARCKAH
CCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHH
RVFGSPVKVSKAETLSAQQREELVSALEDALYCAKIVSYAQGFELLSHTAKRRGWTLDFS
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
RIASLWRGGCIIRSGFLSKISAAFAQQHDLENLVLAPFFAEELKRACPGWRTIVAESVRQ
HHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCHHEECHHHHHHHHHHCCCHHHHHHHHHHH
ALPVPALSAALAWFDGFTGAALPANLLQAQRDYFGAHTYERTDAPRGEFFHTNWTGTGGD
HCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCC
TIAGTYSI
CCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876