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The map label for this gene is pan [H]

Identifier: 189025563

GI number: 189025563

Start: 353166

End: 354962

Strand: Reverse

Name: pan [H]

Synonym: TPASS_0330

Alternate gene names: 189025563

Gene position: 354962-353166 (Counterclockwise)

Preceding gene: 189025564

Following gene: 189025551

Centisome position: 31.15

GC content: 45.91

Gene sequence:

>1797_bases
GTGCATTCGGGGCAGCAATTACTTGAAAAGAACAGTATTATTATCAGCGGTCTTCCCCCCTGGGCGCAGGAGTTGTCCAA
GAAGTATTGCTCTAAAACGGTCAATCTGTACTTCGTACATGGCAATATCCGTGACTTCCTCCCCCATCGCGATATTCAGG
GCAGCTTCTCCTTCGTTCGCATTAATGACTACATATCTGAGGTTATCTTCGGTAACCGGGATATCATCGTCTTCTATGAC
AAATCTGCAGGGCTCACATTTTGTCTACAAGAAATGCTGAGCGCTTACTTAGAGCGTATGCATGCCCAGTATCCTACTGA
GGCACTTGCTGACTTTCTTTCGCGTGATCCGGTGAAAGCTTTTGCGTACCTTGAGCGCTACTTTATTATGAACATGAAAC
AGAATAAGCGTATGGTCCTCATCATCGACTATTCTGAATCTCTCGTTCCCTCAGAAGATATTGCAAACTTAAGCGAAACA
GATCGCTATTGCTTCGTCACCCTCAATCGCTGGGCAAATGATCCGGTGTTCACAAACGAAGACATATCCGTTGTGATGCT
CACGGAGAATATCACTGACATCAACAGTCGGTTCACCGCTTCTCCTTCCACCGTTAAGATTCACATACCCCTGCCAAATG
AAGAAACACGGATACGCTTTCTTGAATATCTCAAAACCCAGGAGGAGATTTTAGTACTTGAACGTGGGTTGAATACGGAG
AAAATTGGCAAACTCACTTCCGGTTTGAATTTAGTGAACCTCCACCAGCTTGCGGCAGAGACGTACCAAACGATCGATGC
AAATGGGAAGCCAGAGGACAATATCAGTAGACTTTCCCATACGGACTCTGCAACCTTACAATTTCTAAAAAGGAAGAAAC
AGGAAATTATTGAGCACGAAGCAGGCGGTTTGTTGGAATTTGTCGACACATCCTGCGACCTTTCATACGTTGCAGGAAAT
GTCTTTGTAAAAAAGAGATTGTATAACGCAGTGCGCGCCATTAAGCAAGGAAGAGCAGATGTGTTGCCAATGGGATACCT
TATCTCAGGGCCGATTGGGACAGGCAAATCATTTATGGTTTCCGCATTTGCGGGGGAAATTGGGATTCCCATGGTGCGTT
TGTGTAATTTCCAGGCAACGCAGCCTGGCATTACACAGTCGAACCTAGAAAAAACGCTCAACATCCTCAAAGCGCTTACC
CCGGTAGCGGTGATGGTGGACGAAGCTGATGCGGTGTTTGGTAGGCGTAACGCGCCGGCAGGTGAATCGCGTATTTTTGC
ACAAATTGCAGGGTTTATGGGTAACACCCAACACCGGGGCAATATTATTTGGTTCCTGATTACTTCGCGCCCAGACTTGC
TACCAATAGATCTGAAACGACAGGGACGCGCAGAAGAGCATCTTGCGCTCTTCTACCCTGAAACCACAAAAGAAAAAACG
GAAATTTTTGAAGCACTCAAAAAAAAATTACGTATCAAGCTCAAAGATGTACACGTACCGGCAATCATTCGCAGAATAAA
ATTCGCTGTTTCCGGTTCGGACTTAGAAGCCATTTTAGTACGCGCCCAGCTAACTGCTGCGATGGAAAGTCGCACGATGG
TAACCACACAGGACATCACCCGCACCATTGAAGACTTTATCCCTCCTGCTTATCCGCACGAAATTGAACTGCAAAATTTA
GTGGCAGTACTCGAATGCACAGGAAAGGAAATGCTCCCTGCGCGTTATCAGCATTTAGATCGCTCTAAACTGGTGGCAGA
TATTCGGGAACTAAAACTCCTCATGGGAGAAAAATAA

Upstream 100 bases:

>100_bases
AAGCTGGAGACGTGGGTTCGACTCCCATCATCCGCTTTCCTCCCTACCTCGTTGATTTTTCTGTTCTATACGCGCTATAC
TCGCCCCTCGGAGGGGTAGG

Downstream 100 bases:

>100_bases
CGGCTCCCTCAATGGGAGACACGGGGCCTCACGCAAGAAGACTACATGAACAGCTGTACCTTTTGTTCCTCGTGTGATAG
GCTGCGCGCGGGCCGACGTG

Product: cell division protein

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MHSGQQLLEKNSIIISGLPPWAQELSKKYCSKTVNLYFVHGNIRDFLPHRDIQGSFSFVRINDYISEVIFGNRDIIVFYD
KSAGLTFCLQEMLSAYLERMHAQYPTEALADFLSRDPVKAFAYLERYFIMNMKQNKRMVLIIDYSESLVPSEDIANLSET
DRYCFVTLNRWANDPVFTNEDISVVMLTENITDINSRFTASPSTVKIHIPLPNEETRIRFLEYLKTQEEILVLERGLNTE
KIGKLTSGLNLVNLHQLAAETYQTIDANGKPEDNISRLSHTDSATLQFLKRKKQEIIEHEAGGLLEFVDTSCDLSYVAGN
VFVKKRLYNAVRAIKQGRADVLPMGYLISGPIGTGKSFMVSAFAGEIGIPMVRLCNFQATQPGITQSNLEKTLNILKALT
PVAVMVDEADAVFGRRNAPAGESRIFAQIAGFMGNTQHRGNIIWFLITSRPDLLPIDLKRQGRAEEHLALFYPETTKEKT
EIFEALKKKLRIKLKDVHVPAIIRRIKFAVSGSDLEAILVRAQLTAAMESRTMVTTQDITRTIEDFIPPAYPHEIELQNL
VAVLECTGKEMLPARYQHLDRSKLVADIRELKLLMGEK

Sequences:

>Translated_598_residues
MHSGQQLLEKNSIIISGLPPWAQELSKKYCSKTVNLYFVHGNIRDFLPHRDIQGSFSFVRINDYISEVIFGNRDIIVFYD
KSAGLTFCLQEMLSAYLERMHAQYPTEALADFLSRDPVKAFAYLERYFIMNMKQNKRMVLIIDYSESLVPSEDIANLSET
DRYCFVTLNRWANDPVFTNEDISVVMLTENITDINSRFTASPSTVKIHIPLPNEETRIRFLEYLKTQEEILVLERGLNTE
KIGKLTSGLNLVNLHQLAAETYQTIDANGKPEDNISRLSHTDSATLQFLKRKKQEIIEHEAGGLLEFVDTSCDLSYVAGN
VFVKKRLYNAVRAIKQGRADVLPMGYLISGPIGTGKSFMVSAFAGEIGIPMVRLCNFQATQPGITQSNLEKTLNILKALT
PVAVMVDEADAVFGRRNAPAGESRIFAQIAGFMGNTQHRGNIIWFLITSRPDLLPIDLKRQGRAEEHLALFYPETTKEKT
EIFEALKKKLRIKLKDVHVPAIIRRIKFAVSGSDLEAILVRAQLTAAMESRTMVTTQDITRTIEDFIPPAYPHEIELQNL
VAVLECTGKEMLPARYQHLDRSKLVADIRELKLLMGEK
>Mature_598_residues
MHSGQQLLEKNSIIISGLPPWAQELSKKYCSKTVNLYFVHGNIRDFLPHRDIQGSFSFVRINDYISEVIFGNRDIIVFYD
KSAGLTFCLQEMLSAYLERMHAQYPTEALADFLSRDPVKAFAYLERYFIMNMKQNKRMVLIIDYSESLVPSEDIANLSET
DRYCFVTLNRWANDPVFTNEDISVVMLTENITDINSRFTASPSTVKIHIPLPNEETRIRFLEYLKTQEEILVLERGLNTE
KIGKLTSGLNLVNLHQLAAETYQTIDANGKPEDNISRLSHTDSATLQFLKRKKQEIIEHEAGGLLEFVDTSCDLSYVAGN
VFVKKRLYNAVRAIKQGRADVLPMGYLISGPIGTGKSFMVSAFAGEIGIPMVRLCNFQATQPGITQSNLEKTLNILKALT
PVAVMVDEADAVFGRRNAPAGESRIFAQIAGFMGNTQHRGNIIWFLITSRPDLLPIDLKRQGRAEEHLALFYPETTKEKT
EIFEALKKKLRIKLKDVHVPAIIRRIKFAVSGSDLEAILVRAQLTAAMESRTMVTTQDITRTIEDFIPPAYPHEIELQNL
VAVLECTGKEMLPARYQHLDRSKLVADIRELKLLMGEK

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI21327685, Length=339, Percent_Identity=27.4336283185841, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI7657689, Length=338, Percent_Identity=27.5147928994083, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI229577436, Length=196, Percent_Identity=29.0816326530612, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI6005942, Length=202, Percent_Identity=27.7227722772277, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507173, Length=215, Percent_Identity=28.8372093023256, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789568, Length=205, Percent_Identity=28.780487804878, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531535, Length=200, Percent_Identity=27, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532375, Length=202, Percent_Identity=25.7425742574257, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320077, Length=196, Percent_Identity=25.5102040816327, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322994, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6325281, Length=201, Percent_Identity=27.8606965174129, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323736, Length=225, Percent_Identity=25.7777777777778, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24660075, Length=204, Percent_Identity=28.4313725490196, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281365776, Length=204, Percent_Identity=28.4313725490196, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45552965, Length=204, Percent_Identity=28.4313725490196, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161076486, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17137560, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076488, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665814, Length=217, Percent_Identity=24.4239631336406, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574878, Length=217, Percent_Identity=24.4239631336406, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24649446, Length=216, Percent_Identity=26.8518518518519, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 67730; Mature: 67730

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSGQQLLEKNSIIISGLPPWAQELSKKYCSKTVNLYFVHGNIRDFLPHRDIQGSFSFVR
CCCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCCCCCEEEEE
INDYISEVIFGNRDIIVFYDKSAGLTFCLQEMLSAYLERMHAQYPTEALADFLSRDPVKA
EHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHH
FAYLERYFIMNMKQNKRMVLIIDYSESLVPSEDIANLSETDRYCFVTLNRWANDPVFTNE
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCC
DISVVMLTENITDINSRFTASPSTVKIHIPLPNEETRIRFLEYLKTQEEILVLERGLNTE
CCEEEEEECCCCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCCHH
KIGKLTSGLNLVNLHQLAAETYQTIDANGKPEDNISRLSHTDSATLQFLKRKKQEIIEHE
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHC
AGGLLEFVDTSCDLSYVAGNVFVKKRLYNAVRAIKQGRADVLPMGYLISGPIGTGKSFMV
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECEEEECCCCCCHHHHH
SAFAGEIGIPMVRLCNFQATQPGITQSNLEKTLNILKALTPVAVMVDEADAVFGRRNAPA
HHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCC
GESRIFAQIAGFMGNTQHRGNIIWFLITSRPDLLPIDLKRQGRAEEHLALFYPETTKEKT
CHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCEEEECCCCCHHHH
EIFEALKKKLRIKLKDVHVPAIIRRIKFAVSGSDLEAILVRAQLTAAMESRTMVTTQDIT
HHHHHHHHHHCEEHEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHH
RTIEDFIPPAYPHEIELQNLVAVLECTGKEMLPARYQHLDRSKLVADIRELKLLMGEK
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHSGQQLLEKNSIIISGLPPWAQELSKKYCSKTVNLYFVHGNIRDFLPHRDIQGSFSFVR
CCCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCCCCCCEEEEE
INDYISEVIFGNRDIIVFYDKSAGLTFCLQEMLSAYLERMHAQYPTEALADFLSRDPVKA
EHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHH
FAYLERYFIMNMKQNKRMVLIIDYSESLVPSEDIANLSETDRYCFVTLNRWANDPVFTNE
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCC
DISVVMLTENITDINSRFTASPSTVKIHIPLPNEETRIRFLEYLKTQEEILVLERGLNTE
CCEEEEEECCCCCCCCCEECCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCCHH
KIGKLTSGLNLVNLHQLAAETYQTIDANGKPEDNISRLSHTDSATLQFLKRKKQEIIEHE
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHC
AGGLLEFVDTSCDLSYVAGNVFVKKRLYNAVRAIKQGRADVLPMGYLISGPIGTGKSFMV
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECEEEECCCCCCHHHHH
SAFAGEIGIPMVRLCNFQATQPGITQSNLEKTLNILKALTPVAVMVDEADAVFGRRNAPA
HHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCC
GESRIFAQIAGFMGNTQHRGNIIWFLITSRPDLLPIDLKRQGRAEEHLALFYPETTKEKT
CHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCEEEECCCCCHHHH
EIFEALKKKLRIKLKDVHVPAIIRRIKFAVSGSDLEAILVRAQLTAAMESRTMVTTQDIT
HHHHHHHHHHCEEHEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHH
RTIEDFIPPAYPHEIELQNLVAVLECTGKEMLPARYQHLDRSKLVADIRELKLLMGEK
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]