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The map label for this gene is mutL [H]

Identifier: 189025537

GI number: 189025537

Start: 317150

End: 319096

Strand: Reverse

Name: mutL [H]

Synonym: TPASS_0303

Alternate gene names: 189025537

Gene position: 319096-317150 (Counterclockwise)

Preceding gene: 189025538

Following gene: 189025511

Centisome position: 28.0

GC content: 57.52

Gene sequence:

>1947_bases
GTGGCGTGTGCAAAGCGCGCTACGGGGGCAGCGCTTCGGCAAAACGCGGGAGCTGGCTGTCTACGCTCTGGCAAGGGTTT
TTCTATGCATGAAACGTCCTACAAACCTATCCACCGGCTGTCCCCTGACACCGCTAAAAAAATCGCCGCAGGAGAAGTCA
TCGAGCGGCCCGCCTCCGTCGTGCGCGAATTGCTCGAGAACGCACTCGATGCAGGCGCCACCAAAATCCATCTGGAAATT
AACGCAGGCGGCTGCGCGCTCATCCGCGTGAGCGATAACGGCCACGGCATGTCCCCCCAGGATTTGTTGCTATGCGCTGA
AGCACACACCACGAGCAAAATATCGTCTGCAGACGACTTATTGCAGCTGCGCACGTTAGGCTTCCGGGGAGAAGCACTCG
CCTCCATCGCCGCAGTCAGCCGCCTGCACCTTACGAGCACCCGATCAGGGCCCCTCGCGTGGCACTACCAGCCAAAGGCT
GCAGGCACTGCAGCGCACGTACCGCCGGTGCCGCAGGGCACCGAAGCAGGCGTGCTAGAGCCTGCAAGTCTTGAGCGAGG
CACCGTCGTACGCGTCGAGCAGCTTTTTGAAAACTTTCCTGCGCGCAAACGCTTTCTCGGACGCCAAAGCGCAGAGACCA
CCCTGTGCCGCAGCGCACTCATCGACGTCTCCCTCGCACATCACCCCGTGGAGTTTCGCTTCACCGTCGACGGAACGCAC
AAGCTCACCCTGCTCAGTCAGCAAACCCGGAAGGATCGGTGTCTTGAAACGCAAATGCTCAAAGGAGATCCTGCGCTCTT
CCACACCATAGAAGGAGGTGACTGCTCGTTTCACTTTCACCTTGTACTTTCAGAACCCGCCATCTGCCGCAGAGAACGCC
GCGGTATTTTTACCTTCGTCAACGGACGACGCATTTTTGATTACGGTCTTGTCCAGGCACTTGTGTTAGGAAGCGAGGGA
TACTTCCCCAATGGCACCTTTCCGGTCGCCTGCCTTTTCCTCACCGTTAACAGCGAACGTATTGATTTTAATATCCACCC
TGCCAAAAAGGAGGTTCACTTACAGGACTATGCTCACATCCGCCACACACTCAGCCGCAGCGTTGCGCACTTCTACCGTC
AGTGCACTATTGCTCACTACGTACGTGCAGAACCTGCCCACGCACCTGCCACTCAGGGCAACGCGCCAACACATTCCTCA
CCCCCCTGCACCGGCGTACGAGAAGAACCCGCCGCTCCCTGCGCGCACACACCCCGGTACGAATCCCTGTTCCCTCTACC
CGTGCAGCATGCGCACCTGCTTCCTCCGTCACCTCCTCACATCTCGTGCGAACACGCGCGCGATTGCACTCACCCAGCCC
CCGCTGCCGAAGGAGATGCGCCTGTGCACAACCATACCCATACAGGTGCATTCAAAGTACTCGGACAGGTAGCAGGAACA
TTCATCGCCGTAGAACGCAACAACGCTCTCTACCTTATCGATCAGCACGCAGCACATGAACGCATTATTTTTGATACGCT
ACAGCGGAACCTTGGCACTGCACAAATACTTCTTATTCCCTACCACATTCACCCACGCTCGGATGAAGAGGCGCGCATCA
TGCACCGCGCCTGCACAGAACTTTCTCCTGCAGGATTTCGATTTCACGAAGAACCAGACGGTTCGTGGCACGTAACTGCG
GTGCCGCTCCACTGGCGGGGGAGCGAAGAGCAACTTGCACACGATATCCTCTACTCAGGAAAAAACGCGCACGACATCCT
GCGCCACGTCCTCGCTACCTGTGCCTGCCGGTCTGCGTGTAAAGACGGCACCATCCTGGATGACGCAACGCTCCACTCGT
TAGTGGAGCAGGCTTTTGCATTACCACAATCGAGGTGTCCCCACGGACGGCCCATTTGGATTGTCATTGGCCGAGACGAA
TTGTTCAAACGGATCAAGCGCACGTAA

Upstream 100 bases:

>100_bases
GGCCGGGGTTCAGTACGGCTTCCAACTTGCAGAGACGCAGAGCGCCACAACCCCCGGTTTCAGCCCGATTTTTTCCATGG
CCTTGTAGGAAGGTTCCCCC

Downstream 100 bases:

>100_bases
CGCGCTGCAGATACGCAAAAAGAAGCCTGCTACGTCTGCGCTCTCCGCGTCGGCACGGGGAGGTGCGCCGTGTGCACACA
AACACCACCAGTGAGAGGAT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MACAKRATGAALRQNAGAGCLRSGKGFSMHETSYKPIHRLSPDTAKKIAAGEVIERPASVVRELLENALDAGATKIHLEI
NAGGCALIRVSDNGHGMSPQDLLLCAEAHTTSKISSADDLLQLRTLGFRGEALASIAAVSRLHLTSTRSGPLAWHYQPKA
AGTAAHVPPVPQGTEAGVLEPASLERGTVVRVEQLFENFPARKRFLGRQSAETTLCRSALIDVSLAHHPVEFRFTVDGTH
KLTLLSQQTRKDRCLETQMLKGDPALFHTIEGGDCSFHFHLVLSEPAICRRERRGIFTFVNGRRIFDYGLVQALVLGSEG
YFPNGTFPVACLFLTVNSERIDFNIHPAKKEVHLQDYAHIRHTLSRSVAHFYRQCTIAHYVRAEPAHAPATQGNAPTHSS
PPCTGVREEPAAPCAHTPRYESLFPLPVQHAHLLPPSPPHISCEHARDCTHPAPAAEGDAPVHNHTHTGAFKVLGQVAGT
FIAVERNNALYLIDQHAAHERIIFDTLQRNLGTAQILLIPYHIHPRSDEEARIMHRACTELSPAGFRFHEEPDGSWHVTA
VPLHWRGSEEQLAHDILYSGKNAHDILRHVLATCACRSACKDGTILDDATLHSLVEQAFALPQSRCPHGRPIWIVIGRDE
LFKRIKRT

Sequences:

>Translated_648_residues
MACAKRATGAALRQNAGAGCLRSGKGFSMHETSYKPIHRLSPDTAKKIAAGEVIERPASVVRELLENALDAGATKIHLEI
NAGGCALIRVSDNGHGMSPQDLLLCAEAHTTSKISSADDLLQLRTLGFRGEALASIAAVSRLHLTSTRSGPLAWHYQPKA
AGTAAHVPPVPQGTEAGVLEPASLERGTVVRVEQLFENFPARKRFLGRQSAETTLCRSALIDVSLAHHPVEFRFTVDGTH
KLTLLSQQTRKDRCLETQMLKGDPALFHTIEGGDCSFHFHLVLSEPAICRRERRGIFTFVNGRRIFDYGLVQALVLGSEG
YFPNGTFPVACLFLTVNSERIDFNIHPAKKEVHLQDYAHIRHTLSRSVAHFYRQCTIAHYVRAEPAHAPATQGNAPTHSS
PPCTGVREEPAAPCAHTPRYESLFPLPVQHAHLLPPSPPHISCEHARDCTHPAPAAEGDAPVHNHTHTGAFKVLGQVAGT
FIAVERNNALYLIDQHAAHERIIFDTLQRNLGTAQILLIPYHIHPRSDEEARIMHRACTELSPAGFRFHEEPDGSWHVTA
VPLHWRGSEEQLAHDILYSGKNAHDILRHVLATCACRSACKDGTILDDATLHSLVEQAFALPQSRCPHGRPIWIVIGRDE
LFKRIKRT
>Mature_647_residues
ACAKRATGAALRQNAGAGCLRSGKGFSMHETSYKPIHRLSPDTAKKIAAGEVIERPASVVRELLENALDAGATKIHLEIN
AGGCALIRVSDNGHGMSPQDLLLCAEAHTTSKISSADDLLQLRTLGFRGEALASIAAVSRLHLTSTRSGPLAWHYQPKAA
GTAAHVPPVPQGTEAGVLEPASLERGTVVRVEQLFENFPARKRFLGRQSAETTLCRSALIDVSLAHHPVEFRFTVDGTHK
LTLLSQQTRKDRCLETQMLKGDPALFHTIEGGDCSFHFHLVLSEPAICRRERRGIFTFVNGRRIFDYGLVQALVLGSEGY
FPNGTFPVACLFLTVNSERIDFNIHPAKKEVHLQDYAHIRHTLSRSVAHFYRQCTIAHYVRAEPAHAPATQGNAPTHSSP
PCTGVREEPAAPCAHTPRYESLFPLPVQHAHLLPPSPPHISCEHARDCTHPAPAAEGDAPVHNHTHTGAFKVLGQVAGTF
IAVERNNALYLIDQHAAHERIIFDTLQRNLGTAQILLIPYHIHPRSDEEARIMHRACTELSPAGFRFHEEPDGSWHVTAV
PLHWRGSEEQLAHDILYSGKNAHDILRHVLATCACRSACKDGTILDDATLHSLVEQAFALPQSRCPHGRPIWIVIGRDEL
FKRIKRT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=340, Percent_Identity=30.5882352941176, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505913, Length=369, Percent_Identity=26.8292682926829, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI189458898, Length=169, Percent_Identity=36.6863905325444, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4505911, Length=169, Percent_Identity=36.6863905325444, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI189458896, Length=169, Percent_Identity=36.6863905325444, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI310128478, Length=175, Percent_Identity=36.5714285714286, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992160, Length=219, Percent_Identity=29.6803652968037, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI91992162, Length=219, Percent_Identity=29.6803652968037, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790612, Length=617, Percent_Identity=30.9562398703404, Blast_Score=182, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71991825, Length=337, Percent_Identity=30.5637982195846, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562796, Length=177, Percent_Identity=29.9435028248588, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323819, Length=337, Percent_Identity=30.5637982195846, Blast_Score=143, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6324247, Length=378, Percent_Identity=26.984126984127, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=310, Percent_Identity=25.1612903225806, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=355, Percent_Identity=27.3239436619718, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136968, Length=336, Percent_Identity=30.6547619047619, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17136970, Length=184, Percent_Identity=32.6086956521739, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71233; Mature: 71102

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACAKRATGAALRQNAGAGCLRSGKGFSMHETSYKPIHRLSPDTAKKIAAGEVIERPASV
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
VRELLENALDAGATKIHLEINAGGCALIRVSDNGHGMSPQDLLLCAEAHTTSKISSADDL
HHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHEEEEECCCCCHHCCCHHHH
LQLRTLGFRGEALASIAAVSRLHLTSTRSGPLAWHYQPKAAGTAAHVPPVPQGTEAGVLE
HHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
PASLERGTVVRVEQLFENFPARKRFLGRQSAETTLCRSALIDVSLAHHPVEFRFTVDGTH
CCCCCCCCEEEHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCE
KLTLLSQQTRKDRCLETQMLKGDPALFHTIEGGDCSFHFHLVLSEPAICRRERRGIFTFV
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEECCCHHHHHHCCCEEEEE
NGRRIFDYGLVQALVLGSEGYFPNGTFPVACLFLTVNSERIDFNIHPAKKEVHLQDYAHI
CCCEEEHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHH
RHTLSRSVAHFYRQCTIAHYVRAEPAHAPATQGNAPTHSSPPCTGVREEPAAPCAHTPRY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ESLFPLPVQHAHLLPPSPPHISCEHARDCTHPAPAAEGDAPVHNHTHTGAFKVLGQVAGT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCE
FIAVERNNALYLIDQHAAHERIIFDTLQRNLGTAQILLIPYHIHPRSDEEARIMHRACTE
EEEEECCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHC
LSPAGFRFHEEPDGSWHVTAVPLHWRGSEEQLAHDILYSGKNAHDILRHVLATCACRSAC
CCCCCCEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
KDGTILDDATLHSLVEQAFALPQSRCPHGRPIWIVIGRDELFKRIKRT
CCCCEECHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCHHHHHHHHCC
>Mature Secondary Structure 
ACAKRATGAALRQNAGAGCLRSGKGFSMHETSYKPIHRLSPDTAKKIAAGEVIERPASV
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
VRELLENALDAGATKIHLEINAGGCALIRVSDNGHGMSPQDLLLCAEAHTTSKISSADDL
HHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHEEEEECCCCCHHCCCHHHH
LQLRTLGFRGEALASIAAVSRLHLTSTRSGPLAWHYQPKAAGTAAHVPPVPQGTEAGVLE
HHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
PASLERGTVVRVEQLFENFPARKRFLGRQSAETTLCRSALIDVSLAHHPVEFRFTVDGTH
CCCCCCCCEEEHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCE
KLTLLSQQTRKDRCLETQMLKGDPALFHTIEGGDCSFHFHLVLSEPAICRRERRGIFTFV
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEECCCHHHHHHCCCEEEEE
NGRRIFDYGLVQALVLGSEGYFPNGTFPVACLFLTVNSERIDFNIHPAKKEVHLQDYAHI
CCCEEEHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHH
RHTLSRSVAHFYRQCTIAHYVRAEPAHAPATQGNAPTHSSPPCTGVREEPAAPCAHTPRY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ESLFPLPVQHAHLLPPSPPHISCEHARDCTHPAPAAEGDAPVHNHTHTGAFKVLGQVAGT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCE
FIAVERNNALYLIDQHAAHERIIFDTLQRNLGTAQILLIPYHIHPRSDEEARIMHRACTE
EEEEECCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHC
LSPAGFRFHEEPDGSWHVTAVPLHWRGSEEQLAHDILYSGKNAHDILRHVLATCACRSAC
CCCCCCEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
KDGTILDDATLHSLVEQAFALPQSRCPHGRPIWIVIGRDELFKRIKRT
CCCCEECHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]