Click here to switch to the map view.

The map label for this gene is tpn50

Identifier: 189025526

GI number: 189025526

Start: 306737

End: 307990

Strand: Direct

Name: tpn50

Synonym: TPASS_0292

Alternate gene names: 189025526

Gene position: 306737-307990 (Clockwise)

Preceding gene: 189025525

Following gene: 189025527

Centisome position: 26.92

GC content: 49.84

Gene sequence:

>1254_bases
GTGTGTATGATGGGAAGTGTGTTTTCTAGGAAGGGAATGCTGTGTGTTCTTGCAGTCTGGTGCGCGGCAAGTGCGGCGTA
CCCTCTGCGCTTGCGCTACAAGTTTCGTAAGGGGGATACGCACCGTATCAACTCGCTGATACGCGAGGATGTGTTTGTGA
ACGATACGCTTGCTCACACGGCGGAGATTACGAATCGAATCACGGTGCATGTTTCCGAAGTACGTGTTGCACACGGGTCG
GCGCCTGATGCGGCGCGGTATGTGTGTCACTTCATGACATCCGAGAAAAGTCCCAATAATACGTTTCGTTGGGGGAGGCA
CTACGAAAGTATTTTCTGGCGCGACGCATTTGGTGTGTATGATATTGATCGTTCATTCTTCATGCCGGTAGTACGGAATG
TGCCGGTGTTTCCTGATTATGATATCGAAGTTGGAGATACCTGGGAGCATGAAGCAGAAGAAGCGCATGATCTGCGTGAC
GGCTTTGGTATCCAAACGCCCTTCATTGTGCCGTTTACCGTGTCGTATACCTACCGTGGTGAAGTTCAGCGTGGTAGTCG
GCGCTATCATCACATTACTGCGGCGTATTCTATGAGTTATGAGTCGCCCAAACGGACACATGGCGTGCAGCGCAATGCAA
AAGAAGGAATGTATCCGGTGCGTACTACGGGCGTTTCTAAGCAAAATTTGTATTGGGATAACGAACTTGGGAACATAGCT
GAGTACGACGATGAGTTTCGCATTCTCTTATACCTGAGTGGAGGAACGGTTTTGAGATATCAGGGTACTGCGACGGCAAA
GAATTTTGCACCTGAGCGCTTTGATCCTGCACGCACGGTGGTGGAACTGCAAGAAACGCTCAAGGACTTGCATATGCCTG
ATGCGAAGGTGCGTGAAACAGAAGAGGGAGTAACCATCAGTATAGAAAATGTTCAATTTGACGCAGACTCTGCATCCCTT
GCACCTTCTGAGTACGAGAAGCTGCGCAAAATAGCAGAACTTTTGCGCGCGTTTCCCGATCGAGAGTTGTTGGTGTCTGG
ACATGCGGCACGACGGGGGTCTGTGCAGGATCAACAGAGGATTTCTGAAGAGCGTGCTGATGTGGTTGCACGTTACCTGC
AGGAATTAGGTGTTGTGGATGCAGCGCATGTATATACGCGCGGTTGTGGTGCGCAGCAGTCTATTGCGCCAAATGATTCA
GAGGATGGTCGTAGAAAAAACCGACGGGTAGAAATCACTATCATAAGTAAGTAA

Upstream 100 bases:

>100_bases
AGCAGGTGCTGATAGGGCGTCCTTTTATCACAGCTCTTCTCAAAGGAGGAAAGGGTGGGGTGCAACTTCTCGTGCGGAAT
ATGACGGATAGGTCCGTTCG

Downstream 100 bases:

>100_bases
AGTGTTGCCCTGTGCGCATGACGCGTGTGCGTTCGCTGTGCCTTGCGTATGCAAGGTGTGTTCGCTTGGGTGTGTTTCGT
TGTATTAGCCTGCGCGGATG

Product: outer membrane protein TpN50

Products: NA

Alternate protein names: Antigen tpp57

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHTAEITNRITVHVSEVRVAHGS
APDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVYDIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRD
GFGIQTPFIVPFTVSYTYRGEVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIA
EYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRETEEGVTISIENVQFDADSASL
APSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQRISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDS
EDGRRKNRRVEITIISK

Sequences:

>Translated_417_residues
MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHTAEITNRITVHVSEVRVAHGS
APDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVYDIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRD
GFGIQTPFIVPFTVSYTYRGEVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIA
EYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRETEEGVTISIENVQFDADSASL
APSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQRISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDS
EDGRRKNRRVEITIISK
>Mature_417_residues
MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHTAEITNRITVHVSEVRVAHGS
APDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVYDIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRD
GFGIQTPFIVPFTVSYTYRGEVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIA
EYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRETEEGVTISIENVQFDADSASL
APSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQRISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDS
EDGRRKNRRVEITIISK

Specific function: Could function as a porin

COG id: COG2885

COG function: function code M; Outer membrane protein and related peptidoglycan-associated (lipo)proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 OmpA-like domain

Homologues:

Organism=Escherichia coli, GI48994946, Length=137, Percent_Identity=33.5766423357664, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPN50_TREPA (P38369)

Other databases:

- EMBL:   U02628
- EMBL:   L28427
- EMBL:   AE000520
- PIR:   G71344
- RefSeq:   NP_218733.1
- ProteinModelPortal:   P38369
- SMR:   P38369
- IntAct:   P38369
- MINT:   MINT-6480570
- GeneID:   2611738
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0292
- NMPDR:   fig|243276.1.peg.292
- TIGR:   TP_0292
- HOGENOM:   HBG731849
- OMA:   HITASYD
- ProtClustDB:   CLSK544895
- BioCyc:   TPAL243276:TP_0292-MONOMER
- InterPro:   IPR006664
- InterPro:   IPR006690
- InterPro:   IPR006665
- Gene3D:   G3DSA:3.30.1330.60
- PRINTS:   PR01021

Pfam domain/function: PF00691 OmpA; SSF103088 OmpA/MotB_C

EC number: NA

Molecular weight: Translated: 47609; Mature: 47609

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS01068 OMPA_1; PS51123 OMPA_2; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHT
CCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHH
AEITNRITVHVSEVRVAHGSAPDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVY
HHHCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEE
DIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRDGFGIQTPFIVPFTVSYTYRG
ECCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEC
EVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIA
CCCCCCCCEEEEEEEEEECCCCCHHHHCCCCCHHCCCCCEEECCCCCCCCEECCCCCCCC
EYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRET
CCCCCEEEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHC
EEGVTISIENVQFDADSASLAPSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQR
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
ISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDSEDGRRKNRRVEITIISK
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEEEEECC
>Mature Secondary Structure
MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHT
CCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHH
AEITNRITVHVSEVRVAHGSAPDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVY
HHHCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEE
DIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRDGFGIQTPFIVPFTVSYTYRG
ECCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEC
EVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIA
CCCCCCCCEEEEEEEEEECCCCCHHHHCCCCCHHCCCCCEEECCCCCCCCEECCCCCCCC
EYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRET
CCCCCEEEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHC
EEGVTISIENVQFDADSASLAPSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQR
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
ISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDSEDGRRKNRRVEITIISK
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8112835; 7623668; 9665876