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The map label for this gene is rluC [H]

Identifier: 189025464

GI number: 189025464

Start: 241496

End: 242146

Strand: Direct

Name: rluC [H]

Synonym: TPASS_0231

Alternate gene names: 189025464

Gene position: 241496-242146 (Clockwise)

Preceding gene: 189025463

Following gene: 189025465

Centisome position: 21.19

GC content: 54.99

Gene sequence:

>651_bases
GTGGCACTGCCGATTATTTTTCAGGACGCAGCGGTGGTGGCCGTTGATAAGCCGGCAGGACTTGCAGTACAGCCGGGTGC
GCGGGTGCGGGTGTGCGTAGTTGACGTATTACAGAAACAGCTTGGGGTGCGTCTGTTTCCTCTGCATCGTTTGGACAAGG
ACACCGCGGGCGTGCTGCTGTTTGCAAAACATGCACGGGCAGCTGCTCTGTACCAGGGGATTTTAGGCAGCATGCGTGTG
ATTAAGCGCTATCGCGCACTTTGTTTTGGGCGACCTCCCCGAGAGTGTGGTGATATTCGCGTTCCTATCCGTACCGGTAC
GGCAGCAAGGCGGCGTCAGGTTGTGCGTGCCGCGCATACTGCATACCGTGTGTTGCGTGCGACTGATACGCATACATATC
TTGAACTCACGTTGCACAGTGGTCGGACCCATCAGATTCGTATTCATCTGGCTGCGCTAGGATGTCCTATAATTGGGGAT
GACAAATACGGTGATTTCGCGCGTAACAAGGCGTGTGCTCGTGCGTGGGGAGTAAAAAGGCTCCAGTTATTCGCACACAG
TCTTGTGTTGCCATGTGCATGTAAACCGCTGGTGTTGCGTGCACGTATGCCTGTACACTTCCTGCGTGCTCTTGATGCCG
TTGCGCTATGA

Upstream 100 bases:

>100_bases
GGCGAGTAGATGTACTCCGTGTTATCCTGCTGTTTGCGTGTTTGGTTGACCGGTAGTATGCGGTGCCTGGTATAGGTGCG
GGACGGAAAGGAGAGAGGAT

Downstream 100 bases:

>100_bases
TTGCCTGTAGCAGGGCATTCTGGTAGGCGGTGTGTGGTTTTGAGTTCTGCCGGTAACAGAAAGAGTGTCGTGTGAATTTC
AATAGTTTTTCTCTAGGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: rRNA pseudouridylate synthase C; rRNA-uridine isomerase C [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MALPIIFQDAAVVAVDKPAGLAVQPGARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLLFAKHARAAALYQGILGSMRV
IKRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRAAHTAYRVLRATDTHTYLELTLHSGRTHQIRIHLAALGCPIIGD
DKYGDFARNKACARAWGVKRLQLFAHSLVLPCACKPLVLRARMPVHFLRALDAVAL

Sequences:

>Translated_216_residues
MALPIIFQDAAVVAVDKPAGLAVQPGARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLLFAKHARAAALYQGILGSMRV
IKRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRAAHTAYRVLRATDTHTYLELTLHSGRTHQIRIHLAALGCPIIGD
DKYGDFARNKACARAWGVKRLQLFAHSLVLPCACKPLVLRARMPVHFLRALDAVAL
>Mature_215_residues
ALPIIFQDAAVVAVDKPAGLAVQPGARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLLFAKHARAAALYQGILGSMRVI
KRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRAAHTAYRVLRATDTHTYLELTLHSGRTHQIRIHLAALGCPIIGDD
KYGDFARNKACARAWGVKRLQLFAHSLVLPCACKPLVLRARMPVHFLRALDAVAL

Specific function: Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA [H]

COG id: COG0564

COG function: function code J; Pseudouridylate synthases, 23S RNA-specific

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI221316667, Length=231, Percent_Identity=32.9004329004329, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI221316663, Length=255, Percent_Identity=30.5882352941176, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI23308689, Length=183, Percent_Identity=31.6939890710383, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1789155, Length=231, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1788946, Length=199, Percent_Identity=30.1507537688442, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787327, Length=210, Percent_Identity=30, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786244, Length=168, Percent_Identity=30.952380952381, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534965, Length=172, Percent_Identity=32.5581395348837, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324506, Length=172, Percent_Identity=28.4883720930233, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321608, Length=184, Percent_Identity=32.0652173913043, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320168, Length=172, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583449, Length=167, Percent_Identity=29.940119760479, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583447, Length=167, Percent_Identity=29.940119760479, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583445, Length=167, Percent_Identity=29.940119760479, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921090, Length=168, Percent_Identity=30.952380952381, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006225
- InterPro:   IPR006224
- InterPro:   IPR006145
- InterPro:   IPR002942 [H]

Pfam domain/function: PF00849 PseudoU_synth_2; PF01479 S4 [H]

EC number: NA

Molecular weight: Translated: 23860; Mature: 23729

Theoretical pI: Translated: 11.42; Mature: 11.42

Prosite motif: PS01129 PSI_RLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPIIFQDAAVVAVDKPAGLAVQPGARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLL
CCCCEEECCCEEEEEECCCCEEECCCCCEEHHHHHHHHHHHCCEEEEHHHCCCCCCCEEE
FAKHARAAALYQGILGSMRVIKRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRAAHT
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
AYRVLRATDTHTYLELTLHSGRTHQIRIHLAALGCPIIGDDKYGDFARNKACARAWGVKR
HHHHHHCCCCCEEEEEEEECCCEEEEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHH
LQLFAHSLVLPCACKPLVLRARMPVHFLRALDAVAL
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALPIIFQDAAVVAVDKPAGLAVQPGARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLL
CCCEEECCCEEEEEECCCCEEECCCCCEEHHHHHHHHHHHCCEEEEHHHCCCCCCCEEE
FAKHARAAALYQGILGSMRVIKRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRAAHT
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
AYRVLRATDTHTYLELTLHSGRTHQIRIHLAALGCPIIGDDKYGDFARNKACARAWGVKR
HHHHHHCCCCCEEEEEEEECCCEEEEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHH
LQLFAHSLVLPCACKPLVLRARMPVHFLRALDAVAL
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA