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The map label for this gene is murA

Identifier: 189025263

GI number: 189025263

Start: 36908

End: 38185

Strand: Direct

Name: murA

Synonym: TPASS_0029

Alternate gene names: 189025263

Gene position: 36908-38185 (Clockwise)

Preceding gene: 189025262

Following gene: 189025264

Centisome position: 3.24

GC content: 50.08

Gene sequence:

>1278_bases
ATGAGTTGCTATCGTGTTGAAGGTGGGTTTCCCGTTTCAGGTTGTATTCGCGTGTGTGGAAATAAGAATGCAGCGCTTCC
CTGTATTGCGGCGGCAGTTCTCACACAAGAGCCAGTGTTACTGCAAAATGTGCCCGACATTGAGGATGTGGCGGTGATGT
TAACTATCTTTCGTGCGTTTGGTGGGAGTGTTGAAAGGCGTGGTAATCATGAGTACATGTTACATCTTCCTCAGTTACAG
ACGTGCGAAGTGCCGTGCGAGGCTGCGCAGAAAGTGCGTGCTTCCATTCTTTTTGCAGGGCCACTTCTTGCGCGTGGTAG
AAAAGCAGTGCTTCCACCACCTGGTGGTGATGTTATTGGGCGCAGGAGACTTGATACGCATTTTCTTGCGCTTGCCGCAC
TTGGCGCACAAGTTCGTTTAGATGGGGTGTTTACTTTCTCTGCAAATAAGCTGGTGGGATGTGATGTCTTCTTAGACGAG
GCATCTGTGACGGCGACAGAGAATGTGCTTATGGCTTCAGTTCTTGCCGAGGGGGTTACGGTAATCACGAACGCGGCGAG
CGAACCGCATGTGCAAGATCTATGCCATTTGTTGAATGCGATGGGTGCGCGCGTCTCTGGCATCGGATCGAATGTTTTAA
CAATTGAGGGGGTGAGCGCGTTGCATGGTACCACATATACACTTGGGGCTGATTTCATGGAAGTAGGTTCGCTTATTGGG
CTTGCGGTAGTAACGCGTGGAGCATTGACGATTTCGGATGTGAACGTACGTGATCTACGTCCACTAGGTTTTGCGTTTAA
AAAACTTGGAGTAATTTGGAGCGAGCAAGAGCACGCGGTAAGCGTCTCTGCGTCGCAGGATCTGCGGGTAAATTACGATT
TTGGCGGTATGATTCCTAAAATAGATGATGGCCCGTGGCCTGCATTTCCGCCGGATCTGACTAGCATTATGACAGTGGTG
GCGACTCAAGTCGAAGGGGTTATATTGATTCATGAGAAAATGTTTGAGTCGCGTATGTTTTTTGTGGACAAGTTAATTAC
CATGGGTGCGCGTATCATCCTGTGTGACCCGCATCGGGCGCTTGTTTCAGGTCCGAGTGCATTGCATGGGAGTGACCTGG
TATCTCCTGATGTGCGTGCGGGAATGGCGATGGTGCTTGCAGCGTGTTGTGCGCGCGGGGTAAGTATAATCCGTAACGTG
TATCAAATTGAGCGTGGATATGAACGTCTAGTGGAGCGTTTGCAGGCAATTGGTGTCCGTATTTGGAAAGAGGGTTGA

Upstream 100 bases:

>100_bases
GTAAGTACACAGGATGGGGCCGTACTTTTGCGGTATTCGTGCAATTAAGTTGTATGTTGATCGGTGTTCTACAGGAATGT
GTGCGCAAAGGGGTGAGAGC

Downstream 100 bases:

>100_bases
TCGTATTATGCGGTAATTTGATGAAAAGATGTGAAGTGTTGCCAAGAATCTTTTTTTTTAGTACCCTCGGGGACCGTTAC
ATATGAGGTGTTAACCTTAC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSCYRVEGGFPVSGCIRVCGNKNAALPCIAAAVLTQEPVLLQNVPDIEDVAVMLTIFRAFGGSVERRGNHEYMLHLPQLQ
TCEVPCEAAQKVRASILFAGPLLARGRKAVLPPPGGDVIGRRRLDTHFLALAALGAQVRLDGVFTFSANKLVGCDVFLDE
ASVTATENVLMASVLAEGVTVITNAASEPHVQDLCHLLNAMGARVSGIGSNVLTIEGVSALHGTTYTLGADFMEVGSLIG
LAVVTRGALTISDVNVRDLRPLGFAFKKLGVIWSEQEHAVSVSASQDLRVNYDFGGMIPKIDDGPWPAFPPDLTSIMTVV
ATQVEGVILIHEKMFESRMFFVDKLITMGARIILCDPHRALVSGPSALHGSDLVSPDVRAGMAMVLAACCARGVSIIRNV
YQIERGYERLVERLQAIGVRIWKEG

Sequences:

>Translated_425_residues
MSCYRVEGGFPVSGCIRVCGNKNAALPCIAAAVLTQEPVLLQNVPDIEDVAVMLTIFRAFGGSVERRGNHEYMLHLPQLQ
TCEVPCEAAQKVRASILFAGPLLARGRKAVLPPPGGDVIGRRRLDTHFLALAALGAQVRLDGVFTFSANKLVGCDVFLDE
ASVTATENVLMASVLAEGVTVITNAASEPHVQDLCHLLNAMGARVSGIGSNVLTIEGVSALHGTTYTLGADFMEVGSLIG
LAVVTRGALTISDVNVRDLRPLGFAFKKLGVIWSEQEHAVSVSASQDLRVNYDFGGMIPKIDDGPWPAFPPDLTSIMTVV
ATQVEGVILIHEKMFESRMFFVDKLITMGARIILCDPHRALVSGPSALHGSDLVSPDVRAGMAMVLAACCARGVSIIRNV
YQIERGYERLVERLQAIGVRIWKEG
>Mature_424_residues
SCYRVEGGFPVSGCIRVCGNKNAALPCIAAAVLTQEPVLLQNVPDIEDVAVMLTIFRAFGGSVERRGNHEYMLHLPQLQT
CEVPCEAAQKVRASILFAGPLLARGRKAVLPPPGGDVIGRRRLDTHFLALAALGAQVRLDGVFTFSANKLVGCDVFLDEA
SVTATENVLMASVLAEGVTVITNAASEPHVQDLCHLLNAMGARVSGIGSNVLTIEGVSALHGTTYTLGADFMEVGSLIGL
AVVTRGALTISDVNVRDLRPLGFAFKKLGVIWSEQEHAVSVSASQDLRVNYDFGGMIPKIDDGPWPAFPPDLTSIMTVVA
TQVEGVILIHEKMFESRMFFVDKLITMGARIILCDPHRALVSGPSALHGSDLVSPDVRAGMAMVLAACCARGVSIIRNVY
QIERGYERLVERLQAIGVRIWKEG

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=430, Percent_Identity=33.2558139534884, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_TREPA (O54312)

Other databases:

- EMBL:   X54111
- EMBL:   AE000520
- PIR:   G71374
- RefSeq:   NP_218469.1
- ProteinModelPortal:   O54312
- SMR:   O54312
- IntAct:   O54312
- GeneID:   2610859
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0029
- NMPDR:   fig|243276.1.peg.28
- TIGR:   TP_0029
- HOGENOM:   HBG482701
- OMA:   IGGKVTY
- ProtClustDB:   PRK09369
- BioCyc:   TPAL243276:TP_0029-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45543; Mature: 45411

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCYRVEGGFPVSGCIRVCGNKNAALPCIAAAVLTQEPVLLQNVPDIEDVAVMLTIFRAF
CCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHH
GGSVERRGNHEYMLHLPQLQTCEVPCEAAQKVRASILFAGPLLARGRKAVLPPPGGDVIG
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEECHHHHCCCEEECCCCCCCCCC
RRRLDTHFLALAALGAQVRLDGVFTFSANKLVGCDVFLDEASVTATENVLMASVLAEGVT
CHHHHHHHHHHHHHCCEEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCE
VITNAASEPHVQDLCHLLNAMGARVSGIGSNVLTIEGVSALHGTTYTLGADFMEVGSLIG
EEECCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEECCHHHCCCEEEECHHHHHHHHHHH
LAVVTRGALTISDVNVRDLRPLGFAFKKLGVIWSEQEHAVSVSASQDLRVNYDFGGMIPK
HHHHHCCCEEEECCCHHHCCHHHHHHHHHCCEECCCCCEEEEECCCCEEEEECCCCCCCC
IDDGPWPAFPPDLTSIMTVVATQVEGVILIHEKMFESRMFFVDKLITMGARIILCDPHRA
CCCCCCCCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LVSGPSALHGSDLVSPDVRAGMAMVLAACCARGVSIIRNVYQIERGYERLVERLQAIGVR
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
IWKEG
EECCC
>Mature Secondary Structure 
SCYRVEGGFPVSGCIRVCGNKNAALPCIAAAVLTQEPVLLQNVPDIEDVAVMLTIFRAF
CEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHH
GGSVERRGNHEYMLHLPQLQTCEVPCEAAQKVRASILFAGPLLARGRKAVLPPPGGDVIG
CCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEECHHHHCCCEEECCCCCCCCCC
RRRLDTHFLALAALGAQVRLDGVFTFSANKLVGCDVFLDEASVTATENVLMASVLAEGVT
CHHHHHHHHHHHHHCCEEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCE
VITNAASEPHVQDLCHLLNAMGARVSGIGSNVLTIEGVSALHGTTYTLGADFMEVGSLIG
EEECCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEECCHHHCCCEEEECHHHHHHHHHHH
LAVVTRGALTISDVNVRDLRPLGFAFKKLGVIWSEQEHAVSVSASQDLRVNYDFGGMIPK
HHHHHCCCEEEECCCHHHCCHHHHHHHHHCCEECCCCCEEEEECCCCEEEEECCCCCCCC
IDDGPWPAFPPDLTSIMTVVATQVEGVILIHEKMFESRMFFVDKLITMGARIILCDPHRA
CCCCCCCCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LVSGPSALHGSDLVSPDVRAGMAMVLAACCARGVSIIRNVYQIERGYERLVERLQAIGVR
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
IWKEG
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876