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The map label for this gene is dnaC [H]

Identifier: 188587499

GI number: 188587499

Start: 3145275

End: 3146621

Strand: Reverse

Name: dnaC [H]

Synonym: Nther_2910

Alternate gene names: 188587499

Gene position: 3146621-3145275 (Counterclockwise)

Preceding gene: 188587500

Following gene: 188587498

Centisome position: 99.4

GC content: 37.64

Gene sequence:

>1347_bases
GTGGCTGGTATAACAGATCGAATTCCACCGCAAAATATAGAAGCTGAACAATCAGTTCTTGGTGCGATGTTACTTGATGG
TGAAGCTATATCATCCGTGACGGAATTTCTCAGACCAGGTGATTTTTACAAAGAGGCTCATGAAAAGATATTTAGAGCGG
TGGTTTCCCTGGCAGAAAACAATGAGCCAGTAGATTTAGTTACTCTTTCAGAACAGTTACGCAATGAGGGGCTGCTAGAA
GAAGTTGGTGGTGCATCATATTTGGCTGACTTAGCTAATGCGGTGCCCACAGCAGCCCATGTTCATTATTATGCAAAAAT
AGTAGAAGAAAAATCTTTGCTCCGCCAACTAATCTCAGCATCAACAAAAATTGTTAGTATGAGTTATGAAGATCCCGATG
AAGTTGATAAAATTCTTGACGAAGCAGAAAAACTTATTTTTGAAGTTAGTCAAAAGACTACTACTCAGGATTTCGTTCCA
GTGAAAGAAATTTTAATGGAAACCTTTGATAACATTGAAAATTTATATCATAATCAAGGGAATGTTACAGGACTTCCTAC
TGGTTTTATTGATTTAGATCAAAGGTTGTCAGGGTTTCAACCTTCTGATTTAATCATTCTTGCGGCTAGGCCTTCCATGG
GTAAAACAACTTTGGCCTTGAATATGGCTCAACATGTATCTATTAGAGAGTCCCGACCAGTGGCAATTTTTAGTTTAGAG
ATGAGTAAAGATCAACTGGTACAAAGAATGCTATGTGCCGAGGCTAATATCGACGCCCATCGTTTACGTACAGGTGATTT
AACAAGTGAAGACTGGCCTAAACTAACCAAAGCTATTGGACCGATATCAGAGGCACCTATATTCATTGATGATACGGCTT
CTATTTCTGTAATGGAAATGAGGGCTAAGGCCAGACGATTAAAGGCAGAGCATGGATTAGAGGCAATATTTATTGACTAT
CTGCAATTAATGCAGGGTCATCAGAACCCAGAAAACAGACAGCAAGAAATTTCACAAATTTCCAGATCATTGAAGTCTCT
AGCTAAAGAATTAAATGTACCTGTCATAGCTCTTTCTCAGTTATCTAGAGCGGTTGAGCAAAGACAGGACAAGCGTCCAA
TGTTAAGTGATTTGCTTGAATCAGGTGGAATTGAAGCTAATGCTGACGTTGTATTATTTATTTACAGAGATGGTTATTAT
AATAGTGAAAGCGAAAAACCAAATATAGCAGAGGTAATAGTTGCCAAACAAAGAAACGGTCCTGTAGGAACTGTTGAATT
ATTTTTCAAAAATGACTTTAATAAGTTCTTAAATACTGAATATAGATATGATGAACAGGTAGAATGA

Upstream 100 bases:

>100_bases
TACACCCCGAAGTCACTGTAGATATAGATGTTCAGGTATCAGAAAAAAAGTAAAATAAATCAATACAGTATGGAACAAAT
TTTAGAAAGAAGGGATAGGA

Downstream 100 bases:

>100_bases
ATAATACAAGGGAATACTCCCTTGTATTATTTTGTTTATGGAAATTAACGGTTATATAATAGAGTTTATTTGGAGGAAGT
CTCTCAATAGTATAGAGCTT

Product: primary replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAGITDRIPPQNIEAEQSVLGAMLLDGEAISSVTEFLRPGDFYKEAHEKIFRAVVSLAENNEPVDLVTLSEQLRNEGLLE
EVGGASYLADLANAVPTAAHVHYYAKIVEEKSLLRQLISASTKIVSMSYEDPDEVDKILDEAEKLIFEVSQKTTTQDFVP
VKEILMETFDNIENLYHNQGNVTGLPTGFIDLDQRLSGFQPSDLIILAARPSMGKTTLALNMAQHVSIRESRPVAIFSLE
MSKDQLVQRMLCAEANIDAHRLRTGDLTSEDWPKLTKAIGPISEAPIFIDDTASISVMEMRAKARRLKAEHGLEAIFIDY
LQLMQGHQNPENRQQEISQISRSLKSLAKELNVPVIALSQLSRAVEQRQDKRPMLSDLLESGGIEANADVVLFIYRDGYY
NSESEKPNIAEVIVAKQRNGPVGTVELFFKNDFNKFLNTEYRYDEQVE

Sequences:

>Translated_448_residues
MAGITDRIPPQNIEAEQSVLGAMLLDGEAISSVTEFLRPGDFYKEAHEKIFRAVVSLAENNEPVDLVTLSEQLRNEGLLE
EVGGASYLADLANAVPTAAHVHYYAKIVEEKSLLRQLISASTKIVSMSYEDPDEVDKILDEAEKLIFEVSQKTTTQDFVP
VKEILMETFDNIENLYHNQGNVTGLPTGFIDLDQRLSGFQPSDLIILAARPSMGKTTLALNMAQHVSIRESRPVAIFSLE
MSKDQLVQRMLCAEANIDAHRLRTGDLTSEDWPKLTKAIGPISEAPIFIDDTASISVMEMRAKARRLKAEHGLEAIFIDY
LQLMQGHQNPENRQQEISQISRSLKSLAKELNVPVIALSQLSRAVEQRQDKRPMLSDLLESGGIEANADVVLFIYRDGYY
NSESEKPNIAEVIVAKQRNGPVGTVELFFKNDFNKFLNTEYRYDEQVE
>Mature_447_residues
AGITDRIPPQNIEAEQSVLGAMLLDGEAISSVTEFLRPGDFYKEAHEKIFRAVVSLAENNEPVDLVTLSEQLRNEGLLEE
VGGASYLADLANAVPTAAHVHYYAKIVEEKSLLRQLISASTKIVSMSYEDPDEVDKILDEAEKLIFEVSQKTTTQDFVPV
KEILMETFDNIENLYHNQGNVTGLPTGFIDLDQRLSGFQPSDLIILAARPSMGKTTLALNMAQHVSIRESRPVAIFSLEM
SKDQLVQRMLCAEANIDAHRLRTGDLTSEDWPKLTKAIGPISEAPIFIDDTASISVMEMRAKARRLKAEHGLEAIFIDYL
QLMQGHQNPENRQQEISQISRSLKSLAKELNVPVIALSQLSRAVEQRQDKRPMLSDLLESGGIEANADVVLFIYRDGYYN
SESEKPNIAEVIVAKQRNGPVGTVELFFKNDFNKFLNTEYRYDEQVE

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=445, Percent_Identity=45.3932584269663, Blast_Score=394, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 50160; Mature: 50028

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGITDRIPPQNIEAEQSVLGAMLLDGEAISSVTEFLRPGDFYKEAHEKIFRAVVSLAEN
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
NEPVDLVTLSEQLRNEGLLEEVGGASYLADLANAVPTAAHVHYYAKIVEEKSLLRQLISA
CCCEEEEEHHHHHCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
STKIVSMSYEDPDEVDKILDEAEKLIFEVSQKTTTQDFVPVKEILMETFDNIENLYHNQG
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NVTGLPTGFIDLDQRLSGFQPSDLIILAARPSMGKTTLALNMAQHVSIRESRPVAIFSLE
CCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
MSKDQLVQRMLCAEANIDAHRLRTGDLTSEDWPKLTKAIGPISEAPIFIDDTASISVMEM
CCHHHHHHHHHHHHCCCCHHHEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
RAKARRLKAEHGLEAIFIDYLQLMQGHQNPENRQQEISQISRSLKSLAKELNVPVIALSQ
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHH
LSRAVEQRQDKRPMLSDLLESGGIEANADVVLFIYRDGYYNSESEKPNIAEVIVAKQRNG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHEECCCCC
PVGTVELFFKNDFNKFLNTEYRYDEQVE
CCEEEEEEEEHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AGITDRIPPQNIEAEQSVLGAMLLDGEAISSVTEFLRPGDFYKEAHEKIFRAVVSLAEN
CCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
NEPVDLVTLSEQLRNEGLLEEVGGASYLADLANAVPTAAHVHYYAKIVEEKSLLRQLISA
CCCEEEEEHHHHHCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
STKIVSMSYEDPDEVDKILDEAEKLIFEVSQKTTTQDFVPVKEILMETFDNIENLYHNQG
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
NVTGLPTGFIDLDQRLSGFQPSDLIILAARPSMGKTTLALNMAQHVSIRESRPVAIFSLE
CCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
MSKDQLVQRMLCAEANIDAHRLRTGDLTSEDWPKLTKAIGPISEAPIFIDDTASISVMEM
CCHHHHHHHHHHHHCCCCHHHEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
RAKARRLKAEHGLEAIFIDYLQLMQGHQNPENRQQEISQISRSLKSLAKELNVPVIALSQ
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHH
LSRAVEQRQDKRPMLSDLLESGGIEANADVVLFIYRDGYYNSESEKPNIAEVIVAKQRNG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHEECCCCC
PVGTVELFFKNDFNKFLNTEYRYDEQVE
CCEEEEEEEEHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]