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The map label for this gene is atpA

Identifier: 188587436

GI number: 188587436

Start: 3079949

End: 3081475

Strand: Reverse

Name: atpA

Synonym: Nther_2846

Alternate gene names: 188587436

Gene position: 3081475-3079949 (Counterclockwise)

Preceding gene: 188587437

Following gene: 188587435

Centisome position: 97.34

GC content: 43.22

Gene sequence:

>1527_bases
ATGAGTATTCGTCCTGATGAAATTAGTACGGTGTTAAAAGATAAAATTGCAAATTATGAGTCTCAAGTAGACGTTTATGA
AGTGGGCACCGTGCTTTACATCGGGGATGGTATCGCCAGGGTCCACGGACTAGAAAATGTTATGGCTAACGAGTTGGTCG
AGTTTCCAGGCGAAATTTACGGGATGGCTCTGAACTTGGAAGAGGACAATGTAGGTTGTGTTTTATTAGGTGAATACAGC
CACATTAAAGAAGGTGACCAAGTTAAACGAACTGGCCGTATTATTGAGGTACCTGTTGGTGACGACCTGGTAGGCAGAGT
TGTTAACCCCGTTGGTGAACCGAGAGATGGAAAGGGGCCAATTGAAGCAACAGACTTCAGGCCTGTAGAAACTCGTGCTC
CGGGAGTTATTGACAGGAAGCCCGTTGAAGAACCCCTACAAACAGGGTTGAAAGCTATTGACTCTATGATTCCTATTGGT
CGTGGTCAGAGAGAGCTGATCATAGGTGATAGGGGAACGGGTAAGAGTGCTATTGGAATTGATACCATCCTAAATCAGAA
AGATTCCGATGTATATTGCATTTATGTGGCCATAGGACAGAAAAAGTCTACTGTTGCCCAGGTTGTTGATGTCCTCGAAC
GACATGGAGCTATGGATTATACCACGGTGGTAGCTGCTACAGCTGATGAACCAGCACCACTACTATATCTTGCACCCTAT
GCTGGTTGCAGTATGGGTGAAAAGTTTATGCACGAAGGGAAGCATGTATTAGTTGTGTATGATGATCTTTCTAAACATGC
TGCCAGTTATAGGGAACTGTCCTTGCTACTAAGACGACCACCAGGCAGGGAAGCTTATCCTGGGGATATATTTTACCTCC
ACTCTCGTCTGTTAGAGCGTGCTGCTAAACTGAATGATGAGAATGGTGGCGGCTCCTTGACAGCACTTCCAATTATAGAA
ACCCAAGCTGGTGACGTGTCAGCTTACATCCCAACAAACGTTATTTCAATTACAGACGGTCAGATTTATCTGATCAGTGA
TCTATTCCACGCAGGGCAGCGACCTGCAGTTGATGTCGGTATCTCTGTTTCAAGAGTTGGTGGTTCAGCACAGCTGAAAG
GAATGAAACAAGTTTCAGGGACATTACGTTTGGACTTAGCTCAGTACAGGGAGCTAGAAGCTTTTGCCCAGTTTGGAACT
GATTTGGATAAATCCACACAACAAAAACTTGCGCGCGGAAAGAGAACCTTTGAAATACTAAAACAAGATCAGTATCAGCC
GATGCCCGTAGCGGATCAGATAGTTATCATATTCTGTGCTACCCACGGTTTATTAGACGATCTAGAAGTTGAGCAAATCA
AAGAGTTTGAGAAGTTCTTATTGAGCTATGTAAAAGATAATGAACCAGGAATTTACCAGCAGGTGGAAACTGGTGAGAAA
ATATCCGATGAACTTGAAGACCAGTTAAAAGAAGTTATAAATAAAGCTAAAGAACAATTTAAAGAAGAAAAAGAACTAAC
CGGTTAA

Upstream 100 bases:

>100_bases
AGAATCGGGGACCGAGTCTTTGATTATAGCTTAAAGGGTCAGTTAAATAGTCTCCGAGAACAACTTAAAAAGACAACTAT
CACAAGTTGAGGTGAAGGTT

Downstream 100 bases:

>100_bases
CAGACTACGCTTAACTTGTTTACTGGTTTGAGACTGTTTTTTACAGATATTAATTTTCTTCGGAGAATTAGGTGGTGATG
GAATGGCACAGAGTACCCGT

Product: ATP synthase F1, alpha subunit

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSIRPDEISTVLKDKIANYESQVDVYEVGTVLYIGDGIARVHGLENVMANELVEFPGEIYGMALNLEEDNVGCVLLGEYS
HIKEGDQVKRTGRIIEVPVGDDLVGRVVNPVGEPRDGKGPIEATDFRPVETRAPGVIDRKPVEEPLQTGLKAIDSMIPIG
RGQRELIIGDRGTGKSAIGIDTILNQKDSDVYCIYVAIGQKKSTVAQVVDVLERHGAMDYTTVVAATADEPAPLLYLAPY
AGCSMGEKFMHEGKHVLVVYDDLSKHAASYRELSLLLRRPPGREAYPGDIFYLHSRLLERAAKLNDENGGGSLTALPIIE
TQAGDVSAYIPTNVISITDGQIYLISDLFHAGQRPAVDVGISVSRVGGSAQLKGMKQVSGTLRLDLAQYRELEAFAQFGT
DLDKSTQQKLARGKRTFEILKQDQYQPMPVADQIVIIFCATHGLLDDLEVEQIKEFEKFLLSYVKDNEPGIYQQVETGEK
ISDELEDQLKEVINKAKEQFKEEKELTG

Sequences:

>Translated_508_residues
MSIRPDEISTVLKDKIANYESQVDVYEVGTVLYIGDGIARVHGLENVMANELVEFPGEIYGMALNLEEDNVGCVLLGEYS
HIKEGDQVKRTGRIIEVPVGDDLVGRVVNPVGEPRDGKGPIEATDFRPVETRAPGVIDRKPVEEPLQTGLKAIDSMIPIG
RGQRELIIGDRGTGKSAIGIDTILNQKDSDVYCIYVAIGQKKSTVAQVVDVLERHGAMDYTTVVAATADEPAPLLYLAPY
AGCSMGEKFMHEGKHVLVVYDDLSKHAASYRELSLLLRRPPGREAYPGDIFYLHSRLLERAAKLNDENGGGSLTALPIIE
TQAGDVSAYIPTNVISITDGQIYLISDLFHAGQRPAVDVGISVSRVGGSAQLKGMKQVSGTLRLDLAQYRELEAFAQFGT
DLDKSTQQKLARGKRTFEILKQDQYQPMPVADQIVIIFCATHGLLDDLEVEQIKEFEKFLLSYVKDNEPGIYQQVETGEK
ISDELEDQLKEVINKAKEQFKEEKELTG
>Mature_507_residues
SIRPDEISTVLKDKIANYESQVDVYEVGTVLYIGDGIARVHGLENVMANELVEFPGEIYGMALNLEEDNVGCVLLGEYSH
IKEGDQVKRTGRIIEVPVGDDLVGRVVNPVGEPRDGKGPIEATDFRPVETRAPGVIDRKPVEEPLQTGLKAIDSMIPIGR
GQRELIIGDRGTGKSAIGIDTILNQKDSDVYCIYVAIGQKKSTVAQVVDVLERHGAMDYTTVVAATADEPAPLLYLAPYA
GCSMGEKFMHEGKHVLVVYDDLSKHAASYRELSLLLRRPPGREAYPGDIFYLHSRLLERAAKLNDENGGGSLTALPIIET
QAGDVSAYIPTNVISITDGQIYLISDLFHAGQRPAVDVGISVSRVGGSAQLKGMKQVSGTLRLDLAQYRELEAFAQFGTD
LDKSTQQKLARGKRTFEILKQDQYQPMPVADQIVIIFCATHGLLDDLEVEQIKEFEKFLLSYVKDNEPGIYQQVETGEKI
SDELEDQLKEVINKAKEQFKEEKELTG

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=497, Percent_Identity=60.3621730382294, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI4757810, Length=497, Percent_Identity=60.3621730382294, Blast_Score=615, Evalue=1e-176,
Organism=Homo sapiens, GI19913426, Length=301, Percent_Identity=30.5647840531561, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI19913428, Length=301, Percent_Identity=31.2292358803987, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI32189394, Length=411, Percent_Identity=26.0340632603406, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI19913424, Length=253, Percent_Identity=28.4584980237154, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790172, Length=508, Percent_Identity=56.1023622047244, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1788251, Length=272, Percent_Identity=31.6176470588235, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790170, Length=360, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=58.4493041749503, Blast_Score=606, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=58.4493041749503, Blast_Score=603, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71988074, Length=504, Percent_Identity=54.5634920634921, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17510931, Length=378, Percent_Identity=28.8359788359788, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17570191, Length=298, Percent_Identity=29.5302013422819, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144756, Length=416, Percent_Identity=24.5192307692308, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71988068, Length=71, Percent_Identity=52.112676056338, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509265, Length=52, Percent_Identity=61.5384615384615, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=252, Percent_Identity=26.5873015873016, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=505, Percent_Identity=57.4257425742574, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319603, Length=303, Percent_Identity=28.3828382838284, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=420, Percent_Identity=25.7142857142857, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24658560, Length=506, Percent_Identity=58.498023715415, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=30.2325581395349, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=30.2325581395349, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=30.2325581395349, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24638766, Length=417, Percent_Identity=25.8992805755396, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574560, Length=424, Percent_Identity=26.6509433962264, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583992, Length=253, Percent_Identity=28.0632411067194, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583988, Length=253, Percent_Identity=28.0632411067194, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583986, Length=253, Percent_Identity=28.0632411067194, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583984, Length=253, Percent_Identity=28.0632411067194, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129479, Length=254, Percent_Identity=28.740157480315, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_NATTJ (B2A3G4)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001918981.1
- ProteinModelPortal:   B2A3G4
- SMR:   B2A3G4
- GeneID:   6316461
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_2846
- HOGENOM:   HBG565875
- OMA:   EFEDKML
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55936; Mature: 55805

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRPDEISTVLKDKIANYESQVDVYEVGTVLYIGDGIARVHGLENVMANELVEFPGEIY
CCCCHHHHHHHHHHHHHCCCCCCCCEECCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCE
GMALNLEEDNVGCVLLGEYSHIKEGDQVKRTGRIIEVPVGDDLVGRVVNPVGEPRDGKGP
EEEEEECCCCCCEEEECCCHHCCCCHHHHHCCCEEEECCCCHHHHHHHCCCCCCCCCCCC
IEATDFRPVETRAPGVIDRKPVEEPLQTGLKAIDSMIPIGRGQRELIIGDRGTGKSAIGI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCH
DTILNQKDSDVYCIYVAIGQKKSTVAQVVDVLERHGAMDYTTVVAATADEPAPLLYLAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEECCC
AGCSMGEKFMHEGKHVLVVYDDLSKHAASYRELSLLLRRPPGREAYPGDIFYLHSRLLER
CCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKLNDENGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLISDLFHAGQRPAVDVG
HHHCCCCCCCCCEEEEEEEEECCCCEEEECCCCEEEECCCCEEEEEHHHHCCCCCCEEEC
ISVSRVGGSAQLKGMKQVSGTLRLDLAQYRELEAFAQFGTDLDKSTQQKLARGKRTFEIL
EEEEECCCCHHHCHHHHHCCHHEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHH
KQDQYQPMPVADQIVIIFCATHGLLDDLEVEQIKEFEKFLLSYVKDNEPGIYQQVETGEK
HHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHH
ISDELEDQLKEVINKAKEQFKEEKELTG
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SIRPDEISTVLKDKIANYESQVDVYEVGTVLYIGDGIARVHGLENVMANELVEFPGEIY
CCCHHHHHHHHHHHHHCCCCCCCCEECCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCE
GMALNLEEDNVGCVLLGEYSHIKEGDQVKRTGRIIEVPVGDDLVGRVVNPVGEPRDGKGP
EEEEEECCCCCCEEEECCCHHCCCCHHHHHCCCEEEECCCCHHHHHHHCCCCCCCCCCCC
IEATDFRPVETRAPGVIDRKPVEEPLQTGLKAIDSMIPIGRGQRELIIGDRGTGKSAIGI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCH
DTILNQKDSDVYCIYVAIGQKKSTVAQVVDVLERHGAMDYTTVVAATADEPAPLLYLAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEECCC
AGCSMGEKFMHEGKHVLVVYDDLSKHAASYRELSLLLRRPPGREAYPGDIFYLHSRLLER
CCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKLNDENGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLISDLFHAGQRPAVDVG
HHHCCCCCCCCCEEEEEEEEECCCCEEEECCCCEEEECCCCEEEEEHHHHCCCCCCEEEC
ISVSRVGGSAQLKGMKQVSGTLRLDLAQYRELEAFAQFGTDLDKSTQQKLARGKRTFEIL
EEEEECCCCHHHCHHHHHCCHHEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHH
KQDQYQPMPVADQIVIIFCATHGLLDDLEVEQIKEFEKFLLSYVKDNEPGIYQQVETGEK
HHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHH
ISDELEDQLKEVINKAKEQFKEEKELTG
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA