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The map label for this gene is pyrC [H]

Identifier: 188587357

GI number: 188587357

Start: 2984348

End: 2985673

Strand: Reverse

Name: pyrC [H]

Synonym: Nther_2764

Alternate gene names: 188587357

Gene position: 2985673-2984348 (Counterclockwise)

Preceding gene: 188587358

Following gene: 188587356

Centisome position: 94.32

GC content: 42.01

Gene sequence:

>1326_bases
ATGGGGATATTGCTTAAGGGAGGTATTATTTATACAGGAGAACCCGTTAGTGATGGAACACAAATGGATATTTTAATAGA
AGATGGTATGATTAAGGATCAACAAAGGAATATTAATCCCGAGGAGCTGGGAAAATCCGAATCCGAGCAGCTTGAAATAA
TTGATGTTTCAGGACTAACTATTGTACCTGGATTAGTTGATATGCATGTACATTTAAGAGAACCTGGTTTTGAATATAAG
GAAACTATCGCCACTGGGACAAAAAGTGCCGCCAGAGGTGGTTTTACCAGCATAGCTTGCATGCCAAATACTAAACCAAC
TGCTGATAATAGTGGTACTATTGAGTTTATTAAACAGAGGGCGAAAGAACAAGGACTAGTTCACACATATCCCATCGCAG
CCCTAACTGTTGATCGGGTAGGTAAAGAAATTGTGGAAATGGATGATCTATACTCTGCTGGTGCAGTAGCCTTTTCTGAT
GATGGAAGCTGGGTACATGACTCCGGTGTCATGAGAACAGCTTTGGAATACTCTCAACTATTCAATGTTCCTGTCATAAG
TCACTGTGAAGACGAAGGGCTTTCGGATTCTGGTCAAGTAAATGAAGGTTATCTGGCTTCCGTAATGGGTCTAAGCGGAA
TTCCCAATGAATCCGAAAGTATCGCTGTAGCCCGGGATGTGATGCTTTCTGAGTTAACAGGTGCTCATCTTCACATAGCT
CATATCAGTACCGCCCAGTCCGTTGATATAATTAGAAAGGCGAAAGATAGAGGAGTACCTGTAACCGCAGAAGTTACTCC
TCATCATCTAATATTAACTGATTCAACAATCCAAAATTACAATACAATGGCCAAGGTAAACCCTCCTCTCAGAACAGAAG
AAGATGTTAAGGCCCTACGCCAGGGTATAAAAGAAGGAGTGATCGACTGTATAGCCACTGACCATGCCCCCCACAGTACA
GACGAAAAAAATGTGGAATTTGACAATGCCCCCTTTGGATTAGTTGGTTTGGAAACAGCCTTTTCCGTGTCCAAAAAAGC
TCTAGTGGACAGTGGTGTGTTGTCACTTTCAGAACTAATTGAAAAAATGTCCACAAATCCTGCTAAGCTGTTAAAACTTC
CTAGTGGAAAGTTAGTACATGAAGCCCCAGCTGATTTGACCATTTTGTCATTAGATGAAAAATATACCGTAAATCCAGGC
GACTTCGCTTCCCTGGGCAAAAACAGCCCCTTTGCTGGATGGGAGTTGGAAGGTAAAATCGTCGCTACAATGGTTTCAGG
GGAATTTAGTTATCGACAATTTGGGAGCGATGACCATGTGGTATGA

Upstream 100 bases:

>100_bases
GAACTAATGAACAGCGAAAAATCAGTTATTGAAGAACAGGTGACTAACGGAGTTGCTATCCGAATGGCATTGCTTTATCA
CTTATCTGGAGGTGAAGATA

Downstream 100 bases:

>100_bases
TGAATTAGGAAAAATAAGCTATCACACTAAGATTGCCCCACAAATTTTTTTAATGAAGATAAAGCTTCCAAAAATTAGCA
CTAGTATTCATCCGGGGCAG

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MGILLKGGIIYTGEPVSDGTQMDILIEDGMIKDQQRNINPEELGKSESEQLEIIDVSGLTIVPGLVDMHVHLREPGFEYK
ETIATGTKSAARGGFTSIACMPNTKPTADNSGTIEFIKQRAKEQGLVHTYPIAALTVDRVGKEIVEMDDLYSAGAVAFSD
DGSWVHDSGVMRTALEYSQLFNVPVISHCEDEGLSDSGQVNEGYLASVMGLSGIPNESESIAVARDVMLSELTGAHLHIA
HISTAQSVDIIRKAKDRGVPVTAEVTPHHLILTDSTIQNYNTMAKVNPPLRTEEDVKALRQGIKEGVIDCIATDHAPHST
DEKNVEFDNAPFGLVGLETAFSVSKKALVDSGVLSLSELIEKMSTNPAKLLKLPSGKLVHEAPADLTILSLDEKYTVNPG
DFASLGKNSPFAGWELEGKIVATMVSGEFSYRQFGSDDHVV

Sequences:

>Translated_441_residues
MGILLKGGIIYTGEPVSDGTQMDILIEDGMIKDQQRNINPEELGKSESEQLEIIDVSGLTIVPGLVDMHVHLREPGFEYK
ETIATGTKSAARGGFTSIACMPNTKPTADNSGTIEFIKQRAKEQGLVHTYPIAALTVDRVGKEIVEMDDLYSAGAVAFSD
DGSWVHDSGVMRTALEYSQLFNVPVISHCEDEGLSDSGQVNEGYLASVMGLSGIPNESESIAVARDVMLSELTGAHLHIA
HISTAQSVDIIRKAKDRGVPVTAEVTPHHLILTDSTIQNYNTMAKVNPPLRTEEDVKALRQGIKEGVIDCIATDHAPHST
DEKNVEFDNAPFGLVGLETAFSVSKKALVDSGVLSLSELIEKMSTNPAKLLKLPSGKLVHEAPADLTILSLDEKYTVNPG
DFASLGKNSPFAGWELEGKIVATMVSGEFSYRQFGSDDHVV
>Mature_440_residues
GILLKGGIIYTGEPVSDGTQMDILIEDGMIKDQQRNINPEELGKSESEQLEIIDVSGLTIVPGLVDMHVHLREPGFEYKE
TIATGTKSAARGGFTSIACMPNTKPTADNSGTIEFIKQRAKEQGLVHTYPIAALTVDRVGKEIVEMDDLYSAGAVAFSDD
GSWVHDSGVMRTALEYSQLFNVPVISHCEDEGLSDSGQVNEGYLASVMGLSGIPNESESIAVARDVMLSELTGAHLHIAH
ISTAQSVDIIRKAKDRGVPVTAEVTPHHLILTDSTIQNYNTMAKVNPPLRTEEDVKALRQGIKEGVIDCIATDHAPHSTD
EKNVEFDNAPFGLVGLETAFSVSKKALVDSGVLSLSELIEKMSTNPAKLLKLPSGKLVHEAPADLTILSLDEKYTVNPGD
FASLGKNSPFAGWELEGKIVATMVSGEFSYRQFGSDDHVV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=386, Percent_Identity=28.2383419689119, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=23.4649122807018, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786722, Length=406, Percent_Identity=28.0788177339901, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=25.601750547046, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=381, Percent_Identity=29.9212598425197, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI86575075, Length=434, Percent_Identity=22.5806451612903, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322218, Length=450, Percent_Identity=26.8888888888889, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=28.9473684210526, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI18859883, Length=224, Percent_Identity=27.2321428571429, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47486; Mature: 47355

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILLKGGIIYTGEPVSDGTQMDILIEDGMIKDQQRNINPEELGKSESEQLEIIDVSGLT
CCEEEECCEEEECCCCCCCCEEEEEEECCCCCHHHCCCCHHHHCCCCCCCEEEEEECCCE
IVPGLVDMHVHLREPGFEYKETIATGTKSAARGGFTSIACMPNTKPTADNSGTIEFIKQR
ECCCCEEEEEEECCCCCHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
AKEQGLVHTYPIAALTVDRVGKEIVEMDDLYSAGAVAFSDDGSWVHDSGVMRTALEYSQL
HHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCHHHHHHHHHHH
FNVPVISHCEDEGLSDSGQVNEGYLASVMGLSGIPNESESIAVARDVMLSELTGAHLHIA
CCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
HISTAQSVDIIRKAKDRGVPVTAEVTPHHLILTDSTIQNYNTMAKVNPPLRTEEDVKALR
EECCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHCCCCEEECCCCCCCHHHHHHHH
QGIKEGVIDCIATDHAPHSTDEKNVEFDNAPFGLVGLETAFSVSKKALVDSGVLSLSELI
HHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
EKMSTNPAKLLKLPSGKLVHEAPADLTILSLDEKYTVNPGDFASLGKNSPFAGWELEGKI
HHHCCCHHHEEECCCCCEEECCCCCEEEEEECCCEECCCCCHHHCCCCCCCCCEEECCEE
VATMVSGEFSYRQFGSDDHVV
EEEEECCCCHHHHCCCCCCCC
>Mature Secondary Structure 
GILLKGGIIYTGEPVSDGTQMDILIEDGMIKDQQRNINPEELGKSESEQLEIIDVSGLT
CEEEECCEEEECCCCCCCCEEEEEEECCCCCHHHCCCCHHHHCCCCCCCEEEEEECCCE
IVPGLVDMHVHLREPGFEYKETIATGTKSAARGGFTSIACMPNTKPTADNSGTIEFIKQR
ECCCCEEEEEEECCCCCHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
AKEQGLVHTYPIAALTVDRVGKEIVEMDDLYSAGAVAFSDDGSWVHDSGVMRTALEYSQL
HHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCHHHHHHHHHHH
FNVPVISHCEDEGLSDSGQVNEGYLASVMGLSGIPNESESIAVARDVMLSELTGAHLHIA
CCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
HISTAQSVDIIRKAKDRGVPVTAEVTPHHLILTDSTIQNYNTMAKVNPPLRTEEDVKALR
EECCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHCCCCEEECCCCCCCHHHHHHHH
QGIKEGVIDCIATDHAPHSTDEKNVEFDNAPFGLVGLETAFSVSKKALVDSGVLSLSELI
HHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
EKMSTNPAKLLKLPSGKLVHEAPADLTILSLDEKYTVNPGDFASLGKNSPFAGWELEGKI
HHHCCCHHHEEECCCCCEEECCCCCEEEEEECCCEECCCCCHHHCCCCCCCCCEEECCEE
VATMVSGEFSYRQFGSDDHVV
EEEEECCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA