Click here to switch to the map view.

The map label for this gene is gbh [H]

Identifier: 188587352

GI number: 188587352

Start: 2980253

End: 2981254

Strand: Direct

Name: gbh [H]

Synonym: Nther_2759

Alternate gene names: 188587352

Gene position: 2980253-2981254 (Clockwise)

Preceding gene: 188587339

Following gene: 188587360

Centisome position: 94.15

GC content: 40.22

Gene sequence:

>1002_bases
ATGAGTCGAAGAAGTTTGTGGCGAGGTTTATATCGCAAAGACTTTTCTCCAGGTGAAGCCGATTTTACAATTTTAGGTAT
TCCCTTTGATAAAGGTTGTAGTTTTAGGGAAGGTACGTGCTCCGGGCCTGAGTACATCCGCTCAAGTTCAGATCGGAATC
CTCCTGTTACAGAAGATGGGGCACAATTAACTGCCAGTGTTTGTGATATGGGAAATATCCCTTTTCAAGATGTCTTCGAA
ACTCAAAGAGATTATTTTGAAAAAGTACAAGACCAAGTTGAAGAAATTTTCAAGGCCAAGTATCTCCAAAATGATCACAT
GTTCCCAATTTTCTTGGGCGGAGATCACTCAATAACCATACCTTTGTTAAGAGCTATAGATCAGGTCTATAAAGGTGACG
AAGAAGATATCGCCATTATTCACTTTGACACTCATCTCGATATATGTGACACATTGGACGAAAATCCCCTTTCCCATGGC
AGTACCCATAGGAGGGGCTGGGAGTTAGATGTTTTCAAGCCGGAACACACTTATTTTGTCGGAATCAGATGTTCAGAAGC
CCAAGAACATAATTTCCTCCATGGAAAACAGACTAATATAGTCACAGCAAAGCAGATCTTTATGGAGGGCCCTCTTAAAA
TGGCTCAACAAATCGCTGATTTAGTTGGAAATCGCAAAACTTATTTAACTTTGGATATCGATGTCTTAGATCCAGCTTTT
GCTCCAGGAACGGGCACTCCTGTGGCAGGAGGGCTAAGCAGCCGGGAACTGTTAATAATGCTAGAAGAATTATCTAAACT
AAATTTGATTGGCATGGACTTGGTAGAGGTATCTCCACCTTGGGATAATTCTGAAATCACTCTTTACTCGGCTCAAAAAA
TTATTTTCGAAATGATGGGATACATGGCACCAAAAGATAAAAAGGGTGACTCCATCTTAAATCAGTTTTCCTTAAAACAA
ACCGGTTCTTTTAACTATCAATATTACGACTCCCAGGCTTAA

Upstream 100 bases:

>100_bases
TTTATAACTTGTTAAGCTATAATCAAACTAGCACACAAATCCTTGTCCTAGATTTGGACAAGGATAATACTACAACTATA
CAAGTAGAGGTGATCAGTAA

Downstream 100 bases:

>100_bases
CAGGTGTGCTCCCCTGTTCACACAGGGGACAATCCTGTTCTTCATAGGATTTGATATTCATTTCTATTAGGGAAACAAAT
CCATTTTCAACCCCTGAAAA

Product: agmatinase

Products: NA

Alternate protein names: GBase; D-arginase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSRRSLWRGLYRKDFSPGEADFTILGIPFDKGCSFREGTCSGPEYIRSSSDRNPPVTEDGAQLTASVCDMGNIPFQDVFE
TQRDYFEKVQDQVEEIFKAKYLQNDHMFPIFLGGDHSITIPLLRAIDQVYKGDEEDIAIIHFDTHLDICDTLDENPLSHG
STHRRGWELDVFKPEHTYFVGIRCSEAQEHNFLHGKQTNIVTAKQIFMEGPLKMAQQIADLVGNRKTYLTLDIDVLDPAF
APGTGTPVAGGLSSRELLIMLEELSKLNLIGMDLVEVSPPWDNSEITLYSAQKIIFEMMGYMAPKDKKGDSILNQFSLKQ
TGSFNYQYYDSQA

Sequences:

>Translated_333_residues
MSRRSLWRGLYRKDFSPGEADFTILGIPFDKGCSFREGTCSGPEYIRSSSDRNPPVTEDGAQLTASVCDMGNIPFQDVFE
TQRDYFEKVQDQVEEIFKAKYLQNDHMFPIFLGGDHSITIPLLRAIDQVYKGDEEDIAIIHFDTHLDICDTLDENPLSHG
STHRRGWELDVFKPEHTYFVGIRCSEAQEHNFLHGKQTNIVTAKQIFMEGPLKMAQQIADLVGNRKTYLTLDIDVLDPAF
APGTGTPVAGGLSSRELLIMLEELSKLNLIGMDLVEVSPPWDNSEITLYSAQKIIFEMMGYMAPKDKKGDSILNQFSLKQ
TGSFNYQYYDSQA
>Mature_332_residues
SRRSLWRGLYRKDFSPGEADFTILGIPFDKGCSFREGTCSGPEYIRSSSDRNPPVTEDGAQLTASVCDMGNIPFQDVFET
QRDYFEKVQDQVEEIFKAKYLQNDHMFPIFLGGDHSITIPLLRAIDQVYKGDEEDIAIIHFDTHLDICDTLDENPLSHGS
THRRGWELDVFKPEHTYFVGIRCSEAQEHNFLHGKQTNIVTAKQIFMEGPLKMAQQIADLVGNRKTYLTLDIDVLDPAFA
PGTGTPVAGGLSSRELLIMLEELSKLNLIGMDLVEVSPPWDNSEITLYSAQKIIFEMMGYMAPKDKKGDSILNQFSLKQT
GSFNYQYYDSQA

Specific function: Catalyzes The Formation Of Putrescine From Agmatine. [C]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family. Agmatinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI37537722, Length=289, Percent_Identity=31.4878892733564, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI10947139, Length=281, Percent_Identity=27.7580071174377, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4502215, Length=326, Percent_Identity=24.2331288343558, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1789306, Length=301, Percent_Identity=34.21926910299, Blast_Score=145, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6325146, Length=216, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24638886, Length=317, Percent_Identity=24.9211356466877, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005925
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.7; =3.5.3.10 [H]

Molecular weight: Translated: 37678; Mature: 37547

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00147 ARGINASE_1 ; PS01053 ARGINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRSLWRGLYRKDFSPGEADFTILGIPFDKGCSFREGTCSGPEYIRSSSDRNPPVTEDG
CCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
AQLTASVCDMGNIPFQDVFETQRDYFEKVQDQVEEIFKAKYLQNDHMFPIFLGGDHSITI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHH
PLLRAIDQVYKGDEEDIAIIHFDTHLDICDTLDENPLSHGSTHRRGWELDVFKPEHTYFV
HHHHHHHHHHCCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEE
GIRCSEAQEHNFLHGKQTNIVTAKQIFMEGPLKMAQQIADLVGNRKTYLTLDIDVLDPAF
EEEECCCCCCCCCCCCCCCEEHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
APGTGTPVAGGLSSRELLIMLEELSKLNLIGMDLVEVSPPWDNSEITLYSAQKIIFEMMG
CCCCCCCCCCCCCCCHHHHHHHHHHHCCEECCEEEECCCCCCCCCEEEEHHHHHHHHHHH
YMAPKDKKGDSILNQFSLKQTGSFNYQYYDSQA
HCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCC
>Mature Secondary Structure 
SRRSLWRGLYRKDFSPGEADFTILGIPFDKGCSFREGTCSGPEYIRSSSDRNPPVTEDG
CHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
AQLTASVCDMGNIPFQDVFETQRDYFEKVQDQVEEIFKAKYLQNDHMFPIFLGGDHSITI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHH
PLLRAIDQVYKGDEEDIAIIHFDTHLDICDTLDENPLSHGSTHRRGWELDVFKPEHTYFV
HHHHHHHHHHCCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEE
GIRCSEAQEHNFLHGKQTNIVTAKQIFMEGPLKMAQQIADLVGNRKTYLTLDIDVLDPAF
EEEECCCCCCCCCCCCCCCEEHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
APGTGTPVAGGLSSRELLIMLEELSKLNLIGMDLVEVSPPWDNSEITLYSAQKIIFEMMG
CCCCCCCCCCCCCCCHHHHHHHHHHHCCEECCEEEECCCCCCCCCEEEEHHHHHHHHHHH
YMAPKDKKGDSILNQFSLKQTGSFNYQYYDSQA
HCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA