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The map label for this gene is iclR [H]

Identifier: 188587299

GI number: 188587299

Start: 2915717

End: 2916481

Strand: Reverse

Name: iclR [H]

Synonym: Nther_2702

Alternate gene names: 188587299

Gene position: 2916481-2915717 (Counterclockwise)

Preceding gene: 188587300

Following gene: 188587298

Centisome position: 92.13

GC content: 33.86

Gene sequence:

>765_bases
ATGAGCGATAGCGAATCTAAAAATATTCAAGCCATTGAAAGAGCCCTGGATGTACTACTACTATTTTTAGAAAAAAAACG
AGAACTAGGTGTGAGTGAGATCAGTCATTCTTTAGGTTATTATAAAAGTACTGTACATAGGATACTATCAACTTTAAGTA
GCCGTGGCTTTATTTACAAAAATCCCATTACAAATAAATACTGGTTAGGAGTTAAAAATTTCTCCTTAGGCATGTTATAT
CAAGACAAATTTGTATTAAAAGATGTGGCCTATCCGTATCTAAAAAAATTGTCAGAGGATGTAAATGAAACAGTCAATCT
TGCAATACTTGATGAGATAGATGATCCAGAAGTTATTGTTGTTGAGAAGATTCAGACTGAACATATGTTGACTATTTCAC
CTCCAGTAGGGTCACGAACACCAGCTCATTGTTCCGGTGTTGGAAAAGTTTTATTGGCATACAGTGATGAAGGCGTACTA
GAACAGCTTAAACAAAAACCATTAGAAGAATTTACTTCAAATACAATTGCCGACTTTAAAGAGTTATATAGAATTTTAGA
AGAGGTAAGAGAAAAAGGTTATGCTATCGACTATGAAGAAATAGAGATTGGCTTGAGTTGTTTGGCAACTCCTATATTTG
ATCAAGAAGGTCATGCTGTAGCGGCAGTTAGTGTTTCAGGTCCAGTAAATAGAATTTATAATCGTTTTCCGGAAATAATT
AAACAATTAAAACTAACATCGGCTCAGATTTCCAAATTTCTCTGA

Upstream 100 bases:

>100_bases
CACAGCTTAAATTTACCAAAAATCAACAATCTGTTATAATTAACACAATATAAAATGAAACTCAGTTTAGATAACTTTTA
TGTAAAGGATGGGATCCAAA

Downstream 100 bases:

>100_bases
TTGAAAGTCTAAAAATTTTTATCTTTTTATGGAACACCGTTCCATACAATGGAACTATAAATAAATTATGAAGAGTTAAT
ATTTTAAAAAATCTTTTCAA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSDSESKNIQAIERALDVLLLFLEKKRELGVSEISHSLGYYKSTVHRILSTLSSRGFIYKNPITNKYWLGVKNFSLGMLY
QDKFVLKDVAYPYLKKLSEDVNETVNLAILDEIDDPEVIVVEKIQTEHMLTISPPVGSRTPAHCSGVGKVLLAYSDEGVL
EQLKQKPLEEFTSNTIADFKELYRILEEVREKGYAIDYEEIEIGLSCLATPIFDQEGHAVAAVSVSGPVNRIYNRFPEII
KQLKLTSAQISKFL

Sequences:

>Translated_254_residues
MSDSESKNIQAIERALDVLLLFLEKKRELGVSEISHSLGYYKSTVHRILSTLSSRGFIYKNPITNKYWLGVKNFSLGMLY
QDKFVLKDVAYPYLKKLSEDVNETVNLAILDEIDDPEVIVVEKIQTEHMLTISPPVGSRTPAHCSGVGKVLLAYSDEGVL
EQLKQKPLEEFTSNTIADFKELYRILEEVREKGYAIDYEEIEIGLSCLATPIFDQEGHAVAAVSVSGPVNRIYNRFPEII
KQLKLTSAQISKFL
>Mature_253_residues
SDSESKNIQAIERALDVLLLFLEKKRELGVSEISHSLGYYKSTVHRILSTLSSRGFIYKNPITNKYWLGVKNFSLGMLYQ
DKFVLKDVAYPYLKKLSEDVNETVNLAILDEIDDPEVIVVEKIQTEHMLTISPPVGSRTPAHCSGVGKVLLAYSDEGVLE
QLKQKPLEEFTSNTIADFKELYRILEEVREKGYAIDYEEIEIGLSCLATPIFDQEGHAVAAVSVSGPVNRIYNRFPEIIK
QLKLTSAQISKFL

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=230, Percent_Identity=33.9130434782609, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786468, Length=225, Percent_Identity=36.4444444444444, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1786715, Length=250, Percent_Identity=33.6, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1788131, Length=235, Percent_Identity=33.6170212765957, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789999, Length=249, Percent_Identity=28.9156626506024, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790752, Length=222, Percent_Identity=28.8288288288288, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788581, Length=252, Percent_Identity=25.3968253968254, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28692; Mature: 28561

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSESKNIQAIERALDVLLLFLEKKRELGVSEISHSLGYYKSTVHRILSTLSSRGFIYK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
NPITNKYWLGVKNFSLGMLYQDKFVLKDVAYPYLKKLSEDVNETVNLAILDEIDDPEVIV
CCCCCCEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEE
VEKIQTEHMLTISPPVGSRTPAHCSGVGKVLLAYSDEGVLEQLKQKPLEEFTSNTIADFK
EEEECCCEEEEECCCCCCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ELYRILEEVREKGYAIDYEEIEIGLSCLATPIFDQEGHAVAAVSVSGPVNRIYNRFPEII
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
KQLKLTSAQISKFL
HHHHHHHHHHHHCC
>Mature Secondary Structure 
SDSESKNIQAIERALDVLLLFLEKKRELGVSEISHSLGYYKSTVHRILSTLSSRGFIYK
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
NPITNKYWLGVKNFSLGMLYQDKFVLKDVAYPYLKKLSEDVNETVNLAILDEIDDPEVIV
CCCCCCEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEE
VEKIQTEHMLTISPPVGSRTPAHCSGVGKVLLAYSDEGVLEQLKQKPLEEFTSNTIADFK
EEEECCCEEEEECCCCCCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ELYRILEEVREKGYAIDYEEIEIGLSCLATPIFDQEGHAVAAVSVSGPVNRIYNRFPEII
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
KQLKLTSAQISKFL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]