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The map label for this gene is 188587292

Identifier: 188587292

GI number: 188587292

Start: 2907000

End: 2908316

Strand: Reverse

Name: 188587292

Synonym: Nther_2695

Alternate gene names: NA

Gene position: 2908316-2907000 (Counterclockwise)

Preceding gene: 188587293

Following gene: 188587291

Centisome position: 91.87

GC content: 42.9

Gene sequence:

>1317_bases
TTGCGGCCTAAGCTCGCTGGTTTTAAAATGAGTCTGTTTGTACTGGCGTTTCTTTTAATGATGGTGCCGGCCCAAACCGA
GGCAAGCGGGGACAGTGAATTTGTAGTTACTTTTGAAAAAGAAGAGATCGACCAAGAAGCTCTGGAAGAACTAAAAGAAT
TAGAAGTAGAGGTTAATACTCAAATTCCTCAGATTGGTGTAATTGCTGTTGAAGCTGATGAAAAAGACTTTTTAGAGAAA
GCTTCCCAGATAGACGGCATCGAACATGTCACTAGAGAAGTATTTTGGGAACCCCCGGAAATTGAAAAAGAGACTTTTGA
TCAGGAAGAGGCTAGTGAAGAATCTAGTTTATATGAGGTATTCCAGTGGGATATCAAAAGAGTTACTCAGAATGAAAAGG
CCTGGGACATTACCCGGGGAGATGATTCAGTTACGGTAGGTGTTATTGATACTGGTATTGATGCTGATCATCCGGATTTG
AAGGAAAACTTAGAATTTGCTACGGTTCACTATGAAGATGCCGAAGAAGAGGACGCTTATGTAGACCCCAATGGTCACGG
AACTCATGTAGCAGGTTCCATCGCTGCAGATGGTGAAGTGAAAGGTGTCGGCCCTGATCTGGGATTGGCTTCTTTCAGGG
TTATGAATGATGAAGGTGTAATTCCTTCTGTTGCCACTGCCGATGCTATTGCAACGGCTGCCGATAAGGGTGTAGATGTG
GTGAATATCAGCTTGGGTGCTTTACGGGATATTACAGATGAAGAATCGAGAGAGTTATACCATATGACAAGAAGAGTAGT
GGAATACGCCGATGACCAGGGGATGATAATGGCAGTTTCTGCAGGTAATGATTCCAGGGATTTAAGAAAACCTATGGGTG
AATTTGATGACGAAATAGATTTTGATGAAACAGGACCATTATTTGATGTATATTCTTATTTCCCTGACACTATTGCTGTT
TCCGCCAGTGATATCCAAGATAATTTAGCAAGCTATTCAAATTACGGCCAGGCCAGAGTTGACTTGGGTGCTCCAGGAGG
AGACTTTAATCCGGAAGACCCTGAAGATCCAACTACATTGTGTCTTAGCACATATCCGGGAGAAGGATATGCATGGATGG
CAGGTACCAGTATGGCCTCACCCAAAGCTGCTGCTGTGGCAGGATTGATTATCAGTGAAAATCCAGGACTCTCTCATGAT
GAAGTTATTACCCAACTAAAAGAAACTGCAGAGACTATTGATCATCCATCAGACAGCAGACGGAACTTTGGTCACGGTCT
GGTAAATTCTTATGAGGCGTTAAAAGACCTTGAATAA

Upstream 100 bases:

>100_bases
ACAAAGTTCTGATTACGCAGTTGATACAATAAAAGCACCCAGAAATTATAGGGTTAAACAATGAAGAAATTCAAACACTT
TTAGGAGGTGAAGAGTTATT

Downstream 100 bases:

>100_bases
CATGTGATTAACATTCAATTGATATTTAATTTAAAATAAATAATTGATTCCCAGATAAAAGTGATTATTTATCCCCTCTT
AATTCGTCCTTCTTCCAGGA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRPKLAGFKMSLFVLAFLLMMVPAQTEASGDSEFVVTFEKEEIDQEALEELKELEVEVNTQIPQIGVIAVEADEKDFLEK
ASQIDGIEHVTREVFWEPPEIEKETFDQEEASEESSLYEVFQWDIKRVTQNEKAWDITRGDDSVTVGVIDTGIDADHPDL
KENLEFATVHYEDAEEEDAYVDPNGHGTHVAGSIAADGEVKGVGPDLGLASFRVMNDEGVIPSVATADAIATAADKGVDV
VNISLGALRDITDEESRELYHMTRRVVEYADDQGMIMAVSAGNDSRDLRKPMGEFDDEIDFDETGPLFDVYSYFPDTIAV
SASDIQDNLASYSNYGQARVDLGAPGGDFNPEDPEDPTTLCLSTYPGEGYAWMAGTSMASPKAAAVAGLIISENPGLSHD
EVITQLKETAETIDHPSDSRRNFGHGLVNSYEALKDLE

Sequences:

>Translated_438_residues
MRPKLAGFKMSLFVLAFLLMMVPAQTEASGDSEFVVTFEKEEIDQEALEELKELEVEVNTQIPQIGVIAVEADEKDFLEK
ASQIDGIEHVTREVFWEPPEIEKETFDQEEASEESSLYEVFQWDIKRVTQNEKAWDITRGDDSVTVGVIDTGIDADHPDL
KENLEFATVHYEDAEEEDAYVDPNGHGTHVAGSIAADGEVKGVGPDLGLASFRVMNDEGVIPSVATADAIATAADKGVDV
VNISLGALRDITDEESRELYHMTRRVVEYADDQGMIMAVSAGNDSRDLRKPMGEFDDEIDFDETGPLFDVYSYFPDTIAV
SASDIQDNLASYSNYGQARVDLGAPGGDFNPEDPEDPTTLCLSTYPGEGYAWMAGTSMASPKAAAVAGLIISENPGLSHD
EVITQLKETAETIDHPSDSRRNFGHGLVNSYEALKDLE
>Mature_438_residues
MRPKLAGFKMSLFVLAFLLMMVPAQTEASGDSEFVVTFEKEEIDQEALEELKELEVEVNTQIPQIGVIAVEADEKDFLEK
ASQIDGIEHVTREVFWEPPEIEKETFDQEEASEESSLYEVFQWDIKRVTQNEKAWDITRGDDSVTVGVIDTGIDADHPDL
KENLEFATVHYEDAEEEDAYVDPNGHGTHVAGSIAADGEVKGVGPDLGLASFRVMNDEGVIPSVATADAIATAADKGVDV
VNISLGALRDITDEESRELYHMTRRVVEYADDQGMIMAVSAGNDSRDLRKPMGEFDDEIDFDETGPLFDVYSYFPDTIAV
SASDIQDNLASYSNYGQARVDLGAPGGDFNPEDPEDPTTLCLSTYPGEGYAWMAGTSMASPKAAAVAGLIISENPGLSHD
EVITQLKETAETIDHPSDSRRNFGHGLVNSYEALKDLE

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=272, Percent_Identity=29.0441176470588, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324576, Length=308, Percent_Identity=29.2207792207792, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45550681, Length=258, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 47982; Mature: 47982

Theoretical pI: Translated: 3.85; Mature: 3.85

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPKLAGFKMSLFVLAFLLMMVPAQTEASGDSEFVVTFEKEEIDQEALEELKELEVEVNT
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHCCHHHHHHHHHCCEEECC
QIPQIGVIAVEADEKDFLEKASQIDGIEHVTREVFWEPPEIEKETFDQEEASEESSLYEV
CCCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHH
FQWDIKRVTQNEKAWDITRGDDSVTVGVIDTGIDADHPDLKENLEFATVHYEDAEEEDAY
HHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHCCEEEEEEECCCCCCCCE
VDPNGHGTHVAGSIAADGEVKGVGPDLGLASFRVMNDEGVIPSVATADAIATAADKGVDV
ECCCCCCCEEEEEEECCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEE
VNISLGALRDITDEESRELYHMTRRVVEYADDQGMIMAVSAGNDSRDLRKPMGEFDDEID
EEECHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCC
FDETGPLFDVYSYFPDTIAVSASDIQDNLASYSNYGQARVDLGAPGGDFNPEDPEDPTTL
CCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEE
CLSTYPGEGYAWMAGTSMASPKAAAVAGLIISENPGLSHDEVITQLKETAETIDHPSDSR
EEECCCCCCEEEEECCCCCCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCH
RNFGHGLVNSYEALKDLE
HHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRPKLAGFKMSLFVLAFLLMMVPAQTEASGDSEFVVTFEKEEIDQEALEELKELEVEVNT
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHCCHHHHHHHHHCCEEECC
QIPQIGVIAVEADEKDFLEKASQIDGIEHVTREVFWEPPEIEKETFDQEEASEESSLYEV
CCCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHH
FQWDIKRVTQNEKAWDITRGDDSVTVGVIDTGIDADHPDLKENLEFATVHYEDAEEEDAY
HHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHCCEEEEEEECCCCCCCCE
VDPNGHGTHVAGSIAADGEVKGVGPDLGLASFRVMNDEGVIPSVATADAIATAADKGVDV
ECCCCCCCEEEEEEECCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEE
VNISLGALRDITDEESRELYHMTRRVVEYADDQGMIMAVSAGNDSRDLRKPMGEFDDEID
EEECHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCC
FDETGPLFDVYSYFPDTIAVSASDIQDNLASYSNYGQARVDLGAPGGDFNPEDPEDPTTL
CCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEE
CLSTYPGEGYAWMAGTSMASPKAAAVAGLIISENPGLSHDEVITQLKETAETIDHPSDSR
EEECCCCCCEEEEECCCCCCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCH
RNFGHGLVNSYEALKDLE
HHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]