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The map label for this gene is tuaD [H]

Identifier: 188587139

GI number: 188587139

Start: 2732328

End: 2733611

Strand: Reverse

Name: tuaD [H]

Synonym: Nther_2536

Alternate gene names: 188587139

Gene position: 2733611-2732328 (Counterclockwise)

Preceding gene: 188587140

Following gene: 188587138

Centisome position: 86.35

GC content: 34.35

Gene sequence:

>1284_bases
ATGTATAAAATATCTGTCATTGGTACAGGGTATGTGGGTTTGTCAACAGGAGTTTGTCTATCTGATATGGGTAACCAAGT
CACATGTGTTGACATCGACGAAGAAAAGATAAATACATTAAAAAATGGAAAGTCTCCTATATATGAACCGGGAATGGAAG
ATCTAATACATAAAAATACGAAAGCTGATAGGTTGCAGTTTACTACCAACTTAGAAAGTGCAGTCCAAAATACAGATATC
ATATTTATAGCTGTAGGAACACCATCTAGAGATGATGGTTCAGCTGATTTATCTTTTATATACGAAGCATCTAAAACAAT
AGCTAAAGCAATGAATGATTATAAAATAATAGTAACTAAGAGCACAGTACCAGTGGGAACCAACAAAGAAATCGAAGATA
GTATATCCCAAAATACTGATCAAGATTTTTCAGTGGTTTCCAGCCCTGAATTCCTGAGAGAAGGATCTGCAATATATGAT
ACAATGAATCCTGATCGAATAGTAATAGGTTACCGTGATGAACAAGCTGGACAAACTATCAAGGACTTATATAAAGACTT
TGATACTGAATTTGTTATGACTACTACAGAAAGCTCTGAGATGATTAAATATGCCTCTAATGCTTTCTTAGCTACTAAGA
TATCTTTTATTAACGAAATGGCTAATATTTGTGAACGAGTTGGGGCCAATGTAGAGGAAGTAGCTAAAGGAATGGGCCTT
GATCATAGAATAAGTGATAAATTCTTAAATGCAGGTATAGGTTACGGAGGTAGTTGTTTCCCGAAAGACACTAAAGCATT
AATTAATAAAGCTGAAGAAGTGGATTATAATCTAAAGATAGTTAAAGCTGCTGAAGAAGTGAATGAAAAACAAAAGCTGA
TTGTAGTTGATAAATTGAAAGAAGTACTAGGTGACTTAGAAGGAAAGACAATAGGGATATTAGGACTTGCATTCAAACCA
AACACCGATGATATAAGAGAGTCACCAGCATTAAAGATTATCCCAAAACTATTGGAGGCTGGTGCCAATGTTAAAGCTTA
TGACCCAAAGGCCATGGAAAATGCTAGAAAAGTACTTCCTGGTGATGTTGTGTATTGTTCTGTTTCTGAAGAGGTAGCAA
AAGGTGTAGACGCTGTGGCTTTGCTTACAGAATGGAATGAATTTATAGAAATTGAGTGGAAGGACATCTCAATTAAAATG
AATCAAGCAATTATAATTGATGGCAGAAATTTCTTAGATGTTACTTATTTACAAGAACAAGGTTTTAGATACATATGTAT
TTAA

Upstream 100 bases:

>100_bases
CGGTAGAATTTGCCTTGGAGCGAGAAGATGTTAAAGATGAATTTAAGGAATACTTGAAGTCTAGGTTTGGTCAAATATAA
TTTAAGTGAAGGTGAGTATA

Downstream 100 bases:

>100_bases
AAAGGATCTATATAAATTATAACGTGGGATTTAACATATGATTTGTATGAATTGCCTCTTTACCATGTCGAAATGGAGGT
TTTATTTTGGAAAAACTAAT

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MYKISVIGTGYVGLSTGVCLSDMGNQVTCVDIDEEKINTLKNGKSPIYEPGMEDLIHKNTKADRLQFTTNLESAVQNTDI
IFIAVGTPSRDDGSADLSFIYEASKTIAKAMNDYKIIVTKSTVPVGTNKEIEDSISQNTDQDFSVVSSPEFLREGSAIYD
TMNPDRIVIGYRDEQAGQTIKDLYKDFDTEFVMTTTESSEMIKYASNAFLATKISFINEMANICERVGANVEEVAKGMGL
DHRISDKFLNAGIGYGGSCFPKDTKALINKAEEVDYNLKIVKAAEEVNEKQKLIVVDKLKEVLGDLEGKTIGILGLAFKP
NTDDIRESPALKIIPKLLEAGANVKAYDPKAMENARKVLPGDVVYCSVSEEVAKGVDAVALLTEWNEFIEIEWKDISIKM
NQAIIIDGRNFLDVTYLQEQGFRYICI

Sequences:

>Translated_427_residues
MYKISVIGTGYVGLSTGVCLSDMGNQVTCVDIDEEKINTLKNGKSPIYEPGMEDLIHKNTKADRLQFTTNLESAVQNTDI
IFIAVGTPSRDDGSADLSFIYEASKTIAKAMNDYKIIVTKSTVPVGTNKEIEDSISQNTDQDFSVVSSPEFLREGSAIYD
TMNPDRIVIGYRDEQAGQTIKDLYKDFDTEFVMTTTESSEMIKYASNAFLATKISFINEMANICERVGANVEEVAKGMGL
DHRISDKFLNAGIGYGGSCFPKDTKALINKAEEVDYNLKIVKAAEEVNEKQKLIVVDKLKEVLGDLEGKTIGILGLAFKP
NTDDIRESPALKIIPKLLEAGANVKAYDPKAMENARKVLPGDVVYCSVSEEVAKGVDAVALLTEWNEFIEIEWKDISIKM
NQAIIIDGRNFLDVTYLQEQGFRYICI
>Mature_427_residues
MYKISVIGTGYVGLSTGVCLSDMGNQVTCVDIDEEKINTLKNGKSPIYEPGMEDLIHKNTKADRLQFTTNLESAVQNTDI
IFIAVGTPSRDDGSADLSFIYEASKTIAKAMNDYKIIVTKSTVPVGTNKEIEDSISQNTDQDFSVVSSPEFLREGSAIYD
TMNPDRIVIGYRDEQAGQTIKDLYKDFDTEFVMTTTESSEMIKYASNAFLATKISFINEMANICERVGANVEEVAKGMGL
DHRISDKFLNAGIGYGGSCFPKDTKALINKAEEVDYNLKIVKAAEEVNEKQKLIVVDKLKEVLGDLEGKTIGILGLAFKP
NTDDIRESPALKIIPKLLEAGANVKAYDPKAMENARKVLPGDVVYCSVSEEVAKGVDAVALLTEWNEFIEIEWKDISIKM
NQAIIIDGRNFLDVTYLQEQGFRYICI

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=460, Percent_Identity=37.3913043478261, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI296040443, Length=453, Percent_Identity=33.7748344370861, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI296040438, Length=362, Percent_Identity=37.8453038674033, Blast_Score=205, Evalue=6e-53,
Organism=Escherichia coli, GI1788340, Length=359, Percent_Identity=29.8050139275766, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI48994968, Length=350, Percent_Identity=29.4285714285714, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560350, Length=463, Percent_Identity=35.4211663066955, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI17136908, Length=458, Percent_Identity=37.3362445414847, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47189; Mature: 47189

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKISVIGTGYVGLSTGVCLSDMGNQVTCVDIDEEKINTLKNGKSPIYEPGMEDLIHKNT
CEEEEEEECCCCCCCCCCHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHCCC
KADRLQFTTNLESAVQNTDIIFIAVGTPSRDDGSADLSFIYEASKTIAKAMNDYKIIVTK
CCCCEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEE
STVPVGTNKEIEDSISQNTDQDFSVVSSPEFLREGSAIYDTMNPDRIVIGYRDEQAGQTI
CCCCCCCCCHHHHHHHCCCCCCCEECCCHHHHHCCCCEEECCCCCEEEEEECCHHHCHHH
KDLYKDFDTEFVMTTTESSEMIKYASNAFLATKISFINEMANICERVGANVEEVAKGMGL
HHHHHCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
DHRISDKFLNAGIGYGGSCFPKDTKALINKAEEVDYNLKIVKAAEEVNEKQKLIVVDKLK
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHCCCCCEEEEHHHHH
EVLGDLEGKTIGILGLAFKPNTDDIRESPALKIIPKLLEAGANVKAYDPKAMENARKVLP
HHHHCCCCCEEEEEEEEECCCCHHHHCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHCCC
GDVVYCSVSEEVAKGVDAVALLTEWNEFIEIEWKDISIKMNQAIIIDGRNFLDVTYLQEQ
CCEEEEECCHHHHCCHHHHHHHHCCCCEEEEEEEEEEEEECCEEEEECCCEEEEEEEHHC
GFRYICI
CCEEEEC
>Mature Secondary Structure
MYKISVIGTGYVGLSTGVCLSDMGNQVTCVDIDEEKINTLKNGKSPIYEPGMEDLIHKNT
CEEEEEEECCCCCCCCCCHHHHCCCEEEEEECCHHHHHHHHCCCCCCCCCCHHHHHHCCC
KADRLQFTTNLESAVQNTDIIFIAVGTPSRDDGSADLSFIYEASKTIAKAMNDYKIIVTK
CCCCEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEE
STVPVGTNKEIEDSISQNTDQDFSVVSSPEFLREGSAIYDTMNPDRIVIGYRDEQAGQTI
CCCCCCCCCHHHHHHHCCCCCCCEECCCHHHHHCCCCEEECCCCCEEEEEECCHHHCHHH
KDLYKDFDTEFVMTTTESSEMIKYASNAFLATKISFINEMANICERVGANVEEVAKGMGL
HHHHHCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
DHRISDKFLNAGIGYGGSCFPKDTKALINKAEEVDYNLKIVKAAEEVNEKQKLIVVDKLK
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHCCCCCEEEEHHHHH
EVLGDLEGKTIGILGLAFKPNTDDIRESPALKIIPKLLEAGANVKAYDPKAMENARKVLP
HHHHCCCCCEEEEEEEEECCCCHHHHCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHCCC
GDVVYCSVSEEVAKGVDAVALLTEWNEFIEIEWKDISIKMNQAIIIDGRNFLDVTYLQEQ
CCEEEEECCHHHHCCHHHHHHHHCCCCEEEEEEEEEEEEECCEEEEECCCEEEEEEEHHC
GFRYICI
CCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]