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The map label for this gene is sucD2 [H]

Identifier: 188587003

GI number: 188587003

Start: 2559247

End: 2560119

Strand: Reverse

Name: sucD2 [H]

Synonym: Nther_2395

Alternate gene names: 188587003

Gene position: 2560119-2559247 (Counterclockwise)

Preceding gene: 188587004

Following gene: 188587002

Centisome position: 80.87

GC content: 43.99

Gene sequence:

>873_bases
ATGGCTATTTTACTGGATAAAAATAGTAAAATTTTGGTGCAGGGCATCACCGGATATCAGGGACGGTTTCACACCAGGCA
GATGCTAGAATACGGAAGTAATGTAGTGGCGGGAGTTTCTCCCGGAAAAGGTGGCCAGGAAGTTGAGGGAGTACCAGTTT
ATAATAGTGCGGCTTCAGCAGTGAGAGAAACTGATGCTAATGTATCAGCTGTAATGGTACCGGCTTCCTTTGGAAAAGAT
GCAGTTTTTGAGGCTATTGATGCAGGCATGGATTTAGTTGCCATAATCACGGAACATATACCCGTTCAAGATGCCATGGA
AATCATGGCCTTTGCCAGGGAAAGAGGGACAACTATTATCGGTCCCAACACTTTTGGGATTATCACTCCAGGTCAAAGTA
AGTTGGGGATAATGCCTAACGAAAGTTATCAACCGGGTAGAACTGGTTTGGTTGCCAGAAGCGGTACACTGAGCTATCAA
ATAGCAGAAGGATTGAGTCGTGTGGGAGTAGGTCAGAGCACGGCAATAGGATTAGGTGGTGACCGAGTTGTAGGTTCAGA
ATTTATTGATATGTTAGAACATTTTGAACAAGATCCTGGAACTGATCAGGTTGTCATGGTCGGTGAAATTGGGGGTACTG
CAGAAGAAGAAGCGGCTGAATTTATAGCAAATAAAATGACCAAACCTGTATATGCTTACATAGCAGGCAAAAGTGCTCCA
CCGGGAAAACGCATGGGCCATGCTGGAGCTATAATTGAACGTGGAAAAGGGACTTTTGACTCAAAGGTGCAAGCTTTAAG
GTCAGCTGGAGTAGAAGTTGCCAGTCTTCCCTGGGAATTAGTTGAAATTTTAAAAAAGAGTGGTGTACAATAA

Upstream 100 bases:

>100_bases
TCAAAATTTTAGGACAACACGGTATTTCCGCCTATCAAGATATGGGAGAGGCGGCCAAAAAAGCTGTTGAATTAGCTGCT
GAGGGAGGAGTTGGTGTATA

Downstream 100 bases:

>100_bases
ACGAAAGTTAACACGAAAATGGGAATGTTAACTGATTGTTAACTGATAGGGGGAGTGCTAATTGGCAAAAACACTTGCAG
AAGTGATTATTAGAGAAATG

Product: succinyl-CoA synthetase (ADP-forming) alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha 2; SCS-alpha 2 [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MAILLDKNSKILVQGITGYQGRFHTRQMLEYGSNVVAGVSPGKGGQEVEGVPVYNSAASAVRETDANVSAVMVPASFGKD
AVFEAIDAGMDLVAIITEHIPVQDAMEIMAFARERGTTIIGPNTFGIITPGQSKLGIMPNESYQPGRTGLVARSGTLSYQ
IAEGLSRVGVGQSTAIGLGGDRVVGSEFIDMLEHFEQDPGTDQVVMVGEIGGTAEEEAAEFIANKMTKPVYAYIAGKSAP
PGKRMGHAGAIIERGKGTFDSKVQALRSAGVEVASLPWELVEILKKSGVQ

Sequences:

>Translated_290_residues
MAILLDKNSKILVQGITGYQGRFHTRQMLEYGSNVVAGVSPGKGGQEVEGVPVYNSAASAVRETDANVSAVMVPASFGKD
AVFEAIDAGMDLVAIITEHIPVQDAMEIMAFARERGTTIIGPNTFGIITPGQSKLGIMPNESYQPGRTGLVARSGTLSYQ
IAEGLSRVGVGQSTAIGLGGDRVVGSEFIDMLEHFEQDPGTDQVVMVGEIGGTAEEEAAEFIANKMTKPVYAYIAGKSAP
PGKRMGHAGAIIERGKGTFDSKVQALRSAGVEVASLPWELVEILKKSGVQ
>Mature_289_residues
AILLDKNSKILVQGITGYQGRFHTRQMLEYGSNVVAGVSPGKGGQEVEGVPVYNSAASAVRETDANVSAVMVPASFGKDA
VFEAIDAGMDLVAIITEHIPVQDAMEIMAFARERGTTIIGPNTFGIITPGQSKLGIMPNESYQPGRTGLVARSGTLSYQI
AEGLSRVGVGQSTAIGLGGDRVVGSEFIDMLEHFEQDPGTDQVVMVGEIGGTAEEEAAEFIANKMTKPVYAYIAGKSAPP
GKRMGHAGAIIERGKGTFDSKVQALRSAGVEVASLPWELVEILKKSGVQ

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=283, Percent_Identity=48.7632508833922, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI38569421, Length=251, Percent_Identity=33.4661354581673, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI38569423, Length=251, Percent_Identity=33.4661354581673, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1786949, Length=285, Percent_Identity=52.280701754386, Blast_Score=303, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=45.8620689655172, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17550194, Length=283, Percent_Identity=46.643109540636, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17557344, Length=283, Percent_Identity=30.7420494699647, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17551266, Length=262, Percent_Identity=30.5343511450382, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324716, Length=291, Percent_Identity=41.9243986254296, Blast_Score=212, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21356559, Length=282, Percent_Identity=45.0354609929078, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI28574296, Length=281, Percent_Identity=44.1281138790036, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI281363475, Length=264, Percent_Identity=30.6818181818182, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281363473, Length=264, Percent_Identity=30.6818181818182, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281363477, Length=239, Percent_Identity=30.9623430962343, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30471; Mature: 30340

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILLDKNSKILVQGITGYQGRFHTRQMLEYGSNVVAGVSPGKGGQEVEGVPVYNSAASA
CEEEEECCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHH
VRETDANVSAVMVPASFGKDAVFEAIDAGMDLVAIITEHIPVQDAMEIMAFARERGTTII
HHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHCCCEEE
GPNTFGIITPGQSKLGIMPNESYQPGRTGLVARSGTLSYQIAEGLSRVGVGQSTAIGLGG
CCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEECCCC
DRVVGSEFIDMLEHFEQDPGTDQVVMVGEIGGTAEEEAAEFIANKMTKPVYAYIAGKSAP
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
PGKRMGHAGAIIERGKGTFDSKVQALRSAGVEVASLPWELVEILKKSGVQ
CCCCCCCCCHHEECCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AILLDKNSKILVQGITGYQGRFHTRQMLEYGSNVVAGVSPGKGGQEVEGVPVYNSAASA
EEEEECCCEEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHH
VRETDANVSAVMVPASFGKDAVFEAIDAGMDLVAIITEHIPVQDAMEIMAFARERGTTII
HHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHCCCEEE
GPNTFGIITPGQSKLGIMPNESYQPGRTGLVARSGTLSYQIAEGLSRVGVGQSTAIGLGG
CCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEECCCC
DRVVGSEFIDMLEHFEQDPGTDQVVMVGEIGGTAEEEAAEFIANKMTKPVYAYIAGKSAP
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
PGKRMGHAGAIIERGKGTFDSKVQALRSAGVEVASLPWELVEILKKSGVQ
CCCCCCCCCHHEECCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]