Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 188586913

GI number: 188586913

Start: 2447966

End: 2448898

Strand: Reverse

Name: cysK [H]

Synonym: Nther_2304

Alternate gene names: 188586913

Gene position: 2448898-2447966 (Counterclockwise)

Preceding gene: 188586914

Following gene: 188586909

Centisome position: 77.36

GC content: 37.62

Gene sequence:

>933_bases
ATGATGACTTTTAAAAGTAATAATCCCTTAGATTTTGTCGGTAATACACCCATGATAGAACTGCAAAATACCAACAACTC
TCACGGAAATATTCTGGTTAAATTGGAAGCTTTCAATCCCGGAGGAAGTATTAAGACAAGAACGGCTTTAGGAATGATAA
TAGAGGCTGAAAGAAATGGACAGATAAATGAAAATTCAATTTTAGTAGAACCAACTAGTGGGAATCAAGGAATAGGTATT
GCCCTGGTAGCTGCTATTAAGGGTTATCGGGCTAAAATTGTCATGCCAGAAAGCATGAGTACAGAAAGAAGGAAGATGAT
AGAAAATCTAGGAGCAGAAATTGATATCAGCCCTGATGGAAATAATATTTCGGAAACCTTTGATAATTGTAAATCTCGGG
CAAGAGAATTAGCTGAACAGGACTCCAGAGTATTTATTTTAAATCAATTTGAAAACAAAGCCAATCCGAACGCCCATCGC
CTGACTACAGCCAAAGAAATTATTGAACAGACAGGTGAACAAATAGATGCTTTTGTGGCGGGAGTGGGTACAGGAGGAAC
TTTGACAGGTGTGGGTGAAGTCTTAAAACAGAAATATCCCGAAGTTAAGATAATAGCAGTAGAACCTGAAAAAGCAGCAG
TTTTAAGCCAGAGTGAAATATCTAGTCATATTCAGCAGGGGATTGGTGATGGTTTCATACCAGGGGTGTTAAACCAGGAT
ATAATTGATGAAGTGTTGACTGTTACCGACGAAGAAGCTCTTGAAACTGCCAAAAGCTTAAATAGAAGAGATGGACTGTT
TTCTGGTATCTCTAGTGGAACTAATGTTTTTGCAGCTATGAAAATAGCAGAAAAATTACCACCTAGTGCAAATATTGTAA
CTGTATTACCTGATAGTGGAGACAGATACTTCAGCACACCTTTATTTAGTTAA

Upstream 100 bases:

>100_bases
AGCTCAATATTAGCGATTTAAAAAAGTATATTGACTTGTATCATGATATGTGACTTTTAATAGGAAGCTTAAAACACAAT
TAATTAAGAAAGGAAGTGGA

Downstream 100 bases:

>100_bases
CGAATGTGTTGAAGATTGTTTAGAGCAATGCAATTGTGAACCTCTCATGACTAAAGTCACGAGTACGTGATGACTTTTCA
AATTTATAGATAATAGGGCA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MMTFKSNNPLDFVGNTPMIELQNTNNSHGNILVKLEAFNPGGSIKTRTALGMIIEAERNGQINENSILVEPTSGNQGIGI
ALVAAIKGYRAKIVMPESMSTERRKMIENLGAEIDISPDGNNISETFDNCKSRARELAEQDSRVFILNQFENKANPNAHR
LTTAKEIIEQTGEQIDAFVAGVGTGGTLTGVGEVLKQKYPEVKIIAVEPEKAAVLSQSEISSHIQQGIGDGFIPGVLNQD
IIDEVLTVTDEEALETAKSLNRRDGLFSGISSGTNVFAAMKIAEKLPPSANIVTVLPDSGDRYFSTPLFS

Sequences:

>Translated_310_residues
MMTFKSNNPLDFVGNTPMIELQNTNNSHGNILVKLEAFNPGGSIKTRTALGMIIEAERNGQINENSILVEPTSGNQGIGI
ALVAAIKGYRAKIVMPESMSTERRKMIENLGAEIDISPDGNNISETFDNCKSRARELAEQDSRVFILNQFENKANPNAHR
LTTAKEIIEQTGEQIDAFVAGVGTGGTLTGVGEVLKQKYPEVKIIAVEPEKAAVLSQSEISSHIQQGIGDGFIPGVLNQD
IIDEVLTVTDEEALETAKSLNRRDGLFSGISSGTNVFAAMKIAEKLPPSANIVTVLPDSGDRYFSTPLFS
>Mature_310_residues
MMTFKSNNPLDFVGNTPMIELQNTNNSHGNILVKLEAFNPGGSIKTRTALGMIIEAERNGQINENSILVEPTSGNQGIGI
ALVAAIKGYRAKIVMPESMSTERRKMIENLGAEIDISPDGNNISETFDNCKSRARELAEQDSRVFILNQFENKANPNAHR
LTTAKEIIEQTGEQIDAFVAGVGTGGTLTGVGEVLKQKYPEVKIIAVEPEKAAVLSQSEISSHIQQGIGDGFIPGVLNQD
IIDEVLTVTDEEALETAKSLNRRDGLFSGISSGTNVFAAMKIAEKLPPSANIVTVLPDSGDRYFSTPLFS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=41.042345276873, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=41.042345276873, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=41.042345276873, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI11345492, Length=283, Percent_Identity=26.8551236749117, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=38.9261744966443, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=43.1818181818182, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=40.1315789473684, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=42.671009771987, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=38.8157894736842, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32566674, Length=298, Percent_Identity=38.255033557047, Blast_Score=197, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=39.1447368421053, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=310, Percent_Identity=35.8064516129032, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=36.2179487179487, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=217, Percent_Identity=36.8663594470046, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=36.4406779661017, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539800, Length=349, Percent_Identity=24.0687679083095, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=319, Percent_Identity=37.3040752351097, Blast_Score=195, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=36.3914373088685, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24643623, Length=314, Percent_Identity=34.3949044585987, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129101, Length=314, Percent_Identity=34.3949044585987, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33420; Mature: 33420

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00901 CYS_SYNTHASE ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTFKSNNPLDFVGNTPMIELQNTNNSHGNILVKLEAFNPGGSIKTRTALGMIIEAERNG
CCEECCCCCEEECCCCCEEEEECCCCCCCEEEEEEEEECCCCCEEEHEEEEEEEEECCCC
QINENSILVEPTSGNQGIGIALVAAIKGYRAKIVMPESMSTERRKMIENLGAEIDISPDG
CCCCCEEEEEECCCCCCCHHHHEEHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCC
NNISETFDNCKSRARELAEQDSRVFILNQFENKANPNAHRLTTAKEIIEQTGEQIDAFVA
CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHE
GVGTGGTLTGVGEVLKQKYPEVKIIAVEPEKAAVLSQSEISSHIQQGIGDGFIPGVLNQD
ECCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
IIDEVLTVTDEEALETAKSLNRRDGLFSGISSGTNVFAAMKIAEKLPPSANIVTVLPDSG
HHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCC
DRYFSTPLFS
CCEECCCCCC
>Mature Secondary Structure
MMTFKSNNPLDFVGNTPMIELQNTNNSHGNILVKLEAFNPGGSIKTRTALGMIIEAERNG
CCEECCCCCEEECCCCCEEEEECCCCCCCEEEEEEEEECCCCCEEEHEEEEEEEEECCCC
QINENSILVEPTSGNQGIGIALVAAIKGYRAKIVMPESMSTERRKMIENLGAEIDISPDG
CCCCCEEEEEECCCCCCCHHHHEEHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCC
NNISETFDNCKSRARELAEQDSRVFILNQFENKANPNAHRLTTAKEIIEQTGEQIDAFVA
CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHE
GVGTGGTLTGVGEVLKQKYPEVKIIAVEPEKAAVLSQSEISSHIQQGIGDGFIPGVLNQD
ECCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
IIDEVLTVTDEEALETAKSLNRRDGLFSGISSGTNVFAAMKIAEKLPPSANIVTVLPDSG
HHHHHHHCCCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCC
DRYFSTPLFS
CCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA