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The map label for this gene is pcp [H]

Identifier: 188586681

GI number: 188586681

Start: 2191546

End: 2192169

Strand: Reverse

Name: pcp [H]

Synonym: Nther_2071

Alternate gene names: 188586681

Gene position: 2192169-2191546 (Counterclockwise)

Preceding gene: 188586682

Following gene: 188586680

Centisome position: 69.25

GC content: 34.78

Gene sequence:

>624_bases
ATGCCCAAAAAATTGACAAAATTAATGATAACTGGTTTTGATCCATTTGGAACAGAAAAAGTCAATCCTTCCTGGAGGGC
GGTAAGTAATATCCCTGATAAAATTGAATCAGTGGAGATAATTAAGCAGCAATTACCTACTGTATTTGATAAGTCACTTG
AAAAGTTGATTTCACAAATTGAAGACAAGGACCCTGATGCAATAATATTGACTGGTCAAGCTGGAGGTCGACATGCAATT
TCAGTAGAACGTGTTGCAATAAATGTTAATGATGCGAATATACCTGATAATGAAAATAACAAGCCCAAAGATAATTATAT
ATTTGATCATGGACCAACAGCTTTTTTCTCAACTCTACCTTATAAAGAAATAGTAGATCAAATAAGGAACTATGAACAAA
TTCCGGCAGAGGTTTCAAACTCTGCCGGTACCTTTGTTTGTAATCACGTTATGTATGGTATGCTTTATCATCTGCATCAG
CGAAATAAACCCATTAAAGGCGGATTTATTCATGTGCCTTTTTTACCAGAACAGGTACTAAATAAACCTGGTAAACCTTA
TATGGCTTTAGATGATATAGTAAAAGGATTACTCCGAGCTATCAAGGTAACTTGTGAAGTCTAA

Upstream 100 bases:

>100_bases
AAACTGGCCCTAGTTTTTGGGTGCCAGTTTTTTTATTATAGCTATGCTAAAATTGATAGTGTCTTTAATATTGAAACACC
AAAAGGAGGTGTAGGGCACC

Downstream 100 bases:

>100_bases
TAAATTAAAGGAGGGTTTTGTTTTGACTGGGTCTAATATTTATATTTTTCAGGTTGATGCTTTTACTAAAAAGCCTTTTT
CAGGCAACCCCGCCGCTGTT

Product: pyroglutamyl-peptidase I

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MPKKLTKLMITGFDPFGTEKVNPSWRAVSNIPDKIESVEIIKQQLPTVFDKSLEKLISQIEDKDPDAIILTGQAGGRHAI
SVERVAINVNDANIPDNENNKPKDNYIFDHGPTAFFSTLPYKEIVDQIRNYEQIPAEVSNSAGTFVCNHVMYGMLYHLHQ
RNKPIKGGFIHVPFLPEQVLNKPGKPYMALDDIVKGLLRAIKVTCEV

Sequences:

>Translated_207_residues
MPKKLTKLMITGFDPFGTEKVNPSWRAVSNIPDKIESVEIIKQQLPTVFDKSLEKLISQIEDKDPDAIILTGQAGGRHAI
SVERVAINVNDANIPDNENNKPKDNYIFDHGPTAFFSTLPYKEIVDQIRNYEQIPAEVSNSAGTFVCNHVMYGMLYHLHQ
RNKPIKGGFIHVPFLPEQVLNKPGKPYMALDDIVKGLLRAIKVTCEV
>Mature_206_residues
PKKLTKLMITGFDPFGTEKVNPSWRAVSNIPDKIESVEIIKQQLPTVFDKSLEKLISQIEDKDPDAIILTGQAGGRHAIS
VERVAINVNDANIPDNENNKPKDNYIFDHGPTAFFSTLPYKEIVDQIRNYEQIPAEVSNSAGTFVCNHVMYGMLYHLHQR
NKPIKGGFIHVPFLPEQVLNKPGKPYMALDDIVKGLLRAIKVTCEV

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=205, Percent_Identity=27.3170731707317, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23253; Mature: 23122

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKLTKLMITGFDPFGTEKVNPSWRAVSNIPDKIESVEIIKQQLPTVFDKSLEKLISQI
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDKDPDAIILTGQAGGRHAISVERVAINVNDANIPDNENNKPKDNYIFDHGPTAFFSTLP
CCCCCCEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCHHHHHCCC
YKEIVDQIRNYEQIPAEVSNSAGTFVCNHVMYGMLYHLHQRNKPIKGGFIHVPFLPEQVL
HHHHHHHHHCHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHH
NKPGKPYMALDDIVKGLLRAIKVTCEV
CCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKKLTKLMITGFDPFGTEKVNPSWRAVSNIPDKIESVEIIKQQLPTVFDKSLEKLISQI
CHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDKDPDAIILTGQAGGRHAISVERVAINVNDANIPDNENNKPKDNYIFDHGPTAFFSTLP
CCCCCCEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCHHHHHCCC
YKEIVDQIRNYEQIPAEVSNSAGTFVCNHVMYGMLYHLHQRNKPIKGGFIHVPFLPEQVL
HHHHHHHHHCHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHH
NKPGKPYMALDDIVKGLLRAIKVTCEV
CCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA