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The map label for this gene is glcK [H]

Identifier: 188586615

GI number: 188586615

Start: 2113418

End: 2114185

Strand: Reverse

Name: glcK [H]

Synonym: Nther_2005

Alternate gene names: 188586615

Gene position: 2114185-2113418 (Counterclockwise)

Preceding gene: 188586616

Following gene: 188586614

Centisome position: 66.79

GC content: 38.41

Gene sequence:

>768_bases
ATGTTAGAATGTCAAAACCAAGACAAAAACAATGTTATAGGTTTAGGGATAGGAGTGCCCGGATTTGTTCCATTAAAAGG
AGATAGGATACCGCAATTAGTTAACATGGGTTTAGAAAATGTTCCCTTGAAATTCAAATTAGAGCAAAAATTTAATGCAC
ATGTTCTTGTAGAGAATGATGCAAATGCTGCTGCATGGGGAGAACATAAAGCCGGGGCTTCACAAGGAACCCGGGACAAT
CTATTAATAACTTTAGGTACAGGAGTAGGTAGTGGCGTAATTGTAAACGAGGCAATTCATCGTGGAAACTTAGGTTTGAC
TGGGGAGATAGGACATATATTGGTGAGACCTATAGATGGAAAGCTTTGTAACTGTGGAAAAGTTGGCTGTTTAGAAACAG
AATGTTCAGGTGTTGCTATTGAAAGTAAAGCTAAAGCTCTATATGATGAGCATCAGTTGACAGCACGGGAAGTCTTTAAC
AGGGCCGATAATGGAGACGAAACTGCAAAAAGAGTAATTCAAGAAGCATCGTATTACTTAGCCTGGGGGATATCCCATGC
TTTACATGTATTGGAGTTTGAAGTTGTTGTATTAGGTGGTGGAATTTCCAGAGGAGGGAATTTATTATTACAGCCAGTCA
GAGCTTATTTAGAGGATTTTATGGGGGACTGTCCTGAATTTCCCACAGAAAAGGTGTTAGTCTCTAAACTCGGGAATAAA
GTTGCTCTACATGGATTGTATTATTTAATATATGAAAAGATAAACTAA

Upstream 100 bases:

>100_bases
TAATACTTCAAGTAATTTAATATTCGAGGCAAACCGATCTTCACGAAATGTAAATAGTGTCGATGAATTAGTTGATATAA
TAGAAGATTTAGCCCAGGAA

Downstream 100 bases:

>100_bases
AATTCATAGTATAAAATGGCCTGGAAGTAAAATCAAAATTAATTAGAATGAGCTTAAGGGGGTACTTTCAGTGAAAAAAA
TTGGAGTTTTAACCAGTGGA

Product: ROK family protein

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLECQNQDKNNVIGLGIGVPGFVPLKGDRIPQLVNMGLENVPLKFKLEQKFNAHVLVENDANAAAWGEHKAGASQGTRDN
LLITLGTGVGSGVIVNEAIHRGNLGLTGEIGHILVRPIDGKLCNCGKVGCLETECSGVAIESKAKALYDEHQLTAREVFN
RADNGDETAKRVIQEASYYLAWGISHALHVLEFEVVVLGGGISRGGNLLLQPVRAYLEDFMGDCPEFPTEKVLVSKLGNK
VALHGLYYLIYEKIN

Sequences:

>Translated_255_residues
MLECQNQDKNNVIGLGIGVPGFVPLKGDRIPQLVNMGLENVPLKFKLEQKFNAHVLVENDANAAAWGEHKAGASQGTRDN
LLITLGTGVGSGVIVNEAIHRGNLGLTGEIGHILVRPIDGKLCNCGKVGCLETECSGVAIESKAKALYDEHQLTAREVFN
RADNGDETAKRVIQEASYYLAWGISHALHVLEFEVVVLGGGISRGGNLLLQPVRAYLEDFMGDCPEFPTEKVLVSKLGNK
VALHGLYYLIYEKIN
>Mature_255_residues
MLECQNQDKNNVIGLGIGVPGFVPLKGDRIPQLVNMGLENVPLKFKLEQKFNAHVLVENDANAAAWGEHKAGASQGTRDN
LLITLGTGVGSGVIVNEAIHRGNLGLTGEIGHILVRPIDGKLCNCGKVGCLETECSGVAIESKAKALYDEHQLTAREVFN
RADNGDETAKRVIQEASYYLAWGISHALHVLEFEVVVLGGGISRGGNLLLQPVRAYLEDFMGDCPEFPTEKVLVSKLGNK
VALHGLYYLIYEKIN

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI4885285, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI190014632, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI298566325, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI298566315, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786891, Length=232, Percent_Identity=30.1724137931034, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI87081733, Length=245, Percent_Identity=29.3877551020408, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082127, Length=218, Percent_Identity=28.4403669724771, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787363, Length=203, Percent_Identity=32.512315270936, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082230, Length=166, Percent_Identity=37.9518072289157, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787878, Length=215, Percent_Identity=26.9767441860465, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790522, Length=224, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 27586; Mature: 27586

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLECQNQDKNNVIGLGIGVPGFVPLKGDRIPQLVNMGLENVPLKFKLEQKFNAHVLVEND
CCCCCCCCCCCEEEEECCCCCEEECCCCCCHHHHHCCCCCCCEEEEECCCCCEEEEEECC
ANAAAWGEHKAGASQGTRDNLLITLGTGVGSGVIVNEAIHRGNLGLTGEIGHILVRPIDG
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEHHHHCCCCCCEECCCEEEEEECCC
KLCNCGKVGCLETECSGVAIESKAKALYDEHQLTAREVFNRADNGDETAKRVIQEASYYL
CEECCCCCCCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHE
AWGISHALHVLEFEVVVLGGGISRGGNLLLQPVRAYLEDFMGDCPEFPTEKVLVSKLGNK
EHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCH
VALHGLYYLIYEKIN
HHHHHHEEEEEEECC
>Mature Secondary Structure
MLECQNQDKNNVIGLGIGVPGFVPLKGDRIPQLVNMGLENVPLKFKLEQKFNAHVLVEND
CCCCCCCCCCCEEEEECCCCCEEECCCCCCHHHHHCCCCCCCEEEEECCCCCEEEEEECC
ANAAAWGEHKAGASQGTRDNLLITLGTGVGSGVIVNEAIHRGNLGLTGEIGHILVRPIDG
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEHHHHCCCCCCEECCCEEEEEECCC
KLCNCGKVGCLETECSGVAIESKAKALYDEHQLTAREVFNRADNGDETAKRVIQEASYYL
CEECCCCCCCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHE
AWGISHALHVLEFEVVVLGGGISRGGNLLLQPVRAYLEDFMGDCPEFPTEKVLVSKLGNK
EHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCH
VALHGLYYLIYEKIN
HHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]