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The map label for this gene is ymxG [H]

Identifier: 188586079

GI number: 188586079

Start: 1521292

End: 1522545

Strand: Direct

Name: ymxG [H]

Synonym: Nther_1453

Alternate gene names: 188586079

Gene position: 1521292-1522545 (Clockwise)

Preceding gene: 188586078

Following gene: 188586080

Centisome position: 48.06

GC content: 32.62

Gene sequence:

>1254_bases
ATGTTTGAAAAACACACTTTACCAAACGGATTAAGAATTGTAGCTGAACCCATGGAAAGTGTCAGATCAGTAACTGTAGG
TATTTGGATCAAAAGTGGCAGTAGATTTGAAAATCTTTCCCAGCAAGGGATTTCTCACTTATTAGAACATATGTTATTCA
AAGGTACTGACTCGAGAACCGCTCAAGATATTGCGGAGGAAATTGATAGTATTGGTGGGCATATAAATGCATTTACTAGT
AAAGAGTATACCTGTATTTATATAAAAGTCATTGATAGTCACTTTGAAACTGCTCTTGCCATATTAGCCGATATGTTTTT
TAATTCCAAATTTGACCAAGAAGATTTAGAAAAAGAAAAGCAGGTAATTTTTGAGGAATTAAAAATGTACGAAGATACAC
CGGATGAATATGTACATGACCTGTTAATCCAATCATGTTATGGAGAACATGAATTAGCTCACAATATTTTGGGTGATAGG
GAATCAGTAAGTAATTTGAGTTCTGAAGCATTAATTAATCATCATAAAAGATATTTTACCCCAGAAAAAACAGTTATTTC
AGTTAGTGGTAATGTTTCTATGGATAATGTAGTCGAAACAGCCACTAAATATTTTGGAAGCTTTGTAAATATAAACAATA
ATGACAATCACCCTCTTCGGGGACCTTCTTATTATACAGATAGCATTGTAAAAGGGAAAGATACAGAACAAGTTCATTTT
TGTCTAGCTTTTCCCGGTCTCAGTGTAGAAAATTCTCAATTATATCATTTAGGGCTGTTAAATAATATTTTGGGAGGTAG
CATGAGTTCTAAATTTTTTCAAGAAATAAGGGAAAAGCGTGGCTTATGTTATTCAGTGTATTCTTATTACTTAAACTTTA
CCGACTCTGGGTTATTTGTAATTTATGCCGGTTTTAGTCAGGACAATTTTAACGAAACCTATGATTTAATATGGAGCATA
TTAGATGAAATTAAACAAGGATCTATCACCGATGAAGAGCTCAACAGATCCAAAGAACAAGTTAAAGGTAATATATTAAT
GGGCTTAGAAAGTACAAGCAATAGAATGGCTCGATTAGGCCGTGATGAATTATTAAAAGGGGAAATTCTAACTTATGAGC
AGATAATCGAAAAAATTGAAAATATAACAAAGGAAGATTTGTTGAAACTTGCTCAAGATCTATTTCAAAAGAATCAAATG
TCTTCAGCAGTAATTGGGCCCATGAGTGAAGAAGAAGTTCATTCAATTGTATAA

Upstream 100 bases:

>100_bases
GTAATGAGACCTGTCCCCCTTGCTTTTAATAACAATTAATAATAAAATTACTATATTGGGAACCAATTTAGCCTTAGTTT
ATAAAGCGAGGGGGATCATA

Downstream 100 bases:

>100_bases
CTGAGATATTTTAAGATACTTTATCAGCAGTCGGTACAAATACCGGCTGCTTTTATTATTTTTTGCGCTATTATACTTCG
TTGGTCAAATAACAGGATGT

Product: peptidase M16 domain protein

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFEKHTLPNGLRIVAEPMESVRSVTVGIWIKSGSRFENLSQQGISHLLEHMLFKGTDSRTAQDIAEEIDSIGGHINAFTS
KEYTCIYIKVIDSHFETALAILADMFFNSKFDQEDLEKEKQVIFEELKMYEDTPDEYVHDLLIQSCYGEHELAHNILGDR
ESVSNLSSEALINHHKRYFTPEKTVISVSGNVSMDNVVETATKYFGSFVNINNNDNHPLRGPSYYTDSIVKGKDTEQVHF
CLAFPGLSVENSQLYHLGLLNNILGGSMSSKFFQEIREKRGLCYSVYSYYLNFTDSGLFVIYAGFSQDNFNETYDLIWSI
LDEIKQGSITDEELNRSKEQVKGNILMGLESTSNRMARLGRDELLKGEILTYEQIIEKIENITKEDLLKLAQDLFQKNQM
SSAVIGPMSEEEVHSIV

Sequences:

>Translated_417_residues
MFEKHTLPNGLRIVAEPMESVRSVTVGIWIKSGSRFENLSQQGISHLLEHMLFKGTDSRTAQDIAEEIDSIGGHINAFTS
KEYTCIYIKVIDSHFETALAILADMFFNSKFDQEDLEKEKQVIFEELKMYEDTPDEYVHDLLIQSCYGEHELAHNILGDR
ESVSNLSSEALINHHKRYFTPEKTVISVSGNVSMDNVVETATKYFGSFVNINNNDNHPLRGPSYYTDSIVKGKDTEQVHF
CLAFPGLSVENSQLYHLGLLNNILGGSMSSKFFQEIREKRGLCYSVYSYYLNFTDSGLFVIYAGFSQDNFNETYDLIWSI
LDEIKQGSITDEELNRSKEQVKGNILMGLESTSNRMARLGRDELLKGEILTYEQIIEKIENITKEDLLKLAQDLFQKNQM
SSAVIGPMSEEEVHSIV
>Mature_417_residues
MFEKHTLPNGLRIVAEPMESVRSVTVGIWIKSGSRFENLSQQGISHLLEHMLFKGTDSRTAQDIAEEIDSIGGHINAFTS
KEYTCIYIKVIDSHFETALAILADMFFNSKFDQEDLEKEKQVIFEELKMYEDTPDEYVHDLLIQSCYGEHELAHNILGDR
ESVSNLSSEALINHHKRYFTPEKTVISVSGNVSMDNVVETATKYFGSFVNINNNDNHPLRGPSYYTDSIVKGKDTEQVHF
CLAFPGLSVENSQLYHLGLLNNILGGSMSSKFFQEIREKRGLCYSVYSYYLNFTDSGLFVIYAGFSQDNFNETYDLIWSI
LDEIKQGSITDEELNRSKEQVKGNILMGLESTSNRMARLGRDELLKGEILTYEQIIEKIENITKEDLLKLAQDLFQKNQM
SSAVIGPMSEEEVHSIV

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=419, Percent_Identity=26.9689737470167, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI46593007, Length=416, Percent_Identity=24.5192307692308, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI24308013, Length=439, Percent_Identity=23.4624145785877, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI50592988, Length=418, Percent_Identity=20.3349282296651, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=426, Percent_Identity=27.2300469483568, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17553678, Length=398, Percent_Identity=27.8894472361809, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17510601, Length=428, Percent_Identity=21.0280373831776, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323192, Length=421, Percent_Identity=30.4038004750594, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321813, Length=420, Percent_Identity=23.8095238095238, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357875, Length=415, Percent_Identity=26.9879518072289, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24646943, Length=415, Percent_Identity=26.9879518072289, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19921772, Length=432, Percent_Identity=26.3888888888889, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47467; Mature: 47467

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKHTLPNGLRIVAEPMESVRSVTVGIWIKSGSRFENLSQQGISHLLEHMLFKGTDSRT
CCCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHH
AQDIAEEIDSIGGHINAFTSKEYTCIYIKVIDSHFETALAILADMFFNSKFDQEDLEKEK
HHHHHHHHHHCCCCEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QVIFEELKMYEDTPDEYVHDLLIQSCYGEHELAHNILGDRESVSNLSSEALINHHKRYFT
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
PEKTVISVSGNVSMDNVVETATKYFGSFVNINNNDNHPLRGPSYYTDSIVKGKDTEQVHF
CCCEEEEECCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
CLAFPGLSVENSQLYHLGLLNNILGGSMSSKFFQEIREKRGLCYSVYSYYLNFTDSGLFV
EEECCCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEE
IYAGFSQDNFNETYDLIWSILDEIKQGSITDEELNRSKEQVKGNILMGLESTSNRMARLG
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHCCCEEEEECHHHHHHHHCC
RDELLKGEILTYEQIIEKIENITKEDLLKLAQDLFQKNQMSSAVIGPMSEEEVHSIV
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHCC
>Mature Secondary Structure
MFEKHTLPNGLRIVAEPMESVRSVTVGIWIKSGSRFENLSQQGISHLLEHMLFKGTDSRT
CCCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHH
AQDIAEEIDSIGGHINAFTSKEYTCIYIKVIDSHFETALAILADMFFNSKFDQEDLEKEK
HHHHHHHHHHCCCCEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QVIFEELKMYEDTPDEYVHDLLIQSCYGEHELAHNILGDRESVSNLSSEALINHHKRYFT
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
PEKTVISVSGNVSMDNVVETATKYFGSFVNINNNDNHPLRGPSYYTDSIVKGKDTEQVHF
CCCEEEEECCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
CLAFPGLSVENSQLYHLGLLNNILGGSMSSKFFQEIREKRGLCYSVYSYYLNFTDSGLFV
EEECCCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEE
IYAGFSQDNFNETYDLIWSILDEIKQGSITDEELNRSKEQVKGNILMGLESTSNRMARLG
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHCCCEEEEECHHHHHHHHCC
RDELLKGEILTYEQIIEKIENITKEDLLKLAQDLFQKNQMSSAVIGPMSEEEVHSIV
HHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]