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The map label for this gene is sipS [H]

Identifier: 188586000

GI number: 188586000

Start: 1444452

End: 1444970

Strand: Direct

Name: sipS [H]

Synonym: Nther_1374

Alternate gene names: 188586000

Gene position: 1444452-1444970 (Clockwise)

Preceding gene: 188585999

Following gene: 188586001

Centisome position: 45.63

GC content: 33.72

Gene sequence:

>519_bases
ATGACAACAAACAAATCACGAGAAGTATTTGAATGGATAAAATCATTAGTAGTAGCTGTTTTACTTGCTTTGCTTATCAG
ATATTTCGTTGTAGAAATTTTTTTAGTAGAGGGACAATCCATGTATCCTACCTTGGAGAATTCCCAGCGCTTGATAGTGA
ATAAATTTGTGTACCGTTTTAGAGAACCTGATCGAGAAGATGTAATAGTTTTTGAATACAGTGATGATAAAGATTTTATT
AAACGAGTAATTGCTCTTCCAGGAGAAGAAATTAAAATATCTGAAGGACAAGTATATATAGATGGTGACCCTCTTGACGA
GTCTGAATATGAAACAAAAAAAATTAATGATAATTACGGTCCTGAAGCAGTACCCGAAGATAAATATTTTGTCTTGGGAG
ATAATCGCGATAATAGTATGGACAGCCGCTCTGACTCAGTTGGGTTTATCCATGAAGATAAGATAAAGGGAAAAGCTTTT
TTAATCTTTTGGCCTTTAGATGATGTTGGGAGTATATAA

Upstream 100 bases:

>100_bases
CTTAAGAGATTTAAAAGGTAAAGCTGCACGTGTCAAAGGCATTCGCTAGTAAAAAAGGGGCTGGATTACAGTCCCTTTTT
TAAACATGGAGGATGAGTTT

Downstream 100 bases:

>100_bases
GATGCTTTTGGTATATATTTTGAGTTGTTCTATATGTCGGAGGGAATTATGATGTATTATTGTGGTATTGATGAAGCTGG
TTTCGGAGCAGGAGCTGCCC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MTTNKSREVFEWIKSLVVAVLLALLIRYFVVEIFLVEGQSMYPTLENSQRLIVNKFVYRFREPDREDVIVFEYSDDKDFI
KRVIALPGEEIKISEGQVYIDGDPLDESEYETKKINDNYGPEAVPEDKYFVLGDNRDNSMDSRSDSVGFIHEDKIKGKAF
LIFWPLDDVGSI

Sequences:

>Translated_172_residues
MTTNKSREVFEWIKSLVVAVLLALLIRYFVVEIFLVEGQSMYPTLENSQRLIVNKFVYRFREPDREDVIVFEYSDDKDFI
KRVIALPGEEIKISEGQVYIDGDPLDESEYETKKINDNYGPEAVPEDKYFVLGDNRDNSMDSRSDSVGFIHEDKIKGKAF
LIFWPLDDVGSI
>Mature_171_residues
TTNKSREVFEWIKSLVVAVLLALLIRYFVVEIFLVEGQSMYPTLENSQRLIVNKFVYRFREPDREDVIVFEYSDDKDFIK
RVIALPGEEIKISEGQVYIDGDPLDESEYETKKINDNYGPEAVPEDKYFVLGDNRDNSMDSRSDSVGFIHEDKIKGKAFL
IFWPLDDVGSI

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 19976; Mature: 19845

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNKSREVFEWIKSLVVAVLLALLIRYFVVEIFLVEGQSMYPTLENSQRLIVNKFVYRF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
REPDREDVIVFEYSDDKDFIKRVIALPGEEIKISEGQVYIDGDPLDESEYETKKINDNYG
CCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCCHHHHCCCCCC
PEAVPEDKYFVLGDNRDNSMDSRSDSVGFIHEDKIKGKAFLIFWPLDDVGSI
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCHHCCCC
>Mature Secondary Structure 
TTNKSREVFEWIKSLVVAVLLALLIRYFVVEIFLVEGQSMYPTLENSQRLIVNKFVYRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
REPDREDVIVFEYSDDKDFIKRVIALPGEEIKISEGQVYIDGDPLDESEYETKKINDNYG
CCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCCHHHHCCCCCC
PEAVPEDKYFVLGDNRDNSMDSRSDSVGFIHEDKIKGKAFLIFWPLDDVGSI
CCCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCEEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]