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The map label for this gene is dapL

Identifier: 188585898

GI number: 188585898

Start: 1341262

End: 1342422

Strand: Direct

Name: dapL

Synonym: Nther_1272

Alternate gene names: 188585898

Gene position: 1341262-1342422 (Clockwise)

Preceding gene: 188585897

Following gene: 188585899

Centisome position: 42.37

GC content: 37.12

Gene sequence:

>1161_bases
TTGCAATCGGCCCACCGCTTAAATAATTTGCCACCTTATTTATTTGCTGATCTCGATAAAATGGTCCAAAAAGAACAGGC
CAAAGGTAAAGAGATAATCAAATTGGGAATTGGTGATCCTGGCATGAAACCACCTGAAGGAATAATTAAAGCAGCTACTC
AGGAAATGTATAAGGGTGAAAATCATGGTTATCCAGCCTATGATGGTATTGATAAATTAAAACATGCTATAAAAGAATAC
TATCAAAGCAGGTTTGGAGTTGAATTGAATCCTGATCGGGAAATCCTAACTTTAATTGGCTCTAAAGAGGGTATCGCTAA
TATTTCACAAGCCATCTTAAACCCGGGAGACATTAATTTTATCCCCGATCCTTCTTATCCTGTCTATAAAAATGGAACTA
TTCTGGCTGGTGGTACACCTCATTCTATGCCATTAAAGCAGGATAATGGTTTTATTCCGGAATTAGAAAGTATTCCCCAG
TCCCGATTAAGTAAAGGTAAAATTGTTTTTATGAATTATCCTAACAACCCTACTTCGGCTGTAGCCAGCAAAGATTTCTA
CAGTCATGCTGTGAAATTCTGTCAAAAAAATAAGTTATTATTGTGTAATGATGCTGCCTATAGTGAAATTGCATTTGATG
ATTATCAACCTCAGAGTCTATTATCAGTACCTGGTGCCAAAGAAGTAGCCATCGAATTTAATTCCCTATCTAAAACCTTT
AATATGACCGGTTGGCGTGTAGGTTTTGTTGTAGGTAATGAAAAGGCAATTTCTGCATTAGCTAAGTACAAAACCAATGT
AGATTCTGGAGTGTTCACACCATTGCAGTTAGCTGCTACCCATGCTTTGGAAAATAGACATGAATACATTCCGGATATAT
TGAAGGCATACAAAGAACGAAGAGACTTGGTTATTGAATTTTTGGAAGAAGCAGGTTTTCATGTCTATCACCCCAAAGCC
ACTTTTTATGTTTGGGCACAAGTACCTGGCAATCAAGATTCTTTCAATTTCACTAAATCTTTACTTACCAAGACTGGTGT
GGTAGTTACCCCAGGTATTGGATTTGGAAAACACGGTGAGGGGTATTTTAGAATTGCCCTGACGGTGACAAAGGACAGAC
TAAAAACAGCTATGGAAAAAATATGTGAGTATTTTTCTTAA

Upstream 100 bases:

>100_bases
CGGTTAATAGCCGATTCTTTTTTTTATTATGTAATTAATAGAGAACAAAATTAATACATATCTATAAGAAAATCCTCGTA
TTGCTAAAGGAGGTTTTTAA

Downstream 100 bases:

>100_bases
TTAAAGGGGAGAGGATAATTGTCTTTTAAATTAGGCGTTGTAGGTGCTACCGGTTTAGTTGGTGGCAAGATCTTGGAAGT
TCTTGAAGAACGGAATATTA

Product: aminotransferase class I and II

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MQSAHRLNNLPPYLFADLDKMVQKEQAKGKEIIKLGIGDPGMKPPEGIIKAATQEMYKGENHGYPAYDGIDKLKHAIKEY
YQSRFGVELNPDREILTLIGSKEGIANISQAILNPGDINFIPDPSYPVYKNGTILAGGTPHSMPLKQDNGFIPELESIPQ
SRLSKGKIVFMNYPNNPTSAVASKDFYSHAVKFCQKNKLLLCNDAAYSEIAFDDYQPQSLLSVPGAKEVAIEFNSLSKTF
NMTGWRVGFVVGNEKAISALAKYKTNVDSGVFTPLQLAATHALENRHEYIPDILKAYKERRDLVIEFLEEAGFHVYHPKA
TFYVWAQVPGNQDSFNFTKSLLTKTGVVVTPGIGFGKHGEGYFRIALTVTKDRLKTAMEKICEYFS

Sequences:

>Translated_386_residues
MQSAHRLNNLPPYLFADLDKMVQKEQAKGKEIIKLGIGDPGMKPPEGIIKAATQEMYKGENHGYPAYDGIDKLKHAIKEY
YQSRFGVELNPDREILTLIGSKEGIANISQAILNPGDINFIPDPSYPVYKNGTILAGGTPHSMPLKQDNGFIPELESIPQ
SRLSKGKIVFMNYPNNPTSAVASKDFYSHAVKFCQKNKLLLCNDAAYSEIAFDDYQPQSLLSVPGAKEVAIEFNSLSKTF
NMTGWRVGFVVGNEKAISALAKYKTNVDSGVFTPLQLAATHALENRHEYIPDILKAYKERRDLVIEFLEEAGFHVYHPKA
TFYVWAQVPGNQDSFNFTKSLLTKTGVVVTPGIGFGKHGEGYFRIALTVTKDRLKTAMEKICEYFS
>Mature_386_residues
MQSAHRLNNLPPYLFADLDKMVQKEQAKGKEIIKLGIGDPGMKPPEGIIKAATQEMYKGENHGYPAYDGIDKLKHAIKEY
YQSRFGVELNPDREILTLIGSKEGIANISQAILNPGDINFIPDPSYPVYKNGTILAGGTPHSMPLKQDNGFIPELESIPQ
SRLSKGKIVFMNYPNNPTSAVASKDFYSHAVKFCQKNKLLLCNDAAYSEIAFDDYQPQSLLSVPGAKEVAIEFNSLSKTF
NMTGWRVGFVVGNEKAISALAKYKTNVDSGVFTPLQLAATHALENRHEYIPDILKAYKERRDLVIEFLEEAGFHVYHPKA
TFYVWAQVPGNQDSFNFTKSLLTKTGVVVTPGIGFGKHGEGYFRIALTVTKDRLKTAMEKICEYFS

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI95147551, Length=398, Percent_Identity=24.8743718592965, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI169881279, Length=398, Percent_Identity=24.8743718592965, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI56713256, Length=346, Percent_Identity=23.6994219653179, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI56713254, Length=346, Percent_Identity=23.6994219653179, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI169881281, Length=302, Percent_Identity=25.1655629139073, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4507369, Length=379, Percent_Identity=24.0105540897098, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788722, Length=383, Percent_Identity=38.9033942558747, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI1786816, Length=348, Percent_Identity=24.1379310344828, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788627, Length=407, Percent_Identity=24.0786240786241, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17567369, Length=393, Percent_Identity=25.6997455470738, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=321, Percent_Identity=23.6760124610592, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994476, Length=321, Percent_Identity=23.6760124610592, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17567663, Length=409, Percent_Identity=24.2053789731051, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=387, Percent_Identity=24.031007751938, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28573069, Length=390, Percent_Identity=25.6410256410256, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24646114, Length=390, Percent_Identity=25.6410256410256, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573067, Length=390, Percent_Identity=25.6410256410256, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573065, Length=390, Percent_Identity=25.6410256410256, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18859735, Length=386, Percent_Identity=21.7616580310881, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641770, Length=384, Percent_Identity=23.6979166666667, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641760, Length=384, Percent_Identity=23.6979166666667, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641768, Length=384, Percent_Identity=23.6979166666667, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641766, Length=384, Percent_Identity=23.6979166666667, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641764, Length=384, Percent_Identity=23.6979166666667, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45551451, Length=384, Percent_Identity=23.6979166666667, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_NATTJ (B2A250)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917443.1
- ProteinModelPortal:   B2A250
- SMR:   B2A250
- GeneID:   6314245
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1272
- HOGENOM:   HBG645860
- OMA:   YSEIAFD
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 43001; Mature: 43001

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00105 AA_TRANSFER_CLASS_1; PS00626 RCC1_2

Important sites: BINDING 38-38 BINDING 64-64 BINDING 102-102 BINDING 126-126 BINDING 176-176 BINDING 176-176 BINDING 204-204 BINDING 207-207 BINDING 235-235 BINDING 237-237 BINDING 246-246 BINDING 364-364

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSAHRLNNLPPYLFADLDKMVQKEQAKGKEIIKLGIGDPGMKPPEGIIKAATQEMYKGE
CCCCHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
NHGYPAYDGIDKLKHAIKEYYQSRFGVELNPDREILTLIGSKEGIANISQAILNPGDINF
CCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHEEEEECCCCCHHHHHHHHCCCCCCCC
IPDPSYPVYKNGTILAGGTPHSMPLKQDNGFIPELESIPQSRLSKGKIVFMNYPNNPTSA
CCCCCCCEECCCEEEECCCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEEECCCCCHHH
VASKDFYSHAVKFCQKNKLLLCNDAAYSEIAFDDYQPQSLLSVPGAKEVAIEFNSLSKTF
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEHHHHHHH
NMTGWRVGFVVGNEKAISALAKYKTNVDSGVFTPLQLAATHALENRHEYIPDILKAYKER
CCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLVIEFLEEAGFHVYHPKATFYVWAQVPGNQDSFNFTKSLLTKTGVVVTPGIGFGKHGE
HHHHHHHHHHCCCEEECCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCC
GYFRIALTVTKDRLKTAMEKICEYFS
CEEEEEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQSAHRLNNLPPYLFADLDKMVQKEQAKGKEIIKLGIGDPGMKPPEGIIKAATQEMYKGE
CCCCHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
NHGYPAYDGIDKLKHAIKEYYQSRFGVELNPDREILTLIGSKEGIANISQAILNPGDINF
CCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHEEEEECCCCCHHHHHHHHCCCCCCCC
IPDPSYPVYKNGTILAGGTPHSMPLKQDNGFIPELESIPQSRLSKGKIVFMNYPNNPTSA
CCCCCCCEECCCEEEECCCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEEECCCCCHHH
VASKDFYSHAVKFCQKNKLLLCNDAAYSEIAFDDYQPQSLLSVPGAKEVAIEFNSLSKTF
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEHHHHHHH
NMTGWRVGFVVGNEKAISALAKYKTNVDSGVFTPLQLAATHALENRHEYIPDILKAYKER
CCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLVIEFLEEAGFHVYHPKATFYVWAQVPGNQDSFNFTKSLLTKTGVVVTPGIGFGKHGE
HHHHHHHHHHCCCEEECCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCC
GYFRIALTVTKDRLKTAMEKICEYFS
CEEEEEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA