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The map label for this gene is ahcY [H]

Identifier: 188585309

GI number: 188585309

Start: 697605

End: 698861

Strand: Reverse

Name: ahcY [H]

Synonym: Nther_0673

Alternate gene names: 188585309

Gene position: 698861-697605 (Counterclockwise)

Preceding gene: 188585311

Following gene: 188585308

Centisome position: 22.08

GC content: 39.7

Gene sequence:

>1257_bases
ATGGCTACAGTAAAAACTAGTAACAATTTAGTTGAACAAGGTGAAAACAAAATAACTTGGGCAAGAAACAAAATGCCTGT
CTTACAGAGTATTTCTGAACGCTGGAAGGAAAACCAACCTCTAAAAGGTGTTAGGGTTAGTGCATGCTTGCACGTAACAC
CTAAAACCGCTAATTTGTTAATCACTCTAAAAGATGGAGGTGCTGAAGTAGCACTGTGTGGTTCTAATCCTCTTAGTACT
CAAGATGATGTGGTTGCTGCTTTAAATGAAGTATATCAAGTGCCAACTCATGCCAAACGAGGTGAAGGTAAAGAAGACTT
TTACAATCGAATTTTAGAAGTCTTAGATATTAAACCACACATCACAGTTGATGATGGTGCAGACTTAATCAACACATTAC
ACAGTGAAAGAAGAGAACTGCTTGATAACATTTCTGGAGGTACTGAAGAAACTACAACTGGTGTCACTCGTTTAAAAGCT
ATGGCCAGAGACAATTATCTACAGTATCCAGTGATCGCAGTGAACGATGCCATGACAAAACACATGTTTGACAACCGCTA
CGGTACTGGCCAGTCAACTATAGATGGTATCATGAGAGCCACCAATTATTTAATGGCAGGTACCAGTTTTGTTGTAGTTG
GCTACGGCTGGTGCGGCCGTGGTGTTGCCAAAGATGCTAGTGGGCTTGGCGCTAGAGTGACAGTAGTGGAAGTAGATCCT
GTGAGAGCTTTAGAAGCTTCACTGGATGGCTTTGAAGTTAAAAGTATGGAGGAAGCTGCTAAGAATGCAGACTTTGTCGT
AACTACTACTGGTAATAAAAATGTAGTTGATAAACATCATTTAGAAAACATTAAAGACGGCTGCATCCTATCGAATTCTG
GTCATTTCAATGTTGAAATCAATTTAGAATCACTGGAGAAAATGTCTAAAACAAAACGAACAGTACGTCCTGATGTTGAA
GAATACCAGTTGAAAGATGGTCGGAAAGTATATGTTATTGGTGAAGGAAGGCTAGTTAATCTATCTGCTGGAGAAGGACA
CCCGGCAGACGTTATGGACATGAGCTTTTCCAACCAGGCCTTATCAGTAGAATACCTGGCTAATGAAAAAACGAACCTTA
AAAACGATGTATATCCTGTACCAAAACATTTAGACGAAGGTATAGCCGAGTTAAAACTTAAATGTATGGGAATGGAACTT
GAACAGCTAACGGAAGAACAAAAAGAGTATCTAAACTCCTGGGATGTTGGGACTTAA

Upstream 100 bases:

>100_bases
GATTTCTGTCTAAAACTATCTTAACTCCGGGACGGAGACTGATTCAAATATCATATAACTTAACAGAACTAAAATAAATG
GAAGGAGGAGAAGTAGTATT

Downstream 100 bases:

>100_bases
TTAACCACCAAAAGGAGGTGGATATCATGTTAAGAATAATTTCAAATAATAAAATAATATTATTTATGATTGTAATCATC
ACCACAGGTGGCCTGATGGC

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MATVKTSNNLVEQGENKITWARNKMPVLQSISERWKENQPLKGVRVSACLHVTPKTANLLITLKDGGAEVALCGSNPLST
QDDVVAALNEVYQVPTHAKRGEGKEDFYNRILEVLDIKPHITVDDGADLINTLHSERRELLDNISGGTEETTTGVTRLKA
MARDNYLQYPVIAVNDAMTKHMFDNRYGTGQSTIDGIMRATNYLMAGTSFVVVGYGWCGRGVAKDASGLGARVTVVEVDP
VRALEASLDGFEVKSMEEAAKNADFVVTTTGNKNVVDKHHLENIKDGCILSNSGHFNVEINLESLEKMSKTKRTVRPDVE
EYQLKDGRKVYVIGEGRLVNLSAGEGHPADVMDMSFSNQALSVEYLANEKTNLKNDVYPVPKHLDEGIAELKLKCMGMEL
EQLTEEQKEYLNSWDVGT

Sequences:

>Translated_418_residues
MATVKTSNNLVEQGENKITWARNKMPVLQSISERWKENQPLKGVRVSACLHVTPKTANLLITLKDGGAEVALCGSNPLST
QDDVVAALNEVYQVPTHAKRGEGKEDFYNRILEVLDIKPHITVDDGADLINTLHSERRELLDNISGGTEETTTGVTRLKA
MARDNYLQYPVIAVNDAMTKHMFDNRYGTGQSTIDGIMRATNYLMAGTSFVVVGYGWCGRGVAKDASGLGARVTVVEVDP
VRALEASLDGFEVKSMEEAAKNADFVVTTTGNKNVVDKHHLENIKDGCILSNSGHFNVEINLESLEKMSKTKRTVRPDVE
EYQLKDGRKVYVIGEGRLVNLSAGEGHPADVMDMSFSNQALSVEYLANEKTNLKNDVYPVPKHLDEGIAELKLKCMGMEL
EQLTEEQKEYLNSWDVGT
>Mature_417_residues
ATVKTSNNLVEQGENKITWARNKMPVLQSISERWKENQPLKGVRVSACLHVTPKTANLLITLKDGGAEVALCGSNPLSTQ
DDVVAALNEVYQVPTHAKRGEGKEDFYNRILEVLDIKPHITVDDGADLINTLHSERRELLDNISGGTEETTTGVTRLKAM
ARDNYLQYPVIAVNDAMTKHMFDNRYGTGQSTIDGIMRATNYLMAGTSFVVVGYGWCGRGVAKDASGLGARVTVVEVDPV
RALEASLDGFEVKSMEEAAKNADFVVTTTGNKNVVDKHHLENIKDGCILSNSGHFNVEINLESLEKMSKTKRTVRPDVEE
YQLKDGRKVYVIGEGRLVNLSAGEGHPADVMDMSFSNQALSVEYLANEKTNLKNDVYPVPKHLDEGIAELKLKCMGMELE
QLTEEQKEYLNSWDVGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=405, Percent_Identity=41.7283950617284, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=42.3076923076923, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI195539349, Length=404, Percent_Identity=37.1287128712871, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI298286489, Length=404, Percent_Identity=37.1287128712871, Blast_Score=275, Evalue=7e-74,
Organism=Homo sapiens, GI24308043, Length=404, Percent_Identity=37.1287128712871, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI195539337, Length=404, Percent_Identity=37.1287128712871, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI21361647, Length=404, Percent_Identity=37.1287128712871, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17506425, Length=409, Percent_Identity=42.5427872860636, Blast_Score=312, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320882, Length=422, Percent_Identity=38.8625592417062, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642172, Length=407, Percent_Identity=42.2604422604423, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24656245, Length=402, Percent_Identity=37.0646766169154, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI45553387, Length=401, Percent_Identity=37.4064837905237, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI45553385, Length=401, Percent_Identity=37.4064837905237, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46121; Mature: 45989

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKTSNNLVEQGENKITWARNKMPVLQSISERWKENQPLKGVRVSACLHVTPKTANLL
CCEEECCCHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEE
ITLKDGGAEVALCGSNPLSTQDDVVAALNEVYQVPTHAKRGEGKEDFYNRILEVLDIKPH
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
ITVDDGADLINTLHSERRELLDNISGGTEETTTGVTRLKAMARDNYLQYPVIAVNDAMTK
EEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
HMFDNRYGTGQSTIDGIMRATNYLMAGTSFVVVGYGWCGRGVAKDASGLGARVTVVEVDP
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECC
VRALEASLDGFEVKSMEEAAKNADFVVTTTGNKNVVDKHHLENIKDGCILSNSGHFNVEI
HHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCEEEECCCEEEEEE
NLESLEKMSKTKRTVRPDVEEYQLKDGRKVYVIGEGRLVNLSAGEGHPADVMDMSFSNQA
EHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCEEECCCCCCE
LSVEYLANEKTNLKNDVYPVPKHLDEGIAELKLKCMGMELEQLTEEQKEYLNSWDVGT
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ATVKTSNNLVEQGENKITWARNKMPVLQSISERWKENQPLKGVRVSACLHVTPKTANLL
CEEECCCHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEE
ITLKDGGAEVALCGSNPLSTQDDVVAALNEVYQVPTHAKRGEGKEDFYNRILEVLDIKPH
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
ITVDDGADLINTLHSERRELLDNISGGTEETTTGVTRLKAMARDNYLQYPVIAVNDAMTK
EEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
HMFDNRYGTGQSTIDGIMRATNYLMAGTSFVVVGYGWCGRGVAKDASGLGARVTVVEVDP
HHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECC
VRALEASLDGFEVKSMEEAAKNADFVVTTTGNKNVVDKHHLENIKDGCILSNSGHFNVEI
HHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCEEEECCCEEEEEE
NLESLEKMSKTKRTVRPDVEEYQLKDGRKVYVIGEGRLVNLSAGEGHPADVMDMSFSNQA
EHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCEEECCCCCCE
LSVEYLANEKTNLKNDVYPVPKHLDEGIAELKLKCMGMELEQLTEEQKEYLNSWDVGT
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]