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The map label for this gene is baeB [H]

Identifier: 188585206

GI number: 188585206

Start: 595244

End: 595906

Strand: Reverse

Name: baeB [H]

Synonym: Nther_0568

Alternate gene names: 188585206

Gene position: 595906-595244 (Counterclockwise)

Preceding gene: 188585212

Following gene: 188585202

Centisome position: 18.82

GC content: 34.99

Gene sequence:

>663_bases
TTGACTATTGAACAGTTTAAATGTCCTCACAGAGCTAAAAATTTTAGTTATGTAATTTCTTCTCCATCTAGCAACAAAAT
CGCCATAGTAGATCCTTCATTTTGTGATGAATTATTGGCTACCAAGTTAACAGAAGCTCAATACGATGTACAATATATTA
TAAATACCCATGCTCATTTTGACCATACTTGGGGTAATGATACCTTAAAAAACATATTTCCAAAAGCTAAATTAATAGCT
CATACCAACACAAAATATAAGCCTAACGCAAGTTCAGTTGATATTGCAGTCGAGGACGGCGAATCAATCTGGCTCGACCA
ACTAGAAATAAAGATATTACATACCCCTGGTCACACTCCTGAGGATATCTGCCTATTAGTCAATAATTCACTCATTACGG
GAGATACGCTCTTTGTGGGAAAAGTAGGCGGCACAAGAGATCGGGAAACAGCTAAAACACAATTTGAAAGTTTAAAGAAA
TTAATGCAACTTCCTCAAGATACAAAAATTTATCCTGGTCATAATTACGGCCCTAGTCCAAGCTCAACTATACAGGCAGA
AAAGGAAGCTAACCCTTTTTGTCTGAGACTAGATAATTTCGAAAACTTTTATTGGCTCAAAGAAAACTGGAAAACATTTA
AAGAAAAACACAATTTAGATTAA

Upstream 100 bases:

>100_bases
CTTGACACTTGTTATCAAAATAATCAATAATAACAAGTGAGAGTATTCATGAGATAAAGTTCCAAAAAATCAATTCAAAA
TATGAAAGGAGATATTCAGT

Downstream 100 bases:

>100_bases
AAATAGTTTTATCTCTAGCTATGTCTTTTTTTAAGTAACGGGATCAAACAGGCTCAACTTTTAACTAACGGGCTCAACCA
CTTCTGGAAAATCATTTTTA

Product: beta-lactamase domain protein

Products: Reduced glutathione; H+; D-Lactate [C]

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTIEQFKCPHRAKNFSYVISSPSSNKIAIVDPSFCDELLATKLTEAQYDVQYIINTHAHFDHTWGNDTLKNIFPKAKLIA
HTNTKYKPNASSVDIAVEDGESIWLDQLEIKILHTPGHTPEDICLLVNNSLITGDTLFVGKVGGTRDRETAKTQFESLKK
LMQLPQDTKIYPGHNYGPSPSSTIQAEKEANPFCLRLDNFENFYWLKENWKTFKEKHNLD

Sequences:

>Translated_220_residues
MTIEQFKCPHRAKNFSYVISSPSSNKIAIVDPSFCDELLATKLTEAQYDVQYIINTHAHFDHTWGNDTLKNIFPKAKLIA
HTNTKYKPNASSVDIAVEDGESIWLDQLEIKILHTPGHTPEDICLLVNNSLITGDTLFVGKVGGTRDRETAKTQFESLKK
LMQLPQDTKIYPGHNYGPSPSSTIQAEKEANPFCLRLDNFENFYWLKENWKTFKEKHNLD
>Mature_219_residues
TIEQFKCPHRAKNFSYVISSPSSNKIAIVDPSFCDELLATKLTEAQYDVQYIINTHAHFDHTWGNDTLKNIFPKAKLIAH
TNTKYKPNASSVDIAVEDGESIWLDQLEIKILHTPGHTPEDICLLVNNSLITGDTLFVGKVGGTRDRETAKTQFESLKKL
MQLPQDTKIYPGHNYGPSPSSTIQAEKEANPFCLRLDNFENFYWLKENWKTFKEKHNLD

Specific function: Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=189, Percent_Identity=29.1005291005291, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI94538322, Length=179, Percent_Identity=27.9329608938547, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI94538320, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786406, Length=168, Percent_Identity=31.547619047619, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538952, Length=189, Percent_Identity=31.2169312169312, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536925, Length=177, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320478, Length=178, Percent_Identity=30.8988764044944, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324614, Length=192, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330176, Length=203, Percent_Identity=26.6009852216749, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667703, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356335, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667711, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: 3.1.2.6 [C]

Molecular weight: Translated: 25102; Mature: 24970

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEQFKCPHRAKNFSYVISSPSSNKIAIVDPSFCDELLATKLTEAQYDVQYIINTHAHF
CCCCCCCCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCEEEEEEECCCCC
DHTWGNDTLKNIFPKAKLIAHTNTKYKPNASSVDIAVEDGESIWLDQLEIKILHTPGHTP
CCCCCCCHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCEEEEEEEEEEEEECCCCCC
EDICLLVNNSLITGDTLFVGKVGGTRDRETAKTQFESLKKLMQLPQDTKIYPGHNYGPSP
CCEEEEEECCEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCC
SSTIQAEKEANPFCLRLDNFENFYWLKENWKTFKEKHNLD
CCCEEECCCCCCEEEEECCCCCEEEEHHHHHHHHHHCCCC
>Mature Secondary Structure 
TIEQFKCPHRAKNFSYVISSPSSNKIAIVDPSFCDELLATKLTEAQYDVQYIINTHAHF
CCCCCCCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHCEEEEEEECCCCC
DHTWGNDTLKNIFPKAKLIAHTNTKYKPNASSVDIAVEDGESIWLDQLEIKILHTPGHTP
CCCCCCCHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCEEEEEEEEEEEEECCCCCC
EDICLLVNNSLITGDTLFVGKVGGTRDRETAKTQFESLKKLMQLPQDTKIYPGHNYGPSP
CCEEEEEECCEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCC
SSTIQAEKEANPFCLRLDNFENFYWLKENWKTFKEKHNLD
CCCEEECCCCCCEEEEECCCCCEEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; (R)-S-Lactoylglutathione [C]

Specific reaction: H2O + (R)-S-Lactoylglutathione --> Reduced glutathione + H+ + D-Lactate [C]

General reaction: Thioester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA