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The map label for this gene is moaC

Identifier: 188585139

GI number: 188585139

Start: 527786

End: 528265

Strand: Direct

Name: moaC

Synonym: Nther_0500

Alternate gene names: 188585139

Gene position: 527786-528265 (Clockwise)

Preceding gene: 188585138

Following gene: 188585140

Centisome position: 16.67

GC content: 35.21

Gene sequence:

>480_bases
ATGGTTGATGAATTTACCCATTTAGATAATCAAGGAAAGGCTAGAATGGTAGAAATTAATCAAAAACCTGATACAAGTCG
TAGGGCAGTTGCTCGTGGATCTATCTACATGAAAGCTAATACACTACAAAAAGTTAAAACTAACGAAATGGAAAAAGGTG
ATGTACTAGGAGTGGCTCGTGTGGCAGCTATAATGGGGACTAAAAGAACGGGAGATCTTATTCCCATGTGCCATCCTTTG
ATGTTAACTGGAATTGAAGTAAACTTTAATTTTGATGAAGAAAATTGTAAAATAGATATTGAAGTGATTGTTAAAACTAC
AGGGAAAACTGGAGTCGAAATGGAAGCTTTGACAGGGGTTAGTTTGGCTGCTTTAACCATTTATGATATGTGCAAATCTA
TTGATAAAACTATGAAGATAGAGCATATACGATTGGCCAAAAAATCTGGTGGTCAAAGTGGTGAAATAGAAAATGAGTAA

Upstream 100 bases:

>100_bases
ATCTAGAATATACTACAAAGGCATAATATTAAGTACAAGGGACAGTGCGATTGGGGTTACCCCTTTCGCACTGCTTTTGT
TATTGGGAGGTGTTAAATTC

Downstream 100 bases:

>100_bases
AAATCCCCTGTTGTGTTTTTTTGGACAAAGGAGTAAACTATTAGTGACAATAATATAATTCAAAGGGGTTTTCCTTTATG
AAGGGACGAGATTATACTTA

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MVDEFTHLDNQGKARMVEINQKPDTSRRAVARGSIYMKANTLQKVKTNEMEKGDVLGVARVAAIMGTKRTGDLIPMCHPL
MLTGIEVNFNFDEENCKIDIEVIVKTTGKTGVEMEALTGVSLAALTIYDMCKSIDKTMKIEHIRLAKKSGGQSGEIENE

Sequences:

>Translated_159_residues
MVDEFTHLDNQGKARMVEINQKPDTSRRAVARGSIYMKANTLQKVKTNEMEKGDVLGVARVAAIMGTKRTGDLIPMCHPL
MLTGIEVNFNFDEENCKIDIEVIVKTTGKTGVEMEALTGVSLAALTIYDMCKSIDKTMKIEHIRLAKKSGGQSGEIENE
>Mature_159_residues
MVDEFTHLDNQGKARMVEINQKPDTSRRAVARGSIYMKANTLQKVKTNEMEKGDVLGVARVAAIMGTKRTGDLIPMCHPL
MLTGIEVNFNFDEENCKIDIEVIVKTTGKTGVEMEALTGVSLAALTIYDMCKSIDKTMKIEHIRLAKKSGGQSGEIENE

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=158, Percent_Identity=48.1012658227848, Blast_Score=160, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32566331, Length=156, Percent_Identity=45.5128205128205, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI28574490, Length=149, Percent_Identity=45.6375838926174, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574492, Length=137, Percent_Identity=44.5255474452555, Blast_Score=130, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_NATTJ (B2A685)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916684.1
- ProteinModelPortal:   B2A685
- SMR:   B2A685
- GeneID:   6314803
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0500
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 17548; Mature: 17548

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDEFTHLDNQGKARMVEINQKPDTSRRAVARGSIYMKANTLQKVKTNEMEKGDVLGVAR
CCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCEEEEEECCHHHHHCCCCCCCCHHHHHH
VAAIMGTKRTGDLIPMCHPLMLTGIEVNFNFDEENCKIDIEVIVKTTGKTGVEMEALTGV
HHHHHCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEEEEEECCCCCCEEEHHCCC
SLAALTIYDMCKSIDKTMKIEHIRLAKKSGGQSGEIENE
HHHHHHHHHHHHHHHHHHHHHHEEEEHHCCCCCCCCCCC
>Mature Secondary Structure
MVDEFTHLDNQGKARMVEINQKPDTSRRAVARGSIYMKANTLQKVKTNEMEKGDVLGVAR
CCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCEEEEEECCHHHHHCCCCCCCCHHHHHH
VAAIMGTKRTGDLIPMCHPLMLTGIEVNFNFDEENCKIDIEVIVKTTGKTGVEMEALTGV
HHHHHCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEEEEEECCCCCCEEEHHCCC
SLAALTIYDMCKSIDKTMKIEHIRLAKKSGGQSGEIENE
HHHHHHHHHHHHHHHHHHHHHHEEEEHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA