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The map label for this gene is grdA1 [H]

Identifier: 188585112

GI number: 188585112

Start: 501696

End: 502163

Strand: Direct

Name: grdA1 [H]

Synonym: Nther_0473

Alternate gene names: 188585112

Gene position: 501696-502163 (Clockwise)

Preceding gene: 188585111

Following gene: 188585113

Centisome position: 15.85

GC content: 41.88

Gene sequence:

>468_bases
ATGTTTGAAGGTAAAAAAGTAGTTATCTTAGGTGATCGCGATGGCATCCCTGGCCCTGCTATTGAAGAGTGCATCAAAAC
AACAGGAGCAGAAGTTGTATACAGCACTACTGAATGTTTCGTCTGAACGTCCGCAGGTGCCATGGACCTTGAAAATCAAA
AGCGGGTCAAAGAATTAACTGACAAACACGGTCCTGAAAACTTGATTGTAATCATAGGAGGAGCAGATGCAGAAGGTTCA
GGACTAGCAACTGAAACTGTTACTAATGGTGACCCAACTTTTGCAGGTCCATTGGCGGGAGTCCAGTTAGGACTCAAATG
TTATCACATAGTAGAACCGGAAGTGAAGGAAGCTGTAGATTCTTCGGTGTACGAAGAACAGGTAGAAATGATGGAAATGG
TACTTGAAGTTGATGAAATTATACAAGAGGTCAAAGAGTATCGGGAAAAGTATTGTAAGTTCTTGTAA

Upstream 100 bases:

>100_bases
AAATCAACTTGGATTTAACAAGCTCGGAGCTATAGAAGCTTAACTTTAAATTAACATATACCTGAATTTAAAGATATTAC
TATTAAGTGGAGGTGAGTTT

Downstream 100 bases:

>100_bases
TTTCCCCTGAAGAAAGGAGGGACGAAGGTGTCTAAAAAAATAGTCCATTATATAAACCAGTTCTTTGGCCAGATCGGTGG
TGAGGAAAAGGCTGATACGG

Product: glycine/sarcosine/betaine reductase complex protein A

Products: NA

Alternate protein names: Selenoprotein PA 1; Thioredoxin reductase complex selenoprotein A 1 [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MFEGKKVVILGDRDGIPGPAIEECIKTTGAEVVYSTTECFVUTSAGAMDLENQKRVKELTDKHGPENLIVIIGGADAEGS
GLATETVTNGDPTFAGPLAGVQLGLKCYHIVEPEVKEAVDSSVYEEQVEMMEMVLEVDEIIQEVKEYREKYCKFL

Sequences:

>Translated_155_residues
MFEGKKVVILGDRDGIPGPAIEECIKTTGAEVVYSTTECFV*TSAGAMDLENQKRVKELTDKHGPENLIVIIGGADAEGS
GLATETVTNGDPTFAGPLAGVQLGLKCYHIVEPEVKEAVDSSVYEEQVEMMEMVLEVDEIIQEVKEYREKYCKFL
>Mature_155_residues
MFEGKKVVILGDRDGIPGPAIEECIKTTGAEVVYSTTECFV*TSAGAMDLENQKRVKELTDKHGPENLIVIIGGADAEGS
GLATETVTNGDPTFAGPLAGVQLGLKCYHIVEPEVKEAVDSSVYEEQVEMMEMVLEVDEIIQEVKEYREKYCKFL

Specific function: In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a c

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grdA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006812 [H]

Pfam domain/function: PF04723 GRDA [H]

EC number: =1.21.4.2; =1.21.4.3; =1.21.4.4 [H]

Molecular weight: Translated: 16786; Mature: 16786

Theoretical pI: Translated: 4.12; Mature: 4.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEGKKVVILGDRDGIPGPAIEECIKTTGAEVVYSTTECFVTSAGAMDLENQKRVKELTD
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHHEEECCCCCCCHHHHHHHHHHH
KHGPENLIVIIGGADAEGSGLATETVTNGDPTFAGPLAGVQLGLKCYHIVEPEVKEAVDS
CCCCCEEEEEEECCCCCCCCCEECEECCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHH
SVYEEQVEMMEMVLEVDEIIQEVKEYREKYCKFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEGKKVVILGDRDGIPGPAIEECIKTTGAEVVYSTTECFVTSAGAMDLENQKRVKELTD
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHHEEECCCCCCCHHHHHHHHHHH
KHGPENLIVIIGGADAEGSGLATETVTNGDPTFAGPLAGVQLGLKCYHIVEPEVKEAVDS
CCCCCEEEEEEECCCCCCCCCEECEECCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHH
SVYEEQVEMMEMVLEVDEIIQEVKEYREKYCKFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8223622; 1917832; 10091582 [H]