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The map label for this gene is purM [H]

Identifier: 188585095

GI number: 188585095

Start: 481126

End: 482208

Strand: Direct

Name: purM [H]

Synonym: Nther_0456

Alternate gene names: 188585095

Gene position: 481126-482208 (Clockwise)

Preceding gene: 188585094

Following gene: 188585096

Centisome position: 15.2

GC content: 39.15

Gene sequence:

>1083_bases
TTGACTGGAAATAGTTATCGTAAAGCTGGTGTGGATGTGGACAAGGGAAATAAAATAGCGGAAAACATAAAAGAGTTAAC
TTCCTCAGAAGCATCAGGACATGTTATATCAGGTGTAGGTGGATTTGGAGCTCTTTTTCAACCCAAAGGTGAATATAATG
ATCCTGTATACATTGCAGCCACTGATGGAGTTGGTACAAAATTAAAATTAGCTAGACTGGCAAACAAATTTGATACTATC
GGAATAGATTTGGTAGCTATGTGTGTTAATGATGTACTGGCTCAAGGTGGCCAACCGTTGATATTCTTGGATTATCTTGC
CATGGATAGTTTAGAAGAGGATTTGATTCAGGACATAATCCAGGGAATAGTTGCCGGTTGTCATCAATCTGACTGCAGCC
TGGTTGGTGGAGAAACGGCGGAAATGCCAGGTTTTTATCAGAATGGCCTATTTGATCTGGCTGGTTTTTGTGTTGGGGTA
GTTGAAAAAGATAATATTGTGGATGGTTCATCAATAAAAGAAACAGATCAAGTAATAGGGATTTCGTCTTCAGGAGTACA
CAGTAATGGTCTTTCTTTAGTCCGAAAGACCCTAATTAAAGAAGAAGGTGGTCAATATGAACTGGACGAAACTCCTTCAA
ACTTAGAAACTAACTTGGGAGAAGAACTGTTAAAACCGACTAAGATATATGTAAAGCCCGTTTTGAGCTTAATGGAAAAG
TTTTCAGTAGCGGGTATGGCTCATATTACCGGAGGCGGCCTTCCTGATAATCTGAGCAGAATAGTGCCTGATAATTTATC
TTTTTCCCTTGATTTACAAAAACTGCAAAAGATGGTGTTACCTGTATTTTCATTAATTCAAACAACTGGAGATATACCTG
ATCACGATATGTGGAGAACCTTTAATATGGGAATTGGATTTACAGTAGTATTACCTGCCGAAGAAGCTCAGCAAGCCTGC
GAATTTCTTAGAGAGCAGGGAGAAAAGGCTGAAATTATTGGGACGGTAGAACAACTATCCCAACAACAGGGTGATGGTGT
TCAGAGTGGAGAAAGGGTGATGTTTGTAAATGGAGATAAATAA

Upstream 100 bases:

>100_bases
AATTGTTTCGACCCTACTTATTATACCAGAAACGTGGATTATATTTTTGAGAGATTAGGTATCTAATTTATATTTGAGGA
TTAAGAAGGAGGGGACTTCT

Downstream 100 bases:

>100_bases
AGATCCTAGATATGCTGTATTAGCCTCAGGATCGGGAACAATTTTTCAATCTATAATTGATGCTCAAAAGCGAGGAGATA
TTCCCGGGGAACTGGCTCTT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTGNSYRKAGVDVDKGNKIAENIKELTSSEASGHVISGVGGFGALFQPKGEYNDPVYIAATDGVGTKLKLARLANKFDTI
GIDLVAMCVNDVLAQGGQPLIFLDYLAMDSLEEDLIQDIIQGIVAGCHQSDCSLVGGETAEMPGFYQNGLFDLAGFCVGV
VEKDNIVDGSSIKETDQVIGISSSGVHSNGLSLVRKTLIKEEGGQYELDETPSNLETNLGEELLKPTKIYVKPVLSLMEK
FSVAGMAHITGGGLPDNLSRIVPDNLSFSLDLQKLQKMVLPVFSLIQTTGDIPDHDMWRTFNMGIGFTVVLPAEEAQQAC
EFLREQGEKAEIIGTVEQLSQQQGDGVQSGERVMFVNGDK

Sequences:

>Translated_360_residues
MTGNSYRKAGVDVDKGNKIAENIKELTSSEASGHVISGVGGFGALFQPKGEYNDPVYIAATDGVGTKLKLARLANKFDTI
GIDLVAMCVNDVLAQGGQPLIFLDYLAMDSLEEDLIQDIIQGIVAGCHQSDCSLVGGETAEMPGFYQNGLFDLAGFCVGV
VEKDNIVDGSSIKETDQVIGISSSGVHSNGLSLVRKTLIKEEGGQYELDETPSNLETNLGEELLKPTKIYVKPVLSLMEK
FSVAGMAHITGGGLPDNLSRIVPDNLSFSLDLQKLQKMVLPVFSLIQTTGDIPDHDMWRTFNMGIGFTVVLPAEEAQQAC
EFLREQGEKAEIIGTVEQLSQQQGDGVQSGERVMFVNGDK
>Mature_359_residues
TGNSYRKAGVDVDKGNKIAENIKELTSSEASGHVISGVGGFGALFQPKGEYNDPVYIAATDGVGTKLKLARLANKFDTIG
IDLVAMCVNDVLAQGGQPLIFLDYLAMDSLEEDLIQDIIQGIVAGCHQSDCSLVGGETAEMPGFYQNGLFDLAGFCVGVV
EKDNIVDGSSIKETDQVIGISSSGVHSNGLSLVRKTLIKEEGGQYELDETPSNLETNLGEELLKPTKIYVKPVLSLMEKF
SVAGMAHITGGGLPDNLSRIVPDNLSFSLDLQKLQKMVLPVFSLIQTTGDIPDHDMWRTFNMGIGFTVVLPAEEAQQACE
FLREQGEKAEIIGTVEQLSQQQGDGVQSGERVMFVNGDK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=42.5149700598802, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=42.5149700598802, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=42.5149700598802, Blast_Score=271, Evalue=7e-73,
Organism=Escherichia coli, GI1788845, Length=347, Percent_Identity=48.7031700288184, Blast_Score=314, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI17567511, Length=363, Percent_Identity=37.7410468319559, Blast_Score=227, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=41.5929203539823, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=40.1384083044983, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38641; Mature: 38510

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNSYRKAGVDVDKGNKIAENIKELTSSEASGHVISGVGGFGALFQPKGEYNDPVYIAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEE
TDGVGTKLKLARLANKFDTIGIDLVAMCVNDVLAQGGQPLIFLDYLAMDSLEEDLIQDII
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
QGIVAGCHQSDCSLVGGETAEMPGFYQNGLFDLAGFCVGVVEKDNIVDGSSIKETDQVIG
HHHHHCCCCCCCCEECCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEE
ISSSGVHSNGLSLVRKTLIKEEGGQYELDETPSNLETNLGEELLKPTKIYVKPVLSLMEK
CCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
FSVAGMAHITGGGLPDNLSRIVPDNLSFSLDLQKLQKMVLPVFSLIQTTGDIPDHDMWRT
HHHCCCCEECCCCCCHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHEE
FNMGIGFTVVLPAEEAQQACEFLREQGEKAEIIGTVEQLSQQQGDGVQSGERVMFVNGDK
ECCCCCEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
TGNSYRKAGVDVDKGNKIAENIKELTSSEASGHVISGVGGFGALFQPKGEYNDPVYIAA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEE
TDGVGTKLKLARLANKFDTIGIDLVAMCVNDVLAQGGQPLIFLDYLAMDSLEEDLIQDII
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
QGIVAGCHQSDCSLVGGETAEMPGFYQNGLFDLAGFCVGVVEKDNIVDGSSIKETDQVIG
HHHHHCCCCCCCCEECCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEE
ISSSGVHSNGLSLVRKTLIKEEGGQYELDETPSNLETNLGEELLKPTKIYVKPVLSLMEK
CCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
FSVAGMAHITGGGLPDNLSRIVPDNLSFSLDLQKLQKMVLPVFSLIQTTGDIPDHDMWRT
HHHCCCCEECCCCCCHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCHHHEE
FNMGIGFTVVLPAEEAQQACEFLREQGEKAEIIGTVEQLSQQQGDGVQSGERVMFVNGDK
ECCCCCEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA