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The map label for this gene is gor [C]

Identifier: 188585066

GI number: 188585066

Start: 446941

End: 448311

Strand: Reverse

Name: gor [C]

Synonym: Nther_0427

Alternate gene names: 188585066

Gene position: 448311-446941 (Counterclockwise)

Preceding gene: 188585068

Following gene: 188585057

Centisome position: 14.16

GC content: 35.81

Gene sequence:

>1371_bases
GTGGCTAAAAAAGTTATTATCATTGGGGGAAATGCAGCGGGATTGAGTGCAGCCAGTCAAATTAAACGTCAAAATCCACA
CTGGGATACCATTGTCTTTGAAAGAACTGATGAAGTTTCCTATGCCAGTTGCGGCATTCCATATTATATTCAGGAACAGG
TAACAGATTCTAGTAATTTATACGCTTTAAGTGCAAATAAACTTAAACAGGACAGGGGAATTGACCTTCGTCTTCATACA
GAAATCATGAAAATTAACCCCGAGGATAATAAAGTTATATACAATTCGAAAGATTGTCAAAATAATCTTTTAGAAGAAAG
CTATGATTATTTATTAATTGCTACAGGAACTTCTCCAGATTCCAAGGGAATAACTATAAATTCGGATAAAGTTTTTTCTG
TTAAATACGTTGGAGATGGGGTTAGAATAAAAAATTATCTAAAACAACAAACTCCTAAAAAAGTTGCAGTAATAGGAGGC
GGTTACATCGCCTTAGAAATGGCTGAATCTCTCAAAAATTTAGGTTTAGACACTTATTTTATTCACCGTAGAGATCAGCT
GAATAGGGCTTTTATGCCAGATATATCTCAGGAAGCTTTACAAGTTTTAGAACAAAATAATGTCAATTTGCTTTTAAATA
CTGAGGTTACGAAAATTGAAGATAAATCGAATAATAAAGTTGCAGTTACTACAGAGAGTGGTAATTCGTTGGAATTTGAT
ATGATCATAACTGCTATCGGAGTCCGTCCCAACACCAGTTTTTTGAAAGAATCAGGAATAGAGCTAGGCGTTAATGACAC
CATTAAAACTTCTAGATATATGCAAACTAATTATTCAAATATTTATGCTGCTGGGGATGTAGCCGAAACCGTAAATTTAG
TCACCCAAAAGTCTGTTTTCTCACCTCTAGCACTAAAAGCAAATAAAGAAGGTAGTATTGCCGGTAGTAATATTGCAGCT
GAGGCACATGTTGAAAAGTTTCCAGGTGTATTAAAGACTTCTATATTAAAACTTTTCAATACGGGAATAGCACGGACTGG
TTTGACGGAAAATGAAGCTAATCAGGAAGGATTCAATGCAGAGACGATAGTAATAGATTCACCTAATAAACCGGGTTATT
ATCCCGGTAGTAGGAAGTTGAAAACAGTAATTGTGTTTGAATCTAAAACCGGCAAACTTCTGGGAGCTCAATTAATTGGT
CCAATAGAAGATGCCAAAAAAATTGACACCTTTGCAGTCTTAACGCAAACAGGTGCCACAGTAGATGATATATATCATTT
AGATTTGTCTTATGCACCACCCTTTTCCCCCGTATATGATCCCGTTGTTTTAGCGGGACGGGTAGCACGAAAGCAATCAC
AAAAGTCTTAA

Upstream 100 bases:

>100_bases
TATGTTAAATAATAAAAGGACATTTTTATAGCAAAATAGAAATAGTTATTAGTTATTATCATTATTAATTATTTTAAAAT
ATACTGAAGGAGGAATATTT

Downstream 100 bases:

>100_bases
TTTACTTGACTATTTTGCCGTTAATAAAGACTTTATTTACAGAAAGGGAATCAAGTTCTTGGGGAGGAGTGCTATAAGGA
TCCTCCTCCAGGACCACCAT

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MAKKVIIIGGNAAGLSAASQIKRQNPHWDTIVFERTDEVSYASCGIPYYIQEQVTDSSNLYALSANKLKQDRGIDLRLHT
EIMKINPEDNKVIYNSKDCQNNLLEESYDYLLIATGTSPDSKGITINSDKVFSVKYVGDGVRIKNYLKQQTPKKVAVIGG
GYIALEMAESLKNLGLDTYFIHRRDQLNRAFMPDISQEALQVLEQNNVNLLLNTEVTKIEDKSNNKVAVTTESGNSLEFD
MIITAIGVRPNTSFLKESGIELGVNDTIKTSRYMQTNYSNIYAAGDVAETVNLVTQKSVFSPLALKANKEGSIAGSNIAA
EAHVEKFPGVLKTSILKLFNTGIARTGLTENEANQEGFNAETIVIDSPNKPGYYPGSRKLKTVIVFESKTGKLLGAQLIG
PIEDAKKIDTFAVLTQTGATVDDIYHLDLSYAPPFSPVYDPVVLAGRVARKQSQKS

Sequences:

>Translated_456_residues
MAKKVIIIGGNAAGLSAASQIKRQNPHWDTIVFERTDEVSYASCGIPYYIQEQVTDSSNLYALSANKLKQDRGIDLRLHT
EIMKINPEDNKVIYNSKDCQNNLLEESYDYLLIATGTSPDSKGITINSDKVFSVKYVGDGVRIKNYLKQQTPKKVAVIGG
GYIALEMAESLKNLGLDTYFIHRRDQLNRAFMPDISQEALQVLEQNNVNLLLNTEVTKIEDKSNNKVAVTTESGNSLEFD
MIITAIGVRPNTSFLKESGIELGVNDTIKTSRYMQTNYSNIYAAGDVAETVNLVTQKSVFSPLALKANKEGSIAGSNIAA
EAHVEKFPGVLKTSILKLFNTGIARTGLTENEANQEGFNAETIVIDSPNKPGYYPGSRKLKTVIVFESKTGKLLGAQLIG
PIEDAKKIDTFAVLTQTGATVDDIYHLDLSYAPPFSPVYDPVVLAGRVARKQSQKS
>Mature_455_residues
AKKVIIIGGNAAGLSAASQIKRQNPHWDTIVFERTDEVSYASCGIPYYIQEQVTDSSNLYALSANKLKQDRGIDLRLHTE
IMKINPEDNKVIYNSKDCQNNLLEESYDYLLIATGTSPDSKGITINSDKVFSVKYVGDGVRIKNYLKQQTPKKVAVIGGG
YIALEMAESLKNLGLDTYFIHRRDQLNRAFMPDISQEALQVLEQNNVNLLLNTEVTKIEDKSNNKVAVTTESGNSLEFDM
IITAIGVRPNTSFLKESGIELGVNDTIKTSRYMQTNYSNIYAAGDVAETVNLVTQKSVFSPLALKANKEGSIAGSNIAAE
AHVEKFPGVLKTSILKLFNTGIARTGLTENEANQEGFNAETIVIDSPNKPGYYPGSRKLKTVIVFESKTGKLLGAQLIGP
IEDAKKIDTFAVLTQTGATVDDIYHLDLSYAPPFSPVYDPVVLAGRVARKQSQKS

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=334, Percent_Identity=25.4491017964072, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226437568, Length=334, Percent_Identity=25.4491017964072, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI65787454, Length=334, Percent_Identity=25.4491017964072, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI91199540, Length=500, Percent_Identity=25.4, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI50301238, Length=339, Percent_Identity=26.8436578171091, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789915, Length=336, Percent_Identity=26.7857142857143, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789065, Length=297, Percent_Identity=24.9158249158249, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786307, Length=269, Percent_Identity=26.0223048327138, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788892, Length=295, Percent_Identity=24.7457627118644, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789606, Length=333, Percent_Identity=24.9249249249249, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1787114, Length=239, Percent_Identity=30.1255230125523, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17557007, Length=329, Percent_Identity=25.2279635258359, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564386, Length=264, Percent_Identity=24.2424242424242, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71983419, Length=207, Percent_Identity=29.4685990338164, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=207, Percent_Identity=29.4685990338164, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=220, Percent_Identity=25.4545454545455, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=207, Percent_Identity=27.536231884058, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585130, Length=282, Percent_Identity=26.241134751773, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281359715, Length=292, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281359713, Length=292, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639250, Length=292, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI18543267, Length=292, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639252, Length=292, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639257, Length=292, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 50021; Mature: 49890

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKVIIIGGNAAGLSAASQIKRQNPHWDTIVFERTDEVSYASCGIPYYIQEQVTDSSNL
CCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCEEEHHHCCCCCCE
YALSANKLKQDRGIDLRLHTEIMKINPEDNKVIYNSKDCQNNLLEESYDYLLIATGTSPD
EEEEHHHHHHCCCCEEEEEEEEEEECCCCCEEEECCCCHHHHHHHCCCCEEEEEECCCCC
SKGITINSDKVFSVKYVGDGVRIKNYLKQQTPKKVAVIGGGYIALEMAESLKNLGLDTYF
CCCEEECCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEECCEEEEHHHHHHHHCCCCEEE
IHRRDQLNRAFMPDISQEALQVLEQNNVNLLLNTEVTKIEDKSNNKVAVTTESGNSLEFD
EECHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEEEECCCCCEEEEEECCCCCEEEE
MIITAIGVRPNTSFLKESGIELGVNDTIKTSRYMQTNYSNIYAAGDVAETVNLVTQKSVF
EEEEEECCCCCHHHHHHCCCEECCCCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHC
SPLALKANKEGSIAGSNIAAEAHVEKFPGVLKTSILKLFNTGIARTGLTENEANQEGFNA
CCEEEECCCCCCCCCCCEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
ETIVIDSPNKPGYYPGSRKLKTVIVFESKTGKLLGAQLIGPIEDAKKIDTFAVLTQTGAT
EEEEEECCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHCCCHHHHHHHCEEEEEEECCCC
VDDIYHLDLSYAPPFSPVYDPVVLAGRVARKQSQKS
HHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKKVIIIGGNAAGLSAASQIKRQNPHWDTIVFERTDEVSYASCGIPYYIQEQVTDSSNL
CCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCEEEHHHCCCCCCE
YALSANKLKQDRGIDLRLHTEIMKINPEDNKVIYNSKDCQNNLLEESYDYLLIATGTSPD
EEEEHHHHHHCCCCEEEEEEEEEEECCCCCEEEECCCCHHHHHHHCCCCEEEEEECCCCC
SKGITINSDKVFSVKYVGDGVRIKNYLKQQTPKKVAVIGGGYIALEMAESLKNLGLDTYF
CCCEEECCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEECCEEEEHHHHHHHHCCCCEEE
IHRRDQLNRAFMPDISQEALQVLEQNNVNLLLNTEVTKIEDKSNNKVAVTTESGNSLEFD
EECHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEEEECCCCCEEEEEECCCCCEEEE
MIITAIGVRPNTSFLKESGIELGVNDTIKTSRYMQTNYSNIYAAGDVAETVNLVTQKSVF
EEEEEECCCCCHHHHHHCCCEECCCCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHC
SPLALKANKEGSIAGSNIAAEAHVEKFPGVLKTSILKLFNTGIARTGLTENEANQEGFNA
CCEEEECCCCCCCCCCCEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
ETIVIDSPNKPGYYPGSRKLKTVIVFESKTGKLLGAQLIGPIEDAKKIDTFAVLTQTGAT
EEEEEECCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHCCCHHHHHHHCEEEEEEECCCC
VDDIYHLDLSYAPPFSPVYDPVVLAGRVARKQSQKS
HHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA