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The map label for this gene is glsA

Identifier: 188584940

GI number: 188584940

Start: 317499

End: 318425

Strand: Direct

Name: glsA

Synonym: Nther_0299

Alternate gene names: 188584940

Gene position: 317499-318425 (Clockwise)

Preceding gene: 188584938

Following gene: 188584941

Centisome position: 10.03

GC content: 34.95

Gene sequence:

>927_bases
ATGATTAATAATGTTAATCAGGAGATATTAAGGGCATTTGTAGAAAATAATCGTCCCTTGGCCCATGATGGTAGATTACC
AACTTATATTCCTGCATTAATGAATGCAAATAAGCAAGACTTTGGAATACATATAACTGAACTCGATGGAAATTCACATT
ACTATGGGTCTTTTCAAATACCATTCACTGTTCAAAGTATTTCGAAAATAATAACTTTAGCTATGGCAATTATGGATAAT
GGAGAAGAATTAGTTTTTAGTAGGGTAGGGATGGAGCCTACTGAAGATAAATTTAACTCCATATTACCATTAGAAATGAG
TTCTGCTTATCCACCAAATCCAATGATCAATGCGGGTGCAATTGTTGTAACATCATTGATAAAAGGTAGAACAGCAGGCG
AACAATTTGAACGAATTCTTGACTTTACCAGGGCACTTGCTGATAATAAAAACATTCAAGTCGATGAAAATGCTTTTTTA
TCTGAAAGAGAAACAGGAAATATGAACAGGTCCCTTGCCTATTATTTGAAGGATGCCAATGTTATTAATGGGAATGTAGA
AGAGATTTTAGAAACTTACTTCCGACATTGTTCTATTTTAGTAACTGCCGAAGATTTAAGTAGAATAGCTTATATTTTCG
CTAATGACGGAAAAGATATAGAAGGAAAACAGCTGATACCTGCCAAGGTATGTAAAATTGTCCGCGCAATTATGGCCATG
AGTGGTTTCTATGATGAATCTGGTGAATTTGCTGTTAGGGTTGGTATCCCTGCTAAAAGTGGTGTTGGAGGTGGAATTAT
TGGAGTAGTTCCCGGTTATATGGGTATAGGTCTATACGGTCCAGCCTTAAATAATAAAGGTACAAGTATAGTTGGCTTTA
ATGTCCTGGAGGAATTAACAAGTTATTTACAAGTTGGAATTTATTAA

Upstream 100 bases:

>100_bases
TGCAATAACAGGACGTAATTTGCTGATCTTTTTTAAGGATGAATAGCTGATCAAGAACTATAATTCGACTACTTAAAATT
AAGATAGAATGGGGGATTAT

Downstream 100 bases:

>100_bases
TTAGTATTGTTTAATGATATTTGGGGAGGTAAGCGTGTGATAATAGGATTAGGTGTAGATATCATAGAGATTGCTAGGAT
CAAAAAAGTATATAATAAAT

Product: L-glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MINNVNQEILRAFVENNRPLAHDGRLPTYIPALMNANKQDFGIHITELDGNSHYYGSFQIPFTVQSISKIITLAMAIMDN
GEELVFSRVGMEPTEDKFNSILPLEMSSAYPPNPMINAGAIVVTSLIKGRTAGEQFERILDFTRALADNKNIQVDENAFL
SERETGNMNRSLAYYLKDANVINGNVEEILETYFRHCSILVTAEDLSRIAYIFANDGKDIEGKQLIPAKVCKIVRAIMAM
SGFYDESGEFAVRVGIPAKSGVGGGIIGVVPGYMGIGLYGPALNNKGTSIVGFNVLEELTSYLQVGIY

Sequences:

>Translated_308_residues
MINNVNQEILRAFVENNRPLAHDGRLPTYIPALMNANKQDFGIHITELDGNSHYYGSFQIPFTVQSISKIITLAMAIMDN
GEELVFSRVGMEPTEDKFNSILPLEMSSAYPPNPMINAGAIVVTSLIKGRTAGEQFERILDFTRALADNKNIQVDENAFL
SERETGNMNRSLAYYLKDANVINGNVEEILETYFRHCSILVTAEDLSRIAYIFANDGKDIEGKQLIPAKVCKIVRAIMAM
SGFYDESGEFAVRVGIPAKSGVGGGIIGVVPGYMGIGLYGPALNNKGTSIVGFNVLEELTSYLQVGIY
>Mature_308_residues
MINNVNQEILRAFVENNRPLAHDGRLPTYIPALMNANKQDFGIHITELDGNSHYYGSFQIPFTVQSISKIITLAMAIMDN
GEELVFSRVGMEPTEDKFNSILPLEMSSAYPPNPMINAGAIVVTSLIKGRTAGEQFERILDFTRALADNKNIQVDENAFL
SERETGNMNRSLAYYLKDANVINGNVEEILETYFRHCSILVTAEDLSRIAYIFANDGKDIEGKQLIPAKVCKIVRAIMAM
SGFYDESGEFAVRVGIPAKSGVGGGIIGVVPGYMGIGLYGPALNNKGTSIVGFNVLEELTSYLQVGIY

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=282, Percent_Identity=38.6524822695035, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI20336214, Length=282, Percent_Identity=37.2340425531915, Blast_Score=177, Evalue=9e-45,
Organism=Escherichia coli, GI1787804, Length=309, Percent_Identity=37.5404530744337, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786693, Length=307, Percent_Identity=33.5504885993485, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17532727, Length=292, Percent_Identity=37.6712328767123, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17507019, Length=281, Percent_Identity=37.0106761565836, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI193204073, Length=288, Percent_Identity=35.0694444444444, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193204075, Length=290, Percent_Identity=34.4827586206897, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281363241, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653162, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653158, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI281363239, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653164, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653156, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI116008307, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24653166, Length=294, Percent_Identity=37.0748299319728, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_NATTJ (B2A4X5)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916485.1
- ProteinModelPortal:   B2A4X5
- SMR:   B2A4X5
- GeneID:   6316121
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0299
- HOGENOM:   HBG512335
- OMA:   RNASIAY
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33820; Mature: 33820

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNVNQEILRAFVENNRPLAHDGRLPTYIPALMNANKQDFGIHITELDGNSHYYGSFQI
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEC
PFTVQSISKIITLAMAIMDNGEELVFSRVGMEPTEDKFNSILPLEMSSAYPPNPMINAGA
CEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHCCCCEECCCCCCCCCCCCCCH
IVVTSLIKGRTAGEQFERILDFTRALADNKNIQVDENAFLSERETGNMNRSLAYYLKDAN
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCE
VINGNVEEILETYFRHCSILVTAEDLSRIAYIFANDGKDIEGKQLIPAKVCKIVRAIMAM
EECCCHHHHHHHHHHHCEEEEEHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
SGFYDESGEFAVRVGIPAKSGVGGGIIGVVPGYMGIGLYGPALNNKGTSIVGFNVLEELT
HCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCHHHCCEECCCCCCCCCEEEHHHHHHHHH
SYLQVGIY
HHHHHCCC
>Mature Secondary Structure
MINNVNQEILRAFVENNRPLAHDGRLPTYIPALMNANKQDFGIHITELDGNSHYYGSFQI
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEC
PFTVQSISKIITLAMAIMDNGEELVFSRVGMEPTEDKFNSILPLEMSSAYPPNPMINAGA
CEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHCCCCEECCCCCCCCCCCCCCH
IVVTSLIKGRTAGEQFERILDFTRALADNKNIQVDENAFLSERETGNMNRSLAYYLKDAN
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCE
VINGNVEEILETYFRHCSILVTAEDLSRIAYIFANDGKDIEGKQLIPAKVCKIVRAIMAM
EECCCHHHHHHHHHHHCEEEEEHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
SGFYDESGEFAVRVGIPAKSGVGGGIIGVVPGYMGIGLYGPALNNKGTSIVGFNVLEELT
HCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCHHHCCEECCCCCCCCCEEEHHHHHHHHH
SYLQVGIY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA