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The map label for this gene is penA [H]

Identifier: 188528348

GI number: 188528348

Start: 1580949

End: 1582796

Strand: Reverse

Name: penA [H]

Synonym: HPSH_08110

Alternate gene names: 188528348

Gene position: 1582796-1580949 (Counterclockwise)

Preceding gene: 188528349

Following gene: 188528347

Centisome position: 98.4

GC content: 39.56

Gene sequence:

>1848_bases
ATGGATAATAAAAACATTGATCCCAACTTCAACCCAGAGCGATTTTTAGAAACCCAAAAATACAAGGTCATAGTTACGGC
TTTAGTCTTTTTGTTGCTTTTTATTGTTTTTTTAATGGTGGCTTTTAAAAAAGCTTTTTTTGCCCAAGCCAACATGCCCA
CTCTAGTGATGAGCAAACAAGACACTGCGACTAGGGGGACTATCTATAGTCAAGACAACTACAGCCTGGCCACTTCGCAA
ACCCTTTTCAAACTGGGCTTTGACACAAGGTTTTTAAACCCGGATAAAGAAGATTTTTTCATTGATTTCCTTTCTATTTA
TAGCAATATCCCTAAAAAATCCTTAAAAGACGCTATCAATACGAAAGGCTATACCATTCTAGCCTATGATCTCACGCCCA
ATACCGCTGCTAATCTTAGAGACTTGAATAAGAAATTTTTAACCTTTGGGGTTTTTCAAAATTTCAAAGACGCGCGCGAT
AAAGTGTGGCAAAAGCAAGGGCTAAACATTGAAGTGAGCGGCGTTTCTAGGCATTACCCTTATCAAAATAGCCTAGAGCC
AATCATTGGCTATGTGCAAAAACAAGAAGAAAACAAGCTCACTTTAACTACCGGTAAAAAAGGCGTTGAAAAATCTCAAG
ATCACTTGCTTAAAGCCCAACAAAATGGCATAAGAACAGGCAAAAGAGATGTGAGTTTTAACTTTATCCAAAACCACTCT
TATACAGAGATTGAACGGCTTGATGGCTATGAGGTGTATTTGAGCATTCCTTTAAAACTCCAAAGAGAAATTGAAACCCT
ATTAGACAAAGCTAAAGACAAACTCAAGGCTGAAGAAATCCTAGTGGGTATCATCAACCCTAAAAGCGGGGAAATTTTAT
CGTTAGCTTCAAGCAAGCACTTCAACCCTAATGCAATTAAAACCAGCGATTATGAAAGCTTGAATTTGAGCGTTGCCGAA
AAGGTTTTTGAGCCAGGCAGCACGATTAAACCCATTGTTTATTCCTTGCTGTTAGACAAGAATTTAATCAACCCCAAAGA
ACGCATTGATTTAAACCATGGCTATTACCAATTAGGAAAATACACCATTAAAGACGACTTTATCCCCAGTAAAAAAGCCG
TTGTTGAAGACATTTTGATCCAATCTAGCAATGTGGGCATGATAAAAATCAGCAAAAATCTCAACCCGGAGGATTTCTAT
AACGGGCTTTTAGGCTATGGATTTTCTCAAAAAACGGGCATTGATTTATCTCTAGAAGCCACAGGAAAGATCCCTCCTTT
GTCCGCTTTCAAGCGTGAAGTGTTAAAGGGCAGCATTTCTTATGGCTATGGGTTGAACGCGACTTTTTTGCAGCTTTTAA
GGGCTTATGCGGTGTTTTCTAATGAAGGCAAATTGACTACCCCCTATTTAGTGCAACGAGAAACCGCCCCTAATGGCGAT
ATTTACATCCCTAGTCCCAAACCCACTTTTCAAGTCATCAATCCAAAAAGCGCTAGAAAAATGAAAGAAACCTTAATCAA
AGTGGTGCGTTATGGCACAGGCAAAAACGCTCAATTTGAAGGGCTATACATAGGGGGCAAAACGGGCACGGCTAGGGTTG
CTAAAAACGGGAGTTACAGCGTGCAGTCCTACAACAGCTCTTTTTTTGGGTTCGCTGAAGATGAAAAGCAGGTTTTTACT
ATCGGCGTGGTTATCTTAGGCTCGCACGGCAAGGAAGAATATTACGCTAGCAAGATTGCAGCCCCTATTTTTAAAGAAAT
CACCGAAATTTTAGTGCGTTACAATTACCTATCGCCCTCTATTGCGATTCAAAATGCGTTGGAGAAAAACCGCTTTAAGA
TAAAATAA

Upstream 100 bases:

>100_bases
CGTTGTTGCTACGCCCAATTTTGACAGATTTTATCATCAAAAATTCATGTTCTCATGCGTTGTGAAAATCTAGTGCTACG
CCATTTTCAAGTGAGCGTTC

Downstream 100 bases:

>100_bases
AAGGCTCTTTTTAACCCAAACTCCAAAAAAGGAGTCTAAAGTTGCCGGATCCTGCATTAAGGCTAAATTTAGAGAATAGA
TTAGAAAAAAAATCGTTTAT

Product: cell division protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MDNKNIDPNFNPERFLETQKYKVIVTALVFLLLFIVFLMVAFKKAFFAQANMPTLVMSKQDTATRGTIYSQDNYSLATSQ
TLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYTILAYDLTPNTAANLRDLNKKFLTFGVFQNFKDARD
KVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEENKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
YTEIERLDGYEVYLSIPLKLQREIETLLDKAKDKLKAEEILVGIINPKSGEILSLASSKHFNPNAIKTSDYESLNLSVAE
KVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPEDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSISYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVINPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSVQSYNSSFFGFAEDEKQVFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRFKIK

Sequences:

>Translated_615_residues
MDNKNIDPNFNPERFLETQKYKVIVTALVFLLLFIVFLMVAFKKAFFAQANMPTLVMSKQDTATRGTIYSQDNYSLATSQ
TLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYTILAYDLTPNTAANLRDLNKKFLTFGVFQNFKDARD
KVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEENKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
YTEIERLDGYEVYLSIPLKLQREIETLLDKAKDKLKAEEILVGIINPKSGEILSLASSKHFNPNAIKTSDYESLNLSVAE
KVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPEDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSISYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVINPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSVQSYNSSFFGFAEDEKQVFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRFKIK
>Mature_615_residues
MDNKNIDPNFNPERFLETQKYKVIVTALVFLLLFIVFLMVAFKKAFFAQANMPTLVMSKQDTATRGTIYSQDNYSLATSQ
TLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAINTKGYTILAYDLTPNTAANLRDLNKKFLTFGVFQNFKDARD
KVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEENKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
YTEIERLDGYEVYLSIPLKLQREIETLLDKAKDKLKAEEILVGIINPKSGEILSLASSKHFNPNAIKTSDYESLNLSVAE
KVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPEDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSISYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVINPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSVQSYNSSFFGFAEDEKQVFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRFKIK

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=605, Percent_Identity=26.2809917355372, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786854, Length=478, Percent_Identity=25.7322175732218, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69428; Mature: 69428

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNKNIDPNFNPERFLETQKYKVIVTALVFLLLFIVFLMVAFKKAFFAQANMPTLVMSKQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DTATRGTIYSQDNYSLATSQTLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAIN
CCCCCCEEEECCCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHC
TKGYTILAYDLTPNTAANLRDLNKKFLTFGVFQNFKDARDKVWQKQGLNIEVSGVSRHYP
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
YQNSLEPIIGYVQKQEENKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
CCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
YTEIERLDGYEVYLSIPLKLQREIETLLDKAKDKLKAEEILVGIINPKSGEILSLASSKH
CCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCC
FNPNAIKTSDYESLNLSVAEKVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGK
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHEECCCCEEEECC
YTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPEDFYNGLLGYGFSQKTGIDLSLEA
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEC
TGKIPPLSAFKREVLKGSISYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
IYIPSPKPTFQVINPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYS
EECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCEE
VQSYNSSFFGFAEDEKQVFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPS
EEECCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IAIQNALEKNRFKIK
HHHHHHHHCCCEECC
>Mature Secondary Structure
MDNKNIDPNFNPERFLETQKYKVIVTALVFLLLFIVFLMVAFKKAFFAQANMPTLVMSKQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DTATRGTIYSQDNYSLATSQTLFKLGFDTRFLNPDKEDFFIDFLSIYSNIPKKSLKDAIN
CCCCCCEEEECCCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHC
TKGYTILAYDLTPNTAANLRDLNKKFLTFGVFQNFKDARDKVWQKQGLNIEVSGVSRHYP
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
YQNSLEPIIGYVQKQEENKLTLTTGKKGVEKSQDHLLKAQQNGIRTGKRDVSFNFIQNHS
CCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
YTEIERLDGYEVYLSIPLKLQREIETLLDKAKDKLKAEEILVGIINPKSGEILSLASSKH
CCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCC
FNPNAIKTSDYESLNLSVAEKVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGK
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHEECCCCEEEECC
YTIKDDFIPSKKAVVEDILIQSSNVGMIKISKNLNPEDFYNGLLGYGFSQKTGIDLSLEA
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEC
TGKIPPLSAFKREVLKGSISYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
IYIPSPKPTFQVINPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYS
EECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCEE
VQSYNSSFFGFAEDEKQVFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPS
EEECCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IAIQNALEKNRFKIK
HHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]