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The map label for this gene is folC [H]

Identifier: 188528340

GI number: 188528340

Start: 1570865

End: 1572034

Strand: Direct

Name: folC [H]

Synonym: HPSH_08060

Alternate gene names: 188528340

Gene position: 1570865-1572034 (Clockwise)

Preceding gene: 188528339

Following gene: 209406224

Centisome position: 97.66

GC content: 37.44

Gene sequence:

>1170_bases
ATGAAAAATAGCCATGGATTAAAGGCGTTTTTAGAAACAAAGCCTAAAGAATACCACAAGTTTGACCCTAGCCGTTTTAT
TCAAATTTATAAAGATTTTAAAAACGCTTTTTTTGAGCTTCAAGCGAAAGTCATTCATGTGGTAGGGACTAATGGCAAGG
GCAGCACGGGGCGGTTTTTAACCCTTTTATTAGCCGATCAAAATTTTAAGGTGTTGCATTTCACCTCCCCTCATGTTTTT
GAATTTAGGGAGCGCTTTTTTTTGAATGGTTCTATTGTTGGAGAAAGCGTTTTAGAAAACGCCCACCAGCAATTGCAATC
ACACGCTTTCAGCAGCGCTTGCTCGTATTTTGAATACGCTACCTTACTGGCTGTCATGCTCGCTAAAGATTGCGATTATT
TGGTTTTAGAAGCAGGGCTTGGGGGGGAGTTTGACAGCACGAACGCTTTAGAAAAAACCCTAAGCGTTTTCACCCCCATT
GATTATGATCATAAGGAATTTTTAGGGGATAGTTTAGAAAGCATTGCGCAAACTAAATTAAAAGCGATGGGCTCTCTTAA
CATCATCGCTCCCCAGCAAGAACTGGTTTTAAGTGTGGCTCAAAAAATCGCCAAAGAAAAACACGCAAAATTGGTTTTAG
TCCAAAATGAAATTTCAAAAGGAGTTAGGGATTATATTGAACGCCACCATTTAGCCCATTTTTTAGCGATGAATTTAGAA
GTGGCTCTAAAAGCGTTTGAAACGCTTATGCCTTGCAAAGAACAAGAAGTTTTAAAAAACCTAAAGCCCTTGGATTTAAT
CGGCCGTTGCGAGCTTTTAAGCCCTAATATCTTAATAGATGTGGGGCATAACCCCCATAGCGCCAAAGCCTTAAAAGAAG
AAATCAAACGCATTTTTAACGCTAAAATCATTTTAATTTATAATTGCTATCAAGATAAGGACGCTTTTTTGGTGCTAGAA
ATTTTAAAGCCTGTGGTTAAAAAGGTTTTGATTTTAGAATTGCATCAAGAAAGGGTTATCAAGTTAGAAAAGCTTAAGGG
GATTTTAGAAACTTTAGGGTTAGAATACGCTTTGTTTGAAGATTTGAAAGAAAATGAAAATTATTTGGTGTATGGCTCAT
TTCTGGTAGCTAACGCTTTTTATAAGCGCTATCAAAAGAAGAGGGATTGA

Upstream 100 bases:

>100_bases
CTTAATACCTACCAGAACCGCTATTACGCTATCAATCAGGCTGTGGAACAAACTTTGACTAAATTTGTGGCTCAAATCGC
TTATGAGGGGAAATTCAATA

Downstream 100 bases:

>100_bases
TGCCACAAAACCAACTTGTGATCACCATCATTGATGAATCAGGCTCTAAACAGCTCAAATTTTCTAAAAATTTAAAACGC
AACCTCATCATTTCTGTTGT

Product: folylpolyglutamate synthase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKNSHGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFELQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFTSPHVF
EFRERFFLNGSIVGESVLENAHQQLQSHAFSSACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPI
DYDHKEFLGDSLESIAQTKLKAMGSLNIIAPQQELVLSVAQKIAKEKHAKLVLVQNEISKGVRDYIERHHLAHFLAMNLE
VALKAFETLMPCKEQEVLKNLKPLDLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFNAKIILIYNCYQDKDAFLVLE
ILKPVVKKVLILELHQERVIKLEKLKGILETLGLEYALFEDLKENENYLVYGSFLVANAFYKRYQKKRD

Sequences:

>Translated_389_residues
MKNSHGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFELQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFTSPHVF
EFRERFFLNGSIVGESVLENAHQQLQSHAFSSACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPI
DYDHKEFLGDSLESIAQTKLKAMGSLNIIAPQQELVLSVAQKIAKEKHAKLVLVQNEISKGVRDYIERHHLAHFLAMNLE
VALKAFETLMPCKEQEVLKNLKPLDLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFNAKIILIYNCYQDKDAFLVLE
ILKPVVKKVLILELHQERVIKLEKLKGILETLGLEYALFEDLKENENYLVYGSFLVANAFYKRYQKKRD
>Mature_389_residues
MKNSHGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFELQAKVIHVVGTNGKGSTGRFLTLLLADQNFKVLHFTSPHVF
EFRERFFLNGSIVGESVLENAHQQLQSHAFSSACSYFEYATLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPI
DYDHKEFLGDSLESIAQTKLKAMGSLNIIAPQQELVLSVAQKIAKEKHAKLVLVQNEISKGVRDYIERHHLAHFLAMNLE
VALKAFETLMPCKEQEVLKNLKPLDLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFNAKIILIYNCYQDKDAFLVLE
ILKPVVKKVLILELHQERVIKLEKLKGILETLGLEYALFEDLKENENYLVYGSFLVANAFYKRYQKKRD

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=338, Percent_Identity=24.2603550295858, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI66932990, Length=338, Percent_Identity=24.2603550295858, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1788654, Length=358, Percent_Identity=30.7262569832402, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71984923, Length=325, Percent_Identity=27.6923076923077, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17553150, Length=325, Percent_Identity=27.6923076923077, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17553148, Length=325, Percent_Identity=27.6923076923077, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324815, Length=313, Percent_Identity=27.7955271565495, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323760, Length=343, Percent_Identity=24.4897959183673, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641571, Length=183, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 44438; Mature: 44438

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSHGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFELQAKVIHVVGTNGKGSTGRFL
CCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEE
TLLLADQNFKVLHFTSPHVFEFRERFFLNGSIVGESVLENAHQQLQSHAFSSACSYFEYA
EEEEECCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPIDYDHKEFLGDSLESIAQTKL
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KAMGSLNIIAPQQELVLSVAQKIAKEKHAKLVLVQNEISKGVRDYIERHHLAHFLAMNLE
HHHCCCEEECCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VALKAFETLMPCKEQEVLKNLKPLDLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFN
HHHHHHHHHCCCCHHHHHHCCCCCCHHCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHC
AKIILIYNCYQDKDAFLVLEILKPVVKKVLILELHQERVIKLEKLKGILETLGLEYALFE
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DLKENENYLVYGSFLVANAFYKRYQKKRD
HHHCCCCEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNSHGLKAFLETKPKEYHKFDPSRFIQIYKDFKNAFFELQAKVIHVVGTNGKGSTGRFL
CCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEE
TLLLADQNFKVLHFTSPHVFEFRERFFLNGSIVGESVLENAHQQLQSHAFSSACSYFEYA
EEEEECCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLAVMLAKDCDYLVLEAGLGGEFDSTNALEKTLSVFTPIDYDHKEFLGDSLESIAQTKL
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KAMGSLNIIAPQQELVLSVAQKIAKEKHAKLVLVQNEISKGVRDYIERHHLAHFLAMNLE
HHHCCCEEECCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VALKAFETLMPCKEQEVLKNLKPLDLIGRCELLSPNILIDVGHNPHSAKALKEEIKRIFN
HHHHHHHHHCCCCHHHHHHCCCCCCHHCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHC
AKIILIYNCYQDKDAFLVLEILKPVVKKVLILELHQERVIKLEKLKGILETLGLEYALFE
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DLKENENYLVYGSFLVANAFYKRYQKKRD
HHHCCCCEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]