Click here to switch to the map view.

The map label for this gene is ald2 [H]

Identifier: 188528312

GI number: 188528312

Start: 1544291

End: 1545433

Strand: Direct

Name: ald2 [H]

Synonym: HPSH_07920

Alternate gene names: 188528312

Gene position: 1544291-1545433 (Clockwise)

Preceding gene: 188528310

Following gene: 188528313

Centisome position: 96.01

GC content: 45.49

Gene sequence:

>1143_bases
ATGACTATTGGGCTAGTCAAAGAAAGCATGGATTTAGAATCACGAGTGGCTTTGGTGCCTGATGATGTGGCGCTAATCAT
TCAAAAGGGCGTGGGGGTTTTAGTGGAAAATCAAGCCGGCGCTAATAGCGGTTATAGTAACGAAGCGTATGAGAGCGTGG
GGGCTAAAATCGTGGATACTAAAACGGCGTGGGGGCAGGATTTAGTGGTCAAATGCAAAGAACCTTTAGAGCATGAATAC
CCTTTATTGAAAGAAAAAGCCACGCTGTTTAGTTATTTGGATCTAGCGTATCAAAAAAGCTTGTGCGAAATGTTTATAGA
TAAAAAAATCACTTCCATTTGCACTGAAACCATTGCCGGGCCTAAAAACGACTACCCTATTTTAGCGCCTATGAGCGTGG
TGGCTGGGAGGTTGGCTGCGCATTTAGTCCAGCATTATTTGCTGGCTTTAGAGCATGTTAAGGGGTTTATGGGTAAGGGG
GTCATGCTTGGGGGGTTATCGGGCGCGCAAAGGGCTAAAATCGTCGTGGTTGGAGGCGGTGTGGTTGGCATGGAGAGCGC
GAAGGTGTTGAGCCAAATGGGGGCTAAAGTAACGATTTTAGAATTAGACTACGCTAAATTGCAAAACCACCCCTATTACC
ATTTGTATGATTTAGAAGTTTTAAGCGTGAATGAAGCCAATATCATTCAGGCTTTAAGCGGAGCGGTGGGGCTAGTGGGA
GCGGTGCTAGTTACAGCGAGCCAAACCCCTAAAGTGATCTTAAGAAGGCATTTAAAACACATGCAAAAACAAGGGGTAGT
GATAGATGTGGCTTGCGATTTAGGGGGGTGCATAGAAACCATACGCCAGACAAGCCATTCTAACCCGGTGTATGTGGAAG
AGGATTTGTTGCATTATGGCGTGCCGAACATGCCAGGGATTGCCGCTAAAACAAGCTCTGTAGCTTATAGCCATGCGAGT
GCACCGTATTTGTTGTATTATTTAGAGCATGGCTTGAAGGGCTTTTTAAAAGCCAACACTAAAATCGTGGCAAACACCCT
TGGAGGCTTGAGTGCTTATAACGGCTGTATCACCCAAGAAGGCATCGCTAAAACTTTCAATCTAGCGTTCAAATCGCCCC
TAGAGGTTTTAAAGGAGCTTTAA

Upstream 100 bases:

>100_bases
GTAAAAGAGTAAAACCATTCAAGTTTTTGATAGAAAAACACTCAAATAGTCTTATTGAGCGAATATAATCATAACTGACA
TTACTATTTAAAGGATTAAC

Downstream 100 bases:

>100_bases
AAATAGGCTGTAAAAAAGGGCATGGCGATAAACCATGCGTCTTAATGCGTGGAAATATTTCAAAAAAAAACACTTTTTAA
TGTTATAATCTATCCCAAAA

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTIGLVKESMDLESRVALVPDDVALIIQKGVGVLVENQAGANSGYSNEAYESVGAKIVDTKTAWGQDLVVKCKEPLEHEY
PLLKEKATLFSYLDLAYQKSLCEMFIDKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKG
VMLGGLSGAQRAKIVVVGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALSGAVGLVG
AVLVTASQTPKVILRRHLKHMQKQGVVIDVACDLGGCIETIRQTSHSNPVYVEEDLLHYGVPNMPGIAAKTSSVAYSHAS
APYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGCITQEGIAKTFNLAFKSPLEVLKEL

Sequences:

>Translated_380_residues
MTIGLVKESMDLESRVALVPDDVALIIQKGVGVLVENQAGANSGYSNEAYESVGAKIVDTKTAWGQDLVVKCKEPLEHEY
PLLKEKATLFSYLDLAYQKSLCEMFIDKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKG
VMLGGLSGAQRAKIVVVGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALSGAVGLVG
AVLVTASQTPKVILRRHLKHMQKQGVVIDVACDLGGCIETIRQTSHSNPVYVEEDLLHYGVPNMPGIAAKTSSVAYSHAS
APYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGCITQEGIAKTFNLAFKSPLEVLKEL
>Mature_379_residues
TIGLVKESMDLESRVALVPDDVALIIQKGVGVLVENQAGANSGYSNEAYESVGAKIVDTKTAWGQDLVVKCKEPLEHEYP
LLKEKATLFSYLDLAYQKSLCEMFIDKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGV
MLGGLSGAQRAKIVVVGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALSGAVGLVGA
VLVTASQTPKVILRRHLKHMQKQGVVIDVACDLGGCIETIRQTSHSNPVYVEEDLLHYGVPNMPGIAAKTSSVAYSHASA
PYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGCITQEGIAKTFNLAFKSPLEVLKEL

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=349, Percent_Identity=27.5071633237822, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI122939153, Length=349, Percent_Identity=27.5071633237822, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1787887, Length=312, Percent_Identity=25.3205128205128, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550456, Length=352, Percent_Identity=26.4204545454545, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 40914; Mature: 40783

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGLVKESMDLESRVALVPDDVALIIQKGVGVLVENQAGANSGYSNEAYESVGAKIVDT
CCCCCCHHHCCCCCCEEECCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHCCEEEEC
KTAWGQDLVVKCKEPLEHEYPLLKEKATLFSYLDLAYQKSLCEMFIDKKITSICTETIAG
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGVMLGGLSGAQRAKIVVVGGG
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECC
VVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALSGAVGLVG
EECCHHHHHHHHCCCEEEEEEEEHHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHH
AVLVTASQTPKVILRRHLKHMQKQGVVIDVACDLGGCIETIRQTSHSNPVYVEEDLLHYG
HHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCEEEEHHHHHCC
VPNMPGIAAKTSSVAYSHASAPYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGCITQE
CCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHCCCCCHH
GIAKTFNLAFKSPLEVLKEL
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIGLVKESMDLESRVALVPDDVALIIQKGVGVLVENQAGANSGYSNEAYESVGAKIVDT
CCCCCHHHCCCCCCEEECCCHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHCCEEEEC
KTAWGQDLVVKCKEPLEHEYPLLKEKATLFSYLDLAYQKSLCEMFIDKKITSICTETIAG
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGVMLGGLSGAQRAKIVVVGGG
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECC
VVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALSGAVGLVG
EECCHHHHHHHHCCCEEEEEEEEHHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHH
AVLVTASQTPKVILRRHLKHMQKQGVVIDVACDLGGCIETIRQTSHSNPVYVEEDLLHYG
HHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCEEEEHHHHHCC
VPNMPGIAAKTSSVAYSHASAPYLLYYLEHGLKGFLKANTKIVANTLGGLSAYNGCITQE
CCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHCCCCCHH
GIAKTFNLAFKSPLEVLKEL
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA